TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 393.48 | Formula: C26H23N3O
H donors: 0 H acceptors: 1 LogP: 5.46 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1c(c2cccc(c2)C)n2c(n1C)cc(n2)c1ccccc1
InChi: 1S/C26H23N3O/c1-18-8-7-11-21(16-18)26-25(20-12-14-22(30-3)15-13-20)28(2)24-17-23(27-29(24)26)19-9-5-4-6-10-19/h4-17H,1-3H3
InChiKey: PSQXKCQHFKQWQP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Chlamydia trachomatis	hydrolase	0.0021	0.0051	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0086	0.019
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0016	0.0006	0.0051
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0035	0.0031
Echinococcus granulosus	abhydrolase domain containing protein 13	0.0021	0.0051	0.0407
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0361	0.271	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0103
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0028	0.0103	0.0819
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0028	0.0103	0.0819
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0028	0.0103	0.0103
Brugia malayi	steroid hormone receptor	0.0028	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0103
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0189	0.1506
Brugia malayi	hypothetical protein	0.0039	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.1291	1	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0065	0.0395	0.0395
Echinococcus multilocularis	Ankyrin	0.0016	0.0007	0.006
Trypanosoma brucei	carbonic anhydrase-like protein	0.0175	0.1258	0.454
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0086	0.0086
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0091	0.0596	0.4738
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0021	0.0051	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0035
Schistosoma mansoni	thyroid hormone receptor	0.0028	0.0103	0.0819
Onchocerca volvulus		0.0028	0.0103	0.221
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0028	0.0103	0.0819
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0065	0.0395	0.0395
Brugia malayi	MGC79044 protein	0.0021	0.0051	0.0051
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0016	0.0006	0.0051
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0361	0.271	1
Plasmodium falciparum	lysophospholipase, putative	0.0361	0.271	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0086	0.0086
Plasmodium falciparum	BEM46-like protein, putative	0.0021	0.0051	0.0061
Schistosoma mansoni	jun-related protein	0.0074	0.0463	0.3679
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0028	0.0103	0.0103
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0065	0.0395	0.0395
Plasmodium vivax	lysophospholipase, putative	0.0021	0.0051	0.0061
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0086	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0028	0.0103	0.0103
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0103	0.0695	0.552
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0103	0.0695	0.552
Schistosoma mansoni	retinoic acid receptor RXR	0.0028	0.0103	0.0819
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0086	0.019
Mycobacterium ulcerans	hypothetical protein	0.0021	0.0051	0.0061
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0086	0.0129
Schistosoma mansoni	coup transcription factor	0.0028	0.0103	0.0819
Brugia malayi	Nuclear hormone receptor-like 1	0.0028	0.0103	0.0103
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0086	0.019
Leishmania major	hypothetical protein, conserved	0.0021	0.0051	0.000000026566
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0086	0.0086
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0021	0.0051	0.0407
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0086	0.0129
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0103	0.0695	0.552
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0028	0.0103	0.0819
Schistosoma mansoni	netrin receptor unc5	0.0016	0.0006	0.0051
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0175	0.1258	0.1258
Brugia malayi	Uncoordinated protein 44	0.0016	0.0006	0.0006
Echinococcus multilocularis	Phospholipase carboxylesterase	0.0021	0.0051	0.0407
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0028	0.0103	0.0819
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0028	0.0103	0.0103
Echinococcus granulosus	monoacylglycerol lipase abhd12	0.0021	0.0051	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0577	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0103
Loa Loa (eye worm)	carbonic anhydrase 3	0.0175	0.1258	0.1258
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0028	0.0103	0.0819
Schistosoma mansoni	hypothetical protein	0.0039	0.0189	0.1506
Chlamydia trachomatis	acyltransferase family protein	0.0021	0.0051	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0035
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0028	0.0103	0.221
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0028	0.0103	0.0103
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0028	0.0103	0.0103
Brugia malayi	Death domain containing protein	0.0016	0.0006	0.0006
Entamoeba histolytica	hypothetical protein	0.0039	0.0189	0.052
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0086	0.019
Plasmodium falciparum	lysophospholipase, putative	0.0021	0.0051	0.0061
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0028	0.0103	0.0103
Echinococcus granulosus	FTZ F1 alpha	0.0028	0.0103	0.0819
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0028	0.0103	0.0819
Brugia malayi	nuclear receptor NHR-88	0.0028	0.0103	0.0103
Echinococcus multilocularis	FTZ F1 alpha	0.0028	0.0103	0.0819
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0028	0.0103	0.0103
Schistosoma mansoni	hypothetical protein	0.0074	0.0463	0.3679
Echinococcus granulosus	jun protein	0.0091	0.0596	0.4738
Plasmodium vivax	PST-A protein	0.0021	0.0051	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Echinococcus multilocularis	carbonic anhydrase	0.0065	0.0395	0.3137
Schistosoma mansoni	fatty-acid amide hydrolase	0.0103	0.0695	0.552
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0361	0.271	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0006	0.0006
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0175	0.1258	1
Echinococcus granulosus	netrin receptor unc 5	0.0016	0.0006	0.0051
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0028	0.0103	0.0103
Brugia malayi	bZIP transcription factor family protein	0.0091	0.0596	0.0596
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0086	0.022
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0086	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0028	0.0103	0.0103
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0021	0.0051	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0103
Schistosoma mansoni	carbonic anhydrase	0.0065	0.0395	0.3137
Schistosoma mansoni	RAR-like nuclear receptor	0.0028	0.0103	0.0819
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0175	0.1258	0.454
Plasmodium vivax	lysophospholipase, putative	0.0021	0.0051	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0361	0.271	1
Schistosoma mansoni	carbonic anhydrase-related	0.0065	0.0395	0.3137
Brugia malayi	photoreceptor-specific nuclear receptor	0.0028	0.0103	0.0103
Echinococcus multilocularis	netrin receptor unc 5	0.0016	0.0006	0.0051
Schistosoma mansoni	nuclear hormone receptor	0.0028	0.0103	0.0819
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0028	0.0103	0.0103
Mycobacterium ulcerans	hypothetical protein	0.0021	0.0051	0.0061
Plasmodium vivax	unspecified product	0.0021	0.0051	0.0061
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0028	0.0103	0.0819
Echinococcus granulosus	abhydrolase domain containing 3	0.0021	0.0051	0.0407
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0103	0.0695	0.552
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0051	0.0061
Plasmodium vivax	alpha/beta hydrolase, putative	0.0021	0.0051	0.0061
Echinococcus multilocularis	carbonic anhydrase	0.0065	0.0395	0.3137
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0028	0.0103	0.0819
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0086	0.022
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0021	0.0051	0.0061
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0175	0.1258	0.1258
Trypanosoma brucei	monoglyceride lipase, putative	0.0361	0.271	1
Plasmodium falciparum	esterase, putative	0.0361	0.271	1
Plasmodium falciparum	exported lipase 2	0.0021	0.0051	0.0061
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0028	0.0103	0.0819
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0086	0.019
Schistosoma mansoni	carbonic anhydrase-related	0.0065	0.0395	0.3137
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.008	0.0509	0.4042
Schistosoma mansoni	thyroid hormone receptor	0.0028	0.0103	0.0819
Echinococcus granulosus	Phospholipase carboxylesterase	0.0021	0.0051	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Entamoeba histolytica	hypothetical protein	0.0039	0.0189	0.052
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0028	0.0103	0.0819
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0175	0.1258	0.454
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0091	0.0596	0.4738
Echinococcus multilocularis	carbonic anhydrase II	0.0175	0.1258	1
Plasmodium vivax	alpha/beta hydrolase, putative	0.0021	0.0051	0.0061
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0189	0.1506
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.0006	0.0006
Schistosoma mansoni	hypothetical protein	0.0016	0.0006	0.0051
Echinococcus granulosus	carbonic anhydrase II	0.0175	0.1258	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0028	0.0103	0.0819
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0028	0.0103	0.0819
Echinococcus granulosus	nuclear factor of activated T cells 5	0.008	0.0509	0.4042
Brugia malayi	Protein C20orf22	0.0021	0.0051	0.0051
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0065	0.0395	0.0395
Schistosoma mansoni	carbonic anhydrase-related	0.0065	0.0395	0.3137
Echinococcus multilocularis	jun protein	0.0091	0.0596	0.4738
Plasmodium falciparum	alpha/beta hydrolase fold domain containing protein, putative	0.0021	0.0051	0.0061
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0028	0.0103	0.0819
Trypanosoma brucei	monoglyceride lipase, putative	0.0361	0.271	1
Schistosoma mansoni	ankyrin 23/unc44	0.0016	0.0006	0.0051
Giardia lamblia	Cgi67 serine protease precursor-like protein	0.0021	0.0051	0.5
Plasmodium falciparum	prodrug activation and resistance esterase	0.0021	0.0051	0.0061
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0028	0.0103	0.0103
Plasmodium vivax	lysophospholipase, putative	0.0021	0.0051	0.0061
Echinococcus granulosus	ecdysone induced protein 78C	0.0028	0.0103	0.0819
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0028	0.0103	0.0103
Brugia malayi	nuclear hormone receptor	0.0028	0.0103	0.0103
Plasmodium falciparum	lysophospholipase, putative	0.0361	0.271	1
Plasmodium vivax	PST-A protein	0.0021	0.0051	0.0061
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0028	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0086	0.0086
Echinococcus granulosus	Ankyrin	0.0016	0.0007	0.006
Trypanosoma cruzi	monoglyceride lipase, putative	0.0361	0.271	1
Echinococcus granulosus	death domain containing protein	0.0016	0.0006	0.0051
Echinococcus granulosus	carbonic anhydrase	0.0065	0.0395	0.3137
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0028	0.0103	0.0103
Leishmania major	monoglyceride lipase, putative	0.0361	0.271	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0189	0.052
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0028	0.0103	0.0819
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0395	0.0395
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0065	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0103
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0028	0.0103	0.0819
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0086	0.019
Plasmodium vivax	PST-A protein	0.0021	0.0051	0.0061
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0016	0.0006	0.0006
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0361	0.271	1
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0175	0.1258	1
Plasmodium falciparum	epoxide hydrolase 2	0.0021	0.0051	0.0061
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0028	0.0103	0.0819
Onchocerca volvulus		0.0026	0.0086	0.181
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0189	0.1506
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0175	0.1258	0.1258
Onchocerca volvulus		0.0071	0.0443	1
Mycobacterium ulcerans	hypothetical protein	0.0361	0.271	1
Echinococcus multilocularis	carbonic anhydrase	0.0065	0.0395	0.3137
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0361	0.271	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0035
Brugia malayi	amidase	0.0103	0.0695	0.0695
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0051	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0103
Plasmodium falciparum	esterase, putative	0.0021	0.0051	0.0061
Echinococcus multilocularis	monoacylglycerol lipase abhd12	0.0021	0.0051	0.0407
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0028	0.0103	0.0819
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0021	0.0051	0.0061
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0028	0.0103	0.0103
Plasmodium vivax	PST-A protein	0.0361	0.271	1
Schistosoma mansoni	peptidase	0.0021	0.0051	0.0407
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0086	0.019
Echinococcus multilocularis	abhydrolase domain containing 3	0.0021	0.0051	0.0407
Loa Loa (eye worm)	steroid hormone receptor	0.0028	0.0103	0.0103
Brugia malayi	ecdysteroid receptor	0.0028	0.0103	0.0103
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0028	0.0103	0.0103
Onchocerca volvulus	Protein ultraspiracle homolog	0.0028	0.0103	0.221
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0028	0.0103	0.0819
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0028	0.0103	0.0103
Plasmodium falciparum	alpha/beta-hydrolase, putative	0.0021	0.0051	0.0061
Plasmodium falciparum	esterase, putative	0.0021	0.0051	0.0061
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0361	0.271	1
Leishmania major	carbonic anhydrase-like protein	0.0175	0.1258	0.454
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0361	0.271	1
Onchocerca volvulus	Bile acid receptor homolog	0.0028	0.0103	0.221
Plasmodium falciparum	carbonic anhydrase	0.0065	0.0395	0.1345
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0028	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0035
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0051	0.0092
Mycobacterium ulcerans	lysophospholipase	0.0361	0.271	1
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0016	0.0007	0.006
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0028	0.0103	0.0819
Plasmodium falciparum	lysophospholipase, putative	0.0021	0.0051	0.0061
Echinococcus granulosus	carbonic anhydrase	0.0065	0.0395	0.3137
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0051	0.0051
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0021	0.0051	0.0061
Brugia malayi	MGC83647 protein	0.0021	0.0051	0.0051
Plasmodium falciparum	exported lipase 1	0.0021	0.0051	0.0061
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0361	0.271	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0189	0.052
Plasmodium vivax	unspecified product	0.0021	0.0051	0.0061
Toxoplasma gondii	hypothetical protein	0.0065	0.0395	1
Plasmodium vivax	PST-A protein	0.0021	0.0051	0.0061
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0086	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0086	0.0086
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0086	0.0129
Echinococcus granulosus	carbonic anhydrase	0.0065	0.0395	0.3137
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0086	0.0086
Mycobacterium ulcerans	hydrolase	0.0021	0.0051	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0695	0.0695
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0021	0.0051	0.0407
Mycobacterium tuberculosis	Possible lysophospholipase	0.0361	0.271	1
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0051	0.0061
Plasmodium falciparum	lysophospholipase, putative	0.0361	0.271	1
Brugia malayi	hypothetical protein	0.0071	0.0443	0.0443
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0361	0.271	1
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0065	0.0395	0.0395
Brugia malayi	Steroid receptor seven-up type 2	0.0028	0.0103	0.0103
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0028	0.0103	0.0819
Plasmodium vivax	PST-A protein	0.0021	0.0051	0.0061
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0086	0.019
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0103	0.0103
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0361	0.271	1
Schistosoma mansoni	hypothetical protein	0.0065	0.0395	0.3137
Schistosoma mansoni	amidase	0.0103	0.0695	0.552
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0028	0.0103	0.0103
Echinococcus multilocularis	ecdysone induced protein 78C	0.0028	0.0103	0.0819

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 31 uM	Anticancer activity human A549 cells assessed as growth inhibition by MTT colorimetric assay	ChEMBL.	25064349

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3323634

Bibliographic References

No literature references available for this target.

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Detailed information for compound 923084