Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.1066 | 0.3111 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0145 | 0.7285 | 0.8186 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1271 | 0.1271 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.1066 | 0.3111 |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.3429 | 0.3429 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3503 | 0.3503 |
Onchocerca volvulus | 0.0036 | 0.0676 | 0.1311 | |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0025 | 0.0014 | 0.0014 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.121 | 0.121 |
Brugia malayi | Bromodomain containing protein | 0.0049 | 0.1468 | 0.1468 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0524 | 0.0589 |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.3429 | 0.3429 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0524 | 0.0524 |
Trypanosoma brucei | glucosidase, putative | 0.0042 | 0.1066 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1223 | 0.1223 |
Schistosoma mansoni | zinc finger protein | 0.0027 | 0.0149 | 0.0167 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.3429 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.2798 | 0.3144 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.1066 | 0.3111 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0052 | 0.1689 | 0.4927 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.3429 | 0.3852 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0071 | 0.2798 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.7285 | 0.7285 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.121 | 0.136 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0042 | 0.1066 | 0.3111 |
Echinococcus multilocularis | zinc finger protein | 0.0027 | 0.0149 | 0.0149 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.019 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.148 | 0.4317 |
Echinococcus granulosus | acetylcholinesterase | 0.0145 | 0.7285 | 0.7285 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0074 | 0.2976 | 0.2976 |
Schistosoma mansoni | alpha glucosidase | 0.0042 | 0.1066 | 0.1198 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0042 | 0.1066 | 0.3111 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.121 | 0.121 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0046 | 0.1272 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1452 | 0.1452 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0074 | 0.2976 | 0.2976 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.121 | 0.136 |
Brugia malayi | chromobox protein homolog 3 | 0.0045 | 0.1271 | 0.1271 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0042 | 0.1066 | 0.3111 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0042 | 0.1066 | 0.1066 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.3429 | 0.3852 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.019 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.2798 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.849 | 0.9539 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.0467 | 0.1363 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.2798 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.0467 | 0.1363 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.4054 | 0.4054 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0524 | 0.0524 |
Loa Loa (eye worm) | acetyltransferase | 0.0172 | 0.89 | 0.89 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.1066 | 0.5 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0046 | 0.1272 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0052 | 0.1689 | 0.3597 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.148 | 0.4317 |
Brugia malayi | Carboxylesterase family protein | 0.0145 | 0.7285 | 0.7285 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.121 | 0.121 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0145 | 0.7285 | 0.7285 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0676 | 0.0676 |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.3429 | 0.3429 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.849 | 0.9539 |
Schistosoma mansoni | bromodomain containing protein | 0.0078 | 0.3228 | 0.3628 |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.3429 | 0.3429 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0145 | 0.7285 | 0.7285 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0172 | 0.89 | 0.89 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0107 | 0.0121 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.2798 | 0.2798 |
Echinococcus granulosus | zinc finger protein | 0.0027 | 0.0149 | 0.0149 |
Onchocerca volvulus | 0.011 | 0.5159 | 1 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.121 | 0.121 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.121 | 0.136 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0052 | 0.1689 | 0.3597 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0052 | 0.1689 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0071 | 0.2798 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0145 | 0.7285 | 0.7285 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0164 | 0.8446 | 0.8446 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0042 | 0.1066 | 0.3111 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0081 | 0.3429 | 0.3429 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.121 | 0.121 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | carboxylesterase | 0.0145 | 0.7285 | 0.7285 |
Echinococcus multilocularis | geminin | 0.0165 | 0.849 | 0.849 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.019 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1452 | 0.1452 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.1271 | 0.3707 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1452 | 0.1452 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0052 | 0.1689 | 0.1689 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1452 | 0.1452 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.1066 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.1051 | 0.1051 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0052 | 0.1689 | 0.4927 |
Brugia malayi | Heterochromatin protein 1 | 0.0081 | 0.3429 | 0.3429 |
Echinococcus granulosus | geminin | 0.0165 | 0.849 | 0.849 |
Echinococcus multilocularis | acetylcholinesterase | 0.0145 | 0.7285 | 0.7285 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0172 | 0.89 | 0.89 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0045 | 0.1271 | 0.2463 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0042 | 0.1066 | 0.1066 |
Echinococcus granulosus | acetylcholinesterase | 0.0145 | 0.7285 | 0.7285 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.7285 | 0.7285 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1774 | 0.1774 |
Brugia malayi | Carboxylesterase family protein | 0.0145 | 0.7285 | 0.7285 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.2798 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.2798 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0172 | 0.89 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.2798 | 0.3144 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0046 | 0.1272 | 0.5 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0042 | 0.1066 | 0.1066 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.121 | 0.121 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.164 | 0.164 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.019 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0163 | 0.8401 | 0.944 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.1066 | 0.3111 |
Schistosoma mansoni | alpha-glucosidase | 0.0163 | 0.8401 | 0.944 |
Brugia malayi | PHD-finger family protein | 0.0033 | 0.0524 | 0.0524 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0049 | 0.148 | 0.2868 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0042 | 0.1066 | 0.1066 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.2798 | 0.2798 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.1066 | 0.3111 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.1271 | 0.3707 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.3429 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.1051 | 0.1051 |
Echinococcus granulosus | carboxylesterase 5A | 0.0145 | 0.7285 | 0.7285 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 2 % | Displacement of [3H]-DPCPX from human adenosine A1 receptor expressed in CHO cells at 1 uM by scintillation counting analysis relative to control | ChEMBL. | 25063944 |
Inhibition (binding) | = 5 % | Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level at 1 uM by scintillation counting analysis | ChEMBL. | 25063944 |
Inhibition (binding) | = 11 % | Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in CHO cells at 1 uM by scintillation counting analysis relative to control | ChEMBL. | 25063944 |
Inhibition (binding) | = 22 % | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells at 1 uM by scintillation counting analysis relative to control | ChEMBL. | 25063944 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.