Detailed information for compound 923451

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 445.559 | Formula: C24H38F3NO3
  • H donors: 2 H acceptors: 2 LogP: 8.1 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCc1cc(OCCCCCCCCCCC(=O)NCC(F)(F)F)cc(c1)O
  • InChi: 1S/C24H38F3NO3/c1-2-3-10-13-20-16-21(29)18-22(17-20)31-15-12-9-7-5-4-6-8-11-14-23(30)28-19-24(25,26)27/h16-18,29H,2-15,19H2,1H3,(H,28,30)
  • InChiKey: YWPZCFAPNHFVHT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 2 (macrophage) Starlite/ChEMBL References
Homo sapiens cannabinoid receptor 1 (brain) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tubulin gamma 1 chain 0.025 0.5256 0.5256
Leishmania major beta tubulin 0.0462 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0033 0.0383 0.0223
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0256 0.5388 0.5246
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0521 0.0521
Echinococcus granulosus tubulin beta 1 chain 0.0462 1 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0256 0.5388 0.5311
Trichomonas vaginalis tubulin beta chain, putative 0.035 0.7477 0.7436
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0123 0.0123
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.0383 0.0223
Echinococcus granulosus tubulin alpha 3 chain 0.035 0.7477 0.7477
Echinococcus multilocularis multidrug resistance protein 1 0.0023 0.0163 0.0163
Entamoeba histolytica tubulin gamma chain 0.025 0.5256 0.5102
Echinococcus granulosus Ankyrin 0.0087 0.1602 0.1602
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0256 0.5388 0.9074
Trichomonas vaginalis tubulin gamma chain, putative 0.025 0.5256 0.5178
Trichomonas vaginalis abcb9, putative 0.0033 0.0383 0.0223
Trypanosoma brucei tubulin gamma chain 0.025 0.5256 0.5102
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0033 0.0383 0.0263
Echinococcus multilocularis Tubulin beta 2C chain 0.0462 1 1
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1022 0.1022
Leishmania major alpha tubulin 0.035 0.7477 0.7446
Echinococcus multilocularis tubulin alpha 1C chain 0.035 0.7477 0.7477
Leishmania major alpha tubulin 0.035 0.7477 0.7446
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0109 0.2083 0.5
Echinococcus granulosus tubulin delta chain 0.0109 0.2083 0.2083
Echinococcus multilocularis tubulin alpha 3 chain 0.035 0.7477 0.7477
Leishmania major beta tubulin 0.0462 1 1
Echinococcus granulosus tubulin alpha chain 0.035 0.7477 0.7477
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0521 0.0402
Toxoplasma gondii alpha tubulin TUBA1 0.035 0.7477 0.7446
Trypanosoma cruzi zeta tubulin, putative 0.0109 0.2083 0.1984
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0033 0.0383 0.0448
Echinococcus multilocularis tubulin subunit beta 0.0462 1 1
Leishmania major alpha tubulin 0.035 0.7477 0.7446
Echinococcus multilocularis Tubulin beta 2C chain 0.0462 1 1
Schistosoma mansoni hypothetical protein 0.0169 0.3433 0.3433
Echinococcus multilocularis tubulin subunit TubB 0.035 0.7477 0.7477
Schistosoma mansoni tumor necrosis factor receptor related 0.0133 0.263 0.263
Loa Loa (eye worm) hypothetical protein 0.0032 0.0368 0.0368
Onchocerca volvulus 0.0256 0.5388 1
Echinococcus granulosus tubulin alpha chain 0.035 0.7477 0.7477
Loa Loa (eye worm) hypothetical protein 0.0021 0.0123 0.0123
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0109 0.2083 0.1984
Schistosoma mansoni amine oxidase 0.0021 0.0123 0.0123
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.003 0.0315 0.0315
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0315 0.0305
Echinococcus multilocularis Ankyrin 0.0087 0.1602 0.1602
Loa Loa (eye worm) tubulin alpha chain 0.035 0.7477 0.7477
Toxoplasma gondii alpha-tubulin I, putative 0.035 0.7477 0.7446
Loa Loa (eye worm) alpha-tubulin 0.035 0.7477 0.7477
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0521 0.0521
Schistosoma mansoni lipoxygenase 0.0163 0.3299 0.3299
Echinococcus granulosus beta tubulin 0.0462 1 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0462 1 1
Trypanosoma brucei alpha tubulin 0.035 0.7477 0.7396
Schistosoma mansoni tubulin subunit epsilon 0.025 0.5256 0.5256
Trypanosoma brucei beta tubulin 0.0462 1 1
Trypanosoma brucei epsilon tubulin 0.025 0.5256 0.5102
Loa Loa (eye worm) hypothetical protein 0.005 0.0761 0.0761
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0462 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.025 0.5256 0.5197
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.0383 0.0223
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0761 0.0761
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.028 0.5925 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.035 0.7477 0.7477
Echinococcus multilocularis tubulin epsilon chain 0.025 0.5256 0.5256
Toxoplasma gondii beta-tubulin, putative 0.0462 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0462 1 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0123 0.0123
Plasmodium vivax tubulin beta chain, putative 0.0462 1 1
Trichomonas vaginalis tubulin, putative 0.0142 0.2821 0.2702
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0302 0.6401 1
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.003 0.0315 0.0194
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.0383 0.0223
Echinococcus granulosus Tubulin beta 2C chain 0.0462 1 1
Schistosoma mansoni hypothetical protein 0.0039 0.0521 0.0521
Leishmania major zeta tubulin, putative 0.0109 0.2083 0.1984
Brugia malayi MH2 domain containing protein 0.0119 0.2315 0.2315
Brugia malayi hypothetical protein 0.0039 0.0521 0.0521
Leishmania major beta tubulin 0.0462 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.2083 0.1951
Trypanosoma cruzi alpha tubulin, putative 0.035 0.7477 0.7446
Trypanosoma brucei epsilon tubulin 0.025 0.5256 0.5102
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0033 0.0383 0.0383
Entamoeba histolytica P-glycoprotein-1 0.0033 0.0383 0.0071
Brugia malayi Tubulin alpha-2 chain 0.035 0.7477 0.7477
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0087 0.1602 0.1602
Brugia malayi Cell division protein ftsZ 0.0109 0.2083 0.2083
Schistosoma mansoni amine oxidase 0.0021 0.0123 0.0123
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0761 0.0761
Echinococcus granulosus tubulin alpha 1C chain 0.035 0.7477 0.7477
Trichomonas vaginalis tubulin gamma chain, putative 0.025 0.5256 0.5178
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0123 0.0123
Leishmania major alpha tubulin 0.035 0.7477 0.7446
Brugia malayi Immunoglobulin I-set domain containing protein 0.0087 0.1602 0.1602
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0087 0.1602 0.1602
Schistosoma mansoni hypothetical protein 0.0034 0.0409 0.0409
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0133 0.263 0.263
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0208 0.4304 0.4209
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0033 0.0383 0.0223
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0123 0.0123
Loa Loa (eye worm) multidrug resistance protein 3 0.0033 0.0383 0.0383
Schistosoma mansoni netrin receptor unc5 0.0087 0.1602 0.1602
Schistosoma mansoni tubulin subunit beta 0.0462 1 1
Echinococcus multilocularis tubulin alpha 0.025 0.5256 0.5256
Leishmania major alpha tubulin 0.035 0.7477 0.7446
Echinococcus granulosus alpha tubulin 0.035 0.7477 0.7477
Echinococcus multilocularis Tubulin beta 2C chain 0.0462 1 1
Leishmania major alpha tubulin 0.035 0.7477 0.7446
Brugia malayi ABC transporter family protein 0.0025 0.0214 0.0214
Brugia malayi Uncoordinated protein 44 0.0087 0.1602 0.1602
Trichomonas vaginalis ABC transporter, putative 0.0033 0.0383 0.0223
Plasmodium falciparum tubulin beta chain 0.0462 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.0383 0.0223
Leishmania major beta tubulin 0.0462 1 1
Leishmania major alpha tubulin 0.035 0.7477 0.7446
Loa Loa (eye worm) hypothetical protein 0.0021 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0021 0.0123 0.0123
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0256 0.5388 0.5238
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1022 0.1022
Echinococcus granulosus tubulin alpha 3 chain 0.035 0.7477 0.7477
Loa Loa (eye worm) hypothetical protein 0.0021 0.0123 0.0123
Schistosoma mansoni tubulin subunit alpha 0.0109 0.2083 0.2083
Schistosoma mansoni tubulin subunit beta 0.0462 1 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0256 0.5388 0.5238
Leishmania major alpha tubulin 0.035 0.7477 0.7446
Loa Loa (eye worm) hypothetical protein 0.0021 0.0123 0.0123
Giardia lamblia Gamma tubulin 0.025 0.5256 0.511
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0033 0.0383 0.0223
Echinococcus granulosus Tubulin beta 2C chain 0.0462 1 1
Plasmodium falciparum tubulin gamma chain 0.025 0.5256 0.5197
Plasmodium falciparum tubulin delta chain, putative 0.0109 0.2083 0.1984
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1022 0.1022
Echinococcus granulosus geminin 0.0169 0.3433 0.3433
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0109 0.2083 0.1951
Loa Loa (eye worm) tubulin gamma chain 0.025 0.5256 0.5256
Echinococcus granulosus tubulin alpha chain 0.035 0.7477 0.7477
Giardia lamblia Beta tubulin 0.0462 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.0383 0.0223
Leishmania major beta tubulin 0.0462 1 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0233 0.487 0.487
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0315 0.0315
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.0383 0.0223
Entamoeba histolytica tubulin alpha-1 chain 0.035 0.7477 0.7396
Trichomonas vaginalis tubulin beta chain, putative 0.035 0.7477 0.7436
Onchocerca volvulus 0.0039 0.0521 0.0755
Trypanosoma cruzi tubulin delta chain 0.0109 0.2083 0.1984
Trypanosoma cruzi tubulin delta chain 0.0109 0.2083 0.1984
Echinococcus multilocularis multidrug resistance protein 1 0.0033 0.0383 0.0383
Echinococcus granulosus beta tubulin 0.0462 1 1
Trypanosoma brucei alpha tubulin 0.035 0.7477 0.7396
Loa Loa (eye worm) tubulin alpha 2 0.0241 0.5042 0.5042
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.3564 0.6536
Trichomonas vaginalis tubulin beta chain, putative 0.0462 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0033 0.0383 0.0383
Trypanosoma brucei zeta tubulin, putative 0.0109 0.2083 0.1826
Echinococcus multilocularis beta tubulin 0.0462 1 1
Schistosoma mansoni smdr2 0.0033 0.0383 0.0383
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0409 0.0409
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0256 0.5388 0.5388
Schistosoma mansoni alpha tubulin 0.035 0.7477 0.7477
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0033 0.0383 1
Trypanosoma cruzi zeta tubulin, putative 0.0109 0.2083 0.1984
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0163 0.0163
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.0383 0.0223
Loa Loa (eye worm) hypothetical protein 0.0241 0.5042 0.5042
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0256 0.5388 0.5311
Leishmania major beta tubulin 0.0462 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.035 0.7477 0.7477
Echinococcus granulosus tubulin alpha 0.025 0.5256 0.5256
Echinococcus multilocularis 0.0021 0.0123 0.0123
Plasmodium falciparum alpha tubulin 2 0.035 0.7477 0.7446
Echinococcus multilocularis tubulin alpha chain 0.035 0.7477 0.7477
Entamoeba histolytica P-glycoprotein-2 0.0033 0.0383 0.0071
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.0383 0.0223
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2315 0.2315
Trypanosoma brucei beta tubulin 0.0462 1 1
Echinococcus multilocularis tubulin alpha chain 0.035 0.7477 0.7477
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0256 0.5388 0.5311
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0087 0.1602 0.1602
Brugia malayi Doublecortin family protein 0.0039 0.0521 0.0521
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0241 0.5042 0.496
Schistosoma mansoni tubulin subunit beta 0.0462 1 1
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0315 0.0315
Trypanosoma cruzi beta tubulin, putative 0.0462 1 1
Trichomonas vaginalis ABC transporter, putative 0.0033 0.0383 0.0223
Trichomonas vaginalis tubulin epsilon chain, putative 0.0109 0.2083 0.1951
Trichomonas vaginalis tubulin gamma chain, putative 0.0462 1 1
Brugia malayi Tubulin gamma chain 0.025 0.5256 0.5256
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0315 0.0315
Trypanosoma brucei tubulin delta chain 0.0109 0.2083 0.1826
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0032 0.0368 0.0368
Trypanosoma brucei alpha tubulin 0.035 0.7477 0.7396
Brugia malayi hypothetical protein 0.0039 0.0521 0.0521
Echinococcus multilocularis hypothetical protein 0.035 0.7477 0.7477
Schistosoma mansoni tubulin subunit alpha 0.035 0.7477 0.7477
Leishmania major alpha tubulin 0.035 0.7477 0.7446
Echinococcus granulosus death domain containing protein 0.0087 0.1602 0.1602
Entamoeba histolytica tubulin family protein 0.0462 1 1
Schistosoma mansoni hypothetical protein 0.0169 0.3433 0.3433
Trichomonas vaginalis abcb9, putative 0.0033 0.0383 0.0223
Brugia malayi Tubulin alpha-2 chain 0.035 0.7477 0.7477
Toxoplasma gondii beta-1 tubulin, putative 0.0462 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0109 0.2083 0.1951
Entamoeba histolytica P-glyco protein 6, putative 0.0033 0.0383 0.0071
Loa Loa (eye worm) hypothetical protein 0.0039 0.0521 0.0521
Trichomonas vaginalis tubulin alpha chain, putative 0.0462 1 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0123 0.0123
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0256 0.5388 0.5311
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0033 0.0383 0.0383
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0256 0.5388 0.5311
Loa Loa (eye worm) hypothetical protein 0.0087 0.1602 0.1602
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.2083 0.1951
Trichomonas vaginalis tubulin beta chain, putative 0.035 0.7477 0.7436
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0033 0.0383 0.0223
Echinococcus granulosus peroxisome assembly protein 26 0.035 0.7477 0.7477
Trypanosoma brucei beta tubulin 0.025 0.5256 0.5102
Schistosoma mansoni hypothetical protein 0.0025 0.0199 0.0199
Giardia lamblia Epsilon tubulin 0.0109 0.2083 0.1839
Echinococcus granulosus multidrug resistance protein 1 0.0033 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0087 0.1602 0.1602
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0521 0.0521
Echinococcus granulosus tubulin beta 4A class IVa 0.0462 1 1
Schistosoma mansoni multidrug resistance protein 0.0033 0.0383 0.0383
Schistosoma mansoni rab6-interacting 0.0039 0.0521 0.0521
Entamoeba histolytica tubulin alpha chain, putative 0.035 0.7477 0.7396
Trichomonas vaginalis ABC transporter, putative 0.0033 0.0383 0.0223
Toxoplasma gondii beta tubulin 0.0462 1 1
Loa Loa (eye worm) hypothetical protein 0.0208 0.4304 0.4304
Loa Loa (eye worm) BEN-1 protein 0.0462 1 1
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0133 0.263 0.263
Entamoeba histolytica P-glycoprotein-5 0.0033 0.0383 0.0071
Schistosoma mansoni alpha tubulin 0.035 0.7477 0.7477
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1022 0.1022
Trypanosoma cruzi ABC transporter, putative 0.003 0.0315 0.0194
Echinococcus multilocularis ATP binding cassette sub family B 0.0032 0.0368 0.0368
Echinococcus granulosus Tubulin alpha 1 chain 0.035 0.7477 0.7477
Brugia malayi Tubulin alpha chain 0.0109 0.2083 0.2083
Loa Loa (eye worm) BEN-1 protein 0.0462 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.0383 0.0223
Leishmania major beta tubulin 0.0462 1 1
Loa Loa (eye worm) tubulin beta chain 0.0109 0.2083 0.2083
Plasmodium vivax tubulin alpha chain, putative 0.035 0.7477 0.7446
Brugia malayi alpha-tubulin 0.035 0.7477 0.7477
Schistosoma mansoni ankyrin 23/unc44 0.0087 0.1602 0.1602
Mycobacterium ulcerans cell division protein FtsZ 0.0109 0.2083 0.3122
Echinococcus multilocularis tubulin beta 1 chain 0.0462 1 1
Loa Loa (eye worm) tubulin alpha chain 0.035 0.7477 0.7477
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0033 0.0383 0.0263
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.003 0.0315 0.0194
Trypanosoma brucei beta tubulin 0.0462 1 1
Onchocerca volvulus Netrin receptor homolog 0.0087 0.1602 0.2809
Leishmania major beta tubulin 0.0462 1 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0256 0.5388 0.5311
Plasmodium vivax delta tubulin, putative 0.0109 0.2083 0.1984
Trichomonas vaginalis ABC transporter, putative 0.0033 0.0383 0.0223
Trichomonas vaginalis tubulin epsilon chain, putative 0.0462 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0123 0.0123
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.035 0.7477 0.7436
Trichomonas vaginalis tubulin epsilon chain, putative 0.035 0.7477 0.7436
Brugia malayi Tubulin beta chain 0.0109 0.2083 0.2083
Leishmania major beta tubulin 0.0462 1 1
Brugia malayi RNA binding protein 0.0061 0.1022 0.1022
Brugia malayi multidrug resistance protein 3 0.0033 0.0383 0.0383
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0033 0.0383 0.0223
Brugia malayi N-terminal motif family protein 0.0175 0.3564 0.3564
Schistosoma mansoni ABC transporter 0.0025 0.0214 0.0214
Giardia lamblia Beta tubulin 0.0462 1 1
Leishmania major beta tubulin 0.0462 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.025 0.5256 0.5197
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0302 0.6401 1
Leishmania major beta tubulin 0.0462 1 1
Schistosoma mansoni tubulin subunit beta 0.0462 1 1
Plasmodium falciparum tubulin epsilon chain, putative 0.025 0.5256 0.5197
Echinococcus multilocularis Tubulin beta 2C chain 0.0462 1 1
Trypanosoma brucei epsilon tubulin 0.025 0.5256 0.5102
Schistosoma mansoni multidrug resistance protein 0.0033 0.0383 0.0383
Leishmania major epsilon tubulin, putative 0.025 0.5256 0.5197
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0256 0.5388 0.8387
Treponema pallidum cell division protein FtsZ 0.0109 0.2083 0.5
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0109 0.2083 0.1984
Loa Loa (eye worm) hypothetical protein 0.0034 0.0409 0.0409
Schistosoma mansoni tubulin subunit beta 0.0109 0.2083 0.2083
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0033 0.0383 0.0383
Mycobacterium tuberculosis Cell division protein FtsZ 0.0109 0.2083 0.3378
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0033 0.0383 0.0383
Echinococcus multilocularis tubulin alpha chain 0.035 0.7477 0.7477
Loa Loa (eye worm) tubulin alpha-3 chain 0.0208 0.4304 0.4304
Echinococcus granulosus tubulin subunit beta 0.0462 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.035 0.7477 0.7477
Onchocerca volvulus 0.0033 0.0383 0.0494
Brugia malayi TAR-binding protein 0.0061 0.1022 0.1022
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0133 0.263 0.263
Echinococcus granulosus tubulin alpha chain 0.035 0.7477 0.7477
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0521 0.0521
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0033 0.0383 0.0383
Trypanosoma cruzi tubulin gamma chain 0.025 0.5256 0.5197
Echinococcus multilocularis Tubulin beta 2C chain 0.0462 1 1
Plasmodium falciparum ABC transporter G family member 2 0.003 0.0315 0.0194
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0142 0.2821 0.2702
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0033 0.0383 0.0383
Plasmodium falciparum multidrug resistance protein 1 0.0033 0.0383 0.0263
Echinococcus granulosus Tubulin beta 2C chain 0.0462 1 1
Leishmania major alpha tubulin 0.035 0.7477 0.7446
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1022 0.1022
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0033 0.0383 0.0383
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0521 0.0521
Trichomonas vaginalis abcb9, putative 0.0033 0.0383 0.0223
Leishmania major alpha tubulin 0.035 0.7477 0.7446
Loa Loa (eye worm) tubulin beta-1 chain 0.0462 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0142 0.2821 0.2702
Trypanosoma brucei alpha tubulin 0.035 0.7477 0.7396
Echinococcus multilocularis tubulin delta chain 0.0109 0.2083 0.2083
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0521 0.0521
Trichomonas vaginalis tubulin alpha chain, putative 0.0142 0.2821 0.2702
Loa Loa (eye worm) hypothetical protein 0.0039 0.0521 0.0521
Echinococcus multilocularis Tubulin alpha 1 chain 0.035 0.7477 0.7477
Echinococcus granulosus tubulin epsilon chain 0.025 0.5256 0.5256
Entamoeba histolytica tubulin family protein 0.0462 1 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0241 0.5042 0.5042
Loa Loa (eye worm) tubulin beta-2A chain 0.0462 1 1
Brugia malayi tubulin alpha-2 chain 0.035 0.7477 0.7477
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2315 0.2315
Leishmania major alpha tubulin 0.035 0.7477 0.7446
Loa Loa (eye worm) ABC transporter 0.0025 0.0214 0.0214
Entamoeba histolytica P-glycoprotein 5, putative 0.0033 0.0383 0.0071
Brugia malayi SWIRM domain containing protein 0.0021 0.0123 0.0123
Plasmodium vivax tubulin epsilon chain, putative 0.025 0.5256 0.5197
Giardia lamblia Alpha-tubulin 0.035 0.7477 0.74
Echinococcus multilocularis tubulin alpha 3 chain 0.035 0.7477 0.7477
Schistosoma mansoni rab6-interacting 0.0039 0.0521 0.0521
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0033 0.0383 0.0383
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.0383 0.0223
Trichomonas vaginalis tubulin alpha chain, putative 0.0142 0.2821 0.2702
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1022 0.1022
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0521 0.0402
Plasmodium vivax multidrug resistance protein 1, putative 0.0033 0.0383 0.0263
Schistosoma mansoni alpha tubulin 0.035 0.7477 0.7477
Trypanosoma brucei alpha tubulin, putative 0.0142 0.2821 0.2588
Brugia malayi Protein kinase domain containing protein 0.0087 0.1602 0.1602
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0521 0.0521
Leishmania major beta tubulin 0.0462 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1022 0.1022
Echinococcus granulosus tubulin subunit TubB 0.035 0.7477 0.7477
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0033 0.0383 0.0223
Echinococcus granulosus netrin receptor unc 5 0.0087 0.1602 0.1602
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1022 0.1022
Echinococcus multilocularis beta tubulin 0.0462 1 1
Leishmania major beta tubulin 0.0462 1 1
Schistosoma mansoni polycystin 1-related 0.0039 0.0521 0.0521
Plasmodium vivax tubulin gamma chain, putative 0.025 0.5256 0.5197
Schistosoma mansoni tubulin subunit beta 0.0462 1 1
Echinococcus multilocularis tubulin alpha chain 0.035 0.7477 0.7477
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0315 0.0315
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0123 0.0123
Schistosoma mansoni tubulin subunit beta 0.0462 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.035 0.7477 0.7436
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0087 0.1602 0.1602
Schistosoma mansoni tubulin subunit alpha 0.035 0.7477 0.7477
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0233 0.487 0.487
Echinococcus granulosus tar DNA binding protein 0.0061 0.1022 0.1022
Trypanosoma brucei zeta tubulin 0.0109 0.2083 0.1826
Trichomonas vaginalis tubulin beta chain, putative 0.035 0.7477 0.7436
Trichomonas vaginalis tubulin, putative 0.0109 0.2083 0.1951
Loa Loa (eye worm) hypothetical protein 0.0033 0.0383 0.0383
Echinococcus multilocularis RUN 0.0039 0.0521 0.0521
Trichomonas vaginalis tubulin, putative 0.0142 0.2821 0.2702
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.0383 0.0223
Trichomonas vaginalis taga, putative 0.0033 0.0383 0.0223
Trichomonas vaginalis tubulin beta chain, putative 0.0142 0.2821 0.2702
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0033 0.0383 0.0223
Brugia malayi beta-tubulin, identical 0.0462 1 1
Onchocerca volvulus 0.0039 0.0521 0.0755
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.0383 0.0223
Loa Loa (eye worm) RNA binding protein 0.0061 0.1022 0.1022
Schistosoma mansoni multidrug resistance protein 0.0033 0.0383 0.0383
Loa Loa (eye worm) tubulin alpha-2 chain 0.035 0.7477 0.7477
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0133 0.263 0.263
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0033 0.0383 0.0383
Leishmania major beta tubulin 0.0462 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0033 0.0383 0.0383
Leishmania major beta tubulin 0.0462 1 1
Entamoeba histolytica P-glycoprotein-2 0.0033 0.0383 0.0071
Leishmania major beta tubulin 0.0462 1 1
Echinococcus multilocularis tubulin gamma 1 chain 0.025 0.5256 0.5256
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.025 0.5256 0.5197
Brugia malayi Tubulin alpha chain 0.035 0.7477 0.7477
Loa Loa (eye worm) tubulin alpha 2 0.0241 0.5042 0.5042
Loa Loa (eye worm) alpha-tubulin 0.035 0.7477 0.7477
Trichomonas vaginalis tubulin epsilon chain, putative 0.0462 1 1
Loa Loa (eye worm) beta-tubulin 0.0462 1 1
Echinococcus multilocularis geminin 0.0169 0.3433 0.3433
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0315 0.0315
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.003 0.0315 0.0194
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0123 0.0123
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0033 0.0383 0.0383
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.0383 0.0223
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.0383 0.0223
Trypanosoma brucei beta tubulin 0.0462 1 1
Loa Loa (eye worm) tubulin beta chain 0.0462 1 1
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0315 0.0315
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0256 0.5388 0.5388
Trypanosoma cruzi ATP-binding cassette protein, putative 0.003 0.0315 0.0194
Trichomonas vaginalis tubulin beta chain, putative 0.035 0.7477 0.7436
Brugia malayi Death domain containing protein 0.0087 0.1602 0.1602
Echinococcus granulosus Tubulin alpha 1 chain 0.035 0.7477 0.7477
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0163 0.0163
Loa Loa (eye worm) tubulin alpha 2 0.0099 0.1869 0.1869
Plasmodium vivax ABC transporter G family member 2, putative 0.003 0.0315 0.0194
Plasmodium vivax tubulin alpha chain, putative 0.035 0.7477 0.7446
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.0383 0.0263
Giardia lamblia Alpha-tubulin 0.035 0.7477 0.74
Leishmania major delta tubulin, putative 0.0109 0.2083 0.1984
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0315 0.0305
Echinococcus multilocularis tubulin alpha chain 0.035 0.7477 0.7477
Echinococcus granulosus RUN 0.0039 0.0521 0.0521
Echinococcus multilocularis tubulin alpha 1C chain 0.035 0.7477 0.7477
Loa Loa (eye worm) hypothetical protein 0.0175 0.3564 0.3564
Trichomonas vaginalis tubulin epsilon chain, putative 0.035 0.7477 0.7436
Schistosoma mansoni lipoxygenase 0.0233 0.487 0.487
Echinococcus granulosus tubulin alpha chain 0.035 0.7477 0.7477
Entamoeba histolytica P-glycoprotein-2, putative 0.0033 0.0383 0.0071
Echinococcus multilocularis peroxisome assembly protein 26 0.035 0.7477 0.7477
Leishmania major gamma-tubulin 0.025 0.5256 0.5197
Echinococcus multilocularis netrin receptor unc 5 0.0087 0.1602 0.1602
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1022 0.1022
Trichomonas vaginalis tubulin alpha chain, putative 0.025 0.5256 0.5178
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0025 0.0199 0.013
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0315 0.0305
Schistosoma mansoni hypothetical protein 0.0087 0.1602 0.1602
Schistosoma mansoni tubulin subunit gamma 0.025 0.5256 0.5256
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0761 0.0761
Brugia malayi hypothetical protein 0.0021 0.0123 0.0123
Echinococcus granulosus tubulin alpha 1C chain 0.035 0.7477 0.7477
Giardia lamblia Beta tubulin 0.0462 1 1
Leishmania major p-glycoprotein 0.0033 0.0383 0.0263
Plasmodium falciparum alpha tubulin 1 0.035 0.7477 0.7446
Brugia malayi tubulin alpha chain - mouse 0.035 0.7477 0.7477
Schistosoma mansoni loxhd1 0.0039 0.0521 0.0521
Leishmania major beta tubulin 0.0462 1 1
Trichomonas vaginalis tubulin, putative 0.0462 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0033 0.0383 0.0383
Mycobacterium leprae cell division protein FtsZ 0.0109 0.2083 1
Giardia lamblia Delta tubulin 0.0109 0.2083 0.1839
Schistosoma mansoni tubulin subunit delta 0.0109 0.2083 0.2083
Onchocerca volvulus 0.0142 0.2821 0.5125
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.0383 0.0223
Loa Loa (eye worm) hypothetical protein 0.035 0.7477 0.7477
Schistosoma mansoni tubulin subunit alpha 0.035 0.7477 0.7477
Leishmania major beta tubulin 0.0462 1 1
Brugia malayi Tubulin beta chain 0.0142 0.2821 0.2821
Echinococcus granulosus Tubulin beta 2C chain 0.0462 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0383 0.0383
Brugia malayi ABC transporter family protein 0.0033 0.0383 0.0383

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 96.3 nM Displacement of [3H]CP-55,940 from human recombinant CB2 receptor expressed in HEK293 cell membranes ChEMBL. 25065940
Ki (binding) = 438 nM Displacement of [3H]CP-55,940 from human recombinant CB1 receptor expressed in HEK293 cell membranes ChEMBL. 25065940

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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