Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0236 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0236 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0236 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0236 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0236 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0236 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0236 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.5 ug ml-1 | Antituberculosis activity against Mycobacterium tuberculosis H37Rv after 7 days by serial two fold dilution method | ChEMBL. | 25063947 |
MIC (functional) | > 1 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 10538 after 18 hrs by serial microdilution method | ChEMBL. | 25063947 |
MIC (functional) | > 1 ug ml-1 | Antifungal activity against Candida albicans ATCC 10231 after 18 hrs by serial microdilution method | ChEMBL. | 25063947 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.