Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrofolate reductase | 0.3379 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3379 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3379 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3379 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.3379 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.0108 | 0.0108 |
Brugia malayi | hexokinase | 0.0096 | 0.0108 | 0.0108 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.0108 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.3379 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0.0108 | 1 | |
Brugia malayi | Hexokinase family protein | 0.0096 | 0.0108 | 0.0108 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1292 | 0.3711 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1292 | 0.3711 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3379 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.0108 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1292 | 0.3711 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0016 | 0.0016 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3379 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3379 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1292 | 0.3711 | 1 |
Onchocerca volvulus | 0.0096 | 0.0108 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0108 | 0.0108 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.0108 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1292 | 0.3711 | 1 |
Onchocerca volvulus | 0.0096 | 0.0108 | 1 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1292 | 0.3711 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 40 microL/min/mg | Intrinsic clearance in human liver microsomes at 1 uM after 30 mins in presence of NADPH | ChEMBL. | 25001129 |
IC50 (binding) | = 0.309 uM | Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein-labeled GK measured after 2 to 4 hrs by AlphaScreen assay | ChEMBL. | 25001129 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.