Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 10A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | Get druggable targets OG5_135363 | All targets in OG5_135363 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | cAMP-specific phosphodiesterase | phosphodiesterase 10A | 789 aa | 666 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0236 | 0.679 | 0.679 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0236 | 0.679 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0236 | 0.679 | 0.679 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.679 | 0.7187 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0236 | 0.679 | 0.679 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0236 | 0.679 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0236 | 0.679 | 0.679 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0236 | 0.679 | 0.679 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.9448 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.679 | 0.7187 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0236 | 0.679 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0236 | 0.679 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0236 | 0.679 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0236 | 0.679 | 0.679 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0236 | 0.679 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0236 | 0.679 | 0.679 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0236 | 0.679 | 0.7187 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0236 | 0.679 | 0.7187 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0236 | 0.679 | 0.679 |
Onchocerca volvulus | 0.0236 | 0.679 | 0.5 | |
Echinococcus multilocularis | FTZ F1 alpha | 0.0236 | 0.679 | 0.679 |
Schistosoma mansoni | coup transcription factor | 0.0236 | 0.679 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0236 | 0.679 | 0.679 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0236 | 0.679 | 0.679 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0236 | 0.679 | 0.679 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0236 | 0.679 | 0.679 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0236 | 0.679 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0236 | 0.679 | 0.679 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0236 | 0.679 | 0.679 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0236 | 0.679 | 0.679 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0236 | 0.679 | 0.679 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0236 | 0.679 | 0.679 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0236 | 0.679 | 0.679 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0236 | 0.679 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0236 | 0.679 | 0.7187 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0236 | 0.679 | 0.679 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.679 | 0.7187 |
Brugia malayi | ecdysteroid receptor | 0.0236 | 0.679 | 0.679 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.679 | 0.7187 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0236 | 0.679 | 0.679 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0289 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0236 | 0.679 | 0.7187 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0236 | 0.679 | 0.679 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0236 | 0.679 | 0.679 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0236 | 0.679 | 0.7187 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0236 | 0.679 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0236 | 0.679 | 0.679 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0236 | 0.679 | 0.679 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0236 | 0.679 | 0.679 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.679 | 0.7187 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0289 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0236 | 0.679 | 0.679 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.679 | 0.7187 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0236 | 0.679 | 0.679 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0236 | 0.679 | 0.7187 |
Echinococcus granulosus | FTZ F1 alpha | 0.0236 | 0.679 | 0.679 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0236 | 0.679 | 0.679 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0236 | 0.679 | 0.7187 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0236 | 0.679 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0236 | 0.679 | 0.679 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0236 | 0.679 | 0.7187 |
Brugia malayi | nuclear hormone receptor | 0.0236 | 0.679 | 0.679 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0236 | 0.679 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0236 | 0.679 | 0.679 |
Schistosoma mansoni | thyroid hormone receptor | 0.0236 | 0.679 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0236 | 0.679 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0236 | 0.679 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0236 | 0.679 | 0.679 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0236 | 0.679 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0236 | 0.679 | 0.679 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0236 | 0.679 | 0.679 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.679 | 0.7187 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.8018 | 0.8486 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0236 | 0.679 | 0.679 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.679 | 0.7187 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 40 nM | Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta counting | ChEMBL. | 25016376 |
Inhibition (binding) | = 12 % | Inhibition of PDE9A (unknown origin) at 10 uM | ChEMBL. | 25016376 |
Inhibition (binding) | = 17 % | Inhibition of PDE2A (unknown origin) at 10 uM | ChEMBL. | 25016376 |
Inhibition (binding) | = 24 % | Inhibition of PDE1C (unknown origin) at 10 uM | ChEMBL. | 25016376 |
Inhibition (binding) | = 37 % | Inhibition of PDE8A (unknown origin) at 10 uM | ChEMBL. | 25016376 |
Inhibition (binding) | = 37 % | Inhibition of PDE11A (unknown origin) at 2 uM | ChEMBL. | 25016376 |
Inhibition (binding) | = 49 % | Inhibition of PDE3A (unknown origin) at 10 uM | ChEMBL. | 25016376 |
Inhibition (binding) | = 53 % | Inhibition of PDE7B (unknown origin) at 10 uM | ChEMBL. | 25016376 |
Inhibition (binding) | = 59 % | Inhibition of PDE5A (unknown origin) at 10 uM | ChEMBL. | 25016376 |
Inhibition (binding) | = 68 % | Inhibition of PDE4D (unknown origin) at 10 uM | ChEMBL. | 25016376 |
Inhibition (binding) | = 102 % | Inhibition of PDE10A (unknown origin) at 10 uM | ChEMBL. | 25016376 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.