Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Mus musculus | glucokinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase | 465 aa | 473 aa | 29.4 % |
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1379 | 0.361 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3608 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.3608 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.003 | 0.003 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 0.0206 | 0.0206 |
Treponema pallidum | hexokinase (hxk) | 0.0192 | 0.0206 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 0.0206 | 0.0206 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3608 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3608 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.2495 | 0.6809 | 0.6742 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1379 | 0.361 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.2525 | 0.6894 | 0.6894 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1379 | 0.361 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.3608 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0192 | 0.0206 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3608 | 1 | 1 |
Onchocerca volvulus | 0.0192 | 0.0206 | 1 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1379 | 0.361 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0192 | 0.0206 | 0.0206 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1379 | 0.361 | 1 |
Onchocerca volvulus | 0.0192 | 0.0206 | 1 | |
Loa Loa (eye worm) | TK/FAK protein kinase | 0.2525 | 0.6894 | 0.6894 |
Echinococcus multilocularis | protein tyrosine kinase | 0.2495 | 0.6809 | 0.6742 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1379 | 0.361 | 1 |
Brugia malayi | hexokinase | 0.0192 | 0.0206 | 0.0206 |
Onchocerca volvulus | 0.0192 | 0.0206 | 1 | |
Echinococcus granulosus | dihydrofolate reductase | 0.3608 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3608 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3608 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0192 | 0.0206 | 0.5 |
Echinococcus granulosus | protein tyrosine kinase | 0.2495 | 0.6809 | 0.6742 |
Brugia malayi | Hexokinase family protein | 0.0192 | 0.0206 | 0.0206 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 22 microL/min/mg | Intrinsic clearance in human liver microsomes at 1 uM after 30 mins in presence of NADPH | ChEMBL. | 25001129 |
EC50 (binding) | = 0.565 uM | Induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes preincubated for 20 mins followed by glucose challenge measured after 40 mins by Hoechst 33342 staining-based assay | ChEMBL. | 25001129 |
IC50 (binding) | = 0.006 uM | Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein-labeled GK measured after 2 to 4 hrs by AlphaScreen assay | ChEMBL. | 25001129 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.