Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0225 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0225 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0225 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0225 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0225 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0225 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0225 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0225 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Emax (binding) | = 19.51 % | Inverse agonist activity at human CB1 receptor expressed in Sf9 cells coexpressing Gbeta1gamma2 and RSG4 assessed as degradation of [gamma-33P]GTP at 30 uM after 20 mins by steady-state GTPase assay relative to control | ChEMBL. | 25096297 |
Inhibition (binding) | = 0 % | Displacement of [3H] CP-55,940 from human CB2 receptor expressed in HEK cells at 10 uM after 3 hrs by scintillation counting | ChEMBL. | 25096297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.