Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.2355 | 0.2355 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.2355 | 0.2355 |
Brugia malayi | hypothetical protein | 0.0151 | 0.5383 | 0.5383 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.2355 | 0.2355 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.2355 | 0.2355 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.5383 | 0.5383 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0414 | 0.0414 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0414 | 0.0414 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Onchocerca volvulus | 0.0151 | 0.5383 | 1 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0159 | 0.5751 | 0.5751 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0414 | 0.0414 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0159 | 0.5751 | 0.5751 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0041 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0137 | 0.4667 | 0.4667 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0414 | 0.0414 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0159 | 0.5751 | 0.5751 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.2355 | 0.2355 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2355 | 0.2355 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0137 | 0.4667 | 0.4667 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.2355 | 0.2355 |
Onchocerca volvulus | 0.0092 | 0.2469 | 0.4586 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2355 | 0.2355 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0159 | 0.5751 | 0.5751 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0159 | 0.5751 | 0.5751 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2355 | 0.2355 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.666 | Inhibition of equine serum BChE | ChEMBL. | 25047936 |
IC50 (binding) | = 6.174 | Inhibition of human AChE | ChEMBL. | 25047936 |
IC50 (binding) | = 7.323 | Inhibition of electric eel AChE | ChEMBL. | 25047936 |
IC50 (binding) | = 47.5 nM | Inhibition of electric eel AChE | ChEMBL. | 25047936 |
IC50 (binding) | = 669 nM | Inhibition of human AChE | ChEMBL. | 25047936 |
IC50 (binding) | = 2.16 uM | Inhibition of equine serum BChE | ChEMBL. | 25047936 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.