Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5108 | 1 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.0119 | 0.02 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0086 | 0.0082 | 0.008 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0086 | 0.0082 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.0082 | 0.0082 |
Brugia malayi | hypothetical protein | 0.0226 | 0.0359 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0226 | 0.0359 | 1 |
Trypanosoma cruzi | phosphoglycerate mutase protein, putative | 0.0086 | 0.0082 | 0.008 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.3015 | 0.5866 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0226 | 0.0359 | 0.0613 |
Giardia lamblia | Hypothetical protein | 0.3015 | 0.5866 | 0.5 |
Leishmania major | phosphoglycerate mutase family member 5, putative | 0.0086 | 0.0082 | 0.008 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.0142 | 0.024 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0086 | 0.0082 | 0.0082 |
Mycobacterium tuberculosis | Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) | 0.0086 | 0.0082 | 0.0137 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0086 | 0.0082 | 0.5 |
Plasmodium vivax | phosphoglucomutase-2, putative | 0.0086 | 0.0082 | 0.2233 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0086 | 0.0082 | 0.2297 |
Leishmania major | hypothetical protein, unknown function | 0.0086 | 0.0082 | 0.008 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Leishmania major | hypothetical protein, conserved | 0.0086 | 0.0082 | 0.008 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5108 | 1 | 1 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0086 | 0.0082 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0359 | 0.0359 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.0082 | 0.0082 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0086 | 0.0082 | 0.0082 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0003 | 0.0083 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0226 | 0.0359 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0082 | 0.0082 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0086 | 0.0082 | 0.5 |
Brugia malayi | UBASH3A protein homolog | 0.0086 | 0.0082 | 0.2297 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0359 | 0.0359 |
Mycobacterium ulcerans | oxidoreductase | 0.0226 | 0.0359 | 0.0448 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS11 | 0.0086 | 0.0082 | 0.0137 |
Trypanosoma cruzi | phosphoglycerate mutase protein, putative | 0.0086 | 0.0082 | 0.008 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0086 | 0.0082 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0226 | 0.0359 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0003 | 0.0003 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqD | 0.0086 | 0.0082 | 0.0137 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0086 | 0.0082 | 0.008 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.3213 | 0.6257 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0226 | 0.0359 | 1 |
Trypanosoma cruzi | phosphoglycerate mutase family member 5, putative | 0.0086 | 0.0082 | 0.008 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0086 | 0.0082 | 0.008 |
Mycobacterium tuberculosis | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0086 | 0.0082 | 0.0137 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0086 | 0.0082 | 0.008 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0086 | 0.0082 | 0.008 |
Leishmania major | fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein | 0.0086 | 0.0082 | 0.008 |
Mycobacterium ulcerans | dehydrogenase | 0.0226 | 0.0359 | 0.0448 |
Onchocerca volvulus | 0.0226 | 0.0359 | 0.0279 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0226 | 0.0359 | 1 |
Trypanosoma brucei | glycerolphosphate mutase, putative | 0.0086 | 0.0082 | 0.008 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.218 | 0.4217 | 0.4215 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0086 | 0.0082 | 0.2233 |
Toxoplasma gondii | phosphoglycerate mutase PGMII | 0.0086 | 0.0082 | 0.2233 |
Leishmania major | hypothetical protein, conserved | 0.0086 | 0.0082 | 0.008 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.218 | 0.4217 | 0.4215 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.0082 | 0.0082 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0226 | 0.0359 | 0.0359 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Trypanosoma cruzi | phosphoglycerate mutase, putative | 0.0086 | 0.0082 | 0.008 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0226 | 0.0359 | 1 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0086 | 0.0082 | 0.2297 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0226 | 0.0359 | 0.0359 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0003 | 0.0003 |
Plasmodium vivax | phosphoglycerate mutase, putative | 0.0086 | 0.0082 | 0.2233 |
Mycobacterium tuberculosis | Possible hydrolase MutT1 | 0.0086 | 0.0082 | 0.0137 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0226 | 0.0359 | 0.0356 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0226 | 0.0359 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.5108 | 1 | 1 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0086 | 0.0082 | 0.008 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0086 | 0.0082 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.0142 | 0.024 |
Plasmodium falciparum | phosphoglucomutase-2 | 0.0086 | 0.0082 | 0.2233 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0359 | 0.0359 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0086 | 0.0082 | 0.0082 |
Schistosoma mansoni | amine oxidase | 0.0226 | 0.0359 | 0.0359 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0003 | 0.0083 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0105 | 0.0119 | 0.1332 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0086 | 0.0082 | 0.008 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.0119 | 0.02 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.218 | 0.4217 | 0.4215 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0226 | 0.0359 | 0.0613 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.2986 | 0.581 | 1 |
Toxoplasma gondii | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.2233 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0086 | 0.0082 | 0.2233 |
Loa Loa (eye worm) | hypothetical protein | 0.2928 | 0.5695 | 0.5695 |
Mycobacterium tuberculosis | Conserved protein | 0.0086 | 0.0082 | 0.0137 |
Leishmania major | UDP-galactopyranose mutase | 0.0226 | 0.0359 | 0.0356 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Trypanosoma cruzi | glycerolphosphate mutase, putative | 0.0086 | 0.0082 | 0.008 |
Trypanosoma brucei | Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative | 0.0086 | 0.0082 | 0.008 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.0142 | 0.2168 |
Leishmania major | hypothetical protein, conserved | 0.0086 | 0.0082 | 0.008 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.0082 | 0.0082 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.218 | 0.4217 | 0.4215 |
Trypanosoma cruzi | phosphoglycerate mutase family member 5, putative | 0.0086 | 0.0082 | 0.008 |
Echinococcus multilocularis | 0.0226 | 0.0359 | 0.0359 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.5022 | 0.983 | 0.983 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5108 | 1 | 1 |
Onchocerca volvulus | 0.5108 | 1 | 1 | |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5108 | 1 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.0119 | 0.02 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0086 | 0.0082 | 0.0137 |
Trypanosoma brucei | phosphoglycerate mutase protein, putative | 0.0086 | 0.0082 | 0.008 |
Mycobacterium tuberculosis | Conserved protein | 0.0086 | 0.0082 | 0.0137 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.3015 | 0.5866 | 0.9367 |
Trypanosoma cruzi | glycerolphosphate mutase, putative | 0.0086 | 0.0082 | 0.008 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0086 | 0.0082 | 0.008 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.0119 | 0.02 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.0141 | 0.394 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0226 | 0.0359 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.5022 | 0.983 | 0.983 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0086 | 0.0082 | 0.008 |
Mycobacterium tuberculosis | Glucosyl-3-phosphoglycerate phosphatase GpgP | 0.0086 | 0.0082 | 0.0137 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0003 | 0.0003 |
Leishmania major | phosphoglycerate mutase protein, putative | 0.0086 | 0.0082 | 0.008 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0003 | 0.0003 |
Treponema pallidum | phosphoglyceromutase | 0.0086 | 0.0082 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0226 | 0.0359 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0359 | 0.0359 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0359 | 0.0359 |
Mycobacterium ulcerans | hypothetical protein | 0.3015 | 0.5866 | 0.9367 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.0119 | 0.02 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0226 | 0.0359 | 0.0359 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0226 | 0.0359 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.0141 | 0.0141 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0086 | 0.0082 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0226 | 0.0359 | 0.0448 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.0141 | 0.0141 |
Mycobacterium ulcerans | monoamine oxidase | 0.0226 | 0.0359 | 0.0448 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.0082 | 0.0082 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0086 | 0.0082 | 0.008 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.0082 | 0.0082 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Schistosoma mansoni | amine oxidase | 0.0226 | 0.0359 | 0.0359 |
Leishmania major | glycerolphosphate mutase, putative | 0.0086 | 0.0082 | 0.008 |
Leishmania major | phosphoglycerate mutase, putative | 0.0086 | 0.0082 | 0.008 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.0119 | 0.02 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.5022 | 0.983 | 0.983 |
Trypanosoma brucei | phosphoglycerate mutase, putative | 0.0086 | 0.0082 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0359 | 0.0359 |
Brugia malayi | SWIRM domain containing protein | 0.0226 | 0.0359 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0226 | 0.0359 | 1 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.5108 | 1 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0226 | 0.0359 | 0.0359 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0226 | 0.0359 | 0.0359 |
Trypanosoma cruzi | phosphoglycerate mutase, putative | 0.0086 | 0.0082 | 0.008 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0226 | 0.0359 | 0.0359 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0086 | 0.0082 | 0.5 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0086 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.5108 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5022 | 0.983 | 0.983 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0226 | 0.0359 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0226 | 0.0359 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0082 | 0.0082 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0086 | 0.0082 | 0.0082 |
Giardia lamblia | Hypothetical protein | 0.3015 | 0.5866 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.0142 | 0.024 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0086 | 0.0082 | 0.2233 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0086 | 0.0082 | 0.2233 |
Plasmodium falciparum | phosphoglycerate mutase, putative | 0.0086 | 0.0082 | 0.2233 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.3213 | 0.6257 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.5022 | 0.983 | 0.983 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.25 uM | In vitro inhibition of Puromycin reaction in the ribosomes from Escherichia coli | ChEMBL. | 2754719 |
ED50 (functional) | = 0.25 uM | In vitro inhibition of Puromycin reaction in the ribosomes from Escherichia coli | ChEMBL. | 2754719 |
ED50 (functional) | = 1.3 uM | In vitro inhibition of polyuridylic acid dependent polyphenylalanine synthesis using ribosomes from Saccharomyces cerevisiae | ChEMBL. | 2754719 |
ED50 (functional) | = 1.3 uM | In vitro inhibition of polyuridylic acid dependent polyphenylalanine synthesis using ribosomes from Saccharomyces cerevisiae | ChEMBL. | 2754719 |
ED50 (functional) | = 1.6 uM | In vitro inhibition of polyuridylic acid dependent polyphenylalanine synthesis using ribosomes from Escherichia coli | ChEMBL. | 2754719 |
ED50 (functional) | = 1.6 uM | In vitro inhibition of polyuridylic acid dependent polyphenylalanine synthesis using ribosomes from Escherichia coli | ChEMBL. | 2754719 |
ED50 (functional) | = 4.4 uM | Invitro inhibition of cell growth in Escherichia coli | ChEMBL. | 2754719 |
ED50 (functional) | = 4.4 uM | Invitro inhibition of cell growth in Escherichia coli | ChEMBL. | 2754719 |
ED50 (functional) | = 60 uM | In vitro inhibition of modified fragment reaction using ribosomes from Escherichia coli | ChEMBL. | 2754719 |
ED50 (functional) | = 60 uM | In vitro inhibition of modified fragment reaction using ribosomes from Escherichia coli | ChEMBL. | 2754719 |
ED50 (functional) | = 300 uM | In vitro inhibition of modified fragment reaction using ribosomes from Saccharomyces cerevisiae | ChEMBL. | 2754719 |
ED50 (functional) | = 300 uM | In vitro inhibition of modified fragment reaction using ribosomes from Saccharomyces cerevisiae | ChEMBL. | 2754719 |
ID50 (functional) | = 0.05 ug ml-1 | Compound was evaluated in vitro for cytostatic activity and inhibition of leukemia L1210 cells. The dose causing 50% of inhibition of colony formation (ID50) relative to untreated control cells | ChEMBL. | 6699875 |
ID50 (functional) | = 0.06 uM | In vitro inhibition of cell growth in T24 bladder carcinoma cell line | ChEMBL. | 2754719 |
ID50 (functional) | = 0.06 uM | In vitro inhibition of cell growth in T24 bladder carcinoma cell line | ChEMBL. | 2754719 |
ID50 (functional) | = 0.1 uM | In vitro inhibition of cell growth in L1210 murine leukemia cells | ChEMBL. | 2754719 |
ID50 (functional) | = 0.1 uM | In vitro inhibition of cell growth in L1210 murine leukemia cells | ChEMBL. | 2754719 |
ID50 (functional) | = 0.22 uM | In vitro inhibition of cell growth in Human WiDr colon carcinoma cell line | ChEMBL. | 2754719 |
ID50 (functional) | = 0.22 uM | In vitro inhibition of cell growth in Human WiDr colon carcinoma cell line | ChEMBL. | 2754719 |
LD50 (ADMET) | = 29.5 mg kg-1 | In Vivo evaluation of the compound for the acute toxicity in mice | ChEMBL. | 2754719 |
LD50 (ADMET) | = 29.5 mg kg-1 | In Vivo evaluation of the compound for the acute toxicity in mice | ChEMBL. | 2754719 |
Log Ko (ADMET) | = 3.333 | Kinetic constant of the compound was determined | ChEMBL. | 2754719 |
logP (ADMET) | > 2.424 | Partition coefficient (logP) | ChEMBL. | 2754719 |
Rm | = 0.895 | lipophilicityparameter(Rm) of the compound was determined | ChEMBL. | 2754719 |
Solubility (ADMET) | = 0.013 mg ml-1 | Water solubility of the compound was determined | ChEMBL. | 2754719 |
T/C (functional) | = 151 % | In Vivo evaluation of the compound for the acute toxicity by L1210 clonogenic assay | ChEMBL. | 2754719 |
T/C (functional) | = 151 % | In Vivo evaluation of the compound for the acute toxicity by L1210 clonogenic assay | ChEMBL. | 2754719 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.