TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.528 | Formula: C26H31NO5
H donors: 1 H acceptors: 3 LogP: 4.85 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1OCCCCCOc1ccccc1)[C@@]1(CC[C@H](CC1)C(=O)O)C#N
InChi: 1S/C26H31NO5/c1-30-23-11-10-21(26(19-27)14-12-20(13-15-26)25(28)29)18-24(23)32-17-7-3-6-16-31-22-8-4-2-5-9-22/h2,4-5,8-11,18,20H,3,6-7,12-17H2,1H3,(H,28,29)/t20-,26-
InChiKey: OJJUIHKECCXLHJ-AEEMYVKYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative		References
Trypanosoma brucei	cAMP-specific phosphodiesterase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0018	0.002	0.002
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.0022	0.0022
Toxoplasma gondii	melibiase subfamily protein	0.012	0.0628	0.9221
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0144	0.0851
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0042	0.0165	0.0985
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Loa Loa (eye worm)	ICD-1 protein	0.0035	0.0119	0.0119
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Trypanosoma cruzi	PAB1-binding protein , putative	0.0058	0.0258	0.3236
Mycobacterium ulcerans	carboxylesterase, LipT	0.0287	0.1617	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0058	0.0258	0.3752
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0147	0.0789	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0164	0.2357
Plasmodium vivax	ataxin-2 like protein, putative	0.0058	0.0258	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Schistosoma mansoni	glutamate receptor kainate	0.004	0.0153	0.0153
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0131	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0058	0.0258	0.3236
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0125	0.4761
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0125	0.0125
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0018	0.002	0.0085
Loa Loa (eye worm)	glutamate receptor 2	0.004	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0006	0.0006
Toxoplasma gondii	hypothetical protein	0.0129	0.0681	1
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0076	0.0432
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0121	0.0632	0.0632
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0065	0.0299	0.1819
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0125	0.075
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Brugia malayi	glutathione reductase	0.0041	0.0154	0.0154
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0023	0.0105
Echinococcus multilocularis	glutamate receptor NMDA	0.0079	0.0384	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0287	0.1617	0.1617
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0005	0.0005
Onchocerca volvulus		0.0111	0.0571	0.3506
Loa Loa (eye worm)	acetylcholinesterase 1	0.1696	1	1
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0144	0.0768	0.0768
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0018	0.002	0.0197
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0023	0.024
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0161	0.096
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0287	0.1617	0.1617
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0042	0.0165	0.0985
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0018	0.002	0.0085
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0161	0.096
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0018	0.002	0.0197
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0018	0.002	0.002
Loa Loa (eye worm)	glutathione reductase	0.0041	0.0154	0.0154
Brugia malayi	beta-lactamase family protein	0.0036	0.0125	0.0125
Schistosoma mansoni	acetylcholinesterase	0.0287	0.1617	0.1617
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Toxoplasma gondii	ABC1 family protein	0.0036	0.0125	0.1786
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0147	0.0789	0.4858
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0097	0.1174
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0382	0.2186	0.2186
Echinococcus granulosus	glutamate receptor NMDA	0.0079	0.0384	0.0384
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0287	0.1617	0.1617
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0018	0.002	0.002
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0065	0.0299	0.0299
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Mycobacterium ulcerans	lipase LipD	0.0036	0.0125	0.0641
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.012	0.0628	0.0628
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0164	0.0979
Entamoeba histolytica	hypothetical protein	0.0025	0.0062	0.3491
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0507	0.0507
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0287	0.1617	0.1617
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0018	0.002	0.002
Echinococcus granulosus	nmda type glutamate receptor	0.0087	0.043	0.043
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0015	0.0001	0.0001
Brugia malayi	Melibiase family protein	0.008	0.039	0.039
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0144	0.0144
Schistosoma mansoni	hypothetical protein	0.0121	0.0632	0.0632
Echinococcus multilocularis	NMDA receptor	0.0015	0.0001	0.0001
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0125	0.075
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0018	0.002	0.002
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0125	0.0641
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0018	0.002	0.0085
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0097	0.0097
Plasmodium falciparum	GAF domain-related protein, putative	0.0047	0.0192	0.7366
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0097	0.0097
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0097	0.3628
Onchocerca volvulus		0.0287	0.1617	1
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0048	0.1711
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.002	0.0197
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0018	0.002	0.002
Leishmania major	hypothetical protein, conserved	0.0058	0.0258	0.3236
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0048	0.0198	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0287	0.1617	0.1617
Onchocerca volvulus		0.0059	0.0266	0.1611
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0215	0.1192	0.736
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0147	0.0789	0.4858
Loa Loa (eye worm)	hypothetical protein	0.0287	0.1617	0.1617
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0165	0.0985
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0042	0.0165	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0025	0.006	0.0332
Schistosoma mansoni	glutamate receptor AMPA	0.004	0.0153	0.0153
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0018	0.002	0.061
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0131	0.0773
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.012	0.0628	0.0628
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.012	0.0628	0.0628
Echinococcus multilocularis	acetylcholinesterase	0.1696	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0125	0.0739
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0018	0.002	0.0085
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0632	0.0632
Leishmania major	basic transcription factor 3a, putative	0.0035	0.0119	0.1462
Mycobacterium tuberculosis	Probable dehydrogenase	0.0093	0.0464	0.285
Brugia malayi	Glutamate receptor 1 precursor	0.004	0.0153	0.0153
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0023	0.0023
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0382	0.2186	0.2186
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0258	0.0258
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0125	0.075
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0131	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0299	0.0299
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0131	0.1868
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.012	0.0628	0.0628
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0165	0.0985
Mycobacterium ulcerans	putative regulatory protein	0.0047	0.0192	0.1055
Plasmodium vivax	basic transcription factor 3b, putative	0.0035	0.0119	0.4519
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0126	0.0662	0.0662
Echinococcus granulosus	microtubule associated protein 2	0.0811	0.4737	0.4737
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0041	0.0157	0.0157
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0018	0.002	0.061
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0018	0.002	0.002
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0072	0.0072
Leishmania major	GTP-binding protein, putative	0.0023	0.0048	0.0554
Echinococcus granulosus	thioredoxin glutathione reductase	0.0041	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0018	0.002	0.002
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0143	0.8613
Brugia malayi	hypothetical protein	0.0287	0.1617	0.1617
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0025	0.006	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0125	0.0125
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0062	0.0344
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0018	0.002	0.002
Schistosoma mansoni	cpg binding protein	0.0063	0.0286	0.0286
Onchocerca volvulus		0.0287	0.1617	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0023	0.0023
Schistosoma mansoni	chromobox protein	0.0069	0.0325	0.0325
Schistosoma mansoni	hypothetical protein	0.0121	0.0632	0.0632
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0093	0.0464	0.285
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0119	0.0701
Trypanosoma brucei	trypanothione reductase	0.0041	0.0154	0.1908
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0048	0.0198	0.0198
Echinococcus multilocularis	dnaJ subfamily B	0.0407	0.2334	0.2334
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.008	0.039	0.039
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0005	0.0005
Entamoeba histolytica	hypothetical protein	0.0036	0.0125	0.7493
Echinococcus granulosus	lamin	0.0027	0.0072	0.0072
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0119	0.0701
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0025	0.006	0.0332
Loa Loa (eye worm)	PDE1B protein	0.0018	0.002	0.002
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0018	0.002	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.0681	0.4189
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0023	0.024
Plasmodium vivax	phosphodiesterase gamma, putative	0.0018	0.002	0.061
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0042	0.0165	0.2372
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0065	0.0299	0.1819
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0072	0.0072
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0048	0.1711
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0026	0.0068	0.0068
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.0681	0.4189
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0553	0.32	0.32
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0125	0.0125
Toxoplasma gondii	GAF domain-containing protein	0.0047	0.0192	0.2764
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0018	0.002	0.002
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0093	0.0464	0.285
Schistosoma mansoni	hypothetical protein	0.0026	0.0068	0.0068
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0023	0.024
Schistosoma mansoni	glutamate receptor kainate	0.004	0.0153	0.0153
Plasmodium falciparum	thioredoxin reductase	0.0041	0.0154	0.5894
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0018	0.002	0.002
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0507	0.0507
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0192	0.0192
Brugia malayi	intermediate filament protein	0.0027	0.0072	0.0072
Onchocerca volvulus		0.0287	0.1617	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0041	0.0154	0.0928
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0018	0.002	0.0197
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0023	0.0102
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0125	0.0739
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0042	0.0165	0.0985
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0191	0.1051	0.1051
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0131	0.0131
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0048	0.0198	0.0198
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Brugia malayi	Carboxylesterase family protein	0.0287	0.1617	0.1617
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0144	0.0768	0.0768
Brugia malayi	Carboxylesterase family protein	0.0287	0.1617	0.1617
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0147	0.0789	1
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0018	0.002	0.002
Echinococcus granulosus	histone acetyltransferase KAT2B	0.014	0.0744	0.0744
Leishmania major	trypanothione reductase	0.0041	0.0154	0.1908
Echinococcus granulosus	snurportin 1	0.0331	0.1881	0.1881
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0131	0.0675
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0165	0.0985
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0096	0.0483	0.0483
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0507	0.0507
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0093	0.0464	0.285
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.0681	0.4189
Brugia malayi	hypothetical protein	0.0036	0.0125	0.0125
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0287	0.1617	0.1617
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0096	0.0483	0.0483
Onchocerca volvulus		0.0027	0.0072	0.0407
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0026	0.0068	0.0068
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.002	0.0197
Leishmania major	glycosyl hydrolase-like protein	0.0016	0.0006	0.0024
Echinococcus multilocularis	snurportin 1	0.0331	0.1881	0.1881
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.008	0.039	0.2381
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0125	0.075
Echinococcus granulosus	glutamate receptor 2	0.0033	0.0109	0.0109
Plasmodium falciparum	ataxin-2 like protein, putative	0.0058	0.0258	1
Brugia malayi	Heterochromatin protein 1	0.0069	0.0325	0.0325
Echinococcus multilocularis	GPCR, family 2	0.0121	0.0632	0.0632
Brugia malayi	CXXC zinc finger family protein	0.0059	0.0266	0.0266
Brugia malayi	Glutamate receptor 2 precursor	0.004	0.0153	0.0153
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0125	0.075
Schistosoma mansoni	ATP-binding cassette transporter	0.004	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0018	0.002	0.002
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0042	0.0165	0.0165
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0097	0.1361
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0069	0.0069
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0017	0.0014	0.0014
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0144	0.0851
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0147	0.0789	0.4858
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0147	0.0789	0.4858
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0164	0.0164
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0121	0.0632	0.0632
Toxoplasma gondii	exonuclease III APE	0.0019	0.0023	0.0278
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0121	0.0632	0.0632
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0507	0.0507
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.01	0.0507	0.0507
Onchocerca volvulus		0.0027	0.0072	0.0407
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0062	0.073
Plasmodium vivax	hypothetical protein, conserved	0.0047	0.0192	0.7366
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0048	0.0048
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0103	0.0526	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0125	0.0125
Trichomonas vaginalis	spcc417.12 protein, putative	0.0287	0.1617	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0125	0.0739
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0047	0.0192	0.116
Echinococcus multilocularis	para nitrobenzyl esterase	0.0287	0.1617	0.1617
Schistosoma mansoni	hypothetical protein	0.0121	0.0632	0.0632
Schistosoma mansoni	ran	0.0023	0.0048	0.0048
Mycobacterium leprae	conserved hypothetical protein	0.0047	0.0192	0.2
Brugia malayi	Importin beta-1 subunit	0.0031	0.0097	0.0097
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0023	0.0117
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0131	0.0773
Brugia malayi	beta-NAC-like protein	0.0035	0.0119	0.0119
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.002	0.002
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0023	0.1068
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0125	0.075
Plasmodium falciparum	phosphodiesterase delta, putative	0.0018	0.002	0.061
Echinococcus multilocularis	acetylcholinesterase	0.1696	1	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0005	0.0005
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0287	0.1617	0.1617
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0025	0.006	0.0332
Trypanosoma brucei	glucosidase, putative	0.0042	0.0165	0.2046
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0331	0.1881	0.1881
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0125	0.0125
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0018	0.002	0.0197
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0015	0.0001	0.0001
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0125	0.0739
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0165	0.0985
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0507	0.0507
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0018	0.002	0.0197
Trypanosoma brucei	hypothetical protein, conserved	0.0018	0.002	0.0197
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0018	0.002	0.0085
Brugia malayi	Inositol-1	0.0037	0.0131	0.0131
Brugia malayi	beta-lactamase	0.0036	0.0125	0.0125
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0018	0.002	0.0197
Brugia malayi	Carboxylesterase family protein	0.0287	0.1617	0.1617
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0023	0.0102
Onchocerca volvulus		0.0036	0.0125	0.0739
Toxoplasma gondii	hypothetical protein	0.0047	0.0192	0.2764
Echinococcus granulosus	acetylcholinesterase	0.1696	1	1
Plasmodium falciparum	basic transcription factor 3b, putative	0.0035	0.0119	0.4519
Onchocerca volvulus		0.0287	0.1617	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0018	0.002	0.0085
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0125	0.075
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0048	0.0554
Schistosoma mansoni	hypothetical protein	0.0407	0.2334	0.2334
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0048	0.0554
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0023	0.0023
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0048	0.0642
Schistosoma mansoni	BC026374 protein (S09 family)	0.0287	0.1617	0.1617
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0018	0.002	0.002
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0131	0.1611
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0016	0.0006	0.0024
Mycobacterium tuberculosis	Probable reductase	0.0093	0.0464	0.285
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0017	0.0065
Echinococcus granulosus	glutamate receptor 2	0.0048	0.0198	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0125	0.0125
Echinococcus granulosus	GPCR family 2	0.0121	0.0632	0.0632
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.002	0.0197
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.01	0.0507	0.0507
Entamoeba histolytica	hypothetical protein	0.0036	0.0125	0.7493
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0018	0.002	0.061
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0287	0.1617	1
Echinococcus multilocularis	nmda type glutamate receptor	0.0094	0.0473	0.0473
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0018	0.002	0.002
Trypanosoma brucei	PAB1-binding protein , putative	0.0058	0.0258	0.3236
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0005	0.0005
Schistosoma mansoni	ap endonuclease	0.0019	0.0023	0.0023
Schistosoma mansoni	ran	0.0023	0.0048	0.0048
Schistosoma mansoni	glutamate receptor kainate	0.004	0.0153	0.0153
Entamoeba histolytica	hypothetical protein	0.0036	0.0125	0.7493
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0131	0.0773
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0147	0.0789	1
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0018	0.002	0.061
Loa Loa (eye worm)	hypothetical protein	0.0287	0.1617	0.1617
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0023	0.0105
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0125	0.1541
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0125	0.0125
Schistosoma mansoni	glutamate receptor AMPA	0.004	0.0153	0.0153
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0023	0.0023
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Brugia malayi	latrophilin 2 splice variant baaae	0.0261	0.1467	0.1467
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0018	0.002	0.061
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0131	0.1611
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0125	0.0641
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0025	0.006	0.0332
Toxoplasma gondii	thioredoxin reductase	0.0041	0.0154	0.2211
Brugia malayi	Latrophilin receptor protein 2	0.0121	0.0632	0.0632
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0147	0.0789	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.008	0.039	0.039
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0018	0.002	0.002
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0287	0.1617	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0018	0.002	0.0085
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0018	0.002	0.061
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0065	0.0299	0.0299
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0025	0.006	0.0332
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0125	0.0125
Echinococcus multilocularis	glutamate receptor 2	0.0048	0.0198	0.0198
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0076	0.0432
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0125	0.1541
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0325	0.0325
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1696	1	1
Echinococcus multilocularis	geminin	0.0553	0.32	0.32
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.002	0.0085
Schistosoma mansoni	hypothetical protein	0.0121	0.0632	0.0632
Echinococcus multilocularis	lamin dm0	0.0027	0.0072	0.0072
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.01	0.051	0.3124
Echinococcus granulosus	geminin	0.0553	0.32	0.32
Schistosoma mansoni	gliotactin	0.0287	0.1617	0.1617
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0125	0.0125
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0018	0.002	0.0085
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0287	0.1617	0.1617
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0048	0.0198	0.0198
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0005	0.0005
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.012	0.0628	0.0628
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0108	0.0642
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0023	0.074
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0143	0.5455
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0048	0.0198	0.0198
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0015	0.0001	0.0001
Schistosoma mansoni	alpha-glucosidase	0.0165	0.0893	0.0893
Toxoplasma gondii	hypothetical protein	0.0047	0.0192	0.2764
Schistosoma mansoni	transcription factor btf3	0.0035	0.0119	0.0119
Plasmodium vivax	thioredoxin reductase, putative	0.0041	0.0154	0.5894
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0125	0.0125
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0018	0.002	0.061
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0161	0.096
Mycobacterium ulcerans	putative regulatory protein	0.0047	0.0192	0.1055
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0018	0.002	0.0197
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0125	0.0641
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0018	0.002	0.002
Echinococcus multilocularis	cpg binding protein	0.0063	0.0286	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0018	0.002	0.002
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0022	0.0022
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0147	0.0789	0.4858
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0065	0.0299	0.0299
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0005	0.0005
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0147	0.0789	0.0789
Schistosoma mansoni	alpha-glucosidase	0.0165	0.0893	0.0893
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0042	0.0165	0.0165
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0097	0.0097
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0072	0.0072
Echinococcus granulosus	lysosomal alpha glucosidase	0.0191	0.1051	0.1051
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0018	0.002	0.0197
Schistosoma mansoni	alpha glucosidase	0.0042	0.0165	0.0165
Brugia malayi	acetyltransferase, GNAT family protein	0.0144	0.0768	0.0768
Leishmania major	hypothetical protein, conserved	0.0018	0.002	0.0197
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.01	0.051	0.3124
Echinococcus granulosus	BC026374 protein S09 family	0.0287	0.1617	0.1617
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0125	0.0125
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0125	0.0417
Echinococcus granulosus	neuroligin	0.0287	0.1617	0.1617
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0018	0.002	0.002
Brugia malayi	Carboxylesterase family protein	0.1696	1	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Entamoeba histolytica	hypothetical protein	0.0035	0.0119	0.7114
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0072	0.0072
Echinococcus granulosus	chromobox protein 1	0.0069	0.0325	0.0325
Echinococcus multilocularis	nmda type glutamate receptor	0.0087	0.043	0.043
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0164	0.6282
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0165	0.2046
Echinococcus granulosus	intermediate filament protein	0.0027	0.0072	0.0072
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0022	0.0022
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0018	0.002	0.002
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0125	0.0125
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0125	0.1541
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Plasmodium vivax	glutathione reductase, putative	0.0041	0.0154	0.5894
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.002	0.0197
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0125	0.075
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0018	0.002	0.002
Plasmodium falciparum	ataxin-2 like protein, putative	0.0058	0.0258	1
Toxoplasma gondii	NAC domain-containing protein	0.0035	0.0119	0.1695
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0325	0.1977
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0018	0.002	0.0197
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Echinococcus granulosus	dnaJ subfamily B	0.0407	0.2334	0.2334
Echinococcus granulosus	transcription factor btf3	0.0035	0.0119	0.0119
Plasmodium falciparum	glutathione reductase	0.0041	0.0154	0.5894
Echinococcus multilocularis	neuroligin	0.0287	0.1617	0.1617
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0097	0.1174
Schistosoma mansoni	importin beta-1	0.0031	0.0097	0.0097
Leishmania major	hypothetical protein, conserved	0.0018	0.002	0.0197
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.002	0.0085
Onchocerca volvulus		0.0036	0.0125	0.0739
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0018	0.002	0.002
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0125	0.0417
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0025	0.006	0.0332
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0048	0.0048
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0325	0.0325
Loa Loa (eye worm)	carboxylesterase	0.1696	1	1
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0018	0.002	0.061
Onchocerca volvulus		0.0287	0.1617	1
Trichomonas vaginalis	esterase, putative	0.0036	0.0125	0.0739
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0287	0.1617	0.1617
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0191	0.1051	0.1051
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0125	0.0641
Schistosoma mansoni	hypothetical protein	0.0553	0.32	0.32
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0125	0.0125
Schistosoma mansoni	hypothetical protein	0.0015	0.0001	0.0001
Brugia malayi	Thioredoxin reductase	0.0041	0.0154	0.0154
Loa Loa (eye worm)	hypothetical protein	0.003	0.0094	0.0094
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0062	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0287	0.1617	0.1617
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0015	0.0001	0.0001
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0147	0.0789	0.4858
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0131	0.0131
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0048	0.0198	0.0198
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0015	0.0001	0.0001
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0047	0.0192	0.116
Loa Loa (eye worm)	thioredoxin reductase	0.0041	0.0154	0.0154
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0121	0.0632	0.0632
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0165	0.2046
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0093	0.0464	0.8526
Echinococcus multilocularis	glutamate receptor 2	0.004	0.0153	0.0153
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0048	0.0198	0.0198
Brugia malayi	chromobox protein homolog 3	0.0039	0.0144	0.0144
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0018	0.002	0.002
Trypanosoma brucei	transcription factor BTF3, putative	0.0035	0.0119	0.1462
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0147	0.0789	1
Echinococcus granulosus	acetylcholinesterase	0.1696	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0325	0.1977
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0048	0.0198	0.0198
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0131	0.1611
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0192	0.1149
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0125	0.0125
Schistosoma mansoni	hypothetical protein	0.0331	0.1881	0.1881
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0048	0.0048
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0048	0.2272
Echinococcus granulosus	nmda type glutamate receptor	0.0094	0.0473	0.0473
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0042	0.0165	0.0165
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0059	0.0266	0.0266
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0507	0.0507
Loa Loa (eye worm)	carboxylesterase	0.0287	0.1617	0.1617
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0025	0.006	0.0332
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0018	0.002	0.0085
Schistosoma mansoni	lamin	0.0027	0.0072	0.0072
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.002	0.0197
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.0789	0.4858
Schistosoma mansoni	hypothetical protein	0.0261	0.1467	0.1467
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0125	0.075
Leishmania major	hypothetical protein, conserved	0.0036	0.0125	0.1541
Schistosoma mansoni	glutamate receptor NMDA	0.0127	0.067	0.067
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Entamoeba histolytica	transcription factor BTF3, putative	0.0035	0.0119	0.7114
Echinococcus granulosus	cpg binding protein	0.0063	0.0286	0.0286
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0191	0.1051	0.1051
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0164	0.0979
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0191	0.1051	0.1051
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0287	0.1617	1
Loa Loa (eye worm)	acetyltransferase	0.0144	0.0768	0.0768
Onchocerca volvulus		0.0036	0.0125	0.0739
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0018	0.002	0.0197
Schistosoma mansoni	glutamate receptor NMDA	0.0096	0.0483	0.0483
Leishmania major	alpha glucosidase II subunit, putative	0.0042	0.0165	0.2046
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.01	0.051	0.6439
Echinococcus multilocularis	carboxylesterase 5A	0.1696	1	1
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0131	0.785
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0023	0.027
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0507	0.0507
Trichomonas vaginalis	ran, putative	0.0023	0.0048	0.0258
Entamoeba histolytica	Ran family GTPase	0.0023	0.0048	0.262
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0147	0.0789	0.4858
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0125	0.0125
Toxoplasma gondii	Alpha-galactosidase	0.0017	0.0014	0.0134
Echinococcus multilocularis	lamin	0.0027	0.0072	0.0072
Echinococcus granulosus	carboxylesterase 5A	0.1696	1	1
Loa Loa (eye worm)	hypothetical protein	0.0215	0.1192	0.1192
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0103	0.0526	0.3232
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0048	0.0554
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0023	0.074
Loa Loa (eye worm)	hypothetical protein	0.0382	0.2186	0.2186
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0116	0.0603	0.885
Loa Loa (eye worm)	carboxylesterase	0.0287	0.1617	0.1617
Loa Loa (eye worm)	hypothetical protein	0.008	0.039	0.039
Loa Loa (eye worm)	hypothetical protein	0.1696	1	1
Loa Loa (eye worm)	hypothetical protein	0.0261	0.1467	0.1467
Brugia malayi	RNA, U transporter 1	0.0088	0.0437	0.0437
Schistosoma mansoni	microtubule-associated protein tau	0.0811	0.4737	0.4737
Plasmodium falciparum	importin beta, putative	0.0031	0.0097	0.3628
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0015	0.0001	0.0001
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Mycobacterium tuberculosis	Probable oxidoreductase	0.0103	0.0526	0.3232
Echinococcus multilocularis	musashi	0.0027	0.0072	0.0072
Brugia malayi	N-terminal motif family protein	0.0215	0.1192	0.1192
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0125	0.075
Schistosoma mansoni	ap endonuclease	0.0019	0.0023	0.0023
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0287	0.1617	0.1617
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0143	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0042	0.0165	0.0985
Echinococcus multilocularis	transcription factor btf3	0.0035	0.0119	0.0119
Schistosoma mansoni	cpg binding protein	0.0059	0.0266	0.0266
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0023	0.5
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0147	0.0789	0.0789
Trypanosoma cruzi	trypanothione reductase, putative	0.0041	0.0154	0.1908
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0023	0.024
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0005	0.0005
Loa Loa (eye worm)	heterochromatin protein 1	0.0069	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.018	0.0983	0.0983
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.012	0.0628	0.0628
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0287	0.1617	1
Brugia malayi	Carboxylesterase family protein	0.0287	0.1617	0.1617
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0125	0.0125
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0042	0.0165	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0147	0.0789	0.4858
Onchocerca volvulus		0.018	0.0983	0.6065
Loa Loa (eye worm)	cytochrome P450 family protein	0.0045	0.018	0.018
Loa Loa (eye worm)	glutamate receptor 1	0.004	0.0153	0.0153
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0147	0.0789	0.4858
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0016	0.0006	0.0024
Brugia malayi	hypothetical protein	0.0058	0.0258	0.0258
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0065	0.0299	0.1819
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0119	0.0701
Echinococcus multilocularis	glutamate receptor 2	0.0033	0.0109	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0144	0.0851
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0119	0.1462
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0018	0.002	0.0085
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0005	0.0005
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0147	0.0789	0.4858
Brugia malayi	hypothetical protein	0.0038	0.0136	0.0136
Brugia malayi	beta-lactamase family protein	0.0036	0.0125	0.0125
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0018	0.002	0.002
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0047	0.0192	0.1055
Echinococcus granulosus	lamin dm0	0.0027	0.0072	0.0072
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0018	0.002	0.002
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0382	0.2186	0.2186
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0131	0.0131
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0062	0.073
Schistosoma mansoni	chromobox protein	0.0069	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0287	0.1617	0.1617
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0147	0.0789	0.0789
Brugia malayi	Cytochrome P450 family protein	0.0045	0.018	0.018
Schistosoma mansoni	cpg binding protein	0.0063	0.0286	0.0286
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0018	0.002	0.002
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.012	0.0628	0.0628
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0018	0.002	0.002
Loa Loa (eye worm)	inositol-1	0.0037	0.0131	0.0131
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0015	0.0001	0.0001
Brugia malayi	hypothetical protein	0.018	0.0983	0.0983
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.1274	0.7874
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.002	0.0197
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0093	0.0464	0.285
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0018	0.002	0.0229
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0065	0.0299	0.0299
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0018	0.002	0.002
Entamoeba histolytica	hypothetical protein	0.0036	0.0125	0.7493
Loa Loa (eye worm)	hypothetical protein	0.1696	1	1
Onchocerca volvulus		0.003	0.0094	0.0541
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0016	0.0006	0.0024
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0016	0.0006	0.0006
Echinococcus granulosus	neutral alpha glucosidase AB	0.0042	0.0165	0.0165
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0164	0.2357
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0103	0.0526	0.3232
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0121	0.0632	0.0632
Echinococcus granulosus	para nitrobenzyl esterase	0.0287	0.1617	0.1617
Echinococcus granulosus	chromobox protein 1	0.0069	0.0325	0.0325
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0121	0.0632	0.0632
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0015	0.0001	0.0001
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0005	0.0005
Echinococcus multilocularis	microtubule associated protein 2	0.0811	0.4737	0.4737
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0147	0.0789	0.4858
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0062	0.0344
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0125	0.0739
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0048	0.0048
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0042	0.0165	0.0985
Schistosoma mansoni	lamin	0.0027	0.0072	0.0072
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0119	0.1462
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0147	0.0789	0.4858
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0065	0.0299	0.0299

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 9.8 uM	Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate addition	ChEMBL.	25127163
Inhibition (binding)	= 54 %	Inhibition of Trypanosoma brucei recombinant PDEB1 at 10 uM pre-incubated for 5 mins prior to substrate addition	ChEMBL.	25127163

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3321771

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 922990