Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0061 | 0.1345 | 0.257 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0143 | 0.0272 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.089 | 0.089 |
Onchocerca volvulus | 0.0236 | 0.7778 | 0.7746 | |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0364 | 0.0364 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.1605 | 0.2873 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0038 | 0.0483 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1403 | 0.1403 |
Echinococcus multilocularis | dna polymerase eta | 0.0063 | 0.1403 | 0.2476 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0167 | 0.5234 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.05 | 0.0464 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0038 | 0.0483 | 0.0445 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.089 | 0.089 |
Echinococcus granulosus | dna polymerase eta | 0.0063 | 0.1403 | 0.2476 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Loa Loa (eye worm) | glutaminase | 0.0268 | 0.8958 | 0.8958 |
Brugia malayi | glutaminase DH11.1 | 0.0268 | 0.8958 | 0.8958 |
Mycobacterium ulcerans | glutaminase | 0.0268 | 0.8958 | 1 |
Brugia malayi | Pax transcription factor protein 2 | 0.0236 | 0.7778 | 0.7778 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.0167 | 0.5234 | 0.5605 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.0167 | 0.5234 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.0143 | 0.0272 |
Trypanosoma brucei | unspecified product | 0.0026 | 0.0051 | 0.0097 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.1605 | 0.2873 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0038 | 0.0483 | 0.0924 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.032 | 0.032 |
Trypanosoma brucei | phosphoglycerate kinase, putative | 0.0061 | 0.1345 | 0.257 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.032 | 0.032 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0364 | 0.0251 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0038 | 0.0483 | 0.0924 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.1605 | 0.171 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.0167 | 0.5234 | 0.5 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.0167 | 0.5234 | 1 |
Echinococcus multilocularis | geminin | 0.0166 | 0.5207 | 0.9947 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0038 | 0.0483 | 0.0445 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.05 | 0.0464 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0167 | 0.5234 | 0.5775 |
Echinococcus granulosus | dna polymerase kappa | 0.0038 | 0.0483 | 0.067 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Treponema pallidum | phosphoglycerate kinase | 0.0167 | 0.5234 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0068 | 0.1605 | 0.1605 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.0167 | 0.5234 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0389 | 0.0279 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0061 | 0.1345 | 0.257 |
Brugia malayi | jmjC domain containing protein | 0.0094 | 0.2537 | 0.2537 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.5234 | 0.5234 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0236 | 0.7778 | 0.7778 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.0167 | 0.5234 | 1 |
Trypanosoma cruzi | 3-phosphoglycerate kinase, glycosomal | 0.0061 | 0.1345 | 0.257 |
Loa Loa (eye worm) | glutaminase 2 | 0.0268 | 0.8958 | 0.8958 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0364 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.4174 | 0.4174 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.5207 | 0.5745 |
Trichomonas vaginalis | glutaminase, putative | 0.0268 | 0.8958 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0143 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.4174 | 0.4174 |
Echinococcus granulosus | geminin | 0.0166 | 0.5207 | 0.9947 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.34 | 0.34 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.0143 | 0.0143 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0167 | 0.5234 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.05 | 0.05 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0063 | 0.1403 | 0.1403 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0026 | 0.0051 | 0.0097 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.089 | 0.089 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0143 | 0.0272 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.4174 | 0.4174 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0389 | 0.0389 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0026 | 0.0051 | 0.0097 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.4174 | 0.4174 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.4174 | 0.7918 |
Brugia malayi | Heterochromatin protein 1 | 0.0068 | 0.1605 | 0.1605 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.1605 | 0.1659 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0061 | 0.1345 | 0.257 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.0167 | 0.5234 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Giardia lamblia | Phosphoglycerate kinase | 0.0167 | 0.5234 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.34 | 0.34 |
Schistosoma mansoni | DNA polymerase eta | 0.0063 | 0.1403 | 0.143 |
Brugia malayi | Phosphoglycerate kinase | 0.0167 | 0.5234 | 0.5234 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.5207 | 0.5745 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0195 | 0.0195 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.1605 | 0.2873 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Leishmania major | DNA polymerase eta, putative | 0.0037 | 0.0442 | 0.0845 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.089 | 0.089 |
Echinococcus multilocularis | dna polymerase kappa | 0.0038 | 0.0483 | 0.067 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0037 | 0.0442 | 0.0845 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0167 | 0.5234 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.4174 | 0.7918 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0389 | 0.0484 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0138 | 0.4174 | 0.4174 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0555 | 0.081 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0061 | 0.1345 | 0.257 |
Mycobacterium leprae | Probable phosphoglycerate kinase Pgk | 0.0167 | 0.5234 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.032 | 0.0202 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.34 | 0.34 |
Schistosoma mansoni | glutaminase | 0.0268 | 0.8958 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.05 | 0.05 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0026 | 0.0051 | 0.0097 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0038 | 0.0483 | 0.0195 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0364 | 0.0251 |
Onchocerca volvulus | 0.003 | 0.0195 | 0.0054 | |
Trypanosoma brucei | unspecified product | 0.0038 | 0.0483 | 0.0924 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0038 | 0.0483 | 0.067 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0061 | 0.1345 | 0.257 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0894 | 0.0894 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0607 | 0.0471 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0555 | 0.081 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Brugia malayi | Bromodomain containing protein | 0.0029 | 0.0143 | 0.0143 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.1605 | 0.1659 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0167 | 0.5234 | 0.5775 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.1605 | 0.171 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0167 | 0.5234 | 0.5801 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.4174 | 0.4573 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0389 | 0.0279 |
Plasmodium falciparum | phosphoglycerate kinase | 0.0167 | 0.5234 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0063 | 0.1403 | 0.2681 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0038 | 0.0483 | 0.0483 |
Brugia malayi | Phosphoglycerate kinase | 0.0061 | 0.1345 | 0.1345 |
Onchocerca volvulus | 0.0297 | 1 | 1 | |
Leishmania major | DNA polymerase eta, putative | 0.0063 | 0.1403 | 0.2681 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0038 | 0.0483 | 0.0924 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.0167 | 0.5234 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0063 | 0.1403 | 0.2681 |
Echinococcus granulosus | carboxylesterase 5A | 0.0138 | 0.4174 | 0.7918 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.4174 | 0.7918 |
Leishmania major | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.05 | 0.0363 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.1605 | 0.2873 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0061 | 0.1345 | 0.257 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0607 | 0.0585 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0038 | 0.0483 | 0.0924 |
Giardia lamblia | DINP protein human, muc B family | 0.0038 | 0.0483 | 0.067 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.4174 | 0.7918 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.1829 | 0.1913 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0167 | 0.5234 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0364 | 0.0435 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0364 | 0.0364 |
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.0167 | 0.5234 | 1 |
Trypanosoma brucei | unspecified product | 0.0026 | 0.0051 | 0.0097 |
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 0.4174 | 0.4174 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0389 | 0.0484 |
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.0167 | 0.5234 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0038 | 0.0483 | 0.0387 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0143 | 0.0143 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.0167 | 0.5234 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0607 | 0.0585 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 0.2537 | 0.4703 |
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.0167 | 0.5234 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0138 | 0.4174 | 0.7918 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0038 | 0.0483 | 0.0387 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.1263 | 0.1263 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0038 | 0.0483 | 0.067 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0483 | 0.0924 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0143 | 0.0272 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 0.2537 | 0.4703 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0037 | 0.0442 | 0.0845 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0167 | 0.5234 | 0.5801 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 70 % | Inhibition of IFN-gamma/LPS-induced PGE2 production in mouse RAW264.7 cells at 50 uM after 17 to 20 hrs by EIA method | ChEMBL. | 25027933 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.