TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 346.442 | Formula: C22H18O2S
H donors: 1 H acceptors: 2 LogP: 5.18 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC1=C(Sc2cccc3c2cccc3)C(=O)CC(C1)c1ccccc1
InChi: 1S/C22H18O2S/c23-19-13-17(15-7-2-1-3-8-15)14-20(24)22(19)25-21-12-6-10-16-9-4-5-11-18(16)21/h1-12,17,23H,13-14H2
InChiKey: JOKZQBNKCDOWHP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptide Y receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.013	0.0118	0.0118
Schistosoma mansoni	lipoxygenase	0.0044	0.0029	0.0029
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0018	0.0003	0.0003
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.3623	0.3709	0.3695
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus granulosus	lamin	0.0021	0.0006	0.0006
Toxoplasma gondii	hypothetical protein	0.013	0.0118	0.0115
Brugia malayi	Dopamine receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0024	0.0008	0.0008
Echinococcus granulosus	epidermal growth factor receptor	0.0054	0.0039	0.0039
Schistosoma mansoni	opsin-like receptor	0.0335	0.0328	0.0328
Brugia malayi	Heterochromatin protein 1	0.0064	0.005	0.005
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0122	0.0109	0.0109
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0335	0.0328	0.0328
Echinococcus multilocularis	musashi	0.0021	0.0006	0.0006
Echinococcus granulosus	chromobox protein 1	0.0064	0.005	0.005
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0335	0.0328	0.0328
Onchocerca volvulus		0.0335	0.0328	0.4245
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0027	0.0012	0.0544
Echinococcus multilocularis	serotonin transporter	0.0768	0.0773	0.0773
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0039
Echinococcus multilocularis	Chromobox protein 3	0.0018	0.0003	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0025	0.1292
Echinococcus multilocularis	neuropeptides capa receptor	0.0335	0.0328	0.0328
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0335	0.0328	0.0328
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0768	0.0773	0.0773
Schistosoma mansoni	tyrosine kinase	0.0053	0.0039	0.0038
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0335	0.0328	0.4245
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.013	0.0118	0.0118
Loa Loa (eye worm)	melatonin receptor type 1A	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.013	0.0118	0.0118
Mycobacterium leprae	PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE)	0.0061	0.0046	0.5664
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0335	0.0328	0.0328
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0018	0.0003	0.0003
Echinococcus multilocularis	fmrfamide receptor	0.0335	0.0328	0.0328
Onchocerca volvulus		0.0335	0.0328	0.4245
Loa Loa (eye worm)	hypothetical protein	0.0768	0.0773	0.0773
Echinococcus granulosus	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Echinococcus multilocularis	orexin receptor type 2	0.0335	0.0328	0.0328
Brugia malayi	AKH receptor	0.0335	0.0328	0.0328
Brugia malayi	Valyl-tRNA synthetase	0.0018	0.0003	0.0003
Schistosoma mansoni	adenoreceptor	0.0335	0.0328	0.0328
Onchocerca volvulus		0.013	0.0118	0.1525
Schistosoma mansoni	biogenic amine receptor	0.0335	0.0328	0.0328
Brugia malayi	Furin-like cysteine rich region family protein	0.0054	0.0039	0.0039
Plasmodium falciparum	heterochromatin protein 1	0.0018	0.0003	0.0213
Schistosoma mansoni	amine GPCR	0.0335	0.0328	0.0328
Echinococcus multilocularis	lamin	0.0021	0.0006	0.0006
Echinococcus granulosus	7tm_1 domain containing protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	intermediate filament protein	0.0021	0.0006	0.0006
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0335	0.0328	0.0328
Trichomonas vaginalis	chromobox protein, putative	0.0064	0.005	0.2722
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0018	0.0003	0.0003
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0335	0.0328	0.0328
Onchocerca volvulus		0.0042	0.0027	0.0346
Loa Loa (eye worm)	G-protein coupled receptor	0.0335	0.0328	0.0328
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0018	0.0003	0.0213
Onchocerca volvulus		0.0021	0.0006	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0335	0.0328	0.0328
Schistosoma mansoni	biogenic amine receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	sodium/chloride dependent transporter	0.013	0.0118	0.0118
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.013	0.0118	0.0118
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0029	0.0014	0.0014
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.013	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus multilocularis	p2X purinoceptor 4	0.0046	0.0032	0.0032
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0046	0.0046
Onchocerca volvulus		0.0335	0.0328	0.4245
Schistosoma mansoni	P2X receptor subunit	0.0046	0.0032	0.0031
Echinococcus granulosus	Chromobox protein 3	0.0018	0.0003	0.0003
Onchocerca volvulus		0.0187	0.0177	0.2283
Echinococcus multilocularis	chromobox protein 1	0.0064	0.005	0.005
Brugia malayi	neuropeptide F receptor	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Toxoplasma gondii	hypothetical protein	0.013	0.0118	0.0115
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0335	0.0328	0.0328
Onchocerca volvulus		0.0335	0.0328	0.4245
Schistosoma mansoni	sodium/chloride dependent transporter	0.013	0.0118	0.0118
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0054	0.0039	0.0039
Onchocerca volvulus	Putative hydroxypyruvate isomerase	0.0016	0	0.0005
Brugia malayi	G-protein coupled receptor	0.0335	0.0328	0.0328
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.0023	0.0022
Echinococcus granulosus	somatostatin receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	tyrosine kinase	0.0053	0.0039	0.0038
Brugia malayi	hypothetical protein	0.0089	0.0076	0.0076
Onchocerca volvulus		0.0021	0.0006	0.0076
Schistosoma mansoni	chromobox protein	0.0018	0.0003	0.0003
Loa Loa (eye worm)	G-protein coupled receptor	0.0335	0.0328	0.0328
Echinococcus multilocularis	g protein coupled receptor	0.0335	0.0328	0.0328
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0335	0.0328	0.0328
Schistosoma mansoni	multiple ankyrin repeats single kh domain protein	0.0071	0.0057	0.0057
Echinococcus multilocularis	sodium and chloride dependent glycine	0.013	0.0118	0.0118
Brugia malayi	chromobox protein homolog 3	0.004	0.0025	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0025	0.1292
Schistosoma mansoni	neuropeptide receptor	0.0335	0.0328	0.0328
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0335	0.0328	0.0328
Echinococcus multilocularis	neuropeptide receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	biogenic amine receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	tyrosine kinase	0.0118	0.0106	0.0106
Loa Loa (eye worm)	CHromoDomain protein family member	0.0018	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0335	0.0328	0.0328
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0335	0.0328	0.0328
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0003	0.5
Echinococcus granulosus	hypothetical protein	0.0787	0.0794	0.0794
Brugia malayi	Associated with TFs and helicases family protein	0.0018	0.0003	0.0003
Onchocerca volvulus		0.0089	0.0076	0.0977
Schistosoma mansoni	lamin	0.0021	0.0006	0.0006
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.9742	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0024	0.0008	0.0008
Entamoeba histolytica	hypothetical protein	0.0018	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.3623	0.3709	0.3695
Brugia malayi	Intermediate filament tail domain containing protein	0.0021	0.0006	0.0006
Brugia malayi	hypothetical protein	0.0335	0.0328	0.0328
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0335	0.0328	0.0328
Brugia malayi	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Toxoplasma gondii	endonuclease IV APN	0.0061	0.0046	0.0044
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Echinococcus multilocularis	allatostatin A receptor	0.0335	0.0328	0.0328
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.9742	1	1
Echinococcus multilocularis	sex peptide receptor	0.0335	0.0328	0.0328
Brugia malayi	putative neuropeptide receptor NPR1	0.0335	0.0328	0.0328
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.013	0.0118	1
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0039
Echinococcus granulosus	g protein coupled receptor	0.0335	0.0328	0.0328
Echinococcus granulosus	histone lysine methyltransferase setb	0.0024	0.0008	0.0008
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0028	0.143
Echinococcus multilocularis	sodium and chloride dependent glycine	0.013	0.0118	0.0118
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0008	0.0008
Onchocerca volvulus		0.0335	0.0328	0.4245
Schistosoma mansoni	P2X receptor subunit	0.0046	0.0032	0.0031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus multilocularis	Chromo domain	0.0018	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Brugia malayi	CHD4 protein	0.0018	0.0003	0.0003
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0023	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Mycobacterium ulcerans	endonuclease IV	0.0061	0.0046	1
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.013	0.0118	0.0118
Brugia malayi	Melatonin receptor type 1A	0.0335	0.0328	0.0328
Echinococcus multilocularis	serotonin receptor	0.9417	0.9666	0.9666
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0085	0.0072	0.8793
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0023	0.0022
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0335	0.0328	0.0328
Echinococcus granulosus	Ankyrin repeat domain containing protein	0.0071	0.0057	0.0057
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.9742	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	lamin	0.0021	0.0006	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0007	0.0226
Echinococcus multilocularis	neuropeptide Y receptor	0.0335	0.0328	0.0328
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0095	0.0082	1
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0044	0.0029	0.0029
Echinococcus granulosus	insulin receptor	0.0118	0.0106	0.0106
Schistosoma mansoni	tyrosine kinase	0.0053	0.0039	0.0038
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0335	0.0328	0.0328
Plasmodium vivax	SET domain protein, putative	0.0024	0.0008	0.0699
Loa Loa (eye worm)	hypothetical protein	0.013	0.0118	0.0118
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0335	0.0328	0.0328
Schistosoma mansoni	chromobox protein	0.0064	0.005	0.005
Plasmodium falciparum	amino acid transporter, putative	0.013	0.0118	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.013	0.0118	0.0118
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Brugia malayi	hypothetical protein	0.0335	0.0328	0.0328
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.5575	0.5716	0.5716
Loa Loa (eye worm)	hypothetical protein	0.0768	0.0773	0.0773
Onchocerca volvulus		0.0768	0.0773	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.0023	0.0023
Brugia malayi	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus granulosus	dro:myosuppressin receptor	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.9742	1	1
Onchocerca volvulus		0.0335	0.0328	0.4245
Schistosoma mansoni	neuropeptide F-like receptor	0.0335	0.0328	0.0328
Loa Loa (eye worm)	TK/INSR protein kinase	0.0118	0.0106	0.0106
Echinococcus granulosus	intermediate filament protein	0.0021	0.0006	0.0006
Trichomonas vaginalis	set domain proteins, putative	0.0187	0.0177	1
Brugia malayi	Dopamine receptor protein 2	0.0335	0.0328	0.0328
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0028	0.143
Schistosoma mansoni	neuropeptide receptor	0.0335	0.0328	0.0328
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0335	0.0328	0.4245
Echinococcus granulosus	p2X purinoceptor 4	0.0046	0.0032	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0472	0.0469	0.0469
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0335	0.0328	0.0328
Brugia malayi	follicle stimulating hormone receptor	0.0335	0.0328	0.0328
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0122	0.0109	0.0109
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0027	0.0012	0.0544
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0335	0.0328	0.0328
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0018	0.0003	0.0003
Echinococcus multilocularis	serotonin receptor	0.9417	0.9666	0.9666
Loa Loa (eye worm)	heterochromatin protein 1	0.0064	0.005	0.005
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0335	0.0328	0.0328
Plasmodium vivax	hypothetical protein, conserved	0.013	0.0118	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.013	0.0118	0.0118
Brugia malayi	Thioredoxin reductase	0.0037	0.0023	0.0022
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0335	0.0328	0.0328
Entamoeba histolytica	hypothetical protein	0.0018	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus multilocularis	g protein coupled receptor	0.0335	0.0328	0.0328
Trichomonas vaginalis	chromobox protein, putative	0.0064	0.005	0.2722
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.013	0.0118	0.0118
Plasmodium vivax	hypothetical protein, conserved	0.0018	0.0003	0.0213
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0165	0.0153	0.0153
Schistosoma mansoni	neuropeptide F-like receptor	0.0335	0.0328	0.0328
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0024	0.0008	0.0008
Echinococcus granulosus	neuropeptide receptor	0.0335	0.0328	0.0328
Mycobacterium tuberculosis	Probable dehydrogenase	0.0085	0.0072	0.8793
Treponema pallidum	sodium- and chloride- dependent transporter	0.0768	0.0773	0.5
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0018	0.0003	0.0003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0021	0.0006	0.0006
Brugia malayi	hypothetical protein	0.0335	0.0328	0.0328
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.013	0.0118	0.0118
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.013	0.0118	0.0118
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0018	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0335	0.0328	0.0328
Echinococcus granulosus	allatostatin A receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.013	0.0118	0.0118
Schistosoma mansoni	amine GPCR	0.0335	0.0328	0.0328
Echinococcus multilocularis	dro:myosuppressin receptor	0.0335	0.0328	0.0328
Onchocerca volvulus		0.0335	0.0328	0.4245
Brugia malayi	hypothetical protein	0.013	0.0118	0.0118
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.013	0.0118	0.0118
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0335	0.0328	0.0328
Plasmodium vivax	hypothetical protein, conserved	0.0018	0.0003	0.0213
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0335	0.0328	0.0328
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0335	0.0328	0.0328
Onchocerca volvulus		0.0335	0.0328	0.4245
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.3623	0.3709	0.3707
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0025	0.001	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Leishmania major		0.9742	1	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.013	0.0118	0.0118
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.0023	0.272
Schistosoma mansoni	amine GPCR	0.0335	0.0328	0.0328
Echinococcus granulosus	lamin dm0	0.0021	0.0006	0.0006
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.013	0.0118	0.0118
Toxoplasma gondii	thioredoxin reductase	0.0037	0.0023	0.002
Loa Loa (eye worm)	hypothetical protein	0.0251	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0006	0.0006
Schistosoma mansoni	intermediate filament proteins	0.0021	0.0006	0.0006
Echinococcus granulosus	sex peptide receptor	0.0335	0.0328	0.0328
Loa Loa (eye worm)	TYRA-2 protein	0.0335	0.0328	0.0328
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0335	0.0328	0.0328
Echinococcus multilocularis	Ankyrin repeat domain containing protein	0.0071	0.0057	0.0057
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.013	0.0118	0.0115
Onchocerca volvulus		0.0335	0.0328	0.4245
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.013	0.0118	0.0118
Echinococcus multilocularis	G protein coupled receptor 139	0.0335	0.0328	0.0328
Loa Loa (eye worm)	neuropeptide F receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	tyrosine kinase	0.0118	0.0106	0.0106
Toxoplasma gondii	fructose-bisphospatase I	0.3623	0.3709	0.3707
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus granulosus	biogenic amine 5HT receptor	0.0582	0.0582	0.0582
Echinococcus granulosus	neuropeptides capa receptor	0.0335	0.0328	0.0328
Echinococcus granulosus	orexin receptor type 2	0.0335	0.0328	0.0328
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0335	0.0328	0.0328
Onchocerca volvulus		0.013	0.0118	0.1525
Echinococcus multilocularis	chromobox protein 1	0.0064	0.005	0.005
Onchocerca volvulus		0.0335	0.0328	0.4245
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0076	0.0076
Echinococcus multilocularis	p2X purinoceptor 4	0.0046	0.0032	0.0032
Echinococcus multilocularis	p2X purinoceptor 4	0.0046	0.0032	0.0032
Schistosoma mansoni	opsin-like receptor	0.0335	0.0328	0.0328
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.9742	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0335	0.0328	0.0328
Brugia malayi	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.013	0.0118	0.0118
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0007	0.0226
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.013	0.0118	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Schistosoma mansoni	biogenic amine (5HT) receptor	0.9417	0.9666	0.9666
Echinococcus multilocularis	neuropeptide receptor	0.0335	0.0328	0.0328
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0095	0.0082	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0335	0.0328	0.0328
Brugia malayi	GnHR receptor homolog	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0335	0.0328	0.0328
Brugia malayi	Protein cec-1.	0.0018	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.5575	0.5716	0.5716
Onchocerca volvulus		0.0335	0.0328	0.4245
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0018	0.0003	0.0003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0054	0.0039	0.0039
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Mycobacterium tuberculosis	Probable reductase	0.0085	0.0072	0.8793
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0018	0.0003	0.0003
Echinococcus multilocularis	neuropeptide s receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0582	0.0582	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	serotonin transporter b	0.0768	0.0773	0.0773
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0018	0.0003	0.0213
Schistosoma mansoni	chromobox protein	0.0018	0.0003	0.0003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Echinococcus granulosus	neuropeptide FF receptor 2	0.0335	0.0328	0.0328
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.013	0.0118	0.0118
Echinococcus multilocularis	conserved hypothetical protein	0.0453	0.045	0.045
Brugia malayi	putative neuropeptide receptor	0.0335	0.0328	0.0328
Echinococcus granulosus	g protein coupled receptor	0.0335	0.0328	0.0328
Brugia malayi	Serotonin receptor	0.0335	0.0328	0.0328
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0335	0.0328	0.0328
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0018	0.0003	0.0003
Loa Loa (eye worm)	neuropeptide F receptor	0.0335	0.0328	0.0328
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.9742	1	1
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Brugia malayi	G protein-coupled receptor F59B2.13	0.0335	0.0328	0.0328
Schistosoma mansoni	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.013	0.0118	0.0118
Echinococcus granulosus	g-protein coupled receptor	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0009	0.0009
Onchocerca volvulus		0.0335	0.0328	0.4245
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0095	0.0082	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0335	0.0328	0.0328
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0768	0.0773	0.0773
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.004	0.0025	0.0025
Plasmodium vivax	apurinic/apyrimidinic endonuclease Apn1, putative	0.0061	0.0046	0.3924
Plasmodium falciparum	apurinic/apyrimidinic endonuclease Apn1, putative	0.0061	0.0046	0.3924
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Echinococcus multilocularis	g protein coupled receptor	0.0335	0.0328	0.0328
Echinococcus granulosus	neuropeptides capa receptor	0.0335	0.0328	0.0328
Echinococcus granulosus	biogenic amine 5HT receptor	0.9417	0.9666	0.9666
Schistosoma mansoni	neuropeptide receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0335	0.0328	0.0328
Schistosoma mansoni	tyrosine kinase	0.0054	0.0039	0.0039
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.5575	0.5716	0.5716
Loa Loa (eye worm)	hypothetical protein	0.0065	0.005	0.005
Onchocerca volvulus		0.0335	0.0328	0.4245
Schistosoma mansoni	opsin-like receptor	0.0335	0.0328	0.0328
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0025	0.0323
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0085	0.0072	0.8793
Loa Loa (eye worm)	hypothetical protein	0.9417	0.9666	0.9666
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0335	0.0328	0.0328
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0023	0.19
Echinococcus granulosus	neuropeptide Y receptor	0.0335	0.0328	0.0328
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0335	0.0328	0.0328
Echinococcus multilocularis	lamin dm0	0.0021	0.0006	0.0006
Schistosoma mansoni	amine GPCR	0.0335	0.0328	0.0328
Onchocerca volvulus		0.0335	0.0328	0.4245
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Echinococcus granulosus	neuropeptide Y receptor	0.0335	0.0328	0.0328
Echinococcus granulosus	neuropeptide receptor A26	0.0335	0.0328	0.0328
Schistosoma mansoni	chromobox protein	0.0064	0.005	0.005
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0024	0.0008	0.0006
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0003	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0335	0.0328	0.0328
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.9742	1	1
Loa Loa (eye worm)	hypothetical protein	0.9417	0.9666	0.9666
Plasmodium falciparum	glutathione reductase	0.0037	0.0023	0.19
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Plasmodium falciparum	transporter, putative	0.013	0.0118	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.013	0.0118	0.0118
Echinococcus granulosus	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0085	0.0072	0.8793
Schistosoma mansoni	neuropeptide receptor	0.0335	0.0328	0.0328
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0085	0.0072	0.8793
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0335	0.0328	0.0328
Echinococcus granulosus	neuropeptide receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0335	0.0328	0.0328
Loa Loa (eye worm)	norepinephrine transporter	0.0768	0.0773	0.0773
Echinococcus granulosus	G protein coupled receptor 139	0.0335	0.0328	0.0328
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0335	0.0328	0.0328
Echinococcus multilocularis	somatostatin receptor	0.0335	0.0328	0.0328
Echinococcus granulosus	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Schistosoma mansoni	P2X receptor subunit	0.0046	0.0032	0.0031
Schistosoma mansoni	amine GPCR	0.0335	0.0328	0.0328
Onchocerca volvulus		0.0335	0.0328	0.4245
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0006	0.0005
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0029	0.0014	0.0014
Echinococcus granulosus	Chromo domain	0.0018	0.0003	0.0003
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.013	0.0118	0.0118
Onchocerca volvulus		0.0335	0.0328	0.4245
Loa Loa (eye worm)	hypothetical protein	0.013	0.0118	0.0118
Echinococcus granulosus	g protein coupled receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	sodium/chloride dependent transporter	0.0768	0.0773	0.0773
Echinococcus granulosus	fmrfamide receptor	0.0335	0.0328	0.0328
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.3623	0.3709	0.3695
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Brugia malayi	Dopamine receptor protein 1	0.0335	0.0328	0.0328
Echinococcus multilocularis	chromobox protein 2	0.0018	0.0003	0.0003
Schistosoma mansoni	growth hormone secretagogue receptor	0.0335	0.0328	0.0328
Echinococcus multilocularis	fmrfamide receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	P2X receptor subunit	0.0046	0.0032	0.0031
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0051	0.0051
Echinococcus granulosus	epidermal growth factor receptor	0.0054	0.0039	0.0039
Brugia malayi	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Brugia malayi	M-phase phosphoprotein, mpp8	0.0089	0.0076	0.0076
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0024	0.0008	0.0008
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.013	0.0118	0.0118
Echinococcus multilocularis	epidermal growth factor receptor	0.0054	0.0039	0.0039
Brugia malayi	RE15519p	0.0335	0.0328	0.0328
Toxoplasma gondii	fructose-bisphospatase II	0.9742	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0335	0.0328	0.0328
Onchocerca volvulus		0.0024	0.0009	0.0115
Brugia malayi	Serotonin receptor	0.0335	0.0328	0.0328
Brugia malayi	larval opioid receptor	0.0335	0.0328	0.0328
Brugia malayi	hypothetical protein	0.0335	0.0328	0.0328
Brugia malayi	Protein kinase domain containing protein	0.0118	0.0106	0.0106
Schistosoma mansoni	hypothetical protein	0.0018	0.0003	0.0003
Onchocerca volvulus		0.0335	0.0328	0.4245
Echinococcus granulosus	tm gpcr rhodopsin	0.0335	0.0328	0.0328
Brugia malayi	Pre-SET motif family protein	0.0165	0.0153	0.0153
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.013	0.0118	0.0115
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0641	0.0643	0.0643
Brugia malayi	G-protein coupled receptor	0.0335	0.0328	0.0328
Plasmodium vivax	amine transporter, putative	0.013	0.0118	1
Brugia malayi	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus granulosus	chromobox protein 1	0.0064	0.005	0.005
Entamoeba histolytica	hypothetical protein	0.0018	0.0003	0.5
Echinococcus multilocularis	insulin receptor	0.0118	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Brugia malayi	SET domain containing protein	0.0019	0.0004	0.0003
Echinococcus multilocularis	g-protein coupled receptor	0.0335	0.0328	0.0328
Brugia malayi	sulfakinin receptor protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0768	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus granulosus	rhodopsin orphan GPCR	0.0335	0.0328	0.0328
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0335	0.0328	0.0328
Schistosoma mansoni	multiple ankyrin repeats single kh domain protein	0.0071	0.0057	0.0057
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0085	0.0072	0.8793
Loa Loa (eye worm)	hypothetical protein	0.013	0.0118	0.0118
Echinococcus multilocularis	epidermal growth factor receptor	0.0054	0.0039	0.0039
Onchocerca volvulus		0.013	0.0118	0.1525
Brugia malayi	DNA-(Apurinic or apyrimidinic site) lyase	0.0061	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.5575	0.5716	0.5716
Echinococcus granulosus	tm gpcr rhodopsin	0.0335	0.0328	0.0328
Brugia malayi	Pre-SET motif family protein	0.0024	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Echinococcus granulosus	serotonin receptor	0.0335	0.0328	0.0328
Mycobacterium tuberculosis	Probable oxidoreductase	0.0095	0.0082	1
Echinococcus granulosus	p2X purinoceptor 4	0.0046	0.0032	0.0031
Schistosoma mansoni	histamine h1 receptor	0.0335	0.0328	0.0328
Onchocerca volvulus		0.0089	0.0076	0.0977
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Brugia malayi	hypothetical protein	0.0096	0.0083	0.0083
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0335	0.0328	0.0328
Schistosoma mansoni	sodium-dependent amino acid transporter	0.013	0.0118	0.0118
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0028	0.0354
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0024	0.0008	0.0008
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0582	0.0582	0.0582
Mycobacterium tuberculosis	Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)	0.0061	0.0046	0.5664
Echinococcus granulosus	serotonin transporter	0.0768	0.0773	0.0773
Brugia malayi	ORL1-like opioid receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0042	0.0027	0.0027
Echinococcus granulosus	p2X purinoceptor 4	0.0046	0.0032	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0023	0.19
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0023	0.19
Echinococcus granulosus	tm gpcr rhodopsin	0.0335	0.0328	0.0328
Echinococcus granulosus	sodium and chloride dependent glycine	0.013	0.0118	0.0118
Echinococcus granulosus	chromobox protein 2	0.0018	0.0003	0.0003
Schistosoma mansoni	neuropeptide f receptor 76f	0.0335	0.0328	0.0328
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	helicase	0.0018	0.0003	0.0003
Brugia malayi	intermediate filament protein	0.0021	0.0006	0.0006
Schistosoma mansoni	myosin xvIII	0.0335	0.0328	0.0328
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0029	0.0014	0.0014
Brugia malayi	neuropeptide F receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.013	0.0118	0.0118
Plasmodium vivax	heterochromatin protein 1, putative	0.0018	0.0003	0.0213
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.013	0.0118	0.0118
Echinococcus multilocularis	neuropeptide receptor A26	0.0335	0.0328	0.0328
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.013	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0003	0.0003
Brugia malayi	G protein-coupled receptor	0.0335	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0768	0.0773	0.0773
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0335	0.0328	0.0328
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0335	0.0328	0.0328
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0029	0.0014	0.0014
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0335	0.0328	0.0328
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0044	0.0029	0.0029
Brugia malayi	glutathione reductase	0.0037	0.0023	0.0022
Echinococcus granulosus	sodium and chloride dependent glycine	0.013	0.0118	0.0118
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0023	0.0007	0.0007

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 100 uM	Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assay	ChEMBL.	25037916

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3318515

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 922149