Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0027 | 0.0467 | 0.0083 | |
Onchocerca volvulus | 0.0336 | 1 | 1 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0024 | 0.0387 | 0.0387 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0041 | 0.0909 | 0.0909 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0515 | 0.0132 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0028 | 0.0515 | 0.0515 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0061 | 0.1531 | 0.1497 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0028 | 0.0515 | 0.0515 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0028 | 0.0515 | 0.0477 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0041 | 0.0909 | 0.0909 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0336 | 1 | 1 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0095 | 0.2553 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0027 | 0.0467 | 0.0467 |
Echinococcus multilocularis | lamin | 0.0024 | 0.0387 | 0.0387 |
Echinococcus granulosus | intermediate filament protein | 0.0024 | 0.0387 | 0.0387 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0095 | 0.2553 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0095 | 0.2553 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0188 | 0.5417 | 0.5417 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.009 | 0.2407 | 0.2376 |
Echinococcus multilocularis | musashi | 0.0024 | 0.0387 | 0.0387 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0336 | 1 | 1 |
Brugia malayi | Fli-1 protein | 0.0198 | 0.5743 | 0.5726 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0041 | 0.0909 | 0.0909 |
Echinococcus granulosus | GPCR family 2 | 0.0028 | 0.0515 | 0.0515 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0065 | 0.1649 | 0.1649 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0387 | 0.0387 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0041 | 0.0909 | 0.0542 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0065 | 0.1649 | 0.1649 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0028 | 0.0515 | 0.0477 |
Brugia malayi | intermediate filament protein | 0.0024 | 0.0387 | 0.0349 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0515 | 0.0132 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0095 | 0.2553 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.009 | 0.2407 | 0.2376 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0515 | 0.0515 |
Brugia malayi | Pre-SET motif family protein | 0.0027 | 0.0467 | 0.0429 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0095 | 0.2553 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0024 | 0.0387 | 0.0349 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0041 | 0.0909 | 0.0542 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0027 | 0.0467 | 0.0083 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0095 | 0.2553 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0027 | 0.0467 | 0.0083 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0515 | 0.0132 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.009 | 0.2407 | 0.2407 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1358 | 0.1358 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0028 | 0.0515 | 0.0515 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0041 | 0.0909 | 0.0909 |
Echinococcus granulosus | lamin dm0 | 0.0024 | 0.0387 | 0.0387 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0095 | 0.2553 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0065 | 0.1649 | 0.1616 |
Brugia malayi | Ets-domain containing protein | 0.0065 | 0.1649 | 0.1616 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0041 | 0.0909 | 0.0872 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0095 | 0.2553 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0467 | 0.0467 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0095 | 0.2553 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1531 | 0.1531 |
Schistosoma mansoni | ets-related | 0.0198 | 0.5743 | 0.5571 |
Onchocerca volvulus | 0.0214 | 0.6215 | 0.6063 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0214 | 0.6215 | 0.5 |
Loa Loa (eye worm) | fli-1 protein | 0.0198 | 0.5743 | 0.5743 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0028 | 0.0515 | 0.0515 |
Schistosoma mansoni | gabp alpha | 0.0065 | 0.1649 | 0.1313 |
Loa Loa (eye worm) | intermediate filament protein | 0.0024 | 0.0387 | 0.0387 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0027 | 0.0467 | 0.0083 |
Echinococcus granulosus | lamin | 0.0024 | 0.0387 | 0.0387 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0013 | 0.004 | 0.004 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0515 | 0.0132 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0028 | 0.0515 | 0.0515 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0041 | 0.0909 | 0.0909 |
Brugia malayi | Pre-SET motif family protein | 0.0188 | 0.5417 | 0.5399 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0095 | 0.2553 | 0.5 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0095 | 0.2553 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0027 | 0.0467 | 0.0467 |
Entamoeba histolytica | hypothetical protein | 0.0095 | 0.2553 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0028 | 0.0515 | 0.0515 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0027 | 0.0467 | 0.0467 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0336 | 1 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0026 | 0.0437 | 0.0437 |
Echinococcus multilocularis | lamin dm0 | 0.0024 | 0.0387 | 0.0387 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0065 | 0.1649 | 0.1649 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.1531 | 0.119 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0041 | 0.0909 | 0.0542 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0095 | 0.2553 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0027 | 0.0467 | 0.0083 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0095 | 0.2553 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.2407 | 0.2407 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0374 | 0.0374 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antileishmanial activity against Leishmania major JISH118 promastigotes infected in human THP1 cells by Giemsa staining method | ChEMBL. | 25069019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.