Detailed information for compound 92199

Basic information

Technical information
  • TDR Targets ID: 92199
  • Name: (E)-N-[(2S)-1-hydroxy-3-(octylsulfanylmethyls ulfinyl)propan-2-yl]-3-(6-methyl-2,4-dioxo-1H -pyrimidin-5-yl)prop-2-enamide
  • MW: 459.623 | Formula: C20H33N3O5S2
  • H donors: 4 H acceptors: 7 LogP: 3.9 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCSC[S+](C[C@@H](NC(=O)/C=C/c1c(C)nc(nc1O)O)CO)[O-]
  • InChi: 1S/C20H33N3O5S2/c1-3-4-5-6-7-8-11-29-14-30(28)13-16(12-24)22-18(25)10-9-17-15(2)21-20(27)23-19(17)26/h9-10,16,24H,3-8,11-14H2,1-2H3,(H,22,25)(H2,21,23,26,27)/b10-9+/t16-,30?/m0/s1
  • InChiKey: CTSQVSMSXPYTMI-ABRYUWCJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-N-[(1S)-1-(hydroxymethyl)-2-(octylsulfanylmethylsulfinyl)ethyl]-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)prop-2-enamide
  • (E)-N-[(1S)-1-(hydroxymethyl)-2-[(octylthio)methylsulfinyl]ethyl]-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)-2-propenamide
  • (E)-3-(2,4-diketo-6-methyl-1H-pyrimidin-5-yl)-N-[(1S)-1-methylol-2-[(octylthio)methylsulfinyl]ethyl]acrylamide
  • octylsparsomycin
  • (E)-N-[(2S)-1-hydroxy-3-(octylsulfanylmethylsulfinyl)propan-2-yl]-3-(4-methyl-2,6-dioxo-3H-pyrimidin-5-yl)prop-2-enamide
  • (E)-N-[(1S)-1-(hydroxymethyl)-2-(octylsulfanylmethylsulfinyl)ethyl]-3-(4-methyl-2,6-dioxo-3H-pyrimidin-5-yl)prop-2-enamide
  • (E)-N-[(1S)-1-(hydroxymethyl)-2-[(octylthio)methylsulfinyl]ethyl]-3-(4-methyl-2,6-dioxo-3H-pyrimidin-5-yl)prop-2-enamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.5022 0.983 0.983
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.0086 0.0082 0.0137
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0226 0.0359 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0226 0.0359 0.0359
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0086 0.0082 0.008
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.218 0.4217 0.4215
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0086 0.0082 0.008
Toxoplasma gondii phosphoglycerate mutase family protein 0.0086 0.0082 0.2233
Echinococcus granulosus phosphoglycerate mutase 0.0086 0.0082 0.0082
Trypanosoma brucei phosphoglycerate mutase, putative 0.0086 0.0082 0.008
Leishmania major glycerolphosphate mutase, putative 0.0086 0.0082 0.008
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.0086 0.0082 0.0137
Toxoplasma gondii phosphoglycerate mutase family protein 0.0086 0.0082 0.2233
Leishmania major hypothetical protein, conserved 0.0086 0.0082 0.008
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0226 0.0359 0.0359
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.5022 0.983 0.983
Echinococcus multilocularis phosphoglycerate mutase 0.0086 0.0082 0.0082
Brugia malayi Thioredoxin reductase 0.0046 0.0003 0.0083
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.3015 0.5866 0.9367
Onchocerca volvulus 0.0226 0.0359 0.0279
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0226 0.0359 1
Mycobacterium ulcerans oxidoreductase 0.0226 0.0359 0.0448
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.0086 0.0082 0.008
Plasmodium falciparum phosphoglycerate mutase, putative 0.0086 0.0082 0.2233
Mycobacterium ulcerans dehydrogenase 0.0226 0.0359 0.0448
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.0086 0.0082 0.008
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.5108 1 1
Brugia malayi MH2 domain containing protein 0.0116 0.0141 0.394
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0141 0.0141
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.0086 0.0082 0.0137
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0086 0.0082 0.008
Leishmania major hypothetical protein, unknown function 0.0086 0.0082 0.008
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0226 0.0359 0.0448
Onchocerca volvulus 0.5108 1 1
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0086 0.0082 0.5
Echinococcus multilocularis 0.0226 0.0359 0.0359
Plasmodium vivax hypothetical protein, conserved 0.0226 0.0359 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0119 0.1332
Echinococcus multilocularis phosphoglycerate mutase 0.0086 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0226 0.0359 0.0359
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0119 0.02
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0086 0.0082 0.008
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0119 0.02
Brugia malayi SWIRM domain containing protein 0.0226 0.0359 1
Schistosoma mansoni amine oxidase 0.0226 0.0359 0.0359
Schistosoma mansoni 6-phosphofructokinase 0.5108 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0142 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0082 0.5
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0086 0.0082 0.008
Mycobacterium tuberculosis Conserved protein 0.0086 0.0082 0.0137
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0086 0.0082 0.0082
Echinococcus granulosus phosphoglycerate mutase 0.0086 0.0082 0.0082
Schistosoma mansoni phosphoglycerate mutase 0.0086 0.0082 0.0082
Echinococcus granulosus phosphoglycerate mutase 0.0086 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.0086 0.0082 0.0082
Mycobacterium tuberculosis Possible hydrolase MutT1 0.0086 0.0082 0.0137
Schistosoma mansoni hypothetical protein 0.0086 0.0082 0.0082
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0086 0.0082 0.0082
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0142 0.2168
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.0086 0.0082 0.0137
Mycobacterium tuberculosis Conserved protein 0.0086 0.0082 0.0137
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.3213 0.6257 1
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0086 0.0082 0.008
Loa Loa (eye worm) hypothetical protein 0.5108 1 1
Leishmania major phosphoglycerate mutase family member 5, putative 0.0086 0.0082 0.008
Toxoplasma gondii histone lysine-specific demethylase 0.0226 0.0359 1
Brugia malayi UBASH3A protein homolog 0.0086 0.0082 0.2297
Plasmodium falciparum phosphoglucomutase-2 0.0086 0.0082 0.2233
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.5108 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0226 0.0359 0.0613
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.5108 1 1
Leishmania major hypothetical protein, conserved 0.0086 0.0082 0.008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0226 0.0359 0.0613
Brugia malayi hypothetical protein 0.0226 0.0359 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.0359 0.0359
Echinococcus multilocularis phosphoglycerate mutase 0.0086 0.0082 0.0082
Brugia malayi phosphoglycerate mutase family protein 0.0086 0.0082 0.2297
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.5108 1 1
Schistosoma mansoni hypothetical protein 0.0086 0.0082 0.0082
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0226 0.0359 1
Echinococcus granulosus phosphoglycerate mutase 0.0086 0.0082 0.0082
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0119 0.02
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.5022 0.983 0.983
Echinococcus multilocularis protoporphyrinogen oxidase 0.0226 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0226 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.2928 0.5695 0.5695
Schistosoma mansoni hypothetical protein 0.0086 0.0082 0.0082
Brugia malayi glutathione reductase 0.0046 0.0003 0.0083
Loa Loa (eye worm) hypothetical protein 0.0086 0.0082 0.0082
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.0086 0.0082 0.008
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0086 0.0082 0.008
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0003 0.0003
Plasmodium vivax phosphoglucomutase-2, putative 0.0086 0.0082 0.2233
Trypanosoma brucei glycerolphosphate mutase, putative 0.0086 0.0082 0.008
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.5022 0.983 0.983
Loa Loa (eye worm) phosphoglycerate mutase 0.0086 0.0082 0.0082
Trypanosoma cruzi phosphoglycerate mutase, putative 0.0086 0.0082 0.008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0086 0.0082 0.0137
Schistosoma mansoni hypothetical protein 0.0086 0.0082 0.0082
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.0086 0.0082 0.0137
Toxoplasma gondii phosphoglycerate mutase 0.0086 0.0082 0.2233
Echinococcus multilocularis phosphoglycerate mutase 0.0086 0.0082 0.0082
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.0086 0.0082 0.008
Loa Loa (eye worm) hypothetical protein 0.0086 0.0082 0.0082
Echinococcus granulosus lysine specific histone demethylase 1A 0.0226 0.0359 0.0359
Plasmodium vivax hypothetical protein, conserved 0.0226 0.0359 1
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.0086 0.0082 0.008
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0226 0.0359 1
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0086 0.0082 0.5
Treponema pallidum phosphoglyceromutase 0.0086 0.0082 0.5
Mycobacterium ulcerans hypothetical protein 0.3015 0.5866 0.9367
Loa Loa (eye worm) hypothetical protein 0.0226 0.0359 0.0359
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0086 0.0082 0.008
Mycobacterium ulcerans monoamine oxidase 0.0226 0.0359 0.0448
Leishmania major phosphoglycerate mutase, putative 0.0086 0.0082 0.008
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0086 0.0082 0.008
Giardia lamblia Hypothetical protein 0.3015 0.5866 0.5
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0226 0.0359 1
Leishmania major UDP-galactopyranose mutase 0.0226 0.0359 0.0356
Schistosoma mansoni amine oxidase 0.0226 0.0359 0.0359
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0119 0.02
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0003 0.0003
Giardia lamblia Hypothetical protein 0.3015 0.5866 0.5
Echinococcus multilocularis phosphoglycerate mutase 0.0086 0.0082 0.0082
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0086 0.0082 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.218 0.4217 0.4215
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0086 0.0082 0.5
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0086 0.0082 0.008
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0141 0.0141
Brugia malayi phosphoglycerate mutase family protein 0.0086 0.0082 0.2297
Loa Loa (eye worm) hypothetical protein 0.0086 0.0082 0.0082
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0226 0.0359 1
Trichomonas vaginalis phosphoglycerate mutase, putative 0.0086 0.0082 0.5
Trypanosoma cruzi glycerolphosphate mutase, putative 0.0086 0.0082 0.008
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.0086 0.0082 0.0082
Leishmania major hypothetical protein, conserved 0.0086 0.0082 0.008
Trypanosoma cruzi UDP-galactopyranose mutase 0.0226 0.0359 0.0356
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0142 0.024
Echinococcus multilocularis phosphoglycerate mutase 0.0086 0.0082 0.0082
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0226 0.0359 0.0359
Brugia malayi amine oxidase, flavin-containing family protein 0.0226 0.0359 1
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.3015 0.5866 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0226 0.0359 0.0356
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0086 0.0082 0.008
Toxoplasma gondii phosphoglycerate mutase family protein 0.0086 0.0082 0.2233
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.218 0.4217 0.4215
Schistosoma mansoni phosphoglycerate mutase 0.0086 0.0082 0.0082
Plasmodium falciparum protoporphyrinogen oxidase 0.0226 0.0359 1
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0086 0.0082 0.008
Plasmodium vivax phosphoglycerate mutase, putative 0.0086 0.0082 0.2233
Leishmania major phosphoglycerate mutase protein, putative 0.0086 0.0082 0.008
Chlamydia trachomatis protoporphyrinogen oxidase 0.0226 0.0359 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0003 0.0003
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.218 0.4217 0.4215
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0082 0.5
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0142 0.024
Loa Loa (eye worm) hypothetical protein 0.0226 0.0359 0.0359
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0119 0.02
Toxoplasma gondii phosphoglycerate mutase PGMII 0.0086 0.0082 0.2233
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0226 0.0359 0.0359
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.2986 0.581 1
Toxoplasma gondii phosphoglycerate mutase family protein 0.0086 0.0082 0.2233
Echinococcus granulosus phosphoglycerate mutase 0.0086 0.0082 0.0082
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.0086 0.0082 0.008
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0003 0.0003
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.3213 0.6257 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.0359 0.0359
Schistosoma mansoni hypothetical protein 0.0086 0.0082 0.0082
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.5108 1 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.0086 0.0082 0.008
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.0086 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.5022 0.983 0.983
Mycobacterium tuberculosis Probable reductase 0.0105 0.0119 0.02
Loa Loa (eye worm) hypothetical protein 0.0086 0.0082 0.0082
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.0086 0.0082 0.008

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.25 uM In vitro inhibition of Puromycin reaction in the ribosomes from Escherichia coli ChEMBL. 2754719
ED50 (functional) = 0.25 uM In vitro inhibition of Puromycin reaction in the ribosomes from Escherichia coli ChEMBL. 2754719
ED50 (functional) = 1.3 uM In vitro inhibition of polyuridylic acid dependent polyphenylalanine synthesis using ribosomes from Saccharomyces cerevisiae ChEMBL. 2754719
ED50 (functional) = 1.3 uM In vitro inhibition of polyuridylic acid dependent polyphenylalanine synthesis using ribosomes from Saccharomyces cerevisiae ChEMBL. 2754719
ED50 (functional) = 1.6 uM In vitro inhibition of polyuridylic acid dependent polyphenylalanine synthesis using ribosomes from Escherichia coli ChEMBL. 2754719
ED50 (functional) = 1.6 uM In vitro inhibition of polyuridylic acid dependent polyphenylalanine synthesis using ribosomes from Escherichia coli ChEMBL. 2754719
ED50 (functional) = 4.4 uM Invitro inhibition of cell growth in Escherichia coli ChEMBL. 2754719
ED50 (functional) = 4.4 uM Invitro inhibition of cell growth in Escherichia coli ChEMBL. 2754719
ED50 (functional) = 60 uM In vitro inhibition of modified fragment reaction using ribosomes from Escherichia coli ChEMBL. 2754719
ED50 (functional) = 60 uM In vitro inhibition of modified fragment reaction using ribosomes from Escherichia coli ChEMBL. 2754719
ED50 (functional) = 300 uM In vitro inhibition of modified fragment reaction using ribosomes from Saccharomyces cerevisiae ChEMBL. 2754719
ED50 (functional) = 300 uM In vitro inhibition of modified fragment reaction using ribosomes from Saccharomyces cerevisiae ChEMBL. 2754719
ID50 (functional) = 0.05 ug ml-1 Compound was evaluated in vitro for cytostatic activity and inhibition of leukemia L1210 cells. The dose causing 50% of inhibition of colony formation (ID50) relative to untreated control cells ChEMBL. 6699875
ID50 (functional) = 0.06 uM In vitro inhibition of cell growth in T24 bladder carcinoma cell line ChEMBL. 2754719
ID50 (functional) = 0.06 uM In vitro inhibition of cell growth in T24 bladder carcinoma cell line ChEMBL. 2754719
ID50 (functional) = 0.1 uM In vitro inhibition of cell growth in L1210 murine leukemia cells ChEMBL. 2754719
ID50 (functional) = 0.1 uM In vitro inhibition of cell growth in L1210 murine leukemia cells ChEMBL. 2754719
ID50 (functional) = 0.22 uM In vitro inhibition of cell growth in Human WiDr colon carcinoma cell line ChEMBL. 2754719
ID50 (functional) = 0.22 uM In vitro inhibition of cell growth in Human WiDr colon carcinoma cell line ChEMBL. 2754719
LD50 (ADMET) = 29.5 mg kg-1 In Vivo evaluation of the compound for the acute toxicity in mice ChEMBL. 2754719
LD50 (ADMET) = 29.5 mg kg-1 In Vivo evaluation of the compound for the acute toxicity in mice ChEMBL. 2754719
Log Ko (ADMET) = 3.333 Kinetic constant of the compound was determined ChEMBL. 2754719
logP (ADMET) > 2.424 Partition coefficient (logP) ChEMBL. 2754719
Rm = 0.895 lipophilicityparameter(Rm) of the compound was determined ChEMBL. 2754719
Solubility (ADMET) = 0.013 mg ml-1 Water solubility of the compound was determined ChEMBL. 2754719
T/C (functional) = 151 % In Vivo evaluation of the compound for the acute toxicity by L1210 clonogenic assay ChEMBL. 2754719
T/C (functional) = 151 % In Vivo evaluation of the compound for the acute toxicity by L1210 clonogenic assay ChEMBL. 2754719

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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