Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2Y, G-protein coupled, 12 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 201 nM | Displacement of [3H]-2-methyl-thio-adenosine 5'-diphosphate from human recombinant P2Y12 expressed in CHO cell membranes by scintillation counting method | ChEMBL. | 25113932 |
Inhibition (ADMET) | Inhibition of CYP2C9 in human liver microsomes assessed as reduction in diclofenac 4'-hydroxylation | ChEMBL. | 25113932 | |
Inhibition (ADMET) | Inhibition of CYP3A4 in human liver microsomes assessed as reduction in testosterone 6beta-hydroxylation | ChEMBL. | 25113932 | |
Inhibition (ADMET) | Inhibition of CYP3A4 in human liver microsomes assessed as reduction in midazolam 1'-hydroxylation | ChEMBL. | 25113932 | |
Inhibition (binding) | Inhibition of human ERG expressed in HEK cells by patch-clamp assay | ChEMBL. | 25113932 | |
Inhibition (ADMET) | Inhibition of CYP2D6 in human liver microsomes assessed as reduction in dextromethorphan-O demethylation | ChEMBL. | 25113932 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.