Detailed information for compound 923613

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 434.511 | Formula: C23H22N4O3S
  • H donors: 1 H acceptors: 3 LogP: 2.79 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)NC1(c3n2ccc3)CCN(CC1)S(=O)(=O)c1ccc(cc1)C#N
  • InChi: 1S/C23H22N4O3S/c1-30-18-6-9-21-20(15-18)25-23(22-3-2-12-27(21)22)10-13-26(14-11-23)31(28,29)19-7-4-17(16-24)5-8-19/h2-9,12,15,25H,10-11,13-14H2,1H3
  • InChiKey: DGPCRJNIYZFFFI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sodium channel, voltage-gated, type IX, alpha subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) carboxylesterase 0.0024 0.0465 0.0619
Brugia malayi nuclear receptor RXR 0.001 0.006 0.0073
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0383 0.0383
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0776 0.4806
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0383 0.0725
Echinococcus multilocularis smad 0.0009 0.0033 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.161 0.9905
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.161 0.161
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0383 0.0383
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.006 0.006
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0479 0.1309
Onchocerca volvulus Huntingtin homolog 0.0071 0.1842 0.2447
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0776 0.5991
Echinococcus multilocularis para nitrobenzyl esterase 0.0024 0.0465 0.0465
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0005 0.0005
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0009 0.0025 0.0033
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.045 0.3454
Schistosoma mansoni jumonji domain containing protein 0.0126 0.3419 0.6545
Brugia malayi Bromodomain containing protein 0.0035 0.0776 0.1027
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.006 0.008
Brugia malayi jmjC domain containing protein 0.0021 0.0371 0.0488
Schistosoma mansoni tar DNA-binding protein 0.007 0.1809 0.3458
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.1625 0.2451
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0786 0.104
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0479 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.1329 0.2003
Schistosoma mansoni nuclear hormone receptor 0.001 0.006 0.0105
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0007
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0005 0.0005
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.006 0.0073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.006 0.006
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0544 0.0717
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0095 0.0171
Loa Loa (eye worm) hypothetical protein 0.0021 0.0383 0.051
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0298 0.1828
Leishmania major trypanothione reductase 0.0052 0.1292 0.1948
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0027 0.0559 0.3421
Brugia malayi hypothetical protein 0.001 0.006 0.0073
Onchocerca volvulus 0.005 0.1231 0.1633
Schistosoma mansoni survival motor neuron protein 0.005 0.1231 0.2351
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.008
Echinococcus granulosus acetylcholinesterase 0.0142 0.3879 0.3879
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0045 0.1085 0.1633
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0149 0.4095 0.4095
Echinococcus granulosus jumonji domain containing 1A 0.0021 0.0371 0.0371
Loa Loa (eye worm) RNA binding protein 0.007 0.1809 0.2408
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0383 0.0383
Brugia malayi nuclear receptor RXR 0.0011 0.0095 0.0119
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.1329 0.1329
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0383 0.051
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0095 0.0126
Schistosoma mansoni hypothetical protein 0.0035 0.0786 0.1497
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.3241 0.8931
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0008 0.0005 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0095 0.0171
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0005 0.0005
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.006 0.0073
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.01 0.0735
Echinococcus multilocularis citrate lyase subunit beta protein 0.0027 0.0559 0.0559
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.009 0.066
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0559 0.0839
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.008
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.2978 0.396
Loa Loa (eye worm) hypothetical protein 0.0021 0.0383 0.051
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0024 0.0465 0.127
Schistosoma mansoni Smad4 0.0009 0.0033 0.0053
Onchocerca volvulus 0.0247 0.6942 0.924
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.008
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.3628 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1329 0.2003
Echinococcus granulosus sodium channel protein 0.0045 0.1085 0.1085
Onchocerca volvulus 0.0016 0.0245 0.0319
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0479 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.009 0.0301
Schistosoma mansoni phosphatidylserine receptor 0.0021 0.0371 0.0702
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0786 0.0786
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0559 0.3421
Loa Loa (eye worm) hypothetical protein 0.0111 0.2978 0.3964
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0008 0.0005 0.0005
Onchocerca volvulus 0.001 0.006 0.0073
Brugia malayi isocitrate dehydrogenase 0.0018 0.028 0.0365
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.161 0.4429
Loa Loa (eye worm) jmjC domain-containing protein 0.0078 0.2021 0.269
Brugia malayi MH1 domain containing protein 0.0009 0.0033 0.0037
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0133 0.017
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0383 0.0504
Brugia malayi hypothetical protein 0.0247 0.693 0.9224
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.1329 0.2003
Trypanosoma brucei protein kinase, putative 0.0054 0.1329 0.2003
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0479 0.2955
Loa Loa (eye worm) hypothetical protein 0.0016 0.0245 0.0326
Entamoeba histolytica hypothetical protein 0.0024 0.0479 0.1679
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0287 0.1758
Brugia malayi hypothetical protein 0.0024 0.0465 0.0613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1243 0.2372
Brugia malayi jmjC domain containing protein 0.0021 0.0371 0.0488
Brugia malayi MAP kinase sur-1 0.0054 0.1329 0.1763
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.1964 0.2609
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2829 0.4071
Schistosoma mansoni hypothetical protein 0.0035 0.0786 0.1497
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.3628 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0383 0.051
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0675 0.0675
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0786 0.0786
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0559 0.3421
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0544 0.0776
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0033 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.3611 0.4807
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0021 0.0371 0.2281
Echinococcus granulosus oxidoreductase 0.0008 0.0005 0.0005
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0159 0.0204
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0298 0.0298
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0016 0.0245 0.0326
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.2978 0.396
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0383 0.0504
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0095 0.0095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0383 0.0383
Brugia malayi nuclear hormone receptor 0.001 0.006 0.0073
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.1329 0.1329
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0465 0.0882
Loa Loa (eye worm) hypothetical protein 0.0071 0.1842 0.2452
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0675 0.1284
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0383 0.0504
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0383 0.051
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0383 0.0504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1243 0.2372
Brugia malayi hypothetical protein 0.0011 0.0095 0.0119
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.028 0.028
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0929 0.0929
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1329 0.1908
Brugia malayi PHD-finger family protein 0.0035 0.0776 0.1027
Onchocerca volvulus 0.0024 0.0465 0.0613
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0298 0.0809
Echinococcus multilocularis lysine specific demethylase 6a 0.0021 0.0371 0.0371
Schistosoma mansoni hypothetical protein 0.0035 0.0776 0.1478
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.2978 0.3964
Schistosoma mansoni hypothetical protein 0.0011 0.01 0.0181
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0298 0.0444
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.028 0.2132
Loa Loa (eye worm) hypothetical protein 0.0011 0.01 0.0133
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0024 0.0465 0.0465
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.008
Schistosoma mansoni tar DNA-binding protein 0.007 0.1809 0.3458
Trypanosoma cruzi hypothetical protein, conserved 0.0236 0.6614 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.161 0.2428
Brugia malayi ecdysteroid receptor 0.0021 0.0383 0.0504
Echinococcus multilocularis Smad4 0.0009 0.0033 0.0033
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0005 0.0005
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.028 0.028
Echinococcus multilocularis acetylcholinesterase 0.0142 0.3879 0.3879
Loa Loa (eye worm) dehydrogenase 0.0008 0.0005 0.0007
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0479 0.1309
Brugia malayi ecdysone receptor 0.001 0.006 0.0073
Loa Loa (eye worm) carboxylesterase 0.0024 0.0465 0.0619
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0383 0.051
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0383 0.0725
Loa Loa (eye worm) hypothetical protein 0.0035 0.0786 0.1046
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0149 0.4095 0.4095
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.028 0.028
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.1329 0.2003
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0027 0.0559 0.153
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0582 0.3596
Loa Loa (eye worm) hypothetical protein 0.0024 0.0465 0.0619
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0786 0.0786
Leishmania major hypothetical protein, conserved 0.0028 0.0582 0.0873
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0298 0.0444
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0298 0.6185
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.1269 0.2422
Echinococcus granulosus lamin dm0 0.0016 0.0245 0.0245
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0465 0.0882
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0298 0.0444
Schistosoma mansoni hypothetical protein 0.0013 0.0135 0.0249
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0007
Onchocerca volvulus 0.0024 0.0465 0.0613
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2829 0.4071
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0005 0.0005
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.028 0.0415
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0479 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0298 0.0444
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1243 0.1648
Brugia malayi RNA binding protein 0.007 0.1809 0.2403
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0293 0.224
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.161 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.028 0.0415
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.028 0.028
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0011 0.009 0.012
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0383 0.0383
Schistosoma mansoni hypothetical protein 0.0188 0.5222 1
Echinococcus multilocularis oxidoreductase 0.0008 0.0005 0.0005
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.006 0.0105
Loa Loa (eye worm) hypothetical protein 0.0011 0.0095 0.0126
Loa Loa (eye worm) dehydrogenase 0.0008 0.0005 0.0007
Plasmodium falciparum glutathione reductase 0.0018 0.0298 0.2278
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.01 0.059
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.161 0.3075
Brugia malayi nuclear receptor NHR-88 0.001 0.006 0.0073
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0383 0.0383
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0298 0.0444
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0383 0.0504
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0298 0.6185
Echinococcus granulosus steroid dehydrogenase 0.0008 0.0005 0.0005
Schistosoma mansoni nuclear hormone receptor 0.001 0.006 0.0105
Echinococcus multilocularis jumonji domain containing protein 0.0048 0.117 0.117
Echinococcus granulosus geminin 0.0188 0.5222 0.5222
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0776 0.1478
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0024 0.0465 0.127
Schistosoma mansoni tar DNA-binding protein 0.007 0.1809 0.3458
Echinococcus multilocularis lysine specific demethylase 5A 0.0078 0.2021 0.2021
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0479 0.3683
Brugia malayi Isocitrate dehydrogenase 0.0018 0.028 0.0365
Brugia malayi hypothetical protein 0.001 0.006 0.0073
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0383 0.0383
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0479 0.2927
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1329 0.1908
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0582 0.4482
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0776 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0383 0.0504
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0383 0.0725
Echinococcus granulosus jumonji domain containing protein 0.0048 0.117 0.117
Loa Loa (eye worm) carboxylesterase 0.0142 0.3879 0.5163
Schistosoma mansoni zinc finger protein 0.001 0.006 0.0105
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.006 0.006
Onchocerca volvulus 0.001 0.006 0.0073
Loa Loa (eye worm) hypothetical protein 0.0024 0.0465 0.0619
Plasmodium vivax JmjC domain containing protein 0.0021 0.0371 0.2844
Mycobacterium ulcerans carboxylesterase, LipT 0.0024 0.0465 0.2841
Echinococcus granulosus GPCR family 2 0.0035 0.0786 0.0786
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.1329 0.8252
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0929 0.177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1243 0.1243
Toxoplasma gondii thioredoxin reductase 0.0052 0.1292 0.8022
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.1292 0.3553
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0007
Brugia malayi hypothetical protein 0.0018 0.0295 0.0386
Echinococcus granulosus phd:f box containing protein 0.0021 0.0371 0.0371
Trypanosoma brucei trypanothione reductase 0.0052 0.1292 0.1948
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2829 0.4071
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0371 0.0494
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.161 0.3075
Brugia malayi Carboxylesterase family protein 0.0142 0.3879 0.5159
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.1625 1
Echinococcus granulosus carboxylesterase 5A 0.0142 0.3879 0.3879
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.1809 0.2408
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0786 0.0786
Brugia malayi Stress-activated protein kinase jnk-1 0.0092 0.2452 0.3259
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0479 0.2955
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0544 0.0776
Loa Loa (eye worm) hypothetical protein 0.0021 0.0371 0.0494
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0559 0.0839
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0383 0.051
Onchocerca volvulus 0.0024 0.0465 0.0613
Loa Loa (eye worm) hypothetical protein 0.0142 0.3879 0.5163
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.161 0.161
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0033 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0095 0.0119
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.1625 0.2157
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0371 0.0554
Loa Loa (eye worm) acetylcholinesterase 1 0.0142 0.3879 0.5163
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0007
Schistosoma mansoni neuroligin 3 (S09 family) 0.0024 0.0465 0.0882
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0007
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0298 0.2278
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.3241 0.8931
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0005 0.0007
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.006 0.008
Echinococcus multilocularis musashi 0.0016 0.0245 0.0245
Echinococcus granulosus lamin 0.0016 0.0245 0.0245
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.006 0.006
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.006 0.006
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0005 0.0005
Loa Loa (eye worm) pax transcription factor protein 2 0.0267 0.7512 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0184 0.027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0383 0.0383
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0675 0.1284
Loa Loa (eye worm) hypothetical protein 0.0134 0.3658 0.4869
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.1329 0.4688
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0383 0.051
Loa Loa (eye worm) hypothetical protein 0.0142 0.3879 0.5163
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0383 0.0504
Echinococcus multilocularis BC026374 protein (S09 family) 0.0024 0.0465 0.0465
Loa Loa (eye worm) hypothetical protein 0.0071 0.1842 0.2452
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0298 0.0444
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0383 0.0383
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0582 0.0873
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.028 0.0415
Onchocerca volvulus 0.0052 0.1269 0.1683
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1329 0.1908
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0033 0.0044
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0298 0.2278
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0008 0.0005 0.0005
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0298 0.0423
Schistosoma mansoni protein phosphatase 2C 0.0021 0.0371 0.0702
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0008 0.0005 0.0005
Loa Loa (eye worm) glutathione reductase 0.0052 0.1292 0.172
Loa Loa (eye worm) hypothetical protein 0.0028 0.0582 0.0775
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0298 0.0444
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0298 0.0298
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.1292 0.1948
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1329 0.1908
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0675 0.4175
Loa Loa (eye worm) hypothetical protein 0.0021 0.0383 0.051
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1243 0.2372
Echinococcus granulosus Smad4 0.0009 0.0033 0.0033
Echinococcus granulosus WW domain containing oxidoreductase 0.0008 0.0005 0.0005
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.006 0.006
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.009 0.009
Schistosoma mansoni phd/f-box containing protein 0.0021 0.0371 0.0702
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.1292 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.01 0.0143
Onchocerca volvulus 0.0016 0.0245 0.0319
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.3241 0.8931
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0298 0.181
Loa Loa (eye worm) hypothetical protein 0.0011 0.0095 0.0126
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.028 0.171
Loa Loa (eye worm) hypothetical protein 0.0016 0.0236 0.0315
Onchocerca volvulus 0.0176 0.488 0.6493
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0298 0.0444
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0133 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0383 0.0504
Schistosoma mansoni BC026374 protein (S09 family) 0.0024 0.0465 0.0882
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0008 0.0005 0.0005
Plasmodium vivax SET domain protein, putative 0.0031 0.0675 0.5204
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0383 0.0725
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.028 0.0415
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.2829 0.4273
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0383 0.0504
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0007
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.693 0.693
Schistosoma mansoni lamin 0.0016 0.0245 0.046
Schistosoma mansoni intermediate filament proteins 0.0016 0.0245 0.046
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.1292 0.1292
Mycobacterium tuberculosis Conserved protein 0.0027 0.0559 0.153
Loa Loa (eye worm) hypothetical protein 0.0021 0.0383 0.051
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0005 0.0005
Mycobacterium tuberculosis Probable reductase 0.012 0.3241 0.8931
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.006 0.006
Onchocerca volvulus 0.0021 0.0383 0.0504
Brugia malayi conserved hypotetical protein 0.001 0.006 0.0073
Echinococcus multilocularis JmjC domain containing protein 4 0.0021 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0007
Echinococcus granulosus intermediate filament protein 0.0016 0.0245 0.0245
Echinococcus multilocularis sodium channel protein 0.0045 0.1085 0.1085
Brugia malayi RNA recognition motif domain containing protein 0.007 0.1809 0.2403
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.1329 0.2538
Brugia malayi Pre-SET motif family protein 0.0031 0.0675 0.0892
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0383 0.0383
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.028 0.2132
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0786 0.1046
Brugia malayi hypothetical protein 0.0011 0.0095 0.0119
Echinococcus multilocularis retinol dehydrogenase 13 0.0008 0.0005 0.0005
Trypanosoma brucei polo-like protein kinase 0.0105 0.2829 0.4273
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.009 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0383 0.0383
Echinococcus multilocularis lamin 0.0016 0.0245 0.0245
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.2829 0.2829
Loa Loa (eye worm) hypothetical protein 0.0087 0.2288 0.3046
Schistosoma mansoni lamin 0.0016 0.0245 0.046
Echinococcus granulosus BC026374 protein S09 family 0.0024 0.0465 0.0465
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0383 0.051
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.028 0.0372
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0005 0.0005
Onchocerca volvulus 0.0011 0.0101 0.0127
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0069 0.177 0.2356
Brugia malayi Carboxylesterase family protein 0.0024 0.0465 0.0613
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0383 0.0725
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0479 0.3683
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0298 0.0444
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0021 0.0383 0.051
Echinococcus granulosus acetylcholinesterase 0.0142 0.3879 0.3879
Onchocerca volvulus Alhambra homolog 0.0035 0.0776 0.1027
Brugia malayi nuclear receptor NHR-67 0.001 0.006 0.0073
Brugia malayi Carboxylesterase family protein 0.0142 0.3879 0.5159
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1243 0.1243
Onchocerca volvulus 0.0024 0.0465 0.0613
Schistosoma mansoni nuclear receptor 0.001 0.006 0.0105
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.028 0.0415
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0298 0.0444
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0582 0.0873
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0007
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0544 0.0544
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.009 0.0113
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.01 0.059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0371 0.0494
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0184 0.027
Echinococcus multilocularis GPCR, family 2 0.0035 0.0786 0.0786
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0024 0.0465 0.0465
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0005 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0371 0.0494
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0007
Echinococcus granulosus para nitrobenzyl esterase 0.0024 0.0465 0.0465
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0675 0.0675
Brugia malayi jmjC domain containing protein 0.0021 0.0371 0.0488
Onchocerca volvulus 0.0087 0.2288 0.3041
Brugia malayi MH2 domain containing protein 0.0009 0.0033 0.0037
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.006 0.0073
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0383 0.0725
Loa Loa (eye worm) hypothetical protein 0.0011 0.0095 0.0126
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.3628 1
Brugia malayi MH2 domain containing protein 0.0009 0.0033 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.6072 0.8082
Plasmodium vivax glutathione reductase, putative 0.0052 0.1292 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0298 0.0444
Brugia malayi MH1 domain containing protein 0.0009 0.0033 0.0037
Onchocerca volvulus Huntingtin homolog 0.0071 0.1842 0.2447
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0383 0.0504
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.1329 0.2003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0675 0.1284
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.006 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2829 0.4071
Plasmodium vivax hypothetical protein, conserved 0.0011 0.01 0.0735
Schistosoma mansoni hypothetical protein 0.0188 0.5222 1
Leishmania major hypothetical protein, conserved 0.0236 0.6614 1
Brugia malayi hypothetical protein 0.004 0.0929 0.123
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0371 0.0494
Echinococcus granulosus lysine specific demethylase 6a 0.0021 0.0371 0.0371
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.028 0.028
Schistosoma mansoni smad 0.0009 0.0033 0.0053
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.1329 0.1329
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0033 0.0053
Entamoeba histolytica hypothetical protein 0.004 0.0929 0.327
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0298 0.0444
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0005 0.0005
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0005 0.0005
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0371 0.0371
Brugia malayi Carboxylesterase family protein 0.0024 0.0465 0.0613
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0024 0.0465 0.0663
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.1231 0.1633
Loa Loa (eye worm) hypothetical protein 0.0011 0.0095 0.0126
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.2829 0.3761
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0383 0.0504
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0383 0.0725
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0383 0.0504
Brugia malayi AF-10 protein 0.0011 0.01 0.0126
Loa Loa (eye worm) hypothetical protein 0.0247 0.693 0.9224
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.1625 0.1625
Brugia malayi intermediate filament protein 0.0016 0.0245 0.0319
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2829 0.4071
Brugia malayi Carboxylesterase family protein 0.0024 0.0465 0.0613
Echinococcus multilocularis lamin dm0 0.0016 0.0245 0.0245
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0021 0.0371 0.0554
Schistosoma mansoni smad1 5 8 and 0.0009 0.0033 0.0053
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.3241 0.8931
Plasmodium falciparum glutathione reductase 0.0052 0.1292 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.1625 0.4471
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.006 0.008
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0776 0.0776
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.009 0.0529
Brugia malayi hypothetical protein 0.0071 0.1842 0.2447
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.006 0.006
Echinococcus granulosus peregrin 0.0035 0.0776 0.0776
Echinococcus multilocularis conserved hypothetical protein 0.0008 0.0005 0.0005
Echinococcus multilocularis tar DNA binding protein 0.007 0.1809 0.1809
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0559 0.0839
Brugia malayi jmjC domain containing protein 0.0021 0.0371 0.0488
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0005 0.0005
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.2288 0.4377
Brugia malayi MH2 domain containing protein 0.0132 0.3611 0.4803
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0371 0.0371
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.2829 0.5413
Brugia malayi PHD-finger family protein 0.0011 0.01 0.0126
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0033 0.0033
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0383 0.0504
Echinococcus multilocularis geminin 0.0188 0.5222 0.5222
Loa Loa (eye worm) hypothetical protein 0.0021 0.0383 0.051
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0033 0.0044
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0092 0.2452 0.3263
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0298 0.1828
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0383 0.0383
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0184 0.0258
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0135 0.0135
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0383 0.0725
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.008
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0021 0.0371 0.2281
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0383 0.0504
Onchocerca volvulus 0.0267 0.7512 1
Schistosoma mansoni hypothetical protein 0.004 0.0929 0.177
Brugia malayi jmjC domain containing protein 0.0078 0.2021 0.2685
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.028 0.0757
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0176 0.488 0.6496
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.1625 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0007
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0184 0.0633
Entamoeba histolytica hypothetical protein 0.004 0.0929 0.327
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2829 0.4071
Brugia malayi steroid hormone receptor 0.0021 0.0383 0.0504
Onchocerca volvulus 0.0024 0.0465 0.0613
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.009 0.0113
Echinococcus multilocularis phd:f box containing protein 0.0021 0.0371 0.0371
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.009 0.012
Schistosoma mansoni coup transcription factor 0.0021 0.0383 0.0725
Loa Loa (eye worm) intermediate filament protein 0.0016 0.0245 0.0326
Brugia malayi nuclear receptor NHR-88 0.0021 0.0383 0.0504
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0776 0.4806
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0184 0.027
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0005 0.0005
Leishmania major hypothetical protein, conserved 0.0021 0.0371 0.0554
Echinococcus granulosus hypothetical protein 0.0008 0.0005 0.0005
Brugia malayi Nuclear hormone receptor E75 0.001 0.006 0.0073
Loa Loa (eye worm) hypothetical protein 0.0024 0.0465 0.0619
Loa Loa (eye worm) TAR-binding protein 0.007 0.1809 0.2408
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.006 0.006
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0383 0.0504
Loa Loa (eye worm) Smad1 0.0009 0.0033 0.0044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.161 0.9905
Echinococcus multilocularis jumonji domain containing 1A 0.0021 0.0371 0.0371
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0371 0.0554
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.2829 0.3766
Plasmodium falciparum phd finger protein, putative 0.0035 0.0776 0.5991
Mycobacterium ulcerans hypothetical protein 0.0027 0.0559 0.3421
Brugia malayi glutathione reductase 0.0052 0.1292 0.1714
Plasmodium falciparum thioredoxin reductase 0.0018 0.0298 0.2278
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0298 0.0562
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0582 0.0873
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0383 0.0725
Echinococcus multilocularis carboxylesterase 5A 0.0142 0.3879 0.3879
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0095 0.0126
Schistosoma mansoni tar DNA-binding protein 0.007 0.1809 0.3458
Echinococcus granulosus smad 0.0009 0.0033 0.0033
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0298 0.0444
Echinococcus multilocularis acetylcholinesterase 0.0142 0.3879 0.3879
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.1292 0.1292
Echinococcus multilocularis neuroligin 0.0024 0.0465 0.0465
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1243 0.1243
Schistosoma mansoni gliotactin 0.0024 0.0465 0.0882
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0007
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.1329 0.1769
Loa Loa (eye worm) hypothetical protein 0.0024 0.0465 0.0619
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0675 0.1284
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0005 0.0005
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0479 0.0717
Onchocerca volvulus 0.0031 0.0675 0.0892
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.009 0.009
Entamoeba histolytica hypothetical protein 0.004 0.0929 0.327
Echinococcus granulosus tar DNA binding protein 0.007 0.1809 0.1809
Echinococcus multilocularis tumor protein p63 0.0353 1 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0381 0.072
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0095 0.0119
Loa Loa (eye worm) hypothetical protein 0.0031 0.0675 0.0899
Mycobacterium tuberculosis Carboxylesterase LipT 0.0024 0.0465 0.127
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.1625 0.1625
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.008
Schistosoma mansoni tar DNA-binding protein 0.007 0.1809 0.3458
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0142 0.3879 0.7425
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0298 0.2278
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0024 0.0465 0.0619
Brugia malayi cytoplasmic intermediate filament protein 0.0009 0.0025 0.0027
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.006 0.0073
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0675 0.0675
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0383 0.0383
Schistosoma mansoni hypothetical protein 0.0076 0.1964 0.3754
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.006 0.0073
Echinococcus granulosus JmjC domain containing protein 4 0.0021 0.0371 0.0371
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0298 0.0444
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.1295 0.1859
Schistosoma mansoni smad1 5 8 and 0.0009 0.0033 0.0053
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.1329 0.1329
Brugia malayi hypothetical protein 0.0176 0.488 0.6493
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0298 0.0444
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.028 0.0526
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.1295 0.1859
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.2829 0.4273
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.028 0.028
Trypanosoma brucei hypothetical protein, conserved 0.0236 0.6614 1
Trypanosoma cruzi hypothetical protein, conserved 0.0236 0.6614 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1243 0.1243
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.2829 0.3761
Trichomonas vaginalis set domain proteins, putative 0.0247 0.6942 1
Schistosoma mansoni hypothetical protein 0.005 0.1231 0.2351
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.3241 0.8931
Plasmodium falciparum thioredoxin reductase 0.0052 0.1292 1
Brugia malayi Carboxylesterase family protein 0.0024 0.0465 0.0613
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0135 0.0135
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0383 0.0725
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.008
Schistosoma mansoni jumonji domain containing protein 0.0021 0.0371 0.0702
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.2021 0.3864
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0298 0.0444
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.1292 0.172
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0298 0.0391
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0298 0.181
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0479 0.0717
Brugia malayi Thioredoxin reductase 0.0052 0.1292 0.1714
Brugia malayi Pax transcription factor protein 2 0.0267 0.7512 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0095 0.0095
Schistosoma mansoni hypothetical protein 0.0035 0.0786 0.1497
Brugia malayi nuclear hormone receptor 0.0021 0.0383 0.0504
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.006 0.0105
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.161 0.9905
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2829 0.4071
Echinococcus granulosus bloom syndrome protein 0.0027 0.0544 0.0544
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0092 0.2452 0.2452
Echinococcus granulosus c-Jun N-terminal kinases 0.0092 0.2452 0.2452
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0383 0.051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0465 0.0619
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.008
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.1625 0.3105
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0383 0.0504
Schistosoma mansoni acetylcholinesterase 0.0024 0.0465 0.0882
Brugia malayi Intermediate filament tail domain containing protein 0.0016 0.0245 0.0319
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0383 0.0383
Brugia malayi hypothetical protein 0.0028 0.0582 0.0768
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.006 0.0073
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0582 0.4482
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.2288 0.3041
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0076 0.1964 0.2614
Mycobacterium ulcerans hypothetical protein 0.0027 0.0559 0.3421
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.3628 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0383 0.051
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.2829 0.4273
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0021 0.0371 0.0702
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0383 0.0504
Loa Loa (eye worm) hypothetical protein 0.0035 0.0776 0.1033
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0786 0.104
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.006 0.006
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.2288 0.2288
Echinococcus granulosus neuroligin 0.0024 0.0465 0.0465
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.006 0.0105
Trichomonas vaginalis spcc417.12 protein, putative 0.0024 0.0465 0.0663
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0298 0.1038
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.2021 0.3864
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0298 0.181
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0383 0.0504
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0776 0.1033
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.1329 0.2003
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.2288 0.2288
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0045 0.1085 0.1085
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0383 0.0725
Schistosoma mansoni DNA helicase recq5 0.0011 0.009 0.0163
Echinococcus granulosus hypothetical protein 0.0008 0.0005 0.0005
Giardia lamblia Kinase, PLK 0.0105 0.2829 1
Loa Loa (eye worm) RecQ helicase 0.0027 0.0544 0.0724
Loa Loa (eye worm) hypothetical protein 0.0024 0.0465 0.0619
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.2829 0.2829
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0298 0.0444
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0298 0.0423
Loa Loa (eye worm) hypothetical protein 0.0021 0.0383 0.051
Brugia malayi Pre-SET motif family protein 0.0217 0.6072 0.8081
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.1846 0.2458
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0298 0.2278
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.008
Loa Loa (eye worm) DR-78 0.001 0.006 0.008
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.1391 0.1852
Schistosoma mansoni hypothetical protein 0.0035 0.0786 0.1497
Echinococcus granulosus lysine specific demethylase 5A 0.0078 0.2021 0.2021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0383 0.0504
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0027 0.0559 0.0799
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0383 0.0383
Echinococcus granulosus citrate lyase subunit beta protein 0.0027 0.0559 0.0559
Schistosoma mansoni nuclear receptor 0.001 0.006 0.0105
Brugia malayi tailless protein 0.001 0.006 0.0073
Plasmodium falciparum JmjC domain-containing protein, putative 0.0021 0.0371 0.2844
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.693 0.693
Entamoeba histolytica hypothetical protein 0.004 0.0929 0.327
Schistosoma mansoni smad1 5 8 and 0.0009 0.0033 0.0053
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.3241 0.8931
Schistosoma mansoni kinase 0.0054 0.1335 0.2549
Loa Loa (eye worm) hypothetical protein 0.0052 0.1269 0.1689
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0479 0.2927
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.2452 0.469
Brugia malayi Nuclear hormone receptor E75 0.001 0.006 0.0073
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0465 0.0882
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.009 0.0529
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1329 0.2003
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.006 0.006
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0383 0.0725
Echinococcus multilocularis peregrin 0.0035 0.0776 0.0776
Schistosoma mansoni DNA helicase recq1 0.0011 0.009 0.0163
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1243 0.1654
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0159 0.0204
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.2829 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0383 0.0383
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0007
Brugia malayi jmjC domain containing protein 0.0149 0.4095 0.5448
Brugia malayi Smad1 0.0009 0.0033 0.0037
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0007
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.01 0.0143
Giardia lamblia PHD finger protein 15 0.0035 0.0776 0.2731
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0582 0.4482
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.3611 0.4807
Brugia malayi TAR-binding protein 0.007 0.1809 0.2403
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0929 0.0929
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.028 0.171

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6966 nM Inhibition of human Nav1.7 channel expressed in HEK293 cells assessed as membrane potential after 60 mins by FLIPR assay ChEMBL. 25113934

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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