Detailed information for compound 921780

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 492.999 | Formula: C21H21ClN4O4S2
  • H donors: 2 H acceptors: 5 LogP: 4.17 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCC(CC1)S(=O)(=O)c1ccc2c(c1)sc(n2)NC(=O)NC(=O)c1ccccc1Cl
  • InChi: 1S/C21H21ClN4O4S2/c1-26-10-8-13(9-11-26)32(29,30)14-6-7-17-18(12-14)31-21(23-17)25-20(28)24-19(27)15-4-2-3-5-16(15)22/h2-7,12-13H,8-11H2,1H3,(H2,23,24,25,27,28)
  • InChiKey: DCIXBYVDLILGGW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens growth hormone secretagogue receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni rhodopsin-like orphan GPCR growth hormone secretagogue receptor 289 aa 243 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0404 0.1465 0.1531
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.0029 0.003
Echinococcus multilocularis protein TFG 0.011 0.0311 0.0325
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0582 0.2161 0.2753
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0346 0.1238 0.1293
Schistosoma mansoni g1/s-specific cyclin C 0.006 0.0117 0.0108
Echinococcus granulosus Cyclin L1 0.006 0.0117 0.0122
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0346 0.1238 0.4829
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0117 0.05
Echinococcus granulosus cyclin t1 0.006 0.0117 0.0122
Schistosoma mansoni serine/threonine protein kinase 0.0402 0.1455 0.1447
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Plasmodium vivax ferlin, putative 0.007 0.0158 0.1064
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0158 0.1064
Brugia malayi RhoGEF domain containing protein 0.04 0.1451 0.195
Brugia malayi calpain 5 0.007 0.0158 0.0201
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.007 0.0158 0.0165
Entamoeba histolytica calcium-binding protein, putative 0.007 0.0158 0.0711
Giardia lamblia Hypothetical protein 0.0248 0.0854 0.6036
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.007 0.0158 0.0165
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.0889 0.119
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0117 0.05
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.007 0.0158 0.0692
Echinococcus multilocularis Protein lozenge 0.0055 0.0099 0.0103
Brugia malayi Pre-SET motif family protein 0.0207 0.0694 0.0926
Brugia malayi Protein kinase domain containing protein 0.0346 0.1238 0.1662
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.033 0.2291
Loa Loa (eye worm) cyclin C 0.006 0.0117 0.014
Onchocerca volvulus 0.007 0.0158 0.0601
Echinococcus multilocularis cyclin y 0.006 0.0117 0.0122
Echinococcus multilocularis cyclins 0.0248 0.0854 0.0893
Loa Loa (eye worm) sirtuin 4 0.0032 0.0009 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0158 0.1064
Loa Loa (eye worm) hypothetical protein 0.04 0.1451 0.1845
Schistosoma mansoni rac gtpase activating protein 0.04 0.1451 0.1443
Echinococcus granulosus mitogen activated protein kinase 3 0.0078 0.0187 0.0196
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.007 0.0158 0.0165
Brugia malayi Cam kinase protein 1 0.025 0.0862 0.1153
Schistosoma mansoni mctp-related 0.007 0.0158 0.0149
Onchocerca volvulus 0.0441 0.1609 0.6282
Echinococcus multilocularis Cyclin L1 0.006 0.0117 0.0122
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0346 0.1238 0.1293
Echinococcus multilocularis cyclins 0.0248 0.0854 0.0893
Loa Loa (eye worm) cyclin domain-containing protein 0.006 0.0117 0.014
Loa Loa (eye worm) hypothetical protein 0.006 0.0117 0.014
Echinococcus multilocularis calcium dependent protein kinase 0.0222 0.0754 0.0787
Leishmania major hypothetical protein, conserved 0.007 0.0158 0.1064
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0158 0.1064
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.025 0.0862 0.09
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.007 0.0158 0.0165
Echinococcus multilocularis synaptotagmin 0.007 0.0158 0.0165
Plasmodium falciparum calcium-dependent protein kinase 1 0.025 0.0862 0.6089
Echinococcus granulosus synaptotagmin protein 4 0.007 0.0158 0.0165
Trypanosoma brucei predicted C2 domain protein 0.007 0.0158 0.0717
Entamoeba histolytica hypothetical protein, conserved 0.007 0.0158 0.0711
Schistosoma mansoni hypothetical protein 0.007 0.0158 0.0149
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.025 0.0862 0.1092
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0579 0.2646
Brugia malayi Hr1 repeat family protein 0.0582 0.2161 0.291
Entamoeba histolytica C2 domain containing protein 0.007 0.0158 0.0711
Schistosoma mansoni glut4 vesicle protein-related 0.007 0.0158 0.0149
Trypanosoma brucei cdc2-related kinase 1 0.0114 0.033 0.1513
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.006 0.0117 0.0769
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0376 0.1353 0.172
Giardia lamblia Cyclin A 0.0248 0.0854 0.6036
Leishmania major hypothetical protein, conserved 0.007 0.0158 0.1064
Plasmodium vivax hypothetical protein, conserved 0.007 0.0158 0.1064
Echinococcus multilocularis Protein kinase C, brain isozyme 0.2346 0.9069 0.9475
Echinococcus multilocularis synaptotagmin 0.007 0.0158 0.0165
Entamoeba histolytica protein kinase domain containing protein 0.0376 0.1353 0.6252
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0582 0.2161 0.2257
Onchocerca volvulus 0.04 0.1451 0.5662
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0047 0.0065 0.0074
Echinococcus multilocularis cyclin G2 0.006 0.0117 0.0122
Echinococcus multilocularis myotubularin protein 13 0.04 0.1451 0.1516
Plasmodium vivax ferlin, putative 0.007 0.0158 0.1064
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Echinococcus granulosus Immunoglobulin E set 0.007 0.0158 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0065 0.0056
Echinococcus granulosus serine:threonine protein kinase N2 0.0582 0.2161 0.2257
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0889 0.4089
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.0889 0.1127
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.039 0.1409 0.1472
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.022 0.0743 0.3422
Giardia lamblia Cyclin B-like protein 0.006 0.0117 0.0769
Loa Loa (eye worm) hypothetical protein 0.1084 0.4126 0.5266
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.006 0.0117 0.014
Echinococcus granulosus cyclin y 0.006 0.0117 0.0122
Loa Loa (eye worm) CYL-1 protein 0.006 0.0117 0.014
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.001 0.0011
Entamoeba histolytica PH domain containing protein kinase, putative 0.039 0.1409 0.6513
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.039 0.1409 1
Schistosoma mansoni hypothetical protein 0.007 0.0158 0.0149
Echinococcus multilocularis chromatin regulatory protein sir2 0.022 0.0743 0.0776
Leishmania major hypothetical protein, conserved 0.007 0.0158 0.1064
Schistosoma mansoni protein kinase C mu 0.0428 0.1559 0.1551
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.1391 0.533 0.6805
Trypanosoma brucei protein kinase, putative 0.0376 0.1353 0.6255
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0078 0.0187 0.1271
Trypanosoma cruzi cyclin 9, putative 0.006 0.0117 0.0769
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0029 0.003
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.007 0.0158 0.0165
Brugia malayi intracellular kinase 0.0376 0.1353 0.1817
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0158 0.0717
Brugia malayi Protein kinase domain containing protein 0.0582 0.2161 0.291
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.007 0.0158 0.0165
Trypanosoma brucei Silent information regulator 2 related protein 1 0.022 0.0743 0.3427
Schistosoma mansoni unc-13 (munc13) 0.007 0.0158 0.0149
Loa Loa (eye worm) variant SH3 domain-containing protein 0.04 0.1451 0.1845
Loa Loa (eye worm) runx1 0.0055 0.0099 0.0117
Echinococcus granulosus synaptotagmin 0.007 0.0158 0.0165
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0026 0.0024
Entamoeba histolytica protein kinase, putative 0.0098 0.0266 0.1212
Brugia malayi Protein kinase domain containing protein 0.0582 0.2161 0.291
Trichomonas vaginalis CMGC family protein kinase 0.0078 0.0187 0.0827
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0017 0.0034
Toxoplasma gondii cyclin dependent kinase binding protein 0.006 0.0117 0.05
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Toxoplasma gondii hypothetical protein 0.007 0.0158 0.0692
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.007 0.0158 0.0692
Trichomonas vaginalis cyclin B3, putative 0.0248 0.0854 0.3927
Loa Loa (eye worm) hypothetical protein 0.0441 0.1609 0.2047
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.007 0.0158 0.0149
Brugia malayi diacylglycerol kinase 0.04 0.1451 0.195
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.006 0.0117 0.0122
Plasmodium falciparum ferlin, putative 0.007 0.0158 0.1064
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0114 0.033 0.1491
Trichomonas vaginalis cyclin B3, putative 0.006 0.0117 0.05
Mycobacterium ulcerans NAD-dependent deacetylase 0.0032 0.0009 0.5
Toxoplasma gondii hypothetical protein 0.0188 0.062 0.2837
Brugia malayi Copine family protein 0.007 0.0158 0.0201
Schistosoma mansoni cyclin k 0.006 0.0117 0.0108
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.007 0.0083
Trypanosoma cruzi cyclin 6, putative 0.0298 0.1048 0.7419
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0078 0.0187 0.0827
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0032 0.0009 0.002
Echinococcus multilocularis cyclin A3 4 0.006 0.0117 0.0122
Echinococcus granulosus cyclins 0.0248 0.0854 0.0893
Loa Loa (eye worm) C2 domain-containing protein 0.007 0.0158 0.0193
Toxoplasma gondii hypothetical protein 0.007 0.0158 0.0692
Echinococcus granulosus Diacylglycerol kinase theta 0.04 0.1451 0.1516
Loa Loa (eye worm) raf kinase 0.04 0.1451 0.1845
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0806 0.3702
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0471 0.1726 0.1804
Entamoeba histolytica C2 domain containing protein 0.007 0.0158 0.0711
Leishmania major hypothetical protein, conserved 0.007 0.0158 0.1064
Echinococcus granulosus protein kinase C gamma type 0.1946 0.7501 0.7837
Schistosoma mansoni chromatin regulatory protein sir2 0.022 0.0743 0.0734
Schistosoma mansoni diacylglycerol kinase theta 0.04 0.1451 0.1443
Leishmania major mitotic cyclin, putative 0.006 0.0117 0.0769
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.0128 0.0849
Schistosoma mansoni serine/threonine protein kinase 0.039 0.1409 0.1401
Echinococcus granulosus cyclin B3 1 0.0248 0.0854 0.0893
Echinococcus granulosus protein TFG 0.011 0.0311 0.0325
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0346 0.1238 0.1573
Schistosoma mansoni survival motor neuron protein 0.0048 0.007 0.0061
Trichomonas vaginalis cyclins, putative 0.0298 0.1048 0.4827
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0029 0.003
Loa Loa (eye worm) AGC/AKT protein kinase 0.0582 0.2161 0.2753
Brugia malayi Cyclin, N-terminal domain containing protein 0.0359 0.1288 0.173
Loa Loa (eye worm) cyclin domain-containing protein 0.006 0.0117 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0543 0.248
Brugia malayi hypothetical protein 0.0441 0.1609 0.2164
Trichomonas vaginalis AGC family protein kinase 0.0582 0.2161 1
Trichomonas vaginalis cyclin B, putative 0.006 0.0117 0.05
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.007 0.0158 0.0149
Entamoeba histolytica hypothetical protein, conserved 0.0032 0.0009 0.002
Trichomonas vaginalis AGC family protein kinase 0.0582 0.2161 1
Trypanosoma cruzi mitotic cyclin, putative 0.006 0.0117 0.0769
Plasmodium falciparum calcium-dependent protein kinase 4 0.025 0.0862 0.6089
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0889 0.4089
Schistosoma mansoni synaptotagmin 0.007 0.0158 0.0149
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.1888 0.7274 0.7599
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.04 0.1451 0.1845
Leishmania major hypothetical protein, conserved 0.011 0.0311 0.2157
Schistosoma mansoni serine/threonine protein kinase 0.0428 0.1559 0.1551
Brugia malayi Variant SH3 domain containing protein 0.0074 0.0173 0.0221
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Trypanosoma cruzi C2 domain containing protein, putative 0.007 0.0158 0.1064
Plasmodium falciparum ferlin, putative 0.007 0.0158 0.1064
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.025 0.0862 0.09
Plasmodium vivax glutathione reductase, putative 0.0063 0.0128 0.0849
Trypanosoma cruzi synaptotagmin, putative 0.007 0.0158 0.1064
Trichomonas vaginalis cyclin D, putative 0.0248 0.0854 0.3927
Giardia lamblia Hypothetical protein 0.006 0.0117 0.0769
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Trichomonas vaginalis cyclins, putative 0.0248 0.0854 0.3927
Onchocerca volvulus 0.0683 0.2558 1
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.007 0.0158 0.0193
Echinococcus granulosus otoferlin 0.007 0.0158 0.0165
Brugia malayi protein kinase C II. 0.1599 0.6143 0.8297
Trichomonas vaginalis synaptotagmin, putative 0.007 0.0158 0.0692
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0346 0.1238 0.1662
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.022 0.0743 0.524
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.033 0.2291
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0117 0.05
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0376 0.1353 0.6245
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.006 0.0117 0.0122
Loa Loa (eye worm) hypothetical protein 0.0298 0.1048 0.133
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.025 0.0862 0.3978
Loa Loa (eye worm) hypothetical protein 0.04 0.1451 0.1845
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.0804 0.084
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0032 0.0009 0.001
Onchocerca volvulus Cyclin L homolog 0.006 0.0117 0.0439
Trichomonas vaginalis cyclin B, putative 0.006 0.0117 0.05
Echinococcus granulosus synaptotagmin 2 0.007 0.0158 0.0165
Toxoplasma gondii AGC kinase 0.039 0.1409 0.6507
Leishmania major c2 domain protein, putative 0.007 0.0158 0.1064
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0376 0.1353 0.1345
Schistosoma mansoni protein kinase C mu 0.04 0.1451 0.1443
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0032 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.011 0.0311 0.0389
Echinococcus multilocularis cyclins 0.0248 0.0854 0.0893
Entamoeba histolytica cyclin, domain containing protein 0.006 0.0117 0.0519
Echinococcus multilocularis thioredoxin glutathione reductase 0.0063 0.0128 0.0134
Plasmodium vivax thioredoxin reductase, putative 0.0063 0.0128 0.0849
Entamoeba histolytica cyclin, putative 0.0298 0.1048 0.4837
Trypanosoma brucei SIR2-like protein 4, putative 0.0032 0.0009 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0543 0.248
Loa Loa (eye worm) Nedd4-PD 0.007 0.0158 0.0193
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.007 0.0158 0.0717
Schistosoma mansoni Cyclin fold protein 0.006 0.0117 0.0108
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0037 0.0029 0.003
Trichomonas vaginalis cyclin D, putative 0.006 0.0117 0.05
Trichomonas vaginalis AGC family protein kinase 0.0582 0.2161 1
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0362 0.1301 0.1359
Brugia malayi Cyclin, N-terminal domain containing protein 0.006 0.0117 0.0146
Echinococcus granulosus intersectin 2 0.0074 0.0173 0.018
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.006 0.0117 0.0769
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Echinococcus multilocularis protein kinase c eta type 0.04 0.1451 0.1516
Brugia malayi Protein kinase domain containing protein 0.0428 0.1559 0.2096
Echinococcus multilocularis synaptotagmin protein 4 0.007 0.0158 0.0165
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.1637 0.6294 0.8037
Echinococcus granulosus UNCoordinated family member unc 13 0.007 0.0158 0.0165
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0137 0.0419 0.0527
Echinococcus granulosus thioredoxin glutathione reductase 0.0063 0.0128 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0117 0.05
Brugia malayi Cyclin, N-terminal domain containing protein 0.0298 0.1048 0.1405
Plasmodium falciparum double C2-like domain-containing protein 0.007 0.0158 0.1064
Echinococcus multilocularis extended synaptotagmin 2 0.007 0.0158 0.0165
Entamoeba histolytica C2 domain containing protein 0.007 0.0158 0.0711
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.1599 0.6143 0.7843
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.039 0.1409 0.1472
Brugia malayi WW domain containing protein 0.007 0.0158 0.0201
Trypanosoma cruzi cAMP binding protein, putative 0.0075 0.0177 0.12
Echinococcus granulosus cyclin dependent kinase 5 0.0114 0.033 0.0345
Loa Loa (eye worm) PAR-6 protein 0.011 0.0311 0.0389
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.007 0.0158 0.0717
Toxoplasma gondii diacylglycerol kinase, putative 0.04 0.1451 0.67
Schistosoma mansoni hypothetical protein 0.007 0.0158 0.0149
Echinococcus multilocularis active breakpoint cluster region 0.007 0.0158 0.0165
Toxoplasma gondii ferlin family protein 0.007 0.0158 0.0692
Echinococcus granulosus neural cell expressed developmentally 0.007 0.0158 0.0165
Plasmodium falciparum calcium-dependent protein kinase 2 0.025 0.0862 0.6089
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.006 0.0117 0.0525
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0376 0.1353 0.9598
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0047 0.0065 0.0076
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Leishmania major protein kinase A catalytic subunit isoform 1 0.039 0.1409 1
Entamoeba histolytica cyclin family protein 0.0248 0.0854 0.3939
Echinococcus multilocularis mitogen activated protein kinase 0.0078 0.0187 0.0196
Echinococcus granulosus cyclin G2 0.006 0.0117 0.0122
Brugia malayi Cyclin, N-terminal domain containing protein 0.006 0.0117 0.0146
Echinococcus granulosus mitogen activated protein kinase 0.0078 0.0187 0.0196
Trichomonas vaginalis cyclins, putative 0.0298 0.1048 0.4827
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0063 0.0128 1
Echinococcus granulosus active breakpoint cluster region 0.007 0.0158 0.0165
Plasmodium vivax calcium-dependent protein kinase, putative 0.025 0.0862 0.6089
Schistosoma mansoni serine/threonine protein kinase 0.0582 0.2161 0.2153
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Entamoeba histolytica cyclin C, putative 0.006 0.0117 0.0519
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Trypanosoma brucei predicted C2 domain protein 0.007 0.0158 0.0717
Giardia lamblia Kinase, AGC PKA 0.039 0.1409 1
Loa Loa (eye worm) C2 domain-containing protein 0.007 0.0158 0.0193
Echinococcus granulosus cyclins 0.0248 0.0854 0.0893
Trichomonas vaginalis synaptotagmin, putative 0.007 0.0158 0.0692
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0032 0.0009 0.001
Loa Loa (eye worm) thioredoxin reductase 0.0063 0.0128 0.0155
Leishmania major protein kinase A catalytic subunit 0.039 0.1409 1
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.039 0.1409 0.6507
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0029 0.003
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.039 0.1409 0.6516
Entamoeba histolytica diacylglycerol kinase, putative 0.04 0.1451 0.6706
Entamoeba histolytica protein kinase, putative 0.0582 0.2161 1
Trichomonas vaginalis AGC family protein kinase 0.039 0.1409 0.6507
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0543 0.248
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0078 0.0187 0.0851
Loa Loa (eye worm) transcriptional regulator 0.0032 0.0009 0.0003
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.007 0.0158 0.0149
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.007 0.0158 0.0201
Plasmodium falciparum calcium-dependent protein kinase 5 0.025 0.0862 0.6089
Schistosoma mansoni chromatin regulatory protein sir2 0.022 0.0743 0.0734
Trichomonas vaginalis AGC family protein kinase 0.0582 0.2161 1
Brugia malayi follicle stimulating hormone receptor 0.0233 0.0796 0.1065
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0428 0.1559 0.1629
Echinococcus multilocularis cyclin B 0.0298 0.1048 0.1095
Loa Loa (eye worm) hypothetical protein 0.0683 0.2558 0.3261
Loa Loa (eye worm) hypothetical protein 0.04 0.1451 0.1845
Schistosoma mansoni microtubule-associated protein tau 0.0687 0.2572 0.2565
Loa Loa (eye worm) hypothetical protein 0.04 0.1451 0.1845
Trypanosoma brucei synaptotagmin, putative 0.007 0.0158 0.0717
Trichomonas vaginalis calcium-dependent lipid-binding protein, putative 0.007 0.0158 0.0692
Echinococcus granulosus raf serine:threonine protein kinase 0.0402 0.1455 0.152
Loa Loa (eye worm) transcriptional regulator 0.022 0.0743 0.094
Leishmania major trypanothione reductase 0.0063 0.0128 0.0849
Loa Loa (eye worm) hypothetical protein 0.1293 0.4947 0.6314
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0017 0.0034
Schistosoma mansoni cyclins 0.0248 0.0854 0.0846
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.025 0.0862 0.09
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.025 0.0862 0.6089
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0078 0.0187 0.1271
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0003
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.007 0.0158 0.0165
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Plasmodium falciparum glutathione reductase 0.0063 0.0128 0.0849
Echinococcus multilocularis cyclins 0.0248 0.0854 0.0893
Schistosoma mansoni unc-13 (munc13) 0.0471 0.1726 0.1719
Schistosoma mansoni vav2 0.0404 0.1465 0.1457
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0037 0.0029 0.003
Echinococcus granulosus tyrosine protein kinase Src64B 0.0037 0.0029 0.003
Toxoplasma gondii hypothetical protein 0.006 0.0117 0.05
Trichomonas vaginalis synaptotagmin, putative 0.007 0.0158 0.0692
Echinococcus granulosus myotubularin protein 13 0.04 0.1451 0.1516
Onchocerca volvulus 0.0298 0.1048 0.4085
Echinococcus multilocularis RNA directed DNA polymerase 0.1293 0.4947 0.5168
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0158 0.1064
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.007 0.0158 0.0193
Loa Loa (eye worm) AGC/PKA protein kinase 0.039 0.1409 0.1792
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0114 0.033 0.2291
Schistosoma mansoni rho gtpase activating protein 0.007 0.0158 0.0149
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0359 0.1288 0.1346
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0026 0.0023
Brugia malayi protein-tyrosine kinase 0.0034 0.0014 0.0007
Trichomonas vaginalis cyclins, putative 0.0109 0.0311 0.14
Trypanosoma brucei mitotic cyclin 0.006 0.0117 0.0525
Schistosoma mansoni otoferlin 0.007 0.0158 0.0149
Plasmodium falciparum glycogen synthase kinase 3 0.0376 0.1353 0.9598
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.006 0.0117 0.0108
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0359 0.1288 0.1346
Echinococcus multilocularis Rac GTPase activating protein 1 0.04 0.1451 0.1516
Echinococcus granulosus cyclins 0.0248 0.0854 0.0893
Brugia malayi Cyclin, N-terminal domain containing protein 0.006 0.0117 0.0146
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0114 0.033 0.2291
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0158 0.1064
Echinococcus granulosus cyclin b3 0.0248 0.0854 0.0893
Echinococcus granulosus microtubule associated protein 2 0.0687 0.2572 0.2688
Brugia malayi Protein kinase domain containing protein 0.0137 0.0419 0.0555
Trichomonas vaginalis cyclin A, putative 0.0298 0.1048 0.4827
Loa Loa (eye worm) AGC/NDR protein kinase 0.0582 0.2161 0.2753
Schistosoma mansoni diacylglycerol kinase theta 0.04 0.1451 0.1443
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0158 0.0201
Schistosoma mansoni cyclin l 0.006 0.0117 0.0108
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0078 0.0187 0.023
Plasmodium falciparum thioredoxin reductase 0.0063 0.0128 0.0849
Echinococcus granulosus cyclin B 0.0298 0.1048 0.1095
Brugia malayi hypothetical protein 0.0235 0.0804 0.1075
Schistosoma mansoni rabphilin-3a 0.007 0.0158 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Schistosoma mansoni serine/threonine protein kinase 0.0428 0.1559 0.1551
Echinococcus granulosus tyrosine kinase 0.0034 0.0014 0.0015
Trypanosoma cruzi PB1 domain containing protein, putative 0.011 0.0311 0.2157
Entamoeba histolytica C2 domain containing protein 0.007 0.0158 0.0711
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0037 0.0029 0.003
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Entamoeba histolytica hypothetical protein 0.04 0.1451 0.6706
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.039 0.1409 0.1472
Echinococcus multilocularis intersectin 2 0.0074 0.0173 0.018
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.007 0.0158 0.0692
Toxoplasma gondii AGC kinase 0.039 0.1409 0.6507
Trypanosoma cruzi cyclin, putative 0.0298 0.1048 0.7419
Schistosoma mansoni cyclin d 0.006 0.0117 0.0108
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.033 0.2291
Entamoeba histolytica hypothetical protein 0.007 0.0158 0.0711
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Schistosoma mansoni serine/threonine protein kinase 0.039 0.1409 0.1401
Echinococcus granulosus synaptotagmin 0.007 0.0158 0.0165
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0582 0.2161 0.2753
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0032 0.0009 0.001
Trichomonas vaginalis synaptotagmin, putative 0.007 0.0158 0.0692
Loa Loa (eye worm) hypothetical protein 0.025 0.0862 0.1092
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Echinococcus granulosus cyclin dependent kinase 0.0114 0.033 0.0345
Loa Loa (eye worm) hypothetical protein 0.1265 0.4836 0.6173
Echinococcus granulosus beta-adrenergic receptor kinase 0.0047 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Echinococcus multilocularis neural cell expressed, developmentally 0.007 0.0158 0.0165
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0158 0.1064
Loa Loa (eye worm) C2 domain-containing protein 0.007 0.0158 0.0193
Trichomonas vaginalis copine, putative 0.007 0.0158 0.0692
Trichomonas vaginalis synaptotagmin 1,2, putative 0.007 0.0158 0.0692
Brugia malayi cell division control protein 2 homolog 0.0114 0.033 0.0434
Schistosoma mansoni serine/threonine protein kinase 0.2346 0.9069 0.9068
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.007 0.0158 0.1064
Entamoeba histolytica C2 domain containing protein 0.007 0.0158 0.0711
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.033 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Leishmania major cyclin 0.0298 0.1048 0.7419
Entamoeba histolytica C2 domain protein, putative 0.007 0.0158 0.0711
Echinococcus multilocularis serine threonine protein kinase 0.1946 0.7501 0.7837
Echinococcus granulosus extended synaptotagmin 2 0.007 0.0158 0.0165
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0026 0.0027
Trypanosoma cruzi PB1 domain containing protein, putative 0.011 0.0311 0.2157
Trypanosoma brucei rac serine-threonine kinase, putative 0.0582 0.2161 1
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.007 0.0158 0.0165
Echinococcus granulosus cGMP dependent protein kinase 1 0.0032 0.001 0.001
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.025 0.0862 0.09
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.022 0.0743 0.0776
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.039 0.1409 1
Entamoeba histolytica C2 domain containing protein 0.007 0.0158 0.0711
Echinococcus multilocularis 0.007 0.0158 0.0165
Giardia lamblia Hypothetical protein 0.022 0.0743 0.524
Trichomonas vaginalis cyclins, putative 0.006 0.0117 0.05
Echinococcus multilocularis beta adrenergic receptor kinase 0.0047 0.0065 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0694 0.0877
Loa Loa (eye worm) AGC/PKN protein kinase 0.0582 0.2161 0.2753
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.006 0.0117 0.05
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Echinococcus granulosus NEDD4 E3 ubiquitin protein ligase WWP1 0.007 0.0158 0.0165
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.007 0.0158 0.0165
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.039 0.1409 0.6516
Echinococcus granulosus tyrosine protein kinase Lyn 0.0065 0.0137 0.0143
Trypanosoma cruzi Coiled-coil and C2 domain-containing protein 0.007 0.0158 0.1064
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.033 0.0345
Loa Loa (eye worm) cyclin domain-containing protein 0.006 0.0117 0.014
Giardia lamblia G2/mitotic-specific cyclin B 0.0298 0.1048 0.7419
Schistosoma mansoni lozenge 0.0055 0.0099 0.009
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0037 0.0029 0.003
Echinococcus granulosus Rac GTPase activating protein 1 0.04 0.1451 0.1516
Leishmania major phospholipase c-like protein 0.007 0.0158 0.1064
Toxoplasma gondii Elicitor-responsive protein, putative 0.007 0.0158 0.0692
Loa Loa (eye worm) SRC-1 0.0037 0.0029 0.0027
Entamoeba histolytica cell division protein kinase 2, putative 0.0114 0.033 0.1508
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.039 0.1409 1
Onchocerca volvulus 0.007 0.0158 0.0601
Mycobacterium ulcerans Sir2-like regulatory protein 0.0032 0.0009 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.033 0.1491
Loa Loa (eye worm) synaptotagmin-1 0.007 0.0158 0.0193
Echinococcus multilocularis expressed conserved protein 0.0032 0.001 0.001
Schistosoma mansoni serine/threonine protein kinase 0.1599 0.6143 0.6139
Loa Loa (eye worm) copine family protein 0.007 0.0158 0.0193
Entamoeba histolytica hypothetical protein 0.006 0.0117 0.0519
Echinococcus multilocularis synaptotagmin 15 0.007 0.0158 0.0165
Brugia malayi NEDD4.2 0.007 0.0158 0.0201
Brugia malayi Protein kinase domain containing protein 0.0582 0.2161 0.291
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Loa Loa (eye worm) hypothetical protein 0.0235 0.0804 0.1019
Loa Loa (eye worm) transcriptional regulator 0.0032 0.0009 0.0003
Schistosoma mansoni cyclin G2 0.006 0.0117 0.0108
Echinococcus granulosus cyclin dependent kinase 1 0.0114 0.033 0.0345
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.0804 0.084
Brugia malayi RhoGAP domain containing protein 0.0404 0.1465 0.197
Brugia malayi Cyclin, N-terminal domain containing protein 0.006 0.0117 0.0146
Leishmania major hypothetical protein, conserved 0.007 0.0158 0.1064
Echinococcus granulosus myoferlin 0.007 0.0158 0.0165
Loa Loa (eye worm) hypothetical protein 0.0683 0.2558 0.3261
Trichomonas vaginalis copine, putative 0.007 0.0158 0.0692
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0579 0.2646
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.022 0.0743 0.3422
Echinococcus granulosus cyclins 0.0248 0.0854 0.0893
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0065 0.0056
Loa Loa (eye worm) hypothetical protein 0.0683 0.2558 0.3261
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.039 0.1409 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0026 0.0027
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0346 0.1238 0.1573
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Echinococcus multilocularis protein piccolo 0.007 0.0158 0.0165
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.007 0.0158 0.0692
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Echinococcus multilocularis cyclin G2 0.006 0.0117 0.0122
Entamoeba histolytica cyclin, putative 0.0248 0.0854 0.3939
Onchocerca volvulus 0.006 0.0117 0.0439
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0404 0.1465 0.1457
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Onchocerca volvulus 0.04 0.1451 0.5662
Echinococcus granulosus protein kinase shaggy 0.0376 0.1353 0.1413
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Trichomonas vaginalis AGC family protein kinase 0.0582 0.2161 1
Echinococcus multilocularis copine 9 0.007 0.0158 0.0165
Leishmania major protein kinase, putative 0.0032 0.001 0.0001
Trypanosoma brucei C2 domain containing protein, putative 0.007 0.0158 0.0717
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0029 0.003
Plasmodium vivax glycogen synthase kinase 3, putative 0.0376 0.1353 0.9598
Schistosoma mansoni synaptotagmin 0.007 0.0158 0.0149
Loa Loa (eye worm) cyclin domain-containing protein 0.006 0.0117 0.014
Echinococcus granulosus cyclin G2 0.006 0.0117 0.0122
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Brugia malayi Cyclin, N-terminal domain containing protein 0.0298 0.1048 0.1405
Giardia lamblia Kinase, CMGC CDK 0.0114 0.033 0.2291
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0582 0.2161 0.2257
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Loa Loa (eye worm) cyclin domain-containing protein 0.054 0.1995 0.2541
Echinococcus granulosus calcium dependent protein kinase 0.0222 0.0754 0.0787
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0032 0.0009 0.001
Loa Loa (eye worm) C2 domain-containing protein 0.007 0.0158 0.0193
Toxoplasma gondii C2 domain-containing protein 0.007 0.0158 0.0692
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.022 0.0743 0.0776
Echinococcus multilocularis cyclins 0.0248 0.0854 0.0893
Brugia malayi Protein kinase c protein 2 0.1792 0.6899 0.932
Trichomonas vaginalis copine, putative 0.007 0.0158 0.0692
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.039 0.1409 0.1472
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0032 0.0009 0.001
Entamoeba histolytica hypothetical protein 0.007 0.0158 0.0711
Trichomonas vaginalis AGC family protein kinase 0.0582 0.2161 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0037 0.0029 0.003
Onchocerca volvulus 0.007 0.0158 0.0601
Entamoeba histolytica cell division protein kinase 2, putative 0.0114 0.033 0.1508
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0582 0.2161 0.2257
Loa Loa (eye worm) hypothetical protein 0.04 0.1451 0.1845
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0029 0.003
Loa Loa (eye worm) TK protein kinase 0.0034 0.0014 0.0009
Trypanosoma cruzi cyclin, putative 0.0298 0.1048 0.7419
Trypanosoma cruzi cytoskeleton associated protein, putative 0.007 0.0158 0.1064
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0037 0.0029 0.003
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0428 0.1559 0.2096
Brugia malayi Copine VIII 0.007 0.0158 0.0201
Brugia malayi Partitioning defective-6 homolog alpha 0.011 0.0311 0.0409
Brugia malayi Cyclin C 0.006 0.0117 0.0146
Trichomonas vaginalis copine, putative 0.007 0.0158 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Loa Loa (eye worm) hypothetical protein 0.006 0.0117 0.014
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0078 0.0187 0.1271
Leishmania major silent information regulator 2, putative 0.022 0.0743 0.524
Echinococcus multilocularis protein kinase shaggy 0.0376 0.1353 0.1413
Echinococcus multilocularis UNCoordinated family member (unc 13) 0.007 0.0158 0.0165
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.1637 0.6294 0.8503
Schistosoma mansoni protein kinase 0.1888 0.7274 0.7271
Entamoeba histolytica hypothetical protein 0.007 0.0158 0.0711
Entamoeba histolytica diacylglycerol kinase, putative 0.04 0.1451 0.6706
Trichomonas vaginalis CMGC family protein kinase 0.0078 0.0187 0.0827
Plasmodium falciparum cGMP-dependent protein kinase 0.0032 0.001 0.0001
Schistosoma mansoni synaptotagmin-like protein 0.007 0.0158 0.0149
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0014 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0889 0.4089
Echinococcus multilocularis myoferlin 0.007 0.0158 0.0165
Entamoeba histolytica C2 domain containing protein 0.007 0.0158 0.0711
Trichomonas vaginalis cyclin B, putative 0.0298 0.1048 0.4827
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Onchocerca volvulus 0.007 0.0158 0.0601
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.022 0.0743 0.3409
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.006 0.0117 0.0122
Echinococcus granulosus protein piccolo 0.007 0.0158 0.0165
Trichomonas vaginalis cyclins, putative 0.0298 0.1048 0.4827
Echinococcus multilocularis cyclins 0.0248 0.0854 0.0893
Leishmania major cyclin 9, putative 0.006 0.0117 0.0769
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.033 0.0345
Entamoeba histolytica hypothetical protein 0.007 0.0158 0.0711
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0554 0.2053 0.9498
Trypanosoma brucei mitotic cyclin 6 0.0298 0.1048 0.484
Entamoeba histolytica hypothetical protein 0.007 0.0158 0.0711
Echinococcus granulosus cyclin 0.006 0.0117 0.0122
Echinococcus multilocularis cyclins 0.0248 0.0854 0.0893
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.007 0.0158 0.0149
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.022 0.0743 0.524
Echinococcus granulosus copine 9 0.007 0.0158 0.0165
Schistosoma mansoni synaptotagmin 12 0.007 0.0158 0.0149
Trypanosoma brucei cyclin 9 0.006 0.0117 0.0525
Entamoeba histolytica protein kinase, putative 0.0582 0.2161 1
Schistosoma mansoni serine/threonine protein kinase 0.025 0.0862 0.0853
Toxoplasma gondii hypothetical protein 0.007 0.0158 0.0692
Brugia malayi MAP kinase sur-1 0.0078 0.0187 0.0241
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Loa Loa (eye worm) hypothetical protein 0.04 0.1451 0.1845
Loa Loa (eye worm) hypothetical protein 0.039 0.1409 0.1792
Schistosoma mansoni hypothetical protein 0.007 0.0158 0.0149
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0582 0.2161 0.2753
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0014 0.0015
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0039 0.003
Echinococcus granulosus expressed protein 0.0372 0.1337 0.1397
Trypanosoma cruzi cytoskeleton associated protein, putative 0.007 0.0158 0.1064
Entamoeba histolytica protein kinase, putative 0.0376 0.1353 0.6252
Onchocerca volvulus Multiple C2 domain and transmembrane region protein homolog 0.007 0.0158 0.0601
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0428 0.1559 0.1983
Echinococcus multilocularis raf serine:threonine protein kinase 0.0402 0.1455 0.152
Echinococcus multilocularis synaptotagmin 0.007 0.0158 0.0165
Brugia malayi Cyclin, N-terminal domain containing protein 0.054 0.1995 0.2686
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Echinococcus granulosus synaptotagmin 0.007 0.0158 0.0165
Plasmodium falciparum calcium-dependent protein kinase 3 0.025 0.0862 0.6089
Giardia lamblia Kinase, CMGC MAPK 0.0078 0.0187 0.1271
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0404 0.1465 0.1457
Entamoeba histolytica DENN domain protein 0.007 0.0158 0.0711
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.0029 0.003
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0074 0.0173 0.0212
Trichomonas vaginalis CMGC family protein kinase 0.0376 0.1353 0.6245
Entamoeba histolytica C2 domain containing protein 0.007 0.0158 0.0711
Schistosoma mansoni fer-1-related 0.007 0.0158 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.025 0.0862 0.3962
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.039 0.1409 1
Plasmodium vivax hypothetical protein, conserved 0.006 0.0117 0.0769
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.025 0.0862 0.6089
Schistosoma mansoni tyrosine kinase 0.0037 0.0029 0.0019
Trichomonas vaginalis synaptotagmin, putative 0.007 0.0158 0.0692
Trichomonas vaginalis copine, putative 0.007 0.0158 0.0692
Trichomonas vaginalis CMGC family protein kinase 0.0078 0.0187 0.0827
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0037 0.0029 0.003
Brugia malayi Thioredoxin reductase 0.0063 0.0128 0.0161
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.033 0.0413
Echinococcus granulosus cyclin k 0.006 0.0117 0.0122
Entamoeba histolytica protein kinase, putative 0.0582 0.2161 1
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0543 0.248
Onchocerca volvulus 0.007 0.0158 0.0601
Brugia malayi Cyclin, N-terminal domain containing protein 0.006 0.0117 0.0146
Brugia malayi protein kinase C3,putative 0.192 0.7401 1
Leishmania major hypothetical protein, conserved 0.007 0.0158 0.1064
Trichomonas vaginalis cyclin B3, putative 0.006 0.0117 0.05
Onchocerca volvulus 0.011 0.0311 0.1201
Onchocerca volvulus 0.0376 0.1353 0.5279
Plasmodium vivax cyclin homologue, putative 0.006 0.0117 0.0769
Echinococcus granulosus oligomeric golgi complex subunit 3 0.006 0.0117 0.0122
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Echinococcus granulosus C2 calcium dependent membrane targeting 0.007 0.0158 0.0165
Echinococcus multilocularis protein kinase c epsilon type 0.1599 0.6143 0.6418
Echinococcus granulosus C2 calcium dependent membrane targeting 0.007 0.0158 0.0165
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0404 0.1465 0.1864
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.025 0.0862 0.3962
Echinococcus multilocularis partitioning defective protein 6 0.011 0.0311 0.0325
Echinococcus granulosus NDR protein kinase 0.0582 0.2161 0.2257
Onchocerca volvulus 0.007 0.0158 0.0601
Echinococcus multilocularis cyclin dependent kinase 0.0114 0.033 0.0345
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0117 0.0769
Trichomonas vaginalis ion channel nompc, putative 0.007 0.0158 0.0692
Brugia malayi Synaptotagmin protein 3 0.007 0.0158 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Plasmodium falciparum cyclin 1 0.006 0.0117 0.0769
Brugia malayi transcriptional regulator, Sir2 family protein 0.022 0.0743 0.0992
Trypanosoma brucei trypanothione reductase 0.0063 0.0128 0.0577
Echinococcus multilocularis synaptotagmin 0.007 0.0158 0.0165
Entamoeba histolytica cyclin family protein 0.0248 0.0854 0.3939
Echinococcus multilocularis cyclin y 0.006 0.0117 0.0122
Giardia lamblia Hypothetical protein 0.006 0.0117 0.0769
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0158 0.1064
Trichomonas vaginalis synaptotagmin 1,2, putative 0.007 0.0158 0.0692
Entamoeba histolytica hypothetical protein 0.007 0.0158 0.0711
Entamoeba histolytica Rap/Ran GTPase activating protein, putative 0.007 0.0158 0.0711
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.033 0.0321
Schistosoma mansoni hypothetical protein 0.006 0.0117 0.0108
Echinococcus multilocularis cyclin dependent kinase 5 0.0114 0.033 0.0345
Echinococcus multilocularis cyclin 0.006 0.0117 0.0122
Schistosoma mansoni serine/threonine protein kinase 0.0346 0.1238 0.123
Trypanosoma brucei C2 domain containing protein, putative 0.007 0.0158 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Brugia malayi hypothetical protein 0.006 0.0117 0.0146
Loa Loa (eye worm) cyclin domain-containing protein 0.006 0.0117 0.014
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0582 0.2161 0.2753
Schistosoma mansoni serine/threonine protein kinase 0.0582 0.2161 0.2153
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.033 0.1491
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.007 0.0158 0.0149
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.022 0.0743 0.3409
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0582 0.2161 0.2257
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0543 0.248
Loa Loa (eye worm) hypothetical protein 0.1694 0.6515 0.8319
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0032 0.001 0.001
Onchocerca volvulus Protein CNPPD1 homolog 0.006 0.0117 0.0439
Loa Loa (eye worm) hypothetical protein 0.0087 0.0222 0.0275
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0187 0.0178
Schistosoma mansoni Mername-AA248 (C02 family) 0.007 0.0158 0.0149
Trypanosoma brucei C2 domain containing protein, putative 0.007 0.0158 0.0717
Plasmodium falciparum protein kinase 5 0.0114 0.033 0.2291
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0543 0.2108
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Trichomonas vaginalis annexin VII, putative 0.007 0.0158 0.0692
Trichomonas vaginalis CMGC family protein kinase 0.0376 0.1353 0.6245
Echinococcus granulosus unc 13 munc13 0.0471 0.1726 0.1804
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0014 0.0015
Loa Loa (eye worm) C2 domain-containing protein 0.007 0.0158 0.0193
Echinococcus multilocularis protein kinase c iota type 0.2474 0.9571 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.025 0.0862 0.1153
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0298 0.1048 0.7419
Trichomonas vaginalis splicing factor 3A subunit, putative 0.007 0.0158 0.0692
Schistosoma mansoni hypothetical protein 0.04 0.1451 0.1443
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.025 0.0862 0.3962
Trichomonas vaginalis synaptotagmin 1,2, putative 0.007 0.0158 0.0692
Echinococcus granulosus cyclins 0.0248 0.0854 0.0893
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.039 0.1409 1
Trichomonas vaginalis synaptotagmin, putative 0.007 0.0158 0.0692
Echinococcus multilocularis cyclin b3 0.0248 0.0854 0.0893
Schistosoma mansoni cyclin B 0.0298 0.1048 0.1039
Toxoplasma gondii thioredoxin reductase 0.0063 0.0128 0.0552
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.007 0.0158 0.0165
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.033 0.1491
Trichomonas vaginalis cyclin B, putative 0.0248 0.0854 0.3927
Leishmania major copine i-like protein 0.007 0.0158 0.1064
Loa Loa (eye worm) hypothetical protein 0.0298 0.1048 0.133
Echinococcus granulosus N chimaerin 0.0404 0.1465 0.1531
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0376 0.1353 0.1413
Echinococcus granulosus protein kinase c iota type 0.2474 0.9571 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.007 0.0158 0.0149
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.025 0.0862 0.3962
Echinococcus multilocularis serine:threonine protein kinase N2 0.1128 0.4299 0.4491
Brugia malayi LD23056p 0.007 0.0158 0.0201
Trichomonas vaginalis CMGC family protein kinase 0.0078 0.0187 0.0827
Plasmodium vivax cyclin 4, putative 0.006 0.0117 0.0769
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0404 0.1465 0.1531
Brugia malayi C1-like domain containing protein 0.0428 0.1559 0.2096
Leishmania major mitotic cyclin, putative 0.006 0.0117 0.0769
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Schistosoma mansoni chromatin regulatory protein sir2 0.022 0.0743 0.0734
Trichomonas vaginalis cyclins, putative 0.006 0.0117 0.05
Echinococcus granulosus cGMP dependent protein kinase 0.0032 0.001 0.001
Trichomonas vaginalis cyclin B, putative 0.0298 0.1048 0.4827
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0047 0.0065 0.0074
Echinococcus multilocularis G1:S specific cyclin D1 0.006 0.0117 0.0122
Schistosoma mansoni synaptotagmin 0.007 0.0158 0.0149
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0078 0.0187 0.1271
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0158 0.1064
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0428 0.1559 0.1629
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.033 0.2291
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0582 0.2161 0.2257
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0543 0.248
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Echinococcus multilocularis Diacylglycerol kinase theta 0.04 0.1451 0.1516
Brugia malayi Synapse defective protein 1 0.007 0.0158 0.0201
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.1293 0.4947 0.5168
Trichomonas vaginalis cyclins, putative 0.0298 0.1048 0.4827
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0114 0.033 0.0413
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.039 0.1409 0.1472
Loa Loa (eye worm) cyclin domain-containing protein 0.0359 0.1288 0.1637
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.0029 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0889 0.4089
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Echinococcus multilocularis microtubule associated protein 2 0.0687 0.2572 0.2688
Leishmania major protein kinase A catalytic subunit isoform 2 0.039 0.1409 1
Echinococcus granulosus C2 calcium dependent membrane targeting 0.007 0.0158 0.0165
Trypanosoma brucei C2 domain containing protein, putative 0.007 0.0158 0.0717
Echinococcus multilocularis N chimaerin 0.0404 0.1465 0.1531
Schistosoma mansoni synaptotagmin 0.007 0.0158 0.0149
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.033 0.0413
Leishmania major protein kinase, putative 0.025 0.0862 0.6089
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.039 0.1409 0.1894
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0158 0.0717
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0032 0.0009 0.002
Onchocerca volvulus 0.0236 0.0806 0.3137
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Schistosoma mansoni serine/threonine protein kinase 0.2346 0.9069 0.9068
Loa Loa (eye worm) AGC/PKA protein kinase 0.039 0.1409 0.1792
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Echinococcus multilocularis cyclin t1 0.006 0.0117 0.0122
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.039 0.1409 0.1472
Trichomonas vaginalis vab10 spectraplakin, putative 0.007 0.0158 0.0692
Schistosoma mansoni protein kinase C 0.0471 0.1726 0.1719
Echinococcus multilocularis NEDD4 E3 ubiquitin protein ligase WWP1 0.007 0.0158 0.0165
Plasmodium vivax protein kinase Crk2 0.0114 0.033 0.2291
Brugia malayi phospholipase C homolog 0.007 0.0158 0.0201
Brugia malayi cyclin fold protein 1 variant b 0.006 0.0117 0.0146
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0362 0.1301 0.1359
Schistosoma mansoni cell polarity protein 0.011 0.0311 0.0302
Leishmania major c2 domain protein, putative 0.007 0.0158 0.1064
Schistosoma mansoni cyclin G 0.006 0.0117 0.0108
Giardia lamblia Cyclin fold protein 1, putative 0.006 0.0117 0.0769
Trichomonas vaginalis AGC family protein kinase 0.0582 0.2161 1
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0582 0.2161 0.2257
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.025 0.0862 0.09
Echinococcus granulosus cGMP dependent protein kinase 1 0.0032 0.001 0.001
Trichomonas vaginalis AGC family protein kinase 0.0582 0.2161 1
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0032 0.0009 0.0026
Entamoeba histolytica cyclin, domain containing protein 0.006 0.0117 0.0519
Loa Loa (eye worm) RasGEF domain-containing protein 0.04 0.1451 0.1845
Trypanosoma brucei predicted C2 domain protein 0.007 0.0158 0.0717
Echinococcus granulosus synaptotagmin 0.007 0.0158 0.0165
Trypanosoma brucei protein kinase, putative 0.0078 0.0187 0.0851
Trypanosoma cruzi mitotic cyclin, putative 0.006 0.0117 0.0769
Entamoeba histolytica C2 domain containing protein 0.007 0.0158 0.0711
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0014 0.0015
Schistosoma mansoni unc-13 (munc13) 0.0471 0.1726 0.1719
Brugia malayi glutathione reductase 0.0063 0.0128 0.0161
Schistosoma mansoni synaptotagmin 12 0.007 0.0158 0.0149
Entamoeba histolytica hypothetical protein, conserved 0.007 0.0158 0.0711
Leishmania major hypothetical protein, conserved 0.0075 0.0177 0.12
Brugia malayi Ras association domain family 1 isoform A 0.04 0.1451 0.195
Brugia malayi hypothetical protein 0.006 0.0117 0.0146
Trypanosoma brucei cAMP binding protein, putative 0.0075 0.0177 0.0805
Echinococcus granulosus copine 9 0.007 0.0158 0.0165
Trypanosoma brucei cyclin 3 0.006 0.0117 0.0525
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.1888 0.7274 0.7599
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.04 0.1451 0.1845
Schistosoma mansoni hypothetical protein 0.007 0.0158 0.0149
Echinococcus multilocularis serine:threonine protein kinase 38 0.0582 0.2161 0.2257
Brugia malayi Synapse defective protein 1 0.007 0.0158 0.0201
Echinococcus granulosus protein kinase c epsilon type 0.1599 0.6143 0.6418
Toxoplasma gondii Sma protein 0.007 0.0158 0.0692
Echinococcus granulosus protein kinase c eta type 0.04 0.1451 0.1516
Brugia malayi p70 ribosomal S6 kinase beta 0.0582 0.2161 0.291
Trichomonas vaginalis AGC family protein kinase 0.0582 0.2161 1
Echinococcus granulosus Protein kinase C brain isozyme 0.2346 0.9069 0.9475
Echinococcus granulosus G1:S specific cyclin D1 0.006 0.0117 0.0122
Loa Loa (eye worm) glutathione reductase 0.0063 0.0128 0.0155
Toxoplasma gondii cyclin 4, putative 0.006 0.0117 0.05
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.039 0.1409 0.1472
Entamoeba histolytica PH domain containing protein kinase, putative 0.039 0.1409 0.6513
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.007 0.0158 0.0149
Schistosoma mansoni protein kinase 0.1888 0.7274 0.7271
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Onchocerca volvulus Protein TFG homolog 0.011 0.0311 0.1201
Schistosoma mansoni cyclin B3 0.0359 0.1288 0.128
Trichomonas vaginalis Proline-rich protein, putative 0.007 0.0158 0.0692
Echinococcus multilocularis unc 13 (munc13) 0.0471 0.1726 0.1804
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.025 0.0862 0.09
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0158 0.0692
Schistosoma mansoni hypothetical protein 0.0048 0.007 0.0061
Echinococcus multilocularis copine 9 0.007 0.0158 0.0165
Giardia lamblia Kinase, CMGC GSK 0.0376 0.1353 0.9598
Echinococcus granulosus serine:threonine protein kinase N2 0.0574 0.2128 0.2224
Loa Loa (eye worm) hypothetical protein 0.04 0.1451 0.1845
Schistosoma mansoni serine/threonine kinase 0.0582 0.2161 0.2153
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0039 0.003
Trypanosoma brucei Coiled-coil and C2 domain-containing protein 0.007 0.0158 0.0717
Giardia lamblia Kinase, CMGC CDK 0.0114 0.033 0.2291
Schistosoma mansoni synaptotagmin 0.007 0.0158 0.0149
Plasmodium vivax double C2-like domain-containing protein, putative 0.007 0.0158 0.1064
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0065 0.0056
Echinococcus multilocularis cyclin B3 1 0.0248 0.0854 0.0893
Echinococcus multilocularis serine:threonine protein kinase N2 0.0582 0.2161 0.2257
Leishmania major protein kinase, putative 0.0032 0.001 0.0001
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.025 0.0862 0.1092
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.0854 0.3927
Brugia malayi Protein kinase domain containing protein 0.0114 0.033 0.0434
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.007 0.0158 0.1064
Brugia malayi RhoGAP domain containing protein 0.04 0.1451 0.195
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.007 0.0158 0.0165
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0543 0.248
Trichomonas vaginalis cyclin D, putative 0.0248 0.0854 0.3927
Echinococcus granulosus cyclin A3 4 0.006 0.0117 0.0122
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0078 0.0187 0.1271
Onchocerca volvulus Putative cc2d1b protein 0.007 0.0158 0.0601
Trichomonas vaginalis cyclin B, putative 0.0298 0.1048 0.4827
Brugia malayi Synaptotagmin I 0.007 0.0158 0.0201
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0114 0.033 0.0345
Schistosoma mansoni hypothetical protein 0.006 0.0117 0.0108
Trichomonas vaginalis AGC family protein kinase 0.0582 0.2161 1
Entamoeba histolytica protein kinase, putative 0.0582 0.2161 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0076 0.0088
Onchocerca volvulus 0.0471 0.1726 0.6742
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0889 0.4089
Brugia malayi SRC-1 0.0037 0.0029 0.0026
Echinococcus granulosus calpain 5 0.007 0.0158 0.0165
Trypanosoma cruzi CYC2-like cyclin, putative 0.0298 0.1048 0.7419
Brugia malayi Cyclin, N-terminal domain containing protein 0.006 0.0117 0.0146
Schistosoma mansoni copine 0.007 0.0158 0.0149
Entamoeba histolytica PH domain containing protein kinase, putative 0.0574 0.2128 0.9851
Echinococcus multilocularis calpain 5 0.007 0.0158 0.0165
Entamoeba histolytica protein kinase, putative 0.0321 0.1138 0.5254
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0471 0.1726 0.1804
Plasmodium falciparum cyclin 0.0248 0.0854 0.6036
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0032 0.001 0.0001
Echinococcus granulosus cyclin y 0.006 0.0117 0.0122
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0376 0.1353 0.172
Loa Loa (eye worm) zinc finger protein 0.011 0.0311 0.0389
Trypanosoma brucei PB1 domain containing protein, putative 0.011 0.0311 0.1426
Onchocerca volvulus 0.007 0.0158 0.0601
Brugia malayi diacylglycerol kinase 0.04 0.1451 0.195
Onchocerca volvulus 0.0048 0.007 0.0257
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.0796 0.1009
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.006 0.0117 0.0769
Leishmania major hypothetical protein, conserved 0.007 0.0158 0.1064
Trichomonas vaginalis AGC family protein kinase 0.0582 0.2161 1
Trichomonas vaginalis synaptotagmin, putative 0.007 0.0158 0.0692
Schistosoma mansoni serine/threonine protein kinase 0.0582 0.2161 0.2153
Echinococcus multilocularis synaptotagmin 0.007 0.0158 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.039 0.1409 0.1401
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0376 0.1353 0.1413
Loa Loa (eye worm) C2 domain-containing protein 0.007 0.0158 0.0193
Trichomonas vaginalis cyclin A, putative 0.006 0.0117 0.05
Trypanosoma brucei cdc2-related kinase 3 0.0114 0.033 0.1513
Echinococcus multilocularis cyclin k 0.006 0.0117 0.0122
Echinococcus granulosus synaptotagmin 0.007 0.0158 0.0165
Trichomonas vaginalis Circumsporozoite protein precursor, putative 0.007 0.0158 0.0692
Schistosoma mansoni tyrosine kinase 0.0037 0.0029 0.0019
Echinococcus granulosus RNA directed DNA polymerase 0.1293 0.4947 0.5168
Echinococcus granulosus synaptotagmin 15 0.007 0.0158 0.0165
Echinococcus granulosus chromatin regulatory protein sir2 0.022 0.0743 0.0776
Entamoeba histolytica protein kinase domain containing protein 0.0376 0.1353 0.6252
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Trichomonas vaginalis cyclin B, putative 0.0298 0.1048 0.4827
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0032 0.0009 0.001
Brugia malayi Variant SH3 domain containing protein 0.0404 0.1465 0.197
Toxoplasma gondii AGC kinase 0.0582 0.2161 1
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.006 0.0117 0.05
Loa Loa (eye worm) AGC/PKG protein kinase 0.0032 0.001 0.0003
Echinococcus multilocularis expressed protein 0.0372 0.1337 0.1397
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.007 0.0158 0.0165
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.007 0.0158 0.0165
Schistosoma mansoni synaptotagmin 0.007 0.0158 0.0149
Brugia malayi Pleckstrin Homology Domain 0.04 0.1451 0.195
Brugia malayi C2 domain containing protein 0.007 0.0158 0.0201
Schistosoma mansoni protein kinase 0.1888 0.7274 0.7271
Loa Loa (eye worm) hypothetical protein 0.0441 0.1609 0.2047
Loa Loa (eye worm) hypothetical protein 0.007 0.0158 0.0193
Onchocerca volvulus 0.0137 0.0419 0.1624
Loa Loa (eye worm) hypothetical protein 0.0471 0.1726 0.2198
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0014 0.0015
Entamoeba histolytica hypothetical protein, conserved 0.011 0.0311 0.1421
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0078 0.0187 0.1271
Entamoeba histolytica protein kinase, putative 0.025 0.0862 0.3974
Giardia lamblia Kinase, CMGC GSK 0.0376 0.1353 0.9598
Onchocerca volvulus Cyclin L homolog 0.006 0.0117 0.0439
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.203 0.783 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0078 0.0187 0.0196
Echinococcus multilocularis synaptotagmin 2 0.007 0.0158 0.0165
Echinococcus granulosus cyclins 0.006 0.0117 0.0122
Trypanosoma cruzi synaptotagmin, putative 0.007 0.0158 0.1064
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0889 0.4089
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.039 0.1409 0.6516
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.025 0.0862 0.6089
Schistosoma mansoni serine/threonine protein kinase 0.0582 0.2161 0.2153
Loa Loa (eye worm) hypothetical protein 0.04 0.1451 0.1845
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0376 0.1353 0.9598
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.007 0.0158 0.0149

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 65 nM Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method ChEMBL. 24967667
max activation (binding) = 71 % Agonist activity at human GHS-R1a expressed in Tango U2OS-GHS-R1a cells by FLIPR based assay ChEMBL. 24967667

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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