Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0065 | 0.3902 | 0.3144 |
Brugia malayi | Blistered cuticle protein 3 | 0.0065 | 0.3902 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0065 | 0.3902 | 0.3144 |
Onchocerca volvulus | 0.0065 | 0.3902 | 0.3144 | |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0101 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2058 | 0.1071 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0101 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0065 | 0.3902 | 0.3144 |
Schistosoma mansoni | peroxidasin | 0.0065 | 0.3902 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0065 | 0.3902 | 0.3144 |
Onchocerca volvulus | Peroxidase homolog | 0.0065 | 0.3902 | 0.3144 |
Onchocerca volvulus | 0.0065 | 0.3902 | 0.3144 | |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0101 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0101 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0101 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0101 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0053 | 0.2058 | 0.1071 |
Brugia malayi | Bromodomain containing protein | 0.0066 | 0.4173 | 0.3449 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0101 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0053 | 0.2058 | 0.1071 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0101 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0066 | 0.4173 | 0.3449 |
Echinococcus granulosus | peroxidasin | 0.0065 | 0.3902 | 0.3144 |
Schistosoma mansoni | peroxidasin | 0.0065 | 0.3902 | 0.3144 |
Brugia malayi | steroid hormone receptor | 0.0101 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0101 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0101 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2058 | 0.1071 |
Brugia malayi | Animal haem peroxidase family protein | 0.0065 | 0.3902 | 0.3144 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0065 | 0.3902 | 0.3144 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0101 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2058 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0101 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0101 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0101 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0053 | 0.2058 | 0.1071 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0101 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0101 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0065 | 0.3902 | 0.3144 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0053 | 0.2058 | 0.1071 |
Onchocerca volvulus | Peroxidasin homolog | 0.0065 | 0.3902 | 0.3144 |
Onchocerca volvulus | 0.0065 | 0.3902 | 0.3144 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0065 | 0.3902 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.4173 | 0.3449 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0066 | 0.4173 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0065 | 0.3902 | 0.3144 |
Schistosoma mansoni | nuclear hormone receptor | 0.0101 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0101 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.0066 | 0.4173 | 0.3449 |
Echinococcus multilocularis | peroxidasin | 0.0065 | 0.3902 | 0.3144 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0053 | 0.2058 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0053 | 0.2058 | 0.1071 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0065 | 0.3902 | 0.3144 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0101 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0101 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0101 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0101 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0101 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0101 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0101 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0065 | 0.3902 | 0.3144 |
Brugia malayi | hypothetical protein | 0.0053 | 0.2058 | 0.1071 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0053 | 0.2058 | 0.1071 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0101 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2058 | 0.1071 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2058 | 0.1071 |
Brugia malayi | Animal haem peroxidase family protein | 0.0065 | 0.3902 | 0.3144 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0101 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0101 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0101 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0065 | 0.3902 | 0.3144 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0053 | 0.2058 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0101 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0101 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3902 | 0.3144 |
Echinococcus granulosus | bromodomain containing 2 | 0.0066 | 0.4173 | 0.3449 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0053 | 0.2058 | 0.1071 |
Schistosoma mansoni | thyroid hormone receptor | 0.0101 | 1 | 1 |
Onchocerca volvulus | 0.0101 | 1 | 1 | |
Schistosoma mansoni | coup transcription factor | 0.0101 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0065 | 0.3902 | 0.3144 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0066 | 0.4173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0065 | 0.3902 | 0.3144 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0101 | 1 | 1 |
Echinococcus multilocularis | bromodomain containing 2 | 0.0066 | 0.4173 | 0.3449 |
Brugia malayi | nuclear hormone receptor | 0.0101 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0101 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0101 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Induction of anaerobic state electron transport chain maintenance related gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 | |
Activity (functional) | Induction of cytochrome ubiquinol oxidase gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 | |
Activity (functional) | Induction of oxido-reductases gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 | |
Activity (functional) | Induction of fumarate reductase gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 | |
Activity (functional) | Reduction in aminoacyl t-RNA synthetases gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 | |
Activity (functional) | Reduction in RNA metabolism related gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 | |
Activity (functional) | Reduction in RNA polymerase subunits gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 | |
Activity (functional) | Reduction in sigma factors gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 | |
Activity (functional) | Antimicrobial activity against Mycobacterium tuberculosis H37Rv over-expressing InhA cells assessed as upshift of MIC relative to wild type | ChEMBL. | 24967731 | |
Activity (functional) | Induction of fatty acid metabolism related gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 | |
Activity (functional) | Reduction in protein synthesis related gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 | |
Activity (functional) | Induction of nitrate reductase gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 | |
Activity (functional) | Reduction in ribosomal protein synthesis related gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 | |
FC (functional) | = 0.7 | Induction of prrA gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 |
FC (functional) | = 0.7 | Induction of prrB gene expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 7.5 ug/mL incubated for 4 hrs by DNA microarray analysis | ChEMBL. | 24967731 |
IC50 (binding) | > 50 uM | Inhibition of Mycobacterium tuberculosis InhA using NADH and dodecyl coA substrate by LC-MS/MS method | ChEMBL. | 24967731 |
log10CFU/ml (functional) | = 1.5 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 infected in human THP1 cells assessed as reduction in bacterial count at 2 times MIC relative to untreated control | ChEMBL. | 24967731 |
log10CFU/ml (functional) | = 3 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as reduction in bacterial count relative to untreated control | ChEMBL. | 24967731 |
MBC (functional) | = 0.8 ug ml-1 | Bactericidal activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 days by microdilution method | ChEMBL. | 24967731 |
MIC=>80 (functional) | = 0.4 ug ml-1 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as growth inhibition after 5 days by microdilution method | ChEMBL. | 24967731 |
Ratio (functional) | = 2 | Ratio of MBC for Mycobacterium tuberculosis H37Rv ATCC 27294 to MIC for Mycobacterium tuberculosis H37Rv ATCC 27294 | ChEMBL. | 24967731 |
Ratio (functional) | = 8 | Antimicrobial activity against second mutant generation Mycobacterium tuberculosis 1024_8.12 assessed as fold shift in MIC relative to parent strain | ChEMBL. | 24967731 |
Ratio (functional) | = 8 | Antimicrobial activity against first mutant generation Mycobacterium tuberculosis 1024_18 assessed as fold shift in MIC relative to parent strain | ChEMBL. | 24967731 |
Ratio (functional) | = 8 | Antimicrobial activity against second mutant generation Mycobacterium tuberculosis 1024_18 assessed as fold shift in MIC relative to parent strain | ChEMBL. | 24967731 |
Ratio (functional) | = 16 | Antimicrobial activity against second mutant generation Mycobacterium tuberculosis 1024_16.5 assessed as fold shift in MIC relative to parent strain | ChEMBL. | 24967731 |
Ratio (functional) | = 16 | Antimicrobial activity against first mutant generation Mycobacterium tuberculosis 1024_1 assessed as fold shift in MIC relative to parent strain | ChEMBL. | 24967731 |
Ratio (functional) | = 16 | Antimicrobial activity against second mutant generation Mycobacterium tuberculosis 1024_16.6 assessed as fold shift in MIC relative to parent strain | ChEMBL. | 24967731 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.