Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0268 | 0.0096 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0268 | 0.0173 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0691 | 0.1105 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0.1749 | 1 |
Onchocerca volvulus | 0.0116 | 0.4729 | 0.443 | |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0536 | 0.1529 |
Onchocerca volvulus | 0.0116 | 0.4729 | 0.443 | |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2457 | 0.272 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0536 | 0.1529 |
Brugia malayi | hypothetical protein | 0.0067 | 0.2457 | 0.272 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0268 | 0.0288 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.0536 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0116 | 0.4729 | 0.5363 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0268 | 0.0173 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.1712 | 0.1483 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.074 | 0.12 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0268 | 0.1532 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.1712 | 0.3077 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0116 | 0.4729 | 0.5363 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.074 | 0.12 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0536 | 0.1529 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0536 | 0.1446 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1662 | 0.1795 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0.1677 | 0.1447 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.074 | 0.12 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.5295 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.5295 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.5295 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.5295 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.025 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.1712 | 0.3077 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0268 | 0.1532 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1677 | 0.1812 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.5295 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0268 | 0.0288 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0.1749 | 0.7991 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.074 | 0.327 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.1712 | 0.1483 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.1712 | 0.9751 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.2121 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.1712 | 0.1483 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.1712 | 0.1483 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.1712 | 0.9789 |
Onchocerca volvulus | 0.0116 | 0.4729 | 0.443 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0536 | 0.0485 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0116 | 0.4729 | 0.5363 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.1712 | 0.9751 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.1749 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2457 | 0.272 |
Onchocerca volvulus | 0.0116 | 0.4729 | 0.443 | |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0268 | 0.0288 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.1712 | 0.9789 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.025 | 0.0153 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0268 | 0.0288 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.5295 | 0.6022 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0536 | 0.1733 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0.1712 | 0.7792 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0268 | 0.0288 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.1712 | 0.3077 |
Brugia malayi | hypothetical protein | 0.0067 | 0.2457 | 0.272 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0268 | 0.1532 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0268 | 0.1532 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0268 | 0.0288 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.2121 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.2121 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0536 | 0.1529 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2457 | 0.272 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.5295 | 0.6022 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0268 | 0.1532 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.2121 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0067 | 0.2457 | 0.272 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.1749 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.5295 | 0.6022 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0536 | 0.1529 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0536 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.5295 | 0.6022 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.1712 | 0.3077 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0536 | 0.0485 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.5295 | 0.6022 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0268 | 0.0335 |
Brugia malayi | hypothetical protein | 0.005 | 0.1677 | 0.1812 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.1749 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0067 | 0.2457 | 0.272 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.5295 | 1 |
Onchocerca volvulus | 0.0116 | 0.4729 | 0.443 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.1712 | 0.9751 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.8714 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0268 | 0.0288 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0268 | 0.1532 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.1712 | 1 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0116 | 0.4729 | 0.5363 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.025 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1677 | 0.1812 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.4729 | 0.5363 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.2121 | 0.3867 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0536 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0268 | 0.1532 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2457 | 0.272 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.1712 | 0.3077 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0536 | 0.1446 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.1712 | 0.9751 |
Trichomonas vaginalis | set domain proteins, putative | 0.0231 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0268 | 0.1532 |
Onchocerca volvulus | 0.0029 | 0.074 | 0.0216 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0268 | 0.1532 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0536 | 0.1529 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1662 | 0.1795 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.1712 | 0.7037 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.074 | 0.12 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1662 | 0.1795 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.025 | 0.0153 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0948 | 0.1601 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.074 | 0.12 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0067 | 0.2457 | 0.272 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0268 | 0.1532 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0268 | 0.0096 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0268 | 0.1532 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.1749 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0536 | 0.1529 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0268 | 0.0288 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.5295 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0536 | 0.0485 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0268 | 0.1532 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.074 | 0.12 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0023 | 0.0456 | 0.0651 |
Onchocerca volvulus | 0.005 | 0.1677 | 0.1205 | |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0023 | 0.0456 | 0.0651 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0536 | 0.1529 |
Onchocerca volvulus | 0.0067 | 0.2457 | 0.203 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.2121 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0268 | 0.1532 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0051 | 0.1749 | 0.7305 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0948 | 0.0964 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1677 | 0.1812 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1662 | 0.1795 |
Onchocerca volvulus | 0.0116 | 0.4729 | 0.443 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0536 | 0.0485 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0.1749 | 1 |
Onchocerca volvulus | 0.0067 | 0.2457 | 0.203 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.2121 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0536 | 0.1733 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1677 | 0.1812 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0268 | 0.0173 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0536 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0536 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0456 | 0.0651 |
Brugia malayi | hypothetical protein | 0.0051 | 0.1749 | 0.1896 |
Brugia malayi | RNA binding protein | 0.0128 | 0.5295 | 0.6022 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0067 | 0.2457 | 0.272 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0268 | 0.0173 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0268 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2457 | 0.272 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0268 | 0.1532 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.2121 | 0.3867 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0268 | 0.0288 |
Onchocerca volvulus | 0.0116 | 0.4729 | 0.443 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0536 | 0.0485 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0268 | 0.1532 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.074 | 0.0723 |
Brugia malayi | LBP/BPI | 0.005 | 0.1677 | 0.1812 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0.1712 | 0.7792 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.8714 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0948 | 0.0964 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.074 | 0.12 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0536 | 0.0485 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.2121 | 0.3867 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1749 | 0.1896 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.025 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.025 | 0.0153 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.1712 | 0.1853 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0536 | 0.1446 |
Onchocerca volvulus | 0.0116 | 0.4729 | 0.443 | |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.025 | 0.0241 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.1712 | 0.1853 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0067 | 0.2457 | 0.272 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.2121 | 0.3867 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.074 | 0.0723 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0918 | 0.093 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assay | ChEMBL. | 25037916 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.