Detailed information for compound 923621

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 372.42 | Formula: C22H20N4O2
  • H donors: 0 H acceptors: 2 LogP: 2.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1c2cc(OCCCn3cncc3)ccc2nc2n1CCc1c2cccc1
  • InChi: 1S/C22H20N4O2/c27-22-19-14-17(28-13-3-10-25-12-9-23-15-25)6-7-20(19)24-21-18-5-2-1-4-16(18)8-11-26(21)22/h1-2,4-7,9,12,14-15H,3,8,10-11,13H2
  • InChiKey: WYDAWNYRRQAAEA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Electrophorus electricus Acetylcholinesterase Starlite/ChEMBL References
Equus caballus Cholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Cholinesterase   574 aa 551 aa 29.9 %
Brugia malayi Carboxylesterase family protein Cholinesterase   574 aa 538 aa 31.4 %
Onchocerca volvulus Carnitine O-palmitoyltransferase 2, mitochondrial homolog Cholinesterase   574 aa 554 aa 36.1 %
Onchocerca volvulus Acetylcholinesterase   633 aa 648 aa 25.3 %
Onchocerca volvulus Cholinesterase   574 aa 578 aa 25.3 %
Echinococcus multilocularis neuroligin Acetylcholinesterase   633 aa 507 aa 23.9 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   633 aa 517 aa 25.1 %
Schistosoma mansoni gliotactin Cholinesterase   574 aa 587 aa 27.9 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   633 aa 620 aa 28.4 %
Onchocerca volvulus Molybdopterin synthase catalytic subunit homolog Acetylcholinesterase   633 aa 576 aa 28.8 %
Echinococcus granulosus neuroligin Cholinesterase   574 aa 492 aa 24.4 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   633 aa 576 aa 23.4 %
Onchocerca volvulus Putative nuclear protein Cholinesterase   574 aa 572 aa 40.9 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   633 aa 597 aa 25.1 %
Schistosoma japonicum ko:K01050 cholinesterase [EC3.1.1.8], putative Cholinesterase   574 aa 577 aa 36.9 %
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Acetylcholinesterase   633 aa 622 aa 24.9 %
Echinococcus multilocularis BC026374 protein (S09 family) Acetylcholinesterase   633 aa 690 aa 32.3 %
Echinococcus granulosus BC026374 protein S09 family Acetylcholinesterase   633 aa 690 aa 31.7 %
Onchocerca volvulus Galectin homolog Cholinesterase   574 aa 531 aa 39.7 %
Drosophila melanogaster CG10175 gene product from transcript CG10175-RE Acetylcholinesterase   633 aa 549 aa 30.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Echinococcus multilocularis 0.0099 0.0099 0.0123
Onchocerca volvulus 0.004 0.0007 0.0082
Toxoplasma gondii subtilisin SUB8 0.0285 0.0388 0.756
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1575 0.2387 0.3918
Loa Loa (eye worm) hypothetical protein 0.0164 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0333 0.0462 0.0462
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0087 0.0081 0.0132
Onchocerca volvulus 0.004 0.0007 0.0082
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.001 0.0014
Onchocerca volvulus 0.004 0.0008 0.0096
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0313 0.043 0.3835
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0058 0.0035 0.0035
Echinococcus multilocularis integrin alpha ps 0.0067 0.005 0.0061
Schistosoma mansoni hypothetical protein 0.0098 0.0098 0.0098
Echinococcus granulosus adam 0.0059 0.0037 0.0036
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0059 0.0037 0.0059
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0099 0.0099 0.0099
Echinococcus granulosus protein arginine methyltransferase 0.0155 0.0186 0.0185
Toxoplasma gondii PA14 domain-containing protein 0.004 0.0008 0.0144
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0087 0.0081 0.01
Mycobacterium ulcerans Sir2-like regulatory protein 0.01 0.01 0.0027
Loa Loa (eye worm) hypothetical protein 0.0164 0.02 0.02
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.01 0.0163
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Loa Loa (eye worm) hypothetical protein 0.0043 0.0012 0.0012
Brugia malayi hypothetical protein 0.0243 0.0322 0.0321
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0087 0.0081 0.0132
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0087 0.0081 0.0132
Echinococcus granulosus Furin 1 0.1575 0.2387 0.2386
Toxoplasma gondii F5/8 type C domain-containing protein 0.004 0.0008 0.0144
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Toxoplasma gondii subtilisin SUB7 0.0285 0.0388 0.756
Trichomonas vaginalis alpha-L-fucosidase, putative 0.004 0.0008 0.0012
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0228 0.0299 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Plasmodium vivax LCCL domain-containing protein 0.004 0.0008 0.013
Brugia malayi transcriptional regulator, Sir2 family protein 0.01 0.01 0.0099
Toxoplasma gondii subtilisin SUB4 0.0285 0.0388 0.756
Loa Loa (eye worm) TK/ALK protein kinase 0.0098 0.0098 0.0098
Brugia malayi Carboxylesterase family protein 0.0164 0.02 0.0198
Loa Loa (eye worm) hypothetical protein 0.004 0.0008 0.0008
Onchocerca volvulus Putative cubilin 0.0047 0.0019 0.024
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.01 0.0163
Brugia malayi hypothetical protein 0.004 0.0007 0.0006
Echinococcus multilocularis protein kinase c epsilon type 0.0087 0.0081 0.01
Echinococcus multilocularis C type lectin domian containing protein 0.004 0.0007 0.0008
Toxoplasma gondii F5/8 type C domain-containing protein 0.004 0.0008 0.0144
Loa Loa (eye worm) transcriptional regulator 0.01 0.01 0.01
Echinococcus multilocularis adam 0.0059 0.0037 0.0045
Mycobacterium tuberculosis Possible oxidoreductase 0.0099 0.0099 0.2398
Loa Loa (eye worm) aspartyl protease 6 0.0036 0.0001 0.0001
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.01 0.01 0.0124
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0689 0.1013 0.1013
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0098 0.0098 0.0098
Brugia malayi Calcium binding EGF domain containing protein 0.0047 0.0019 0.0018
Toxoplasma gondii hypothetical protein 0.0059 0.0037 0.0705
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0099 0.0099 0.1735
Brugia malayi hypothetical protein 0.0099 0.0099 0.0098
Echinococcus granulosus integrin alpha 3 0.0115 0.0124 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Trypanosoma cruzi UDP-galactopyranose mutase 0.0099 0.0099 0.0198
Plasmodium falciparum plasmepsin V 0.0401 0.0568 1
Brugia malayi Subtilase family protein 0.0285 0.0388 0.0387
Schistosoma mansoni growth factor receptor-bound protein 0.014 0.0162 0.0162
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0285 0.0388 1
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.129 0.1945 0.3192
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0488 0.0701 0.0701
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0675 0.0992 0.0991
Trichomonas vaginalis conserved hypothetical protein 0.129 0.1945 0.3192
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0055 0.0031 0.0031
Onchocerca volvulus 0.0285 0.0388 0.5056
Brugia malayi NAD-dependent deacetylase SIRT1 0.01 0.01 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0285 0.0388 0.0635
Brugia malayi Muscle positioning protein 4 0.004 0.0008 0.0007
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.01 0.01 0.0206
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0155 0.0186 0.3272
Onchocerca volvulus 0.0063 0.0044 0.0557
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0675 0.0992 1
Plasmodium falciparum transcriptional regulatory protein sir2a 0.01 0.01 0.1748
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0029 0.0029
Toxoplasma gondii rhoptry neck protein RON9 0.004 0.0007 0.0123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Trichomonas vaginalis conserved hypothetical protein 0.129 0.1945 0.3192
Echinococcus multilocularis protoporphyrinogen oxidase 0.0099 0.0099 0.0123
Brugia malayi hypothetical protein 0.004 0.0007 0.0006
Loa Loa (eye worm) transcriptional regulator 0.0675 0.0992 0.0992
Trypanosoma brucei Silent information regulator 2 related protein 3 0.01 0.01 0.0206
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Onchocerca volvulus 0.004 0.0007 0.0082
Brugia malayi transcriptional regulator, Sir2 family protein 0.0675 0.0992 0.0991
Onchocerca volvulus 0.004 0.0007 0.0082
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.01 0.01 0.0124
Toxoplasma gondii histone deacetylase SIR2 0.01 0.01 0.1938
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1575 0.2387 0.3918
Plasmodium vivax hypothetical protein, conserved 0.01 0.01 0.1748
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0007
Schistosoma mansoni tyrosine kinase 0.0461 0.066 0.066
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.129 0.1945 0.3192
Echinococcus granulosus methyltransferase protein 5 0.0087 0.0081 0.008
Plasmodium falciparum protoporphyrinogen oxidase 0.0099 0.0099 0.1735
Brugia malayi transcriptional regulator, Sir2 family protein 0.01 0.01 0.0099
Brugia malayi protein kinase C II. 0.0087 0.0081 0.008
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0285 0.0388 1
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0243 0.0322 0.318
Brugia malayi GCC2 and GCC3 family protein 0.0059 0.0038 0.0037
Schistosoma mansoni amine oxidase 0.0099 0.0099 0.0099
Plasmodium vivax subtilisin-like serine protease, putative 0.0285 0.0388 0.6822
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0155 0.0186 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0285 0.0388 0.0635
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0007
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0155 0.0186 0.3272
Plasmodium vivax NAD-dependent deacetylase, putative 0.01 0.01 0.1748
Loa Loa (eye worm) integrin beta-2 0.218 0.3325 0.3325
Brugia malayi hypothetical protein 0.004 0.0007 0.0006
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.01 0.01
Toxoplasma gondii subtilisin SUB12 0.0285 0.0388 0.756
Leishmania major UDP-galactopyranose mutase 0.0099 0.0099 0.0198
Loa Loa (eye worm) hypothetical protein 0.0083 0.0074 0.0074
Brugia malayi EGF-like domain containing protein 0.0059 0.0037 0.0036
Loa Loa (eye worm) sex muscle abnormal protein 5 0.014 0.0162 0.0162
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0001 0.0001
Plasmodium vivax apical sushi protein, putative 0.004 0.0007 0.0111
Toxoplasma gondii SWIRM domain-containing protein 0.0041 0.001 0.0169
Echinococcus multilocularis neuroendocrine convertase 2 0.4097 0.6296 0.7869
Loa Loa (eye worm) Carm1-pending protein 0.0087 0.0081 0.0081
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0285 0.0388 1
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0081 0.0081
Onchocerca volvulus 0.004 0.0007 0.0082
Schistosoma mansoni protein arginine n-methyltransferase 0.0087 0.0081 0.0081
Trichomonas vaginalis alpha-L-fucosidase, putative 0.004 0.0008 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Brugia malayi SWIRM domain containing protein 0.0041 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0155 0.0186 0.0186
Brugia malayi hypothetical protein 0.0333 0.0462 0.0461
Brugia malayi EGF-like domain containing protein 0.0059 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0007
Echinococcus multilocularis discoidin domain receptor 0.004 0.0008 0.0009
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0087 0.0081 0.0081
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3965 0.6091 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0675 0.0992 0.0992
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0036 0.0001 0.0001
Schistosoma mansoni discoidin domain receptor 0.004 0.0008 0.0008
Trypanosoma cruzi subtilisin peptidase 0.0285 0.0388 0.3363
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0675 0.0992 1
Trichomonas vaginalis conserved hypothetical protein 0.129 0.1945 0.3192
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0155 0.0186 0.0186
Echinococcus granulosus furin 0.6487 1 1
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.01 0.01
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0099 0.0099 0.1923
Loa Loa (eye worm) hypothetical protein 0.0139 0.0161 0.0161
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.129 0.1945 0.3192
Trichomonas vaginalis conserved hypothetical protein 0.129 0.1945 0.3192
Giardia lamblia Transcriptional regulator, Sir2 family 0.01 0.01 0.0248
Loa Loa (eye worm) hypothetical protein 0.01 0.01 0.01
Loa Loa (eye worm) WD40 repeat protein 0.0346 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0098 0.0098 0.0097
Echinococcus multilocularis serine:threonine protein kinase N2 0.008 0.007 0.0086
Loa Loa (eye worm) hypothetical protein 0.014 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.004 0.0008 0.0008
Schistosoma mansoni cathepsin D (A01 family) 0.0036 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Echinococcus multilocularis protein will die slowly 0.0346 0.0482 0.0601
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.004 0.0008 0.0009
Schistosoma mansoni discoidin domain receptor 0.004 0.0008 0.0008
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0675 0.0992 0.1627
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Plasmodium vivax LCCL domain-containing protein 0.004 0.0008 0.013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Loa Loa (eye worm) subtilase 0.0285 0.0388 0.0388
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Schistosoma mansoni dock 0.004 0.0008 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0099 0.1735
Echinococcus granulosus carboxylesterase 5A 0.0164 0.02 0.0198
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0675 0.0992 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0675 0.0992 1
Onchocerca volvulus 0.0059 0.0037 0.0472
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0285 0.0388 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.01 0.01 0.0099
Onchocerca volvulus 0.004 0.0007 0.0082
Echinococcus granulosus protein will die slowly 0.0346 0.0482 0.0481
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0122 0.0135 0.0134
Loa Loa (eye worm) hypothetical protein 0.0098 0.0098 0.0098
Echinococcus granulosus neuroendocrine convertase 2 0.4097 0.6296 0.6296
Brugia malayi Protein arginine N-methyltransferase 0.0087 0.0081 0.008
Echinococcus multilocularis acetylcholinesterase 0.0164 0.02 0.0248
Echinococcus granulosus acetylcholinesterase 0.0164 0.02 0.0198
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0675 0.0992 0.1627
Schistosoma mansoni memapsin-2 (A01 family) 0.0036 0.0001 0.0001
Toxoplasma gondii histone lysine-specific demethylase 0.0099 0.0099 0.1923
Echinococcus multilocularis fibrillin 2 0.0059 0.0037 0.0045
Giardia lamblia Tenascin-like 0.0059 0.0037 0.0075
Echinococcus granulosus integrin beta 2 0.1612 0.2444 0.2443
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.0008 0.0008
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0041 0.001 0.0011
Brugia malayi Stress-activated protein kinase jnk-1 0.0228 0.0299 0.0298
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0243 0.0322 0.2643
Onchocerca volvulus 0.0098 0.0098 0.1264
Brugia malayi EGF-like domain containing protein 0.0059 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0055 0.0031 0.0031
Onchocerca volvulus 0.004 0.0007 0.0082
Echinococcus granulosus discoidin domain containing receptor 2 0.004 0.0008 0.0007
Echinococcus multilocularis acetylcholinesterase 0.0164 0.02 0.0248
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0313 0.043 0.3835
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0243 0.0322 0.2643
Onchocerca volvulus 0.0346 0.0482 0.6292
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0087 0.0081 0.0729
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0155 0.0186 0.0304
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.0122 0.012
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.01 0.0163
Echinococcus granulosus c-Jun N-terminal kinases 0.0228 0.0299 0.0298
Brugia malayi pregnancy-associated plasma protein-A 0.004 0.0007 0.0006
Echinococcus multilocularis integrin beta 2 0.1612 0.2444 0.3054
Toxoplasma gondii subtilisin SUB5 0.0285 0.0388 0.756
Echinococcus granulosus fibrillin 1 0.006 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0007
Echinococcus multilocularis chromatin regulatory protein sir2 0.0675 0.0992 0.1239
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0285 0.0388 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Toxoplasma gondii histone deacetylase SIR2-like 0.01 0.01 0.1938
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0118 0.0128 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0243 0.0322 0.0322
Echinococcus granulosus lysine specific histone demethylase 1A 0.0099 0.0099 0.0098
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0285 0.0388 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0001 0.0001
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0087 0.0081 0.0081
Brugia malayi Kelch motif family protein 0.0361 0.0505 0.0504
Giardia lamblia Furin precursor putative serine protease 0.129 0.1945 0.5317
Leishmania major sir2-family protein-like protein 0.01 0.01 0.0206
Echinococcus multilocularis discoidin domain containing receptor 2 0.004 0.0008 0.0009
Brugia malayi Carboxylesterase family protein 0.0164 0.02 0.0198
Brugia malayi hypothetical protein 0.0098 0.0098 0.0097
Plasmodium vivax subtilisin-like protease 2, putative 0.0285 0.0388 0.6822
Entamoeba histolytica hypothetical protein, conserved 0.01 0.01 0.092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Echinococcus granulosus C type lectin domian containing protein 0.004 0.0007 0.0006
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0087 0.0081 0.008
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.01 0.0163
Loa Loa (eye worm) hypothetical protein 0.0113 0.0122 0.0122
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.02 0.02
Schistosoma mansoni cathepsin D (A01 family) 0.0036 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.01 0.0163
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0285 0.0388 0.0387
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0043 0.0012 0.0011
Echinococcus multilocularis protein arginine methyltransferase 0.0155 0.0186 0.0232
Schistosoma mansoni integrin alpha 0.015 0.0178 0.0178
Toxoplasma gondii subtilisin SUB11 0.0285 0.0388 0.756
Trichomonas vaginalis hypothetical protein 0.129 0.1945 0.3192
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0055 0.0031 0.0031
Plasmodium vivax subtilisin-like protease 1 0.0285 0.0388 0.6822
Echinococcus granulosus acetylcholinesterase 0.0164 0.02 0.0198
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Giardia lamblia Tenascin-X 0.0059 0.0037 0.0075
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0001 0.0001
Toxoplasma gondii subtilisin SUB1 0.0285 0.0388 0.756
Schistosoma mansoni SWI/SNF complex-related 0.0041 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0037
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0098 0.0098 0.0098
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0285 0.0388 0.3363
Echinococcus granulosus chromatin regulatory protein sir2 0.0675 0.0992 0.0991
Giardia lamblia Hypothetical protein 0.0675 0.0992 0.2698
Brugia malayi Sushi domain 0.004 0.0007 0.0006
Plasmodium falciparum subtilisin-like protease 3 0.0285 0.0388 0.6822
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3965 0.6091 1
Mycobacterium leprae Possible secreted protease 0.0285 0.0388 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Trichomonas vaginalis hypothetical protein 0.004 0.0008 0.0012
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0001 0.0001
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.01 0.0163
Brugia malayi Furin-like cysteine rich region family protein 0.0461 0.066 0.0659
Onchocerca volvulus 0.004 0.0007 0.0082
Brugia malayi celfurPC protein 0.5197 0.8001 0.8
Brugia malayi hypothetical protein 0.004 0.0007 0.0006
Giardia lamblia hypothetical protein 0.0059 0.0037 0.0075
Schistosoma mansoni protein kinase 0.0122 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0047 0.0019 0.0019
Echinococcus granulosus membrane bound transcription factor site 1 0.0285 0.0388 0.0387
Plasmodium falciparum transcriptional regulatory protein sir2b 0.01 0.01 0.1748
Toxoplasma gondii subtilisin SUB6 0.0285 0.0388 0.756
Echinococcus granulosus epidermal growth factor receptor 0.0461 0.066 0.0659
Loa Loa (eye worm) hypothetical protein 0.0285 0.0388 0.0388
Schistosoma mansoni amine oxidase 0.0099 0.0099 0.0099
Echinococcus granulosus MAM 0.0098 0.0098 0.0097
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0122 0.0135 0.0167
Schistosoma mansoni protein kinase 0.0122 0.0135 0.0135
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0099 0.0099 0.1735
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0239 0.0316 0.0316
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.0299 0.0299
Plasmodium falciparum subtilisin-like protease 1 0.0285 0.0388 0.6822
Brugia malayi hypothetical protein 0.004 0.0007 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Plasmodium vivax plasmepsin V, putative 0.0401 0.0568 1
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0285 0.0388 0.0387
Mycobacterium tuberculosis Conserved hypothetical protein 0.0099 0.0099 0.2398
Trichomonas vaginalis conserved hypothetical protein 0.0285 0.0388 0.0635
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.01 0.01
Echinococcus multilocularis carboxylesterase 5A 0.0164 0.02 0.0248
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0098 0.0098 0.0098
Schistosoma mansoni site-1 peptidase (S08 family) 0.0285 0.0388 0.0388
Echinococcus multilocularis epidermal growth factor receptor 0.0461 0.066 0.0824
Trichomonas vaginalis conserved hypothetical protein 0.129 0.1945 0.3192
Loa Loa (eye worm) TK/EGFR protein kinase 0.0461 0.066 0.066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1575 0.2387 0.3918
Trypanosoma cruzi UDP-galactopyranose mutase 0.0099 0.0099 0.0198
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0488 0.0701 0.0876
Echinococcus granulosus lysine specific histone demethylase 1A 0.0488 0.0701 0.0701
Schistosoma mansoni hypothetical protein 0.0087 0.0081 0.0081
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0087 0.0081 0.157
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.3965 0.6091 0.609
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.01 0.01 0.0206
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0361 0.0505 0.0505
Toxoplasma gondii rhoptry neck protein RON1 0.004 0.0007 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0155 0.0186 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0285 0.0388 0.0635
Giardia lamblia Neurogenic locus Notch protein precursor 0.0059 0.0037 0.0075
Loa Loa (eye worm) carboxylesterase 0.0164 0.02 0.02
Schistosoma mansoni c4b-binding protein beta chain 0.004 0.0007 0.0007
Brugia malayi Carm1-pending protein 0.0087 0.0081 0.008
Brugia malayi amine oxidase, flavin-containing family protein 0.014 0.0163 0.0162
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Plasmodium falciparum apical sushi protein 0.004 0.0007 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Loa Loa (eye worm) proprotein convertase 2 0.1575 0.2387 0.2387
Loa Loa (eye worm) sirtuin 4 0.01 0.01 0.01
Echinococcus multilocularis protein jagged 2 0.0059 0.0037 0.0045
Brugia malayi Angiotensin-converting enzyme family protein 0.0689 0.1013 0.1012
Loa Loa (eye worm) hypothetical protein 0.0043 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Echinococcus multilocularis Furin 1 0.1575 0.2387 0.2982
Brugia malayi SWIRM domain containing protein 0.0529 0.0765 0.0764
Giardia lamblia Sirtuin type 2 0.01 0.01 0.0248
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.01 0.01 0.0099
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.004 0.0007 0.0007
Echinococcus granulosus protein arginine N methyltransferase 8 0.0155 0.0186 0.0185
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.2522 0.3855 0.3855
Chlamydia trachomatis protoporphyrinogen oxidase 0.0099 0.0099 0.5
Brugia malayi hypothetical protein 0.004 0.0007 0.0006
Echinococcus granulosus serine:threonine protein kinase N2 0.0071 0.0056 0.0055
Echinococcus granulosus protein kinase c epsilon type 0.0087 0.0081 0.008
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1575 0.2387 0.2387
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.01 0.01 0.092
Brugia malayi hypothetical protein 0.004 0.0007 0.0006
Schistosoma mansoni chromatin regulatory protein sir2 0.0675 0.0992 0.0992
Toxoplasma gondii subtilisin SUB10 0.0285 0.0388 0.756
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1575 0.2387 0.3918
Echinococcus granulosus discoidin domain containing receptor 2 0.004 0.0008 0.0007
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0675 0.0992 0.1239
Echinococcus multilocularis integrin alpha ps 0.0067 0.005 0.0061
Giardia lamblia Tenascin-37 0.0059 0.0037 0.0075
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0313 0.043 0.3835
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0099 0.1735
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0285 0.0388 0.0388
Toxoplasma gondii bicoid-interacting protein BIN3 0.0087 0.0081 0.157
Echinococcus granulosus integrin alpha ps 0.0067 0.005 0.0049
Leishmania major silent information regulator 2, putative 0.0675 0.0992 1
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.004 0.0008 0.0009
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.004 0.0008 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.129 0.1945 0.3192
Toxoplasma gondii F5/8 type C domain-containing protein 0.004 0.0008 0.0144
Echinococcus multilocularis c4b binding protein beta chain 0.004 0.0007 0.0008
Echinococcus multilocularis 0.5197 0.8001 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Brugia malayi Sex muscle abnormal protein 5 0.014 0.0162 0.0161
Loa Loa (eye worm) hypothetical protein 0.6487 1 1
Onchocerca volvulus 0.004 0.0007 0.0082
Trypanosoma brucei subtilisin peptidase 0.0285 0.0388 0.3363
Echinococcus multilocularis Tolloid protein 1 0.0055 0.0031 0.0037
Schistosoma mansoni chromatin regulatory protein sir2 0.0675 0.0992 0.0992
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0037
Brugia malayi EGF-like domain containing protein 0.0059 0.0037 0.0036
Echinococcus multilocularis fibrillin 1 0.0088 0.0082 0.0101
Schistosoma mansoni hypothetical protein 0.129 0.1945 0.1945
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1315 0.1984 0.1984
Echinococcus multilocularis discoidin domain containing receptor 2 0.004 0.0008 0.0009
Schistosoma mansoni btb and poz domain-containing protein 0.004 0.0008 0.0008
Brugia malayi Integrin alpha pat-2 precursor 0.015 0.0178 0.0177
Schistosoma mansoni hypothetical protein 0.004 0.0008 0.0008
Plasmodium falciparum subtilisin-like protease 2 0.0285 0.0388 0.6822
Schistosoma mansoni hypothetical protein 0.0346 0.0482 0.0482
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Trichomonas vaginalis WD repeat domain, putative 0.0346 0.0482 0.079
Giardia lamblia Tenascin precursor 0.0059 0.0037 0.0075
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.01 0.01 0.0248
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.01 0.0163
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0087 0.0081 0.01
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0056 0.0475
Echinococcus granulosus fibrillin 2 0.0059 0.0037 0.0036
Giardia lamblia High cysteine protein 0.0059 0.0037 0.0075
Loa Loa (eye worm) transcriptional regulator 0.01 0.01 0.01
Schistosoma mansoni growth factor receptor-bound protein 0.014 0.0162 0.0162
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0155 0.0186 0.0304
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0059 0.0037 0.0037
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0087 0.0081 0.157
Onchocerca volvulus 0.0098 0.0098 0.1264
Loa Loa (eye worm) hypothetical protein 0.0099 0.0099 0.0099
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0285 0.0388 0.0388
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0285 0.0388 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.01 0.01 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.129 0.1945 0.3192
Onchocerca volvulus 0.004 0.0007 0.0082
Schistosoma mansoni furin-1 (S08 family) 0.2807 0.4297 0.4297
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0036 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012
Mycobacterium tuberculosis Transcriptional regulatory protein 0.01 0.01 0.2418
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0285 0.0388 0.0483
Brugia malayi Integrin beta pat-3 precursor 0.218 0.3325 0.3324
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.3965 0.6091 0.7612
Schistosoma mansoni protein kinase 0.0122 0.0135 0.0135
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0076 0.0064 0.0064
Entamoeba histolytica hypothetical protein 0.0243 0.0322 0.318
Echinococcus granulosus growth factor receptor bound protein 2 0.014 0.0162 0.0161
Loa Loa (eye worm) hypothetical protein 0.0099 0.0099 0.0099
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0008 0.013
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0008 0.013
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.6487 1 1
Schistosoma mansoni integrin beta subunit 0.1279 0.1928 0.1928
Loa Loa (eye worm) hypothetical protein 0.0059 0.0038 0.0038
Echinococcus granulosus discoidin domain containing receptor 2 0.004 0.0008 0.0007
Onchocerca volvulus 0.004 0.0008 0.0096
Loa Loa (eye worm) hypothetical protein 0.0529 0.0765 0.0765
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.01 0.01 0.0099
Schistosoma mansoni chromatin regulatory protein sir2 0.01 0.01 0.01
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0285 0.0388 1
Trichomonas vaginalis hypothetical protein 0.0059 0.0037 0.0059
Leishmania major subtilisin-like serine peptidase 0.0285 0.0388 0.3363
Trichomonas vaginalis conserved hypothetical protein 0.129 0.1945 0.3192
Echinococcus granulosus protein arginine N methyltransferase 7 0.0087 0.0081 0.008
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0285 0.0388 1
Echinococcus granulosus c4b binding protein beta chain 0.004 0.0007 0.0006
Loa Loa (eye worm) integrin alpha pat-2 0.0231 0.0304 0.0304
Mycobacterium ulcerans NAD-dependent deacetylase 0.01 0.01 0.0027
Leishmania major arginine N-methyltransferase-like protein 0.0155 0.0186 0.1154
Trichomonas vaginalis conserved hypothetical protein 0.129 0.1945 0.3192
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0099 0.0099 0.2398
Echinococcus multilocularis integrin alpha 3 0.0115 0.0124 0.0154
Loa Loa (eye worm) hypothetical protein 0.0488 0.0701 0.0701
Toxoplasma gondii subtilisin SUB9 0.0285 0.0388 0.756
Brugia malayi Protein kinase domain containing protein 0.004 0.0008 0.0007
Giardia lamblia High cysteine membrane protein Group 2 0.239 0.3649 1
Brugia malayi proprotein convertase 2 0.4097 0.6296 0.6296
Toxoplasma gondii aspartyl protease ASP5 0.0366 0.0512 1
Brugia malayi Will die slowly protein 0.0346 0.0482 0.0481
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0099 0.0099 0.1735
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0285 0.0388 1
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.01 0.01 0.0206
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0155 0.0186 0.3626
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0675 0.0992 1
Trichomonas vaginalis conserved hypothetical protein 0.129 0.1945 0.3192
Onchocerca volvulus 0.0529 0.0765 1
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0243 0.0322 0.2643
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0285 0.0388 0.0635
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0107 0.0111 0.011
Toxoplasma gondii subtilisin SUB2 0.0285 0.0388 0.756
Trichomonas vaginalis beta-hexosaminidase B, putative 0.004 0.0008 0.0012
Schistosoma mansoni integrin alpha-ps 0.0067 0.005 0.005
Echinococcus multilocularis MAM 0.0098 0.0098 0.0121
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1575 0.2387 0.3918
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0001 0.0001
Echinococcus multilocularis growth factor receptor bound protein 2 0.014 0.0162 0.0202
Brugia malayi neuroendocrine convertase 1 precursor 0.4097 0.6296 0.6296
Trypanosoma brucei SIR2-like protein 4, putative 0.01 0.01 0.0206
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0107 0.0111 0.0111
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.01 0.0163
Loa Loa (eye worm) acetylcholinesterase 1 0.0164 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0007
Echinococcus multilocularis membrane bound transcription factor site 1 0.0285 0.0388 0.0483
Echinococcus multilocularis discoidin domain containing receptor 2 0.004 0.0008 0.0009
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0155 0.0186 0.0186
Giardia lamblia High cysteine protein 0.0059 0.0037 0.0075
Onchocerca volvulus 0.0135 0.0155 0.2011
Giardia lamblia Neurogenic locus notch-like protein 0.0059 0.0037 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0285 0.0388 0.0635
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0099 0.0099 0.1735
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.01 0.01 0.092
Schistosoma mansoni site-1 peptidase (S08 family) 0.0285 0.0388 0.0388
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.01 0.01 0.0163
Echinococcus granulosus discoidin domain receptor 0.004 0.0008 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1575 0.2387 0.3918
Trichomonas vaginalis conserved hypothetical protein 0.129 0.1945 0.3192
Schistosoma mansoni septate junction protein 0.006 0.0039 0.0039
Loa Loa (eye worm) endoprotease bli-4 0.6487 1 1
Echinococcus granulosus Tolloid protein 1 0.0055 0.0031 0.003
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0228 0.0299 0.0372
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0041 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0488 0.0701 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0008 0.0012

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.061 Inhibition of equine serum BChE ChEMBL. 25047936
IC50 (binding) = 5.613 Inhibition of electric eel AChE ChEMBL. 25047936
IC50 (binding) = 2.44 uM Inhibition of electric eel AChE ChEMBL. 25047936
IC50 (binding) = 8.68 uM Inhibition of equine serum BChE ChEMBL. 25047936

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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