Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 7 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | solute carrier family 6 (neurotransmitter transporter), member 7 | 636 aa | 607 aa | 41.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) | 0.0238 | 0 | 0.5 |
Entamoeba histolytica | kinase, PfkB family | 0.0238 | 0 | 0.5 |
Trichomonas vaginalis | ribokinase, putative | 0.0238 | 0 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.2086 | 1 | 1 |
Onchocerca volvulus | 0.1848 | 0.8714 | 1 | |
Schistosoma mansoni | adenosine kinase | 0.2086 | 1 | 1 |
Mycobacterium leprae | Probable adenosine kinase adk | 0.0238 | 0 | 0.5 |
Trichomonas vaginalis | ribokinase, putative | 0.0238 | 0 | 0.5 |
Giardia lamblia | Ribokinase | 0.0238 | 0 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.2086 | 1 | 1 |
Mycobacterium ulcerans | fructokinase, PfkB | 0.0238 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2086 | 1 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.0238 | 0 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.2086 | 1 | 1 |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.0238 | 0 | 0.5 |
Entamoeba histolytica | fructokinase, putative | 0.0238 | 0 | 0.5 |
Mycobacterium ulcerans | carbohydrate kinase CbhK | 0.0238 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0238 | 0 | 0.5 |
Mycobacterium tuberculosis | Ribokinase RbsK | 0.0238 | 0 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.2086 | 1 | 1 |
Echinococcus multilocularis | adenosine kinase | 0.2086 | 1 | 1 |
Entamoeba histolytica | ribokinase, putative | 0.0238 | 0 | 0.5 |
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.0238 | 0 | 0.5 |
Mycobacterium tuberculosis | Adenosine kinase | 0.0238 | 0 | 0.5 |
Toxoplasma gondii | kinase, pfkB family protein | 0.2086 | 1 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.2086 | 1 | 1 |
Leishmania major | adenosine kinase, putative | 0.2086 | 1 | 1 |
Echinococcus granulosus | adenosine kinase | 0.2086 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.586 uM | Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay | ChEMBL. | 25037917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.