TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 344.32 | Formula: C20H12N2O4
H donors: 0 H acceptors: 3 LogP: 3.24 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccccc1c1noc(c1)COc1ccc2c(c1)ccc(=O)o2
InChi: 1S/C20H12N2O4/c21-11-14-3-1-2-4-17(14)18-10-16(26-22-18)12-24-15-6-7-19-13(9-15)5-8-20(23)25-19/h1-10H,12H2
InChiKey: QOEDRMVQJDTQEW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	jmjC domain containing protein	0.0036	0.0165	0.0165
Echinococcus granulosus	jun protein	0.0091	0.0618	0.7753
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0114	0.0287
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0083	0.0093
Brugia malayi	photoreceptor-specific nuclear receptor	0.0027	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0019	0.003	0.003
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0382	0.2982	1
Schistosoma mansoni	peptidase	0.0022	0.0056	0.0699
Brugia malayi	ecdysteroid receptor	0.0027	0.0095	0.0095
Brugia malayi	nuclear receptor NHR-88	0.0027	0.0095	0.0095
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0083	0.0083
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0027	0.0095	0.1192
Trichomonas vaginalis	conserved hypothetical protein	0.0382	0.2982	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0192	0.0465
Schistosoma mansoni	retinoic acid receptor RXR	0.0027	0.0095	0.1192
Plasmodium vivax	PST-A protein	0.0022	0.0056	0.0088
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0382	0.2982	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0027	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0019	0.003	0.003
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0027	0.0095	0.0095
Echinococcus granulosus	abhydrolase domain containing protein 13	0.0022	0.0056	0.0699
Mycobacterium ulcerans	hypothetical protein	0.0382	0.2982	1
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0114	0.1434
Echinococcus multilocularis	monoacylglycerol lipase abhd12	0.0022	0.0056	0.0699
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0027	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0056	0.0056
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0027	0.0095	0.0095
Schistosoma mansoni	RAR-like nuclear receptor	0.0027	0.0095	0.1192
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0016	0.000000007398	0.000000092852
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0083	0.018
Entamoeba histolytica	hypothetical protein	0.0039	0.0192	0.0465
Plasmodium vivax	lysophospholipase, putative	0.0022	0.0056	0.0088
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0165	0.2073
Plasmodium vivax	unspecified product	0.0022	0.0056	0.0088
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0027	0.0095	0.1192
Plasmodium vivax	lysophospholipase, putative	0.0022	0.0056	0.0088
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0083	0.0093
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0192	0.2406
Plasmodium falciparum	lysophospholipase, putative	0.0022	0.0056	0.0088
Brugia malayi	bZIP transcription factor family protein	0.0091	0.0618	0.0618
Schistosoma mansoni	nuclear hormone receptor	0.0027	0.0095	0.1192
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0056	0.0056
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0027	0.0095	0.0095
Leishmania major	monoglyceride lipase, putative	0.0382	0.2982	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0165	0.2073
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0083	0.018
Brugia malayi	amidase	0.0113	0.0797	0.0797
Echinococcus granulosus	Phospholipase carboxylesterase	0.0022	0.0056	0.0699
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0022	0.0056	0.0088
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0192	0.2406
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0027	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0019	0.003	0.003
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0027	0.0095	0.0095
Schistosoma mansoni	jun-related protein	0.0074	0.0478	0.6
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0083	0.018
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0056	0.0088
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0083	0.0093
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0022	0.0056	0.0088
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0382	0.2982	1
Echinococcus multilocularis	peregrin	0.003	0.0114	0.1434
Plasmodium vivax	lysophospholipase, putative	0.0022	0.0056	0.0088
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0022	0.0056	0.0088
Plasmodium falciparum	lysophospholipase, putative	0.0382	0.2982	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0192	0.0465
Brugia malayi	Steroid receptor seven-up type 2	0.0027	0.0095	0.0095
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0372	0.0372
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0027	0.0095	0.0095
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0027	0.0095	0.1192
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.003	0.0029
Plasmodium vivax	PST-A protein	0.0022	0.0056	0.0088
Plasmodium falciparum	lysophospholipase, putative	0.0382	0.2982	1
Brugia malayi	jmjC domain containing protein	0.0097	0.0665	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0001	0.0001
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0165	0.2073
Plasmodium vivax	hypothetical protein, conserved	0.0022	0.0056	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0019	0.003	0.003
Plasmodium vivax	alpha/beta hydrolase, putative	0.0022	0.0056	0.0088
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.008	0.0526	0.6601
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0114	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0083	0.0083
Plasmodium falciparum	alpha/beta-hydrolase, putative	0.0022	0.0056	0.0088
Echinococcus multilocularis	abhydrolase domain containing 3	0.0022	0.0056	0.0699
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0382	0.2982	1
Plasmodium falciparum	alpha/beta hydrolase fold domain containing protein, putative	0.0022	0.0056	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0095	0.0095
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0114	0.0114
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0382	0.2982	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0027	0.0095	0.1192
Onchocerca volvulus	Bile acid receptor homolog	0.0027	0.0095	0.2076
Echinococcus granulosus	peregrin	0.003	0.0114	0.1434
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0027	0.0095	0.1192
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0113	0.0797	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0027	0.0095	0.2076
Echinococcus granulosus	ecdysone induced protein 78C	0.0027	0.0095	0.1192
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0027	0.0095	0.0095
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0027	0.0095	0.0095
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0056	0.0088
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0083	0.018
Schistosoma mansoni	thyroid hormone receptor	0.0027	0.0095	0.1192
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0056	0.0056
Plasmodium falciparum	esterase, putative	0.0022	0.0056	0.0088
Echinococcus multilocularis	Ankyrin	0.0016	0.0001	0.0014
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0016	0.0001	0.0014
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0027	0.0095	0.1192
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0095	0.0095
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0382	0.2982	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0027	0.0095	0.2076
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0016	0.000000007398	0.000000092852
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0095	0.0095
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0027	0.0095	0.1192
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0027	0.0095	0.1192
Plasmodium vivax	hypothetical protein, conserved	0.0022	0.0056	0.0088
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0027	0.0095	0.0095
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0027	0.0095	0.0095
Plasmodium falciparum	exported lipase 1	0.0022	0.0056	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0095	0.0095
Plasmodium vivax	alpha/beta hydrolase, putative	0.0022	0.0056	0.0088
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0027	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0287	0.0287
Brugia malayi	MGC83647 protein	0.0022	0.0056	0.0056
Brugia malayi	MGC79044 protein	0.0022	0.0056	0.0056
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0022	0.0056	0.0699
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0192	0.2406
Echinococcus granulosus	FTZ F1 alpha	0.0027	0.0095	0.1192
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0097	0.0665	0.8341
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0083	0.0093
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0027	0.0095	0.1192
Brugia malayi	Protein kinase domain containing protein	0.0016	0.000000007398	0.000000007398
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0083	0.0209
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0091	0.0618	0.7753
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0091	0.0618	0.7753
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.0502	0.6298
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0027	0.0095	0.1192
Trichomonas vaginalis	conserved hypothetical protein	0.0382	0.2982	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0027	0.0095	0.1192
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0083	0.0083
Schistosoma mansoni	fatty-acid amide hydrolase	0.0113	0.0797	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0027	0.0095	0.1192
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0056	0.0117
Chlamydia trachomatis	acyltransferase family protein	0.0022	0.0056	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0113	0.0797	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0114	0.0114
Plasmodium falciparum	exported lipase 2	0.0022	0.0056	0.0088
Entamoeba histolytica	hypothetical protein	0.0039	0.0192	0.0465
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0382	0.2982	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.003	0.003
Plasmodium falciparum	esterase, putative	0.0382	0.2982	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0056	0.0056
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0083	0.0083
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0027	0.0095	0.0095
Schistosoma mansoni	hypothetical protein	0.003	0.0114	0.1434
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0114	0.1434
Brugia malayi	steroid hormone receptor	0.0027	0.0095	0.0095
Echinococcus multilocularis	Phospholipase carboxylesterase	0.0022	0.0056	0.0699
Echinococcus granulosus	nuclear factor of activated T cells 5	0.008	0.0526	0.6601
Echinococcus multilocularis	jun protein	0.0091	0.0618	0.7753
Trypanosoma cruzi	monoglyceride lipase, putative	0.0382	0.2982	1
Plasmodium vivax	PST-A protein	0.0022	0.0056	0.0088
Onchocerca volvulus	Alhambra homolog	0.003	0.0114	0.2497
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0027	0.0095	0.1192
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0027	0.0095	0.1192
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0095	0.0095
Echinococcus granulosus	abhydrolase domain containing 3	0.0022	0.0056	0.0699
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0083	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0095	0.0095
Schistosoma mansoni	thyroid hormone receptor	0.0027	0.0095	0.1192
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0083	0.018
Schistosoma mansoni	coup transcription factor	0.0027	0.0095	0.1192
Leishmania major	hypothetical protein, conserved	0.0022	0.0056	0.000000025279
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0027	0.0095	0.0095
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0083	0.0093
Mycobacterium ulcerans	hydrolase	0.0022	0.0056	0.0088
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0027	0.0095	0.1192
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0114	0.1434
Loa Loa (eye worm)	steroid hormone receptor	0.0027	0.0095	0.0095
Echinococcus multilocularis	FTZ F1 alpha	0.0027	0.0095	0.1192
Mycobacterium ulcerans	lysophospholipase	0.0382	0.2982	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0027	0.0095	0.0095
Plasmodium vivax	PST-A protein	0.0022	0.0056	0.0088
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0382	0.2982	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0056	0.0056
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0027	0.0095	0.1192
Brugia malayi	hypothetical protein	0.0039	0.0192	0.0192
Echinococcus multilocularis	ecdysone induced protein 78C	0.0027	0.0095	0.1192
Plasmodium vivax	PST-A protein	0.0382	0.2982	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0165	0.2073
Trypanosoma brucei	monoglyceride lipase, putative	0.0382	0.2982	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0097	0.0665	0.8341
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0165	0.0165
Brugia malayi	Protein C20orf22	0.0022	0.0056	0.0056
Plasmodium falciparum	esterase, putative	0.0022	0.0056	0.0088
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0083	0.018
Brugia malayi	hypothetical protein	0.0072	0.0458	0.0458
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0027	0.0095	0.1192
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0209	0.2623
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0114	1
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0022	0.0056	0.0088
Loa Loa (eye worm)	hypothetical protein	0.1243	1	1
Giardia lamblia	PHD finger protein 15	0.003	0.0114	1
Plasmodium falciparum	phd finger protein, putative	0.003	0.0114	0.0287
Plasmodium falciparum	BEM46-like protein, putative	0.0022	0.0056	0.0088
Plasmodium falciparum	epoxide hydrolase 2	0.0022	0.0056	0.0088
Brugia malayi	Uncoordinated protein 44	0.0016	0.000000007398	0.000000007398
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0027	0.0095	0.0095
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0027	0.0095	0.0095
Onchocerca volvulus		0.0027	0.0095	0.2076
Plasmodium falciparum	prodrug activation and resistance esterase	0.0022	0.0056	0.0088
Mycobacterium tuberculosis	Possible lysophospholipase	0.0382	0.2982	1
Onchocerca volvulus		0.0072	0.0458	1
Plasmodium vivax	hypothetical protein, conserved	0.0022	0.0056	0.0088
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0027	0.0095	0.0095
Schistosoma mansoni	ankyrin 23/unc44	0.0016	0.000000007398	0.000000092852
Schistosoma mansoni	amidase	0.0113	0.0797	1
Schistosoma mansoni	hypothetical protein	0.0074	0.0478	0.6
Brugia malayi	Bromodomain containing protein	0.003	0.0114	0.0114
Plasmodium vivax	unspecified product	0.0022	0.0056	0.0088
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0027	0.0095	0.1192
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0113	0.0797	1
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0382	0.2982	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0027	0.0095	0.1192
Schistosoma mansoni	hypothetical protein	0.0039	0.0192	0.2406
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0209	0.2623
Echinococcus granulosus	monoacylglycerol lipase abhd12	0.0022	0.0056	0.0699
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0027	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0797	0.0797
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0027	0.0095	0.0095
Brugia malayi	nuclear hormone receptor	0.0027	0.0095	0.0095
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0027	0.0095	0.1192
Onchocerca volvulus		0.0026	0.0083	0.181
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0083	0.0209
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0022	0.0056	0.0088
Brugia malayi	PHD-finger family protein	0.003	0.0114	0.0114
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0022	0.0056	0.0699
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0095	0.0095
Brugia malayi	Death domain containing protein	0.0016	0.000000007398	0.000000007398
Plasmodium vivax	PST-A protein	0.0022	0.0056	0.0088
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0083	0.018
Chlamydia trachomatis	hydrolase	0.0022	0.0056	1
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0113	0.0797	1
Trypanosoma brucei	monoglyceride lipase, putative	0.0382	0.2982	1
Plasmodium falciparum	lysophospholipase, putative	0.0022	0.0056	0.0088
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0027	0.0095	0.1192
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0083	0.018
Plasmodium falciparum	lysophospholipase, putative	0.0382	0.2982	1
Echinococcus granulosus	Ankyrin	0.0016	0.0001	0.0014

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 55.8 uM	Cytotoxicity against human A549 cells after 48 hrs by MTT assay	ChEMBL.	25088398

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3322104

Bibliographic References

No literature references available for this target.

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Detailed information for compound 923371