TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.592 | Formula: C23H33N3O2S
H donors: 0 H acceptors: 2 LogP: 3.77 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CC(CN(S(=O)(=O)Cc1ccccc1)Cc1ccc(cc1)N1CCN(CC1)C)C
InChi: 1S/C23H33N3O2S/c1-20(2)17-26(29(27,28)19-22-7-5-4-6-8-22)18-21-9-11-23(12-10-21)25-15-13-24(3)14-16-25/h4-12,20H,13-19H2,1-3H3
InChiKey: UNFKKRWCVCSPTC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	RAR-related orphan receptor C		No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0295	0.8378	1
Brugia malayi	Cathepsin L-like precursor	0.013	0.3237	0.3862
Plasmodium falciparum	serine repeat antigen 7	0.0053	0.0829	0.0868
Entamoeba histolytica	cysteine protease, putative	0.0114	0.273	0.5314
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0829	0.065
Entamoeba histolytica	cysteine protease, putative	0.0114	0.273	0.5314
Schistosoma mansoni	cathepsin F (C01 family)	0.0191	0.5138	0.5043
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0829	0.1613
Echinococcus multilocularis	geminin	0.0191	0.5135	0.504
Trypanosoma cruzi	major cysteine proteinase, putative	0.0157	0.407	0.4857
Onchocerca volvulus		0.0191	0.5138	1
Entamoeba histolytica	cysteine protease, putative	0.0114	0.273	0.5314
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0114	0.273	0.3258
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0191	0.5138	0.6362
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0135	0.3372	0.3509
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0683	0.0623
Giardia lamblia	Cathepsin B precursor	0.0286	0.8075	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0114	0.273	0.2588
Schistosoma mansoni	cathepsin s	0.0061	0.1079	0.0905
Echinococcus granulosus	geminin	0.0191	0.5135	0.504
Entamoeba histolytica	hypothetical protein	0.0053	0.0829	0.1613
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0207	0.0015
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0164	0.4284	0.4172
Plasmodium falciparum	serine repeat antigen 1	0.0053	0.0829	0.0868
Entamoeba histolytica	cysteine protease, putative	0.0114	0.273	0.5314
Echinococcus granulosus	cathepsin b	0.0173	0.4554	0.4448
Entamoeba histolytica	cysteine protease, putative	0.0114	0.273	0.5314
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0295	0.8378	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0053	0.0829	0.1027
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0829	0.065
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0234	0.6477	0.7731
Echinococcus multilocularis	cathepsin L cysteine protease	0.0191	0.5138	0.5043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.013	0.3237	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0829	0.065
Entamoeba histolytica	cysteine protease, putative	0.0114	0.273	0.5314
Giardia lamblia	Cathepsin B precursor	0.0173	0.4554	0.5141
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0829	0.065
Entamoeba histolytica	cysteine protease, putative	0.0191	0.5138	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0829	0.065
Brugia malayi	Cathepsin L-like precursor	0.0191	0.5138	0.6274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0829	0.1027
Schistosoma mansoni	hypothetical protein	0.0347	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0829	0.0808
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0207	0.0019
Entamoeba histolytica	cysteine proteinase 2	0.0114	0.273	0.5314
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0829	0.065
Echinococcus granulosus	cathepsin l1	0.0191	0.5138	0.5043
Schistosoma mansoni	hypothetical protein	0.0033	0.0207	0.0015
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0268	0.7531	0.9249
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0114	0.273	0.3381
Leishmania major	cathepsin L-like protease	0.0191	0.5138	0.6132
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0173	0.4554	0.5329
Brugia malayi	Cathepsin L-like precursor	0.0191	0.5138	0.6274
Trypanosoma cruzi	cysteine peptidase, putative	0.0295	0.8378	1
Brugia malayi	Cathepsin L-like precursor	0.0191	0.5138	0.6274
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0829	0.065
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0187	0.4988	0.6177
Plasmodium falciparum	serine repeat antigen 4	0.0053	0.0829	0.0868
Schistosoma mansoni	cathepsin C	0.0053	0.0829	0.065
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0829	0.1027
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0053	0.0829	0.065
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0053	0.0829	0.0868
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0268	0.7531	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Onchocerca volvulus		0.0191	0.5138	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0191	0.5138	0.6362
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Plasmodium vivax	serine-repeat antigen (SERA)	0.0053	0.0829	0.0868
Leishmania major	cathepsin L-like protease	0.0191	0.5138	0.6132
Leishmania major	cathepsin L-like protease	0.0191	0.5138	0.6132
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0295	0.8378	1
Trypanosoma cruzi	cysteine protease, putative	0.0114	0.273	0.3258
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0191	0.5138	0.6739
Loa Loa (eye worm)	cathepsin B	0.0173	0.4554	0.4448
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0053	0.0829	0.1027
Entamoeba histolytica	cysteine protease, putative	0.0114	0.273	0.5314
Brugia malayi	Cathepsin L-like precursor	0.0191	0.5138	0.6274
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0191	0.5138	0.6362
Toxoplasma gondii	cathepsin CPC1	0.0268	0.7531	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.1079	0.1288
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0295	0.8378	1
Onchocerca volvulus	Cathepsin F homolog	0.0191	0.5138	1
Plasmodium falciparum	serine repeat antigen 5	0.0053	0.0829	0.0868
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0295	0.8378	1
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0268	0.7531	1
Echinococcus multilocularis	cathepsin L	0.0053	0.0829	0.065
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0114	0.273	0.3381
Leishmania major	cathepsin L-like protease	0.0191	0.5138	0.6132
Brugia malayi	fibroinase precursor	0.0053	0.0829	0.0808
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0829	0.065
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0829	0.1027
Entamoeba histolytica	cysteine protease, putative	0.0114	0.273	0.5314
Entamoeba histolytica	cysteine proteinase, putative	0.0191	0.5138	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0173	0.4554	0.5435
Loa Loa (eye worm)	hypothetical protein	0.0197	0.5313	0.5221
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0061	0.1079	0.0905
Onchocerca volvulus		0.0191	0.5138	1
Loa Loa (eye worm)	hypothetical protein	0.0173	0.4554	0.4448
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0829	0.1027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0053	0.0829	0.0868
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0053	0.0829	0.0868
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0829	0.065
Schistosoma mansoni	cathepsin S (C01 family)	0.0053	0.0829	0.065
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.013	0.3237	0.4008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0295	0.8378	1
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0829	0.1027
Brugia malayi	Cathepsin L-like precursor	0.0061	0.1079	0.1126
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	0.4554	0.4448
Brugia malayi	cathepsin F-like cysteine proteinase	0.0053	0.0829	0.0808
Trypanosoma cruzi	cysteine peptidase, putative	0.0295	0.8378	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0191	0.5138	0.6362
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0053	0.0829	0.0868
Trypanosoma cruzi	cysteine peptidase, putative	0.0191	0.5138	0.6132
Toxoplasma gondii	cathepsin CPC2	0.0135	0.3372	0.4333
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0053	0.0829	0.0868
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0053	0.0829	0.1613
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0053	0.0829	0.0868
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0053	0.0829	0.0868
Echinococcus granulosus	cathepsin L	0.0114	0.273	0.2588
Loa Loa (eye worm)	fibroinase	0.0191	0.5138	0.5043
Entamoeba histolytica	cysteine proteinase 1, putative	0.0114	0.273	0.5314
Schistosoma mansoni	hypothetical protein	0.0191	0.5135	0.504
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.0829	0.065
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0173	0.4554	0.4448
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0829	0.1027
Onchocerca volvulus		0.0191	0.5138	1
Leishmania major	cathepsin L-like protease	0.0191	0.5138	0.6132
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0829	0.1027
Schistosoma mansoni	cathepsin F (C01 family)	0.013	0.3237	0.3104
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0286	0.8075	1
Plasmodium falciparum	serine repeat antigen 2	0.0053	0.0829	0.0868
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0191	0.5138	0.6362
Plasmodium falciparum	serine repeat antigen 8	0.0053	0.0829	0.0868
Entamoeba histolytica	cysteine proteinase, putative	0.0114	0.273	0.5314
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0829	0.1613
Entamoeba histolytica	cysteine proteinase, putative	0.0191	0.5138	1
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0829	0.1613
Echinococcus granulosus	cysteine protease	0.0114	0.273	0.2588
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0268	0.7531	1
Plasmodium vivax	vivapain-1	0.0114	0.273	0.3459
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0286	0.8075	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0191	0.5138	0.5043
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0295	0.8378	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0114	0.273	0.3258
Echinococcus granulosus	cathepsin l1	0.013	0.3237	0.3104
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1079	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0829	0.065
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0164	0.4284	0.4172
Echinococcus multilocularis	cathepsin b	0.0173	0.4554	0.4448
Brugia malayi	cathepsin F-like cysteine proteinase	0.0061	0.1079	0.1126
Echinococcus multilocularis	cysteine protease	0.0191	0.5138	0.5043
Onchocerca volvulus	Cathepsin L homolog	0.0191	0.5138	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0191	0.5138	0.6362
Echinococcus multilocularis	snurportin 1	0.0347	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0114	0.273	0.322
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0286	0.8075	1
Brugia malayi	cathepsin L precursor	0.0053	0.0829	0.0808
Entamoeba histolytica	cysteine protease, putative	0.0114	0.273	0.5314
Leishmania major	cathepsin L-like protease	0.0295	0.8378	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0286	0.8075	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0135	0.3372	0.4333
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1079	0.0905
Entamoeba histolytica	cysteine proteinase, putative	0.0114	0.273	0.5314
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0061	0.1079	0.1126
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0191	0.5138	0.5043
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0191	0.5138	0.5043
Brugia malayi	cathepsin L-like cysteine proteinase	0.0053	0.0829	0.0808
Trypanosoma cruzi	cruzipain precursor, putative	0.0295	0.8378	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0295	0.8378	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0191	0.5138	0.6739
Schistosoma mansoni	hypothetical protein	0.0191	0.5135	0.504
Echinococcus multilocularis	cathepsin b	0.0173	0.4554	0.4448
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	0.4554	0.4448
Onchocerca volvulus		0.0191	0.5138	1
Brugia malayi	Papain family cysteine protease containing protein	0.0114	0.273	0.322
Brugia malayi	Cathepsin L-like precursor	0.0191	0.5138	0.6274
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0347	1	1
Echinococcus multilocularis	cysteine protease	0.0191	0.5138	0.5043
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0114	0.273	0.3101
Onchocerca volvulus		0.0191	0.5138	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0268	0.7531	1
Onchocerca volvulus		0.013	0.3237	0.5588
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0053	0.0829	0.1027
Entamoeba histolytica	cysteine proteinase, putative	0.0114	0.273	0.5314
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0829	0.0989
Loa Loa (eye worm)	hypothetical protein	0.013	0.3237	0.3104
Entamoeba histolytica	cysteine protease, putative	0.0114	0.273	0.5314
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0829	0.1027
Plasmodium falciparum	serine repeat antigen 3	0.0053	0.0829	0.0868
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0829	0.1613
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0829	0.1613
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0191	0.5138	0.6739
Plasmodium vivax	vivapain-2	0.0191	0.5138	0.6739
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0829	0.1027
Entamoeba histolytica	cysteine protease, putative	0.0114	0.273	0.5314
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0295	0.8378	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0114	0.273	0.3101
Loa Loa (eye worm)	hypothetical protein	0.0191	0.5138	0.5043
Brugia malayi	RNA, U transporter 1	0.0093	0.2061	0.2371
Trypanosoma cruzi	cysteine peptidase, putative	0.0295	0.8378	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0053	0.0829	0.065
Plasmodium vivax	unspecified product	0.0061	0.1079	0.1209
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0829	0.1027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0191	0.5138	0.6362
Plasmodium vivax	unspecified product	0.0114	0.273	0.3459
Trypanosoma cruzi	cruzipain precursor, putative	0.0061	0.1079	0.1288
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0295	0.8378	1
Loa Loa (eye worm)	ctsf protein	0.0191	0.5138	0.5043
Loa Loa (eye worm)	hypothetical protein	0.013	0.3237	0.3104
Echinococcus granulosus	cathepsin b	0.0173	0.4554	0.4448
Echinococcus multilocularis	cathepsin L	0.0114	0.273	0.2588
Loa Loa (eye worm)	cysteine protease	0.0191	0.5138	0.5043
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0191	0.5138	0.5043
Loa Loa (eye worm)	hypothetical protein	0.013	0.3237	0.3104
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0191	0.5138	0.5043
Plasmodium vivax	serine-repeat antigen (SERA)	0.0053	0.0829	0.0868
Entamoeba histolytica	cysteine proteinase, putative	0.013	0.3237	0.63
Plasmodium falciparum	serine repeat antigen 6	0.0053	0.0829	0.0868
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0829	0.0808
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0286	0.8075	1
Plasmodium vivax	unspecified product	0.0053	0.0829	0.0868
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0286	0.8075	0.8038
Giardia lamblia	Cathepsin B precursor	0.0173	0.4554	0.5141
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0191	0.5138	0.6362
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0114	0.273	0.2588
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0197	0.5313	0.6496
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	0.4554	0.4448
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0114	0.273	0.3459
Brugia malayi	Cathepsin L-like precursor	0.0191	0.5138	0.6274
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0829	0.0808
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0135	0.3372	0.3509
Plasmodium vivax	vivapain-3	0.0114	0.273	0.3459
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Leishmania major	cathepsin L-like protease	0.0295	0.8378	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0173	0.4554	0.5435
Leishmania major	cysteine peptidase A (CPA)	0.0191	0.5138	0.6132
Entamoeba histolytica	cysteine protease, putative	0.0114	0.273	0.5314
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0191	0.5138	0.6362
Trypanosoma cruzi	cysteine proteinase, putative	0.0114	0.273	0.3258
Plasmodium falciparum	serine repeat antigen 9	0.0053	0.0829	0.0868
Onchocerca volvulus	Cathepsin L homolog	0.0191	0.5138	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0053	0.0829	0.065
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1079	0.0905
Echinococcus multilocularis	cathepsin L cysteine protease	0.0191	0.5138	0.5043
Brugia malayi	cathepsin B-like cysteine proteinase	0.0173	0.4554	0.5533
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0191	0.5138	0.5043
Onchocerca volvulus		0.0191	0.5138	1
Echinococcus granulosus	cathepsin L	0.0053	0.0829	0.065
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0829	0.1613
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0053	0.0829	0.0808
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0053	0.0829	0.1027
Schistosoma mansoni	cathepsin B (C01 family)	0.0053	0.0829	0.065
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0683	0.0501
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.0829	0.065
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	0.4554	0.4448
Entamoeba histolytica	cysteine proteinase, putative	0.0114	0.273	0.5314
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0286	0.8075	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Brugia malayi	Papain family cysteine protease containing protein	0.0191	0.5138	0.6274
Giardia lamblia	Cathepsin B precursor	0.0173	0.4554	0.5141
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0191	0.5138	0.5043
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0191	0.5138	0.6362
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0173	0.4554	0.5435
Toxoplasma gondii	cathepsin CPL	0.0191	0.5138	0.6739
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0191	0.5138	0.6362
Brugia malayi	cathepsin L-like precursor	0.013	0.3237	0.3862
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0829	0.065
Entamoeba histolytica	cysteine protease, putative	0.0114	0.273	0.5314
Toxoplasma gondii	cathepsin B	0.0173	0.4554	0.5944
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0114	0.273	0.2588
Giardia lamblia	Encystation-specific protease	0.0135	0.3372	0.3509
Leishmania major	cathepsin L-like protease	0.0295	0.8378	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0268	0.7531	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0135	0.3372	0.4333
Plasmodium vivax	vivapain-2	0.0191	0.5138	0.6739
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0268	0.7531	0.7483
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0173	0.4554	0.564
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0295	0.8378	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.013	0.3237	0.3862
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0191	0.5138	0.6362
Trypanosoma cruzi	cysteine peptidase, putative	0.0114	0.273	0.3258
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0114	0.273	0.2588
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0053	0.0829	0.1613
Brugia malayi	Cathepsin L-like precursor	0.013	0.3237	0.3862

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 23 uM	Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment after 3 hrs by TR-FRET analysis	ChEMBL.	25017032
Efficacy (binding)	= 75 %	Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment after 3 hrs by TR-FRET analysis relative to apo-RORc ligand binding domain	ChEMBL.	25017032
IC50 (binding)	= 480 nM	In Vitro Assay	BINDINGDB.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3317827

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 922103