Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | SH2 domain containing protein | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0111 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0111 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Echinococcus granulosus | c src tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0111 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0111 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobilization assay | ChEMBL. | 25100502 | |
EC50 (binding) | Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay | ChEMBL. | 25100502 | |
EC50 (binding) | Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay | ChEMBL. | 25100502 | |
EC50 (binding) | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay | ChEMBL. | 25100502 | |
EC50 (binding) | Agonist activity at FLAG-tagged human LPA5 expressed in rat B103 cells by Fura-2AM dye based Ca2+ mobilization assay | ChEMBL. | 25100502 | |
Emax (binding) | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay relative to LPA 18:1 | ChEMBL. | 25100502 | |
Emax (binding) | Agonist activity at mouse LPA4 expressed in CHO cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay relative to LPA 18:1 | ChEMBL. | 25100502 | |
Emax (binding) | Agonist activity at FLAG-tagged human LPA5 expressed in rat B103 cells by Fura-2AM dye based Ca2+ mobilization assay relative to LPA 18:1 | ChEMBL. | 25100502 | |
Emax (binding) | Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay relative to LPA 18:1 | ChEMBL. | 25100502 | |
Emax (binding) | Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay relative to LPA 18:1 | ChEMBL. | 25100502 | |
Emax (binding) | Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay | ChEMBL. | 25100502 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.