TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 367.807 | Formula: C15H14ClN3O4S
H donors: 1 H acceptors: 4 LogP: 2.47 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1cc(/C=N/CCc2ccc(cc2)S(=O)(=O)N)ccc1Cl
InChi: 1S/C15H14ClN3O4S/c16-14-6-3-12(9-15(14)19(20)21)10-18-8-7-11-1-4-13(5-2-11)24(17,22)23/h1-6,9-10H,7-8H2,(H2,17,22,23)/b18-10+
InChiKey: LZFYPNCRPBOULI-VCHYOVAHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	epsilon tubulin, putative	0.007	0.3277	0.2999
Leishmania major	alpha tubulin	0.007	0.3277	0.3051
Trypanosoma brucei	SUMO1/Ulp2, putative	0.0039	0.1384	0.1028
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0031	0.0855	0.0548
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0093	0.4685	0.4326
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0093	0.4685	0.4466
Echinococcus granulosus	peroxisome assembly protein 26	0.007	0.3277	0.3051
Schistosoma mansoni	hypothetical protein	0.0031	0.0903	0.0527
Onchocerca volvulus		0.004	0.1418	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0181	1	1
Leishmania major	beta tubulin	0.0181	1	1
Echinococcus multilocularis	tubulin gamma 1 chain	0.007	0.3277	0.3051
Echinococcus granulosus	tubulin alpha	0.007	0.3277	0.3051
Echinococcus multilocularis	Tubulin beta 2C chain	0.0181	1	1
Toxoplasma gondii	alpha-tubulin I, putative	0.007	0.3277	0.3051
Leishmania major	beta tubulin	0.0181	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0031	0.0855	0.0236
Leishmania major	alpha tubulin	0.007	0.3277	0.3051
Loa Loa (eye worm)	serine/threonine protein phosphatase 5	0.0022	0.0324	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0855	0.0236
Trypanosoma cruzi	alpha tubulin, putative	0.007	0.3277	0.2999
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0176	0.9702	0.9654
Brugia malayi	alpha-tubulin	0.007	0.3277	0.3277
Schistosoma mansoni	tubulin subunit beta	0.0181	1	1
Leishmania major	beta tubulin	0.0181	1	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.007	0.3277	0.3051
Echinococcus granulosus	tubulin subunit beta	0.0181	1	1
Trichomonas vaginalis	tubulin, putative	0.004	0.1418	0.0837
Echinococcus multilocularis	tubulin alpha chain	0.007	0.3277	0.3051
Leishmania major	beta tubulin	0.0181	1	1
Leishmania major	alpha tubulin	0.007	0.3277	0.3051
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0551	0.0235
Loa Loa (eye worm)	tubulin beta chain	0.0031	0.0855	0.0566
Trypanosoma brucei	alpha tubulin	0.007	0.3277	0.2999
Schistosoma mansoni	tubulin subunit beta	0.0181	1	1
Echinococcus granulosus	tubulin alpha chain	0.007	0.3277	0.3051
Trypanosoma cruzi	hypothetical protein	0.0093	0.4685	0.4466
Echinococcus multilocularis	tubulin subunit TubB	0.007	0.3277	0.3051
Echinococcus multilocularis	tubulin alpha	0.007	0.3277	0.3051
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0903	0.0616
Echinococcus multilocularis	tubulin alpha 1C chain	0.007	0.3277	0.3051
Echinococcus multilocularis	tubulin alpha chain	0.007	0.3277	0.3051
Echinococcus multilocularis	caspase 8	0.0027	0.0634	0.032
Loa Loa (eye worm)	BEN-1 protein	0.0181	1	1
Leishmania major	zeta tubulin, putative	0.0031	0.0855	0.0548
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.3277	0.2822
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.3277	0.2822
Echinococcus granulosus	tubulin alpha 3 chain	0.007	0.3277	0.3051
Schistosoma mansoni	SET domain protein	0.0033	0.1018	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1061	0.0779
Echinococcus granulosus	caspase	0.0101	0.5121	0.4957
Echinococcus granulosus	Tubulin beta 2C chain	0.0181	1	1
Echinococcus multilocularis	caspase	0.0101	0.5121	0.4957
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0101	0.5121	0.4957
Schistosoma mansoni	cell adhesion molecule	0.003	0.0827	0.0448
Echinococcus multilocularis	histone lysine N methyltransferase NSD3	0.0033	0.1018	0.0717
Trypanosoma cruzi	metacaspase, putative	0.0027	0.0634	0.0247
Echinococcus granulosus	tubulin beta 1 chain	0.0181	1	1
Echinococcus multilocularis	beta tubulin	0.0181	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.007	0.3277	0.3051
Schistosoma mansoni	hypothetical protein	0.0068	0.3115	0.2831
Trichomonas vaginalis	tubulin gamma chain, putative	0.007	0.3277	0.2822
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0039	0.1384	0.0801
Brugia malayi	Tubulin beta chain	0.0031	0.0855	0.0855
Brugia malayi	hypothetical protein	0.0026	0.0551	0.0551
Schistosoma mansoni	tubulin subunit beta	0.0181	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0551	0.0161
Schistosoma mansoni	tubulin subunit beta	0.0181	1	1
Echinococcus granulosus	tubulin alpha 1C chain	0.007	0.3277	0.3051
Leishmania major	alpha tubulin	0.007	0.3277	0.3051
Mycobacterium ulcerans	cell division protein FtsZ	0.0031	0.0855	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.3277	0.2822
Plasmodium falciparum	sentrin-specific protease 1	0.0039	0.1384	0.1095
Loa Loa (eye worm)	BEN-1 protein	0.0181	1	1
Trypanosoma brucei	alpha tubulin	0.007	0.3277	0.2999
Echinococcus granulosus	Tubulin alpha 1 chain	0.007	0.3277	0.3051
Plasmodium falciparum	alpha tubulin 1	0.007	0.3277	0.3051
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0039	0.1384	0.1384
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0551	0.0253
Leishmania major	alpha tubulin	0.007	0.3277	0.3051
Echinococcus granulosus	tubulin beta 4A class IVa	0.0181	1	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0903	0.0598
Trichomonas vaginalis	tubulin, putative	0.004	0.1418	0.0837
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C48, putative	0.0039	0.1384	0.1028
Leishmania major	beta tubulin	0.0181	1	1
Echinococcus multilocularis	sentrin specific protease 1	0.0039	0.1384	0.1095
Treponema pallidum	cell division protein FtsZ	0.0031	0.0855	0.5
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0031	0.0855	0.0236
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0039	0.1384	0.0801
Giardia lamblia	Alpha-tubulin	0.007	0.3277	0.2648
Plasmodium vivax	sentrin-specific protease 1, putative	0.0039	0.1384	0.1095
Plasmodium vivax	tubulin alpha chain, putative	0.007	0.3277	0.3051
Echinococcus multilocularis	beta tubulin	0.0181	1	1
Echinococcus granulosus	defective proboscis extension response	0.0026	0.0602	0.0288
Echinococcus granulosus	tubulin epsilon chain	0.007	0.3277	0.3051
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0855	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1384	0.1112
Plasmodium falciparum	tubulin delta chain, putative	0.0031	0.0855	0.0548
Echinococcus granulosus	tubulin alpha chain	0.007	0.3277	0.3051
Leishmania major	gamma-tubulin	0.007	0.3277	0.3051
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.3277	0.2822
Trypanosoma brucei	zeta tubulin	0.0031	0.0855	0.0477
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0903	0.0598
Trypanosoma brucei	metacaspase MCA2	0.0027	0.0634	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1384	0.1112
Loa Loa (eye worm)	alpha-tubulin	0.007	0.3277	0.3064
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0551	0.0235
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0903	0.0598
Plasmodium falciparum	tubulin epsilon chain, putative	0.007	0.3277	0.3051
Loa Loa (eye worm)	tubulin beta-2A chain	0.0181	1	1
Schistosoma mansoni	tubulin subunit alpha	0.007	0.3277	0.2999
Echinococcus granulosus	tubulin gamma 1 chain	0.007	0.3277	0.3051
Echinococcus granulosus	tubulin alpha 3 chain	0.007	0.3277	0.3051
Echinococcus granulosus	beta tubulin	0.0181	1	1
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0093	0.4685	0.4685
Echinococcus multilocularis	roundabout 2	0.0034	0.1061	0.0762
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0551	0.0161
Trypanosoma brucei	beta tubulin	0.007	0.3277	0.2999
Echinococcus multilocularis	tubulin alpha 3 chain	0.007	0.3277	0.3051
Trypanosoma brucei	epsilon tubulin	0.007	0.3277	0.2999
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0093	0.4685	0.4326
Leishmania major	beta tubulin	0.0181	1	1
Schistosoma mansoni	tubulin subunit gamma	0.007	0.3277	0.2999
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0026	0.0602	0.0215
Schistosoma mansoni	alpha tubulin	0.007	0.3277	0.2999
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0026	0.0602	0.0602
Chlamydia trachomatis	deubiquitinase/deneddylase Dub2	0.0039	0.1384	0.5
Toxoplasma gondii	beta-tubulin, putative	0.0181	1	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.007	0.3277	0.3051
Echinococcus multilocularis	tubulin alpha 1C chain	0.007	0.3277	0.3051
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0903	0.0598
Loa Loa (eye worm)	hypothetical protein	0.003	0.0827	0.0537
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.007	0.3277	0.3051
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0181	1	1
Leishmania major	beta tubulin	0.0181	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0602	0.0306
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0034	0.1056	0.0774
Schistosoma mansoni	tubulin subunit beta	0.0181	1	1
Trypanosoma brucei	alpha tubulin	0.007	0.3277	0.2999
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0176	0.9702	0.969
Loa Loa (eye worm)	tubulin beta chain	0.0181	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0602	0.0306
Plasmodium falciparum	tubulin beta chain	0.0181	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.007	0.3277	0.3064
Leishmania major	epsilon tubulin, putative	0.007	0.3277	0.3051
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0101	0.5121	0.4957
Schistosoma mansoni	nephrin	0.003	0.0837	0.0459
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0039	0.1384	0.0801
Trypanosoma brucei	Metacaspase-4	0.0027	0.0634	0.0247
Plasmodium vivax	sentrin-specific protease 2, putative	0.0039	0.1384	0.1095
Trypanosoma brucei	beta tubulin	0.0181	1	1
Schistosoma mansoni	tubulin subunit epsilon	0.007	0.3277	0.2999
Plasmodium vivax	tubulin alpha chain, putative	0.007	0.3277	0.3051
Entamoeba histolytica	tubulin family protein	0.0181	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.3115	0.3115
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0634	0.0338
Echinococcus granulosus	Tubulin beta 2C chain	0.0181	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0034	0.1056	0.1056
Echinococcus granulosus	caspase 2	0.0027	0.0634	0.032
Trypanosoma brucei	metacaspase MCA3	0.0027	0.0634	0.0247
Trypanosoma cruzi	tubulin gamma chain	0.007	0.3277	0.2999
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0039	0.1384	0.1028
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0031	0.0855	0.0566
Echinococcus multilocularis	tubulin beta 1 chain	0.0181	1	1
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0031	0.0855	0.5
Trypanosoma brucei	zeta tubulin, putative	0.0031	0.0855	0.0477
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0027	0.0634	0.0634
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0551	0.0161
Echinococcus granulosus	tubulin alpha chain	0.007	0.3277	0.3051
Loa Loa (eye worm)	beta-tubulin	0.0181	1	1
Plasmodium vivax	tubulin epsilon chain, putative	0.007	0.3277	0.3051
Echinococcus granulosus	Tubulin beta 2C chain	0.0181	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.004	0.1418	0.0837
Echinococcus granulosus	Immunoglobulin	0.0026	0.0602	0.0288
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.5022	0.4865
Schistosoma mansoni	hypothetical protein	0.0031	0.0903	0.0527
Echinococcus granulosus	sentrin specific protease 8	0.0093	0.4685	0.4507
Leishmania major	SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative	0.0039	0.1384	0.1095
Leishmania major	beta tubulin	0.0181	1	1
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0026	0.0602	0.0288
Leishmania major	beta tubulin	0.0181	1	1
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0039	0.1384	0.1028
Schistosoma mansoni	caspase-7 (C14 family)	0.0101	0.5121	0.4919
Brugia malayi	Tubulin alpha chain	0.007	0.3277	0.3277
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0039	0.1384	0.1384
Leishmania major	alpha tubulin	0.007	0.3277	0.3051
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.003	0.0827	0.052
Echinococcus granulosus	caspase 3	0.0074	0.3483	0.3265
Schistosoma mansoni	caspase-3 (C14 family)	0.0101	0.5121	0.4919
Loa Loa (eye worm)	Ulp1 protease	0.0093	0.4685	0.4518
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0903	0.0903
Echinococcus granulosus	beta tubulin	0.0181	1	1
Trypanosoma brucei	alpha tubulin, putative	0.004	0.1418	0.1064
Echinococcus multilocularis	Tubulin beta 2C chain	0.0181	1	1
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0039	0.1384	0.0801
Echinococcus granulosus	tubulin alpha 1C chain	0.007	0.3277	0.3051
Schistosoma mansoni	vesicular amine transporter	0.0026	0.0602	0.0215
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0031	0.0855	0.0236
Leishmania major	beta tubulin	0.0181	1	1
Leishmania major	alpha tubulin	0.007	0.3277	0.3051
Leishmania major	hypothetical protein, conserved	0.0026	0.0551	0.0235
Echinococcus multilocularis	Tubulin alpha 1 chain	0.007	0.3277	0.3051
Mycobacterium leprae	cell division protein FtsZ	0.0031	0.0855	0.5
Echinococcus granulosus	sentrin specific protease 1	0.0039	0.1384	0.1095
Schistosoma mansoni	tubulin subunit alpha	0.007	0.3277	0.2999
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0551	0.0235
Echinococcus multilocularis	sentrin specific protease 7	0.0176	0.9702	0.9692
Echinococcus multilocularis	Tubulin alpha 1 chain	0.007	0.3277	0.3051
Echinococcus granulosus	Tubulin beta 2C chain	0.0181	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.007	0.3277	0.3051
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0027	0.0634	0.032
Trypanosoma brucei	tubulin gamma chain	0.007	0.3277	0.2999
Echinococcus multilocularis	tubulin alpha chain	0.007	0.3277	0.3051
Toxoplasma gondii	Ulp1 protease family, C-terminal catalytic domain-containing protein	0.0039	0.1384	0.1095
Trichomonas vaginalis	sentrin/sumo-specific protease, senp8, putative	0.0039	0.1384	0.0801
Trypanosoma brucei	metacaspase	0.0027	0.0634	0.0247
Giardia lamblia	Sentrin specific protease, putative	0.0039	0.1384	0.0579
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0027	0.0634	0.0247
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.5022	0.5022
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1384	0.1112
Schistosoma mansoni	tubulin subunit alpha	0.007	0.3277	0.2999
Giardia lamblia	Beta tubulin	0.0181	1	1
Leishmania major	alpha tubulin	0.007	0.3277	0.3051
Trypanosoma cruzi	metacaspase, putative	0.0027	0.0634	0.0247
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0855	0.0236
Entamoeba histolytica	tubulin alpha-1 chain	0.007	0.3277	0.2197
Onchocerca volvulus		0.0039	0.1384	0.9566
Plasmodium vivax	delta tubulin, putative	0.0031	0.0855	0.0548
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0634	0.0338
Loa Loa (eye worm)	tubulin beta-4 chain	0.0181	1	1
Brugia malayi	Tubulin gamma chain	0.007	0.3277	0.3277
Leishmania major	alpha tubulin	0.007	0.3277	0.3051
Trypanosoma cruzi	tubulin delta chain	0.0031	0.0855	0.0477
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0039	0.1384	0.0801
Leishmania major	beta tubulin	0.0181	1	1
Entamoeba histolytica	tubulin gamma chain	0.007	0.3277	0.2197
Plasmodium vivax	hypothetical protein, conserved	0.0027	0.0634	0.032
Giardia lamblia	Beta tubulin	0.0181	1	1
Brugia malayi	Cell division protein ftsZ	0.0031	0.0855	0.0855
Leishmania major	beta tubulin	0.0181	1	1
Echinococcus granulosus	histone lysine N methyltransferase NSD3	0.0033	0.1018	0.0717
Trypanosoma cruzi	epsilon tubulin, putative	0.007	0.3277	0.2999
Brugia malayi	beta-tubulin, identical	0.0181	1	1
Echinococcus granulosus	tubulin alpha chain	0.007	0.3277	0.3051
Echinococcus granulosus	tubulin subunit TubB	0.007	0.3277	0.3051
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0181	1	1
Trypanosoma cruzi	SUMO1/Ulp2, putative	0.0039	0.1384	0.1028
Echinococcus multilocularis	tubulin delta chain	0.0031	0.0855	0.0548
Echinococcus multilocularis	caspase 2	0.0027	0.0634	0.032
Brugia malayi	Fibronectin type III domain containing protein	0.0026	0.0602	0.0602
Brugia malayi	tubulin alpha-2 chain	0.007	0.3277	0.3277
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0181	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0181	1	1
Echinococcus multilocularis	hypothetical protein	0.007	0.3277	0.3051
Trichomonas vaginalis	tubulin, putative	0.0181	1	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0181	1	1
Brugia malayi	Tubulin alpha-2 chain	0.007	0.3277	0.3277
Toxoplasma gondii	alpha tubulin TUBA1	0.007	0.3277	0.3051
Loa Loa (eye worm)	tubulin gamma chain	0.007	0.3277	0.3064
Trypanosoma brucei	beta tubulin	0.0181	1	1
Schistosoma mansoni	alpha tubulin	0.007	0.3277	0.2999
Echinococcus granulosus	alpha tubulin	0.007	0.3277	0.3051
Loa Loa (eye worm)	Ulp1 protease	0.0039	0.1384	0.1112
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0026	0.0602	0.0215
Brugia malayi	Tubulin alpha-2 chain	0.007	0.3277	0.3277
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.3277	0.2822
Echinococcus multilocularis	tubulin epsilon chain	0.007	0.3277	0.3051
Trichomonas vaginalis	tubulin gamma chain, putative	0.0031	0.0855	0.0236
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0027	0.0634	0.032
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0602	0.0306
Trichomonas vaginalis	tubulin alpha chain, putative	0.004	0.1418	0.0837
Trypanosoma cruzi	tubulin delta chain	0.0031	0.0855	0.0477
Plasmodium falciparum	metacaspase-like protein	0.0027	0.0634	0.032
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0027	0.0634	0.032
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0093	0.4685	0.4326
Trichomonas vaginalis	tubulin alpha chain, putative	0.004	0.1418	0.0837
Trypanosoma brucei	tubulin delta chain	0.0031	0.0855	0.0477
Plasmodium falciparum	metacaspase 1	0.0027	0.0634	0.032
Trichomonas vaginalis	tubulin, putative	0.0031	0.0855	0.0236
Trichomonas vaginalis	tubulin gamma chain, putative	0.0181	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.5022	0.4865
Trichomonas vaginalis	tubulin beta chain, putative	0.004	0.1418	0.0837
Trypanosoma brucei	metacaspase 5, putative	0.0027	0.0634	0.0247
Schistosoma mansoni	caspase-7 (C14 family)	0.0027	0.0634	0.0247
Echinococcus multilocularis	Tubulin beta 2C chain	0.0181	1	1
Schistosoma mansoni	alpha tubulin	0.007	0.3277	0.2999
Schistosoma mansoni	tubulin subunit alpha	0.0031	0.0855	0.0477
Echinococcus granulosus	twitchin	0.003	0.0837	0.053
Echinococcus multilocularis	Immunoglobulin	0.0026	0.0602	0.0288
Trichomonas vaginalis	tubulin beta chain, putative	0.007	0.3277	0.2822
Entamoeba histolytica	tubulin family protein	0.0181	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.1418	0.1147
Giardia lamblia	Gamma tubulin	0.007	0.3277	0.2648
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0903	0.0598
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0039	0.1384	0.1384
Trichomonas vaginalis	tubulin alpha chain, putative	0.004	0.1418	0.0837
Echinococcus granulosus	GPCR family 2	0.0031	0.0903	0.0598
Echinococcus multilocularis	tubulin alpha chain	0.007	0.3277	0.3051
Echinococcus granulosus	Tubulin beta 2C chain	0.0181	1	1
Plasmodium falciparum	alpha tubulin 2	0.007	0.3277	0.3051
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0903	0.0903
Trypanosoma cruzi	metacaspase, putative	0.0027	0.0634	0.0247
Echinococcus multilocularis	expressed conserved protein	0.0137	0.7314	0.7224
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.1384	0.0801
Leishmania major	beta tubulin	0.0181	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0602	0.0306
Echinococcus multilocularis	Tubulin beta 2C chain	0.0181	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0551	0.0235
Leishmania major	beta tubulin	0.0181	1	1
Leishmania major	alpha tubulin	0.007	0.3277	0.3051
Loa Loa (eye worm)	tubulin alpha-2 chain	0.007	0.3277	0.3064
Trichomonas vaginalis	tubulin alpha chain, putative	0.007	0.3277	0.2822
Trichomonas vaginalis	Sentrin-specific protease, putative	0.0093	0.4685	0.4326
Loa Loa (eye worm)	alpha-tubulin	0.007	0.3277	0.3064
Leishmania major	beta tubulin	0.0181	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0181	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.004	0.1418	0.0837
Trypanosoma cruzi	metacaspase 5, putative	0.0027	0.0634	0.0247
Brugia malayi	hypothetical protein	0.0026	0.0602	0.0602
Trypanosoma cruzi	zeta tubulin, putative	0.0031	0.0855	0.0477
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0903	0.0616
Trypanosoma cruzi	beta tubulin, putative	0.0181	1	1
Trypanosoma brucei	beta tubulin	0.0181	1	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0903	0.0527
Loa Loa (eye worm)	tubulin alpha chain	0.007	0.3277	0.3064
Leishmania major	beta tubulin	0.0181	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.007	0.3277	0.3051
Trichomonas vaginalis	tubulin beta chain, putative	0.0181	1	1
Brugia malayi	Tubulin alpha chain	0.0031	0.0855	0.0855
Giardia lamblia	Alpha-tubulin	0.007	0.3277	0.2648
Trichomonas vaginalis	tubulin epsilon chain, putative	0.007	0.3277	0.2822
Brugia malayi	tubulin alpha chain - mouse	0.007	0.3277	0.3277
Schistosoma mansoni	hypothetical protein	0.0031	0.0903	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1061	0.0779
Leishmania major	alpha tubulin	0.007	0.3277	0.3051
Toxoplasma gondii	Ulp1 protease family, C-terminal catalytic domain-containing protein	0.0039	0.1384	0.1095
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.004	0.1418	0.1147
Echinococcus multilocularis	neuroglian	0.003	0.0837	0.053
Trypanosoma cruzi	metacaspase, putative	0.0027	0.0634	0.0247
Brugia malayi	Tubulin beta chain	0.004	0.1418	0.1418
Brugia malayi	serine/threonine protein phosphatase 5	0.0022	0.0324	0.0324
Echinococcus multilocularis	tubulin subunit beta	0.0181	1	1
Trypanosoma cruzi	metacaspase 5, putative	0.0027	0.0634	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0602	0.0306
Trichomonas vaginalis	tubulin epsilon chain, putative	0.007	0.3277	0.2822
Leishmania major	delta tubulin, putative	0.0031	0.0855	0.0548
Echinococcus multilocularis	tubulin alpha chain	0.007	0.3277	0.3051
Trypanosoma brucei	alpha tubulin	0.007	0.3277	0.2999
Schistosoma mansoni	tubulin subunit beta	0.0031	0.0855	0.0477
Trypanosoma cruzi	zeta tubulin, putative	0.0031	0.0855	0.0477
Plasmodium vivax	tubulin gamma chain, putative	0.007	0.3277	0.3051
Echinococcus granulosus	tubulin delta chain	0.0031	0.0855	0.0548
Echinococcus multilocularis	sentrin specific protease 8	0.0093	0.4685	0.4507
Leishmania major	metacaspase, putative	0.0027	0.0634	0.032
Schistosoma mansoni	tubulin subunit beta	0.0181	1	1
Leishmania major	alpha tubulin	0.007	0.3277	0.3051
Plasmodium falciparum	tubulin gamma chain	0.007	0.3277	0.3051
Echinococcus granulosus	neuroglian	0.003	0.0837	0.053
Leishmania major	beta tubulin	0.0181	1	1
Trypanosoma brucei	beta tubulin	0.0181	1	1
Toxoplasma gondii	Ulp1 protease family, C-terminal catalytic domain-containing protein	0.0039	0.1384	0.1095
Echinococcus granulosus	roundabout 2	0.0034	0.1061	0.0762
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0039	0.1384	0.0801
Loa Loa (eye worm)	tubulin alpha 2	0.004	0.1418	0.1147
Echinococcus multilocularis	Immunoglobulin	0.0026	0.0602	0.0288
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0093	0.4685	0.3832
Echinococcus granulosus	sentrin specific protease 7	0.0176	0.9702	0.9692
Leishmania major	beta tubulin	0.0181	1	1
Toxoplasma gondii	beta tubulin	0.0181	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.004	0.1418	0.1147
Brugia malayi	Cell death protein 3 precursor	0.0027	0.0634	0.0634
Echinococcus granulosus	caspase 8	0.0027	0.0634	0.032
Giardia lamblia	Beta tubulin	0.0181	1	1
Plasmodium vivax	tubulin beta chain, putative	0.0181	1	1
Trypanosoma brucei	epsilon tubulin	0.007	0.3277	0.2999
Trypanosoma brucei	epsilon tubulin	0.007	0.3277	0.2999
Echinococcus granulosus	expressed conserved protein	0.0137	0.7314	0.7224
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0031	0.0855	0.0548
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0031	0.0855	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.5022	0.5022
Plasmodium vivax	metacaspase 1, putative	0.0027	0.0634	0.032
Trichomonas vaginalis	tubulin gamma chain, putative	0.007	0.3277	0.2822
Chlamydia trachomatis	deubiquitinase/deneddylase Dub1	0.0039	0.1384	0.5
Echinococcus granulosus	tubulin alpha chain	0.007	0.3277	0.3051
Schistosoma mansoni	tubulin subunit delta	0.0031	0.0855	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0068	0.3115	0.2898
Echinococcus multilocularis	caspase 3	0.0074	0.3483	0.3265
Entamoeba histolytica	tubulin alpha chain, putative	0.007	0.3277	0.2197
Loa Loa (eye worm)	hypothetical protein	0.007	0.3277	0.3064
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.007	0.3277	0.2822
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0602	0.0306

Activities

Activity type	Activity value	Assay description	Source	Reference
Kinact (binding)	= 10.7 nM	Inhibition of human cloned CA9 catalytic domain pre-incubated with enzyme for 15 mins by phenol red based CO2 hydration stopped-flow assay	ChEMBL.	25016228
Kinact (binding)	= 12.5 nM	Inhibition of human cloned CA12 catalytic domain pre-incubated with enzyme for 15 mins by phenol red based CO2 hydration stopped-flow assay	ChEMBL.	25016228
Kinact (binding)	= 24.8 nM	Inhibition of human cloned CA2 pre-incubated with enzyme for 15 mins by phenol red based CO2 hydration stopped-flow assay	ChEMBL.	25016228
Kinact (binding)	= 184 nM	Inhibition of human cloned CA1 pre-incubated with enzyme for 15 mins by phenol red based CO2 hydration stopped-flow assay	ChEMBL.	25016228

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3317646

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 921254