Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0002 | 0.0002 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0153 | 0.4541 | 0.4541 |
Echinococcus granulosus | neuroligin | 0.0047 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.0047 | 0.0002 | 0.0005 | |
Loa Loa (eye worm) | carboxylesterase | 0.028 | 1 | 1 |
Onchocerca volvulus | 0.0047 | 0.0002 | 0.0005 | |
Schistosoma mansoni | gliotactin | 0.0047 | 0.0002 | 0.0002 |
Echinococcus multilocularis | neuroligin | 0.0047 | 0.0002 | 0.0002 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0047 | 0.0002 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0153 | 0.4541 | 0.4541 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0192 | 0.0192 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0047 | 0.0002 | 0.0002 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0047 | 0.0002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0002 | 0.0002 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0047 | 0.0002 | 0.0002 |
Echinococcus granulosus | carboxylesterase 5A | 0.028 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0192 | 0.0192 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.028 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | carboxylesterase | 0.0047 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.0047 | 0.0002 | 0.0005 | |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0079 | 0.1349 | 0.1398 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0047 | 0.0002 | 0.0002 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.0047 | 0.0002 | 0.0005 | |
Echinococcus granulosus | acetylcholinesterase | 0.028 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.028 | 1 | 1 |
Onchocerca volvulus | 0.0047 | 0.0002 | 0.0005 | |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0002 | 0.0002 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0047 | 0.0002 | 0.0002 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0272 | 0.9636 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0153 | 0.4541 | 0.4541 |
Schistosoma mansoni | alpha-glucosidase | 0.0153 | 0.4541 | 0.4541 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0047 | 0.0002 | 0.0002 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0192 | 0.0192 |
Schistosoma mansoni | acetylcholinesterase | 0.0047 | 0.0002 | 0.0002 |
Brugia malayi | hypothetical protein | 0.0047 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | carboxylesterase | 0.0047 | 0.0002 | 0.0002 |
Leishmania major | lanosterol synthase, putative | 0.0123 | 0.324 | 0.5 |
Trypanosoma brucei | lanosterol synthase | 0.0142 | 0.4075 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0002 | 0.0002 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0153 | 0.4541 | 0.4541 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0047 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0002 | 0.0002 |
Brugia malayi | Carboxylesterase family protein | 0.028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0002 | 0.0002 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0153 | 0.4541 | 0.4541 |
Onchocerca volvulus | 0.0153 | 0.4541 | 1 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0047 | 0.0002 | 0.0002 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0047 | 0.0002 | 0.0002 |
Echinococcus granulosus | acetylcholinesterase | 0.028 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0047 | 0.0002 | 0.0002 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0002 | 0.0002 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0002 | 0.0002 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0272 | 0.9636 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.028 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0047 | 0.0002 | 0.0002 |
Schistosoma mansoni | alpha-glucosidase | 0.0153 | 0.4541 | 0.4541 |
Echinococcus multilocularis | carboxylesterase 5A | 0.028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0192 | 0.0192 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 1 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0142 | 0.4075 | 0.5 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0142 | 0.4075 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0047 | 0.0002 | 0.0002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 67.34 uM | Anticancer activity against human MCF7 cells assessed as cell viability after 48 hrs by MTT microcultured tetrazolium assay | ChEMBL. | 25096298 |
IZ (functional) | = 8 mm | Antifungal activity against Candida albicans MTCC 183 at 150 ug/ml after 48 hrs by agar well diffusion method | ChEMBL. | 25096298 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.