TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 336.494 | Formula: C21H24N2S
H donors: 0 H acceptors: 0 LogP: 4.1 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN(Cc1ccc2c(c1)CN(CC2c1ccc2c(c1)ccs2)C)C
InChi: 1S/C21H24N2S/c1-22(2)12-15-4-6-19-18(10-15)13-23(3)14-20(19)16-5-7-21-17(11-16)8-9-24-21/h4-11,20H,12-14H2,1-3H3
InChiKey: BDLAKWIEWPJWSY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 2	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 3	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 2	617 aa	638 aa	32.5 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 3	620 aa	579 aa	33.2 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 4	630 aa	574 aa	31.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0131	0.0131
Mycobacterium ulcerans	lipase LipD	0.0072	0.0241	0.0896
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.004	0.0087	0.0275
Loa Loa (eye worm)	carboxylesterase	0.0113	0.044	0.1402
Trypanosoma brucei	DNA topoisomerase IA, putative	0.0023	0.0004	0.0014
Loa Loa (eye worm)	hypothetical protein	0.008	0.0278	0.0885
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0131	0.0131
Schistosoma mansoni	DNA topoisomerase II	0.0431	0.1976	0.1976
Trichomonas vaginalis	esterase, putative	0.0072	0.0241	0.0429
Plasmodium falciparum	SUMO-activating enzyme subunit 2	0.0031	0.0041	0.0152
Mycobacterium ulcerans	DNA topoisomerase I	0.0023	0.0004	0.0014
Trypanosoma brucei	DNA polymerase kappa, putative	0.0026	0.002	0.0073
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.0087	0.0275
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.004	0.0087	0.0275
Onchocerca volvulus		0.005	0.0131	0.0986
Onchocerca volvulus		0.0113	0.044	0.3359
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0241	0.0896
Loa Loa (eye worm)	hypothetical protein	0.004	0.0087	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0003	0.001
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0107	0.0107
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.005	0.0131	0.0131
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0292	0.1305	0.4155
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0251	0.1107	0.4132
Plasmodium falciparum	transporter, putative	0.005	0.0131	0.049
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0671	0.3141	0.3141
Plasmodium vivax	SET domain protein, putative	0.0029	0.0032	0.0119
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0285	0.0908
Entamoeba histolytica	DNA topoisomerase III, putative	0.0023	0.0004	0.0007
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0003	0.0005
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0087	0.0087
Echinococcus multilocularis	lysine specific demethylase 5A	0.006	0.0181	0.0181
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0131	0.0418
Giardia lamblia	Kinase, CMGC MAPK	0.0053	0.0148	0.0263
Schistosoma mansoni	sodium-dependent amino acid transporter	0.005	0.0131	0.0131
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0038	0.0077	0.0077
Echinococcus granulosus	histone lysine methyltransferase setb	0.0047	0.0117	0.0117
Echinococcus granulosus	carboxylesterase 5A	0.0671	0.3141	0.3141
Brugia malayi	hypothetical protein	0.0113	0.044	0.1402
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0038	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0052	0.0165
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0025	0.0014	0.0052
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0107	0.034
Loa Loa (eye worm)	DNA topoisomerase III beta-1	0.0023	0.0004	0.0012
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.004	0.0087	0.0087
Schistosoma mansoni	retinoic acid receptor RXR	0.004	0.0087	0.0087
Plasmodium vivax	DNA gyrase subunit B, putative	0.0251	0.1107	0.4132
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0023	0.0004	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0241	0.0768
Trypanosoma brucei	DNA topoisomerase III, putative	0.0023	0.0004	0.0014
Mycobacterium ulcerans	DNA gyrase subunit A	0.0093	0.034	0.1262
Leishmania major	DNA polymerase eta, putative	0.0038	0.0077	0.0289
Schistosoma mansoni	single-minded	0.005	0.0133	0.0133
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0131	0.0418
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0072	0.0241	0.0896
Onchocerca volvulus		0.0292	0.1305	1
Echinococcus granulosus	muscleblind protein	0.0297	0.1331	0.1331
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0241	0.0429
Schistosoma mansoni	prokaryotic DNA topoisomerase	0.0023	0.0004	0.0004
Schistosoma mansoni	prokaryotic DNA topoisomerase	0.0023	0.0004	0.0004
Echinococcus granulosus	inositol monophosphatase 1	0.0074	0.0247	0.0247
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0166	0.0694	0.0694
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0003	0.001
Loa Loa (eye worm)	carboxylesterase	0.0113	0.044	0.1402
Giardia lamblia	DINP protein human, muc B family	0.0038	0.0077	0.0138
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0038	0.0077	0.0138
Loa Loa (eye worm)	carboxylesterase	0.0671	0.3141	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0003	0.0011
Loa Loa (eye worm)	hypothetical protein	0.005	0.0131	0.0418
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0338	0.0602
Trichomonas vaginalis	flap endonuclease-1, putative	0.0025	0.0014	0.0025
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0053	0.0148	0.0553
Chlamydia trachomatis	DNA gyrase subunit B	0.0198	0.0852	0.7687
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.0338	0.1263
Loa Loa (eye worm)	hypothetical protein	0.0113	0.044	0.1402
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0003	0.0011
Mycobacterium ulcerans	DNA polymerase IV	0.0038	0.0077	0.0287
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0072	0.0241	0.0241
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0053	0.0148	0.0553
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0241	0.0429
Trichomonas vaginalis	spcc417.12 protein, putative	0.0113	0.044	0.0783
Schistosoma mansoni	acetylcholinesterase	0.0113	0.044	0.044
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0113	0.044	0.1636
Brugia malayi	jmjC domain containing protein	0.006	0.0181	0.0577
Onchocerca volvulus		0.0113	0.044	0.3359
Entamoeba histolytica	DNA topoisomerase II, putative	0.0431	0.1976	0.3513
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0011	0.004
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0251	0.1107	0.4112
Trypanosoma brucei	unspecified product	0.0026	0.002	0.0073
Onchocerca volvulus		0.005	0.0131	0.0986
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0131	0.0131
Leishmania major	C-8 sterol isomerase-like protein	0.0358	0.1625	0.6065
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0209	0.0209
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0065	0.0204	0.0363
Onchocerca volvulus		0.0072	0.0241	0.183
Schistosoma mansoni	glutaminase	0.0267	0.1185	0.1185
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0579	0.2692	1
Brugia malayi	DNA topoisomerase I	0.0576	0.268	0.8532
Echinococcus multilocularis	lamin	0.0081	0.0285	0.0285
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0292	0.1305	0.4155
Mycobacterium ulcerans	hypothetical protein	0.0072	0.0241	0.0896
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0003	0.0011
Loa Loa (eye worm)	acetylcholinesterase 1	0.0671	0.3141	1
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0065	0.0204	0.0204
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.004	0.0087	0.0275
Loa Loa (eye worm)	glutaminase	0.0267	0.1185	0.3774
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0061	0.0061
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0251	0.1107	0.1968
Echinococcus granulosus	beta LACTamase domain containing family member	0.0072	0.0241	0.0241
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0241	0.0896
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0025	0.0014	0.0052
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0483	0.2232	0.8328
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0131	0.0131
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0027	0.0027
Echinococcus multilocularis	carboxylesterase 5A	0.0671	0.3141	0.3141
Plasmodium falciparum	DNA topoisomerase 3, putative	0.0023	0.0004	0.0014
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0148	0.0148
Loa Loa (eye worm)	steroid hormone receptor	0.004	0.0087	0.0275
Trichomonas vaginalis	hypothetical protein	0.0033	0.0051	0.009
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.007	0.007
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.004	0.0087	0.0087
Trypanosoma brucei	DNA polymerase eta, putative	0.0038	0.0077	0.0289
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1184	0.5625	1
Loa Loa (eye worm)	CYP4Cod1	0.0057	0.0165	0.0527
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.0087	0.0275
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0011	0.004
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0077	0.0289
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0579	0.2692	1
Loa Loa (eye worm)	hypothetical protein	0.0183	0.0778	0.2476
Plasmodium vivax	topoisomerase I, putative	0.0576	0.268	1
Brugia malayi	intermediate filament protein	0.0081	0.0285	0.0908
Schistosoma mansoni	jumonji domain containing protein	0.006	0.0181	0.0181
Giardia lamblia	DNA topoisomerase III	0.0023	0.0004	0.0007
Brugia malayi	Intermediate filament tail domain containing protein	0.0081	0.0285	0.0908
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0131	0.049
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0107	0.0107
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.005	0.0131	0.1156
Treponema pallidum	sodium- and chloride- dependent transporter	0.0292	0.1305	0.232
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0061	0.0061
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.0087	0.0275
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.0209	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0702	0.2237
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.004	0.0087	0.0275
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.007	0.0124
Toxoplasma gondii	DNA topoisomerase family protein	0.0023	0.0004	0.0014
Onchocerca volvulus		0.0113	0.044	0.3359
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0113	0.044	0.044
Plasmodium vivax	ubiquitin activating enzyme, putative	0.0047	0.0118	0.0442
Onchocerca volvulus		0.005	0.0131	0.0986
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0025	0.0014	0.0052
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0113	0.044	0.0783
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0047	0.0117	0.0117
Trypanosoma cruzi	cytochrome P450, putative	0.0057	0.0165	0.0617
Schistosoma mansoni	hypothetical protein	0.0033	0.0052	0.0052
Entamoeba histolytica	hypothetical protein	0.0035	0.0061	0.0108
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0074	0.0247	0.0919
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0003	0.0005
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0113	0.044	0.1636
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Plasmodium vivax	SUMO-activating enzyme subunit 2, putative	0.0031	0.0041	0.0152
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.007	0.0124
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0166	0.0694	0.2211
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0178	0.0566
Echinococcus multilocularis	musashi	0.0081	0.0285	0.0285
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.004	0.0087	0.0275
Echinococcus multilocularis	FTZ F1 alpha	0.004	0.0087	0.0087
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.004	0.0087	0.0275
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0113	0.044	0.044
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0148	0.0263
Schistosoma mansoni	tsg101-related	0.0046	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0671	0.3141	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.004	0.0087	0.0087
Brugia malayi	MAP kinase sur-1	0.0053	0.0148	0.0472
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0047	0.0117	0.0117
Onchocerca volvulus	Bile acid receptor homolog	0.004	0.0087	0.0641
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0044	0.0102	0.0326
Schistosoma mansoni	steroid hormone receptor ad4bp	0.004	0.0087	0.0087
Echinococcus multilocularis	survival motor neuron protein 1	0.0471	0.217	0.217
Loa Loa (eye worm)	RNA binding protein	0.0066	0.0209	0.0665
Trypanosoma brucei	protein kinase, putative	0.0053	0.0148	0.0553
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0107	0.0107
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0011	0.004
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0081	0.0285	0.0908
Mycobacterium leprae	Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (	0.0023	0.0004	0.0014
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0027	0.002	0.0074
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1184	0.5625	1
Echinococcus multilocularis	neuropeptide s receptor	0.0465	0.2144	0.2144
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0131	0.0418
Schistosoma mansoni	bromodomain containing protein	0.0065	0.0209	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0246	0.0783
Leishmania major	ubiquitin-activating enzyme-like protein	0.0031	0.0041	0.0152
Echinococcus multilocularis	para nitrobenzyl esterase	0.0113	0.044	0.044
Onchocerca volvulus		0.004	0.0087	0.0641
Brugia malayi	nuclear receptor NHR-88	0.004	0.0087	0.0275
Trypanosoma cruzi	DNA polymerase eta, putative	0.0038	0.0077	0.0289
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0065	0.0204	0.0363
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0011	0.004
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0483	0.2232	0.8328
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0062	0.0191	0.0191
Schistosoma mansoni	flap endonuclease-1	0.0023	0.0002	0.0002
Mycobacterium ulcerans	DNA polymerase IV	0.0038	0.0077	0.0287
Echinococcus granulosus	single minded 2	0.0037	0.007	0.007
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.0241	0.0901
Trypanosoma cruzi	DNA topoisomerase IA, putative	0.0023	0.0004	0.0014
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0057	0.0165	0.0614
Giardia lamblia	Kinase, PLK	0.0092	0.0338	0.0602
Echinococcus granulosus	dnaJ subfamily C 6	0.0062	0.0193	0.0193
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0251	0.1107	0.8405
Plasmodium falciparum	amino acid transporter, putative	0.005	0.0131	0.049
Trichomonas vaginalis	set domain proteins, putative	0.023	0.1007	0.179
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0092	0.0338	0.1263
Mycobacterium leprae	cell division protein FtsZ	0.0294	0.1317	0.4892
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.007	0.0221
Leishmania major	hypothetical protein, conserved	0.0025	0.0011	0.004
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0072	0.0241	0.0896
Mycobacterium tuberculosis	Probable lipase LipD	0.0072	0.0241	0.0896
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.0209	0.0665
Brugia malayi	hypothetical protein	0.005	0.0131	0.0418
Loa Loa (eye worm)	norepinephrine transporter	0.0292	0.1305	0.4155
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0092	0.0338	0.0338
Trypanosoma brucei	DNA topoisomerase IB, large subunit	0.0576	0.268	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0338	0.0602
Leishmania major	DNA topoisomerase 1A	0.0023	0.0004	0.0014
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0003	0.001
Mycobacterium ulcerans	glutaminase	0.0267	0.1185	0.4402
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0077	0.0246
Schistosoma mansoni	DNA polymerase eta	0.0038	0.0077	0.0077
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0003	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0241	0.0768
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0011	0.004
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0011	0.0034
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Onchocerca volvulus	Huntingtin homolog	0.0119	0.0468	0.3573
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.004	0.0087	0.0641
Loa Loa (eye worm)	inositol-1	0.0074	0.0247	0.0787
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0126	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0113	0.044	0.1402
Trichomonas vaginalis	inositol monophosphatase, putative	0.0074	0.0247	0.044
Echinococcus multilocularis	sentrin specific protease 8	0.0065	0.0204	0.0204
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0077	0.0289
Echinococcus granulosus	acetylcholinesterase	0.0671	0.3141	0.3141
Brugia malayi	Carboxylesterase family protein	0.0113	0.044	0.1402
Onchocerca volvulus		0.0037	0.007	0.0517
Onchocerca volvulus		0.0113	0.044	0.3359
Plasmodium vivax	DNA topoisomerase 3, putative	0.0023	0.0004	0.0014
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0292	0.1305	0.1305
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.004	0.0087	0.0087
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.0191	0.0191
Toxoplasma gondii	hypothetical protein	0.005	0.0131	0.049
Loa Loa (eye worm)	hypothetical protein	0.0671	0.3141	1
Brugia malayi	Carboxylesterase family protein	0.0113	0.044	0.1402
Brugia malayi	DnaJ domain containing protein	0.0062	0.0193	0.0615
Echinococcus granulosus	survival motor neuron protein 1	0.0471	0.217	0.217
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0031	0.0041	0.0152
Onchocerca volvulus	Protein ultraspiracle homolog	0.004	0.0087	0.0641
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.004	0.0087	0.0087
Chlamydia trachomatis	DNA gyrase subunit A	0.0093	0.034	0.3045
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0166	0.0694	0.0694
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.007	0.0124
Brugia malayi	steroid hormone receptor	0.004	0.0087	0.0275
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0072	0.0241	0.0896
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0038	0.0077	0.0138
Brugia malayi	beta-lactamase	0.0072	0.0241	0.0768
Leishmania major	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Schistosoma mansoni	thyroid hormone receptor	0.004	0.0087	0.0087
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.004	0.0087	0.0275
Brugia malayi	Pre-SET motif family protein	0.0029	0.0032	0.0102
Mycobacterium leprae	conserved hypothetical protein	0.0072	0.0241	0.0896
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0003	0.0011
Schistosoma mansoni	alpha glucosidase	0.0037	0.007	0.007
Loa Loa (eye worm)	flap endonuclease-1	0.0025	0.0014	0.0045
Echinococcus multilocularis	flap endonuclease 1	0.0025	0.0014	0.0014
Brugia malayi	hypothetical protein	0.0471	0.217	0.691
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.0191	0.0191
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.004	0.0087	0.0087
Mycobacterium ulcerans	beta-lactamase	0.0072	0.0241	0.0896
Plasmodium falciparum	DNA gyrase subunit A	0.0093	0.034	0.1268
Schistosoma mansoni	tsg101-related	0.0056	0.0164	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0113	0.044	0.1402
Schistosoma mansoni	DNA topoisomerase type I	0.0576	0.268	0.268
Brugia malayi	hypothetical protein	0.0119	0.0468	0.1491
Brugia malayi	ImpB/MucB/SamB family protein	0.0038	0.0077	0.0246
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.1184	0.5625	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0084	0.0266
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0107	0.034
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Mycobacterium ulcerans	DNA gyrase subunit B	0.0251	0.1107	0.4112
Echinococcus multilocularis	neuropeptide receptor A26	0.0465	0.2144	0.2144
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0247	0.0923
Plasmodium vivax	flap endonuclease 1, putative	0.0025	0.0014	0.0052
Loa Loa (eye worm)	hypothetical protein	0.004	0.0087	0.0275
Plasmodium falciparum	SUMO-activating enzyme subunit 1	0.0047	0.0118	0.0442
Onchocerca volvulus		0.0072	0.0241	0.183
Echinococcus multilocularis	rho GTPase activating protein 20	0.0023	0.0004	0.0004
Trichomonas vaginalis	Sentrin-specific protease, putative	0.0065	0.0204	0.0363
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1184	0.5625	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.004	0.0087	0.0087
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.007	0.026
Echinococcus multilocularis	muscleblind protein 1	0.0297	0.1331	0.1331
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.0209	0.0665
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0155	0.064	0.2037
Schistosoma mansoni	alpha-glucosidase	0.0143	0.0582	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0739	0.2354
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0131	0.0131
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0113	0.044	0.1636
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0241	0.0429
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0003	0.0005
Schistosoma mansoni	lamin	0.0081	0.0285	0.0285
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0092	0.0338	0.2576
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0407	0.1864	0.6955
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0294	0.1317	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0062	0.0191	0.0191
Schistosoma mansoni	DNA topoisomerase type I	0.0576	0.268	0.268
Brugia malayi	serine/threonine-protein kinase plk-2	0.0092	0.0338	0.1078
Schistosoma mansoni	DNA topoisomerase type I	0.0576	0.268	0.268
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0061	0.0061
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0247	0.0923
Brugia malayi	beta-lactamase family protein	0.0072	0.0241	0.0768
Loa Loa (eye worm)	ThiF family protein	0.0031	0.0041	0.013
Loa Loa (eye worm)	hypothetical protein	0.005	0.0131	0.0418
Plasmodium vivax	hypothetical protein, conserved	0.005	0.0131	0.049
Echinococcus granulosus	neuropeptide receptor A26	0.0465	0.2144	0.2144
Brugia malayi	nuclear hormone receptor	0.004	0.0087	0.0275
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0047	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.004	0.0087	0.0275
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.0871	0.2775
Trypanosoma brucei	glucosidase, putative	0.0037	0.007	0.026
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0294	0.1317	0.4892
Echinococcus multilocularis	tumor susceptibility gene 101 protein	0.0068	0.0219	0.0219
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0004	0.0004
Brugia malayi	Cytochrome P450 family protein	0.0057	0.0165	0.0527
Schistosoma mansoni	coup transcription factor	0.004	0.0087	0.0087
Echinococcus multilocularis	dnaJ subfamily C 6	0.0062	0.0193	0.0193
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0131	0.0131
Echinococcus granulosus	lamin	0.0081	0.0285	0.0285
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0053	0.0148	0.0553
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0096	0.0356	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0739	0.2354
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0107	0.0107
Schistosoma mansoni	gliotactin	0.0113	0.044	0.044
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0032	0.0119
Schistosoma mansoni	RAR-like nuclear receptor	0.004	0.0087	0.0087
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0241	0.0901
Onchocerca volvulus		0.0081	0.0285	0.2168
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0003	0.001
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0023	0.0004	0.0014
Echinococcus multilocularis	SUMO activating enzyme subunit 1	0.0047	0.0118	0.0118
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.006	0.0181	0.0181
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0039	0.0081	0.0081
Echinococcus granulosus	neuropeptide s receptor	0.0465	0.2144	0.2144
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0338	0.0602
Loa Loa (eye worm)	hypothetical protein	0.005	0.0131	0.0418
Brugia malayi	follicle stimulating hormone receptor	0.0241	0.106	0.3376
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1184	0.5625	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0061	0.0108
Mycobacterium tuberculosis	Probable esterase LipL	0.0072	0.0241	0.0896
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.004	0.0087	0.0087
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0135	0.0135
Brugia malayi	ThiF family protein	0.0047	0.0118	0.0377
Echinococcus multilocularis	serotonin transporter	0.0292	0.1305	0.1305
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0072	0.0241	0.0768
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0023	0.0004	0.0014
Echinococcus multilocularis	dna polymerase eta	0.0038	0.0077	0.0077
Echinococcus multilocularis	DNA topoisomerase 1	0.0576	0.268	0.268
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0126	0.0402
Echinococcus multilocularis	SUMO activating enzyme subunit 2	0.0031	0.0041	0.0041
Brugia malayi	hypothetical protein	0.0068	0.0219	0.0697
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0035	0.0063	0.0534
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0338	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0096	0.0304
Brugia malayi	Carboxylesterase family protein	0.0671	0.3141	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0057	0.0165	0.0527
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0209	0.0209
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0093	0.034	0.1262
Echinococcus granulosus	tar DNA binding protein	0.0066	0.0209	0.0209
Brugia malayi	Cell division protein ftsZ	0.0145	0.0595	0.1895
Echinococcus multilocularis	inositol monophosphatase 1	0.0074	0.0247	0.0247
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0074	0.0247	0.0923
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0131	0.0131
Echinococcus granulosus	serotonin transporter	0.0292	0.1305	0.1305
Echinococcus multilocularis	dna polymerase kappa	0.0038	0.0077	0.0077
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.006	0.0181	0.0181
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0431	0.1976	0.7375
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0148	0.0553
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.007	0.0124
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0241	0.106	0.3376
Schistosoma mansoni	BC026374 protein (S09 family)	0.0113	0.044	0.044
Echinococcus multilocularis	acetylcholinesterase	0.0671	0.3141	0.3141
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0247	0.0923
Schistosoma mansoni	tsg101-related	0.0056	0.0164	0.0164
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0114	0.0202
Schistosoma mansoni	kinase	0.0047	0.012	0.012
Brugia malayi	Inositol-1	0.0074	0.0247	0.0787
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0338	0.0602
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0113	0.044	0.044
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0579	0.2692	1
Echinococcus granulosus	SUMO activating enzyme subunit 1	0.0047	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.004	0.0087	0.0275
Schistosoma mansoni	hypothetical protein	0.0035	0.0061	0.0061
Loa Loa (eye worm)	serotonin transporter b	0.0292	0.1305	0.4155
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0003	0.0011
Brugia malayi	Pre-SET motif family protein	0.0202	0.0871	0.2775
Plasmodium falciparum	flap endonuclease 1	0.0025	0.0014	0.0052
Echinococcus granulosus	lamin dm0	0.0081	0.0285	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0241	0.0768
Entamoeba histolytica	DNA topoisomerase III, putative	0.0023	0.0004	0.0007
Onchocerca volvulus		0.0113	0.044	0.3359
Brugia malayi	beta-lactamase family protein	0.0072	0.0241	0.0768
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0025	0.0014	0.0052
Onchocerca volvulus		0.0072	0.0241	0.183
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0081	0.0259
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0241	0.0241
Echinococcus granulosus	intermediate filament protein	0.0081	0.0285	0.0285
Brugia malayi	DNA topoisomerase III beta-1	0.0023	0.0004	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0113	0.044	0.1402
Schistosoma mansoni	microtubule-associated protein tau	0.2088	1	1
Loa Loa (eye worm)	hypothetical protein	0.0291	0.1302	0.4146
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0209	0.0209
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.004	0.0087	0.0087
Onchocerca volvulus		0.0081	0.0285	0.2168
Echinococcus granulosus	mitogen activated protein kinase 3	0.0053	0.0148	0.0148
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0241	0.0901
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.007	0.026
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1305	0.4155
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.007	0.026
Leishmania major	DNA topoisomerase III, putative	0.0023	0.0004	0.0014
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0291	0.13	0.9963
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.005	0.0131	0.0418
Toxoplasma gondii	hypothetical protein	0.0047	0.0118	0.0442
Echinococcus multilocularis	acetylcholinesterase	0.0671	0.3141	0.3141
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0209	0.0209
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.007	0.0124
Schistosoma mansoni	intermediate filament proteins	0.0081	0.0285	0.0285
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0131	0.049
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0011	0.004
Mycobacterium ulcerans	cell division protein FtsZ	0.0294	0.1317	0.4892
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0003	0.0011
Mycobacterium ulcerans	putative regulatory protein	0.0037	0.007	0.0261
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0003	0.0011
Onchocerca volvulus		0.0023	0.0004	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0468	0.1491
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0131	0.0131
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.007	0.0124
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0407	0.1864	0.6955
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0468	0.1491
Trichomonas vaginalis	prokaryotic DNA topoisomerase, putative	0.0023	0.0004	0.0007
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.005	0.0131	0.0131
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.1184	0.5625	1
Schistosoma mansoni	ubiquitin-activating enzyme E1b	0.0031	0.0041	0.0041
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0107	0.0107
Onchocerca volvulus	Huntingtin homolog	0.0119	0.0468	0.3573
Brugia malayi	Carboxylesterase family protein	0.0671	0.3141	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0118	0.0377
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0023	0.0004	0.0014
Mycobacterium ulcerans	carboxylesterase, LipT	0.0113	0.044	0.1636
Wolbachia endosymbiont of Brugia malayi	topoisomerase IA, TopA	0.0023	0.0004	0.0029
Plasmodium vivax	DNA topoisomerase II, putative	0.0431	0.1976	0.7375
Giardia lamblia	Fructose-bisphosphate aldolase	0.1184	0.5625	1
Trypanosoma brucei	DNA topoisomerase ii	0.0483	0.2232	0.8328
Loa Loa (eye worm)	DNA topoisomerase III	0.0023	0.0004	0.0012
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1184	0.5625	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0113	0.044	0.044
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0087	0.0087
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0241	0.0896
Echinococcus granulosus	neuroligin	0.0113	0.044	0.044
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0148	0.0553
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0113	0.044	0.1402
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0114	0.0202
Echinococcus granulosus	DNA topoisomerase 3 beta 1	0.0023	0.0004	0.0004
Echinococcus multilocularis	neuroligin	0.0113	0.044	0.044
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1184	0.5625	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0066	0.021	0.078
Brugia malayi	cytoplasmic intermediate filament protein	0.0044	0.0102	0.0326
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0053	0.0148	0.0553
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0038	0.0077	0.0287
Echinococcus multilocularis	muscleblind protein	0.0297	0.1331	0.1331
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0038	0.0077	0.0287
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.004	0.0087	0.0087
Loa Loa (eye worm)	hypothetical protein	0.005	0.0131	0.0418
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0092	0.0338	0.0338
Plasmodium falciparum	DNA gyrase subunit B	0.0251	0.1107	0.4132
Trypanosoma brucei	DNA polymerase kappa, putative	0.0026	0.002	0.0073
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0358	0.1625	0.6065
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0074	0.0247	0.044
Plasmodium falciparum	DNA topoisomerase 2	0.0431	0.1976	0.7375
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0358	0.1625	0.5175
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0053	0.0148	0.0472
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0241	0.0429
Brugia malayi	jmjC domain containing protein	0.0062	0.0191	0.0607
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0066	0.021	0.078
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0077	0.0289
Echinococcus granulosus	dna polymerase eta	0.0038	0.0077	0.0077
Trichomonas vaginalis	glutaminase, putative	0.0267	0.1185	0.2107
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.0087	0.0275
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0074	0.0247	0.0923
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0131	0.0131
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0074	0.0247	0.044
Loa Loa (eye worm)	hypothetical protein	0.0297	0.1331	0.4238
Loa Loa (eye worm)	TOPoisomerase family member	0.0431	0.1976	0.6292
Plasmodium falciparum	topoisomerase I	0.0576	0.268	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0178	0.0566
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0358	0.1625	0.6065
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0003	0.0011
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0074	0.0247	0.044
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0032	0.0032
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0003	0.0011
Chlamydia trachomatis	DNA gyrase subunit A	0.0093	0.034	0.3045
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0299	0.134	0.2383
Mycobacterium tuberculosis	Probable hydrolase	0.0072	0.0241	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0074	0.0237
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0338	0.0602
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0131	0.0418
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0131	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0297	0.1331	0.4238
Mycobacterium leprae	Probable lipase LipE	0.0072	0.0241	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0105	0.0335
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0003	0.0011
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.0338	0.1263
Loa Loa (eye worm)	hypothetical protein	0.005	0.0131	0.0418
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.0087	0.0275
Brugia malayi	ImpB/MucB/SamB family protein	0.0038	0.0077	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0113	0.044	0.1402
Brugia malayi	hypoxia-induced factor 1	0.0155	0.064	0.2037
Echinococcus multilocularis	geminin	0.034	0.1539	0.1539
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0052	0.0165
Trypanosoma cruzi	cytochrome P450, putative	0.0057	0.0165	0.0617
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0087	0.0087
Leishmania major	DNA topoisomerase ii	0.0407	0.1864	0.6955
Brugia malayi	Probable DNA topoisomerase II	0.0431	0.1976	0.6292
Echinococcus granulosus	tumor susceptibility gene 101 protein	0.0068	0.0219	0.0219
Loa Loa (eye worm)	hypothetical protein	0.004	0.0087	0.0275
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0072	0.0241	0.0768
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.1052	0.4984	0.886
Treponema pallidum	cell division protein FtsZ	0.0294	0.1317	0.2342
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0131	0.0131
Onchocerca volvulus		0.023	0.1007	0.7709
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.007	0.007
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.007	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0178	0.0566
Entamoeba histolytica	tumor susceptibility gene 101 protein, putative	0.0046	0.0114	0.0203
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0072	0.0241	0.0896
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0131	0.0131
Brugia malayi	Muscleblind-like protein	0.0297	0.1331	0.4238
Toxoplasma gondii	hypothetical protein	0.005	0.0131	0.049
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.0093	0.034	0.258
Brugia malayi	PAS domain containing protein	0.005	0.0133	0.0424
Treponema pallidum	fructose-bisphosphate aldolase	0.1184	0.5625	1
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0074	0.0247	0.1878
Trichomonas vaginalis	DNA polymerase eta, putative	0.0038	0.0077	0.0138
Echinococcus granulosus	DNA topoisomerase 3 alpha	0.0023	0.0004	0.0004
Trypanosoma brucei	unspecified product	0.0038	0.0077	0.0289
Echinococcus granulosus	lysosomal alpha glucosidase	0.0166	0.0694	0.0694
Leishmania major	mitochondrial DNA topoisomerase II	0.0483	0.2232	0.8328
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0241	0.0241
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0113	0.044	0.044
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.007	0.0124
Onchocerca volvulus		0.0096	0.0356	0.2709
Schistosoma mansoni	alpha-glucosidase	0.0143	0.0582	0.0582
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.004	0.0087	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0358	0.1625	0.5175
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0071	0.0071
Brugia malayi	TAR-binding protein	0.0066	0.0209	0.0665
Echinococcus granulosus	FTZ F1 alpha	0.004	0.0087	0.0087
Echinococcus granulosus	para nitrobenzyl esterase	0.0113	0.044	0.044
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.004	0.0087	0.0275
Giardia lamblia	DNA topoisomerase II	0.0408	0.1868	0.332
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0053	0.0148	0.0553
Plasmodium vivax	DNA gyrase subunit A, putative	0.0093	0.034	0.1268
Echinococcus multilocularis	conserved hypothetical protein	0.0671	0.3141	0.3141
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0062	0.0198
Onchocerca volvulus		0.0029	0.0032	0.0222
Brugia malayi	RNA binding protein	0.0066	0.0209	0.0665
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0032	0.0032
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0291	0.13	0.9963
Trypanosoma cruzi	DNA topoisomerase IB, large subunit, putative	0.0576	0.268	1
Schistosoma mansoni	inositol monophosphatase	0.0074	0.0247	0.0247
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0126	0.0402
Schistosoma mansoni	survival motor neuron protein	0.0096	0.0356	0.0356
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0039	0.0081	0.0081
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0092	0.0338	0.0602
Brugia malayi	Carboxylesterase family protein	0.0113	0.044	0.1402
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0166	0.0694	0.2211
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0003	0.001
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0291	0.13	0.9963
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0087	0.0087
Entamoeba histolytica	hypothetical protein	0.0035	0.0061	0.0108
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.0093	0.034	0.1268
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.004	0.0087	0.0087
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.004	0.0087	0.0087
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0462	0.2127	0.7901
Loa Loa (eye worm)	intermediate filament protein	0.0081	0.0285	0.0908
Brugia malayi	Cytochrome P450 family protein	0.0057	0.0165	0.0527
Schistosoma mansoni	aryl hydrocarbon receptor	0.005	0.0133	0.0133
Echinococcus multilocularis	DNA topoisomerase 3 beta 1	0.0023	0.0004	0.0004
Brugia malayi	Bromodomain containing protein	0.004	0.0083	0.0265
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0209	0.0209
Schistosoma mansoni	hypothetical protein	0.034	0.1539	0.1539
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0431	0.1976	0.6292
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.004	0.0087	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0241	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0126	0.0402
Trypanosoma brucei	unspecified product	0.0026	0.002	0.0073
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0065	0.0204	0.0363
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.0209	0.0209
Leishmania major	cytochrome p450-like protein	0.0057	0.0165	0.0617
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0003	0.0011
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.004	0.0087	0.0087
Echinococcus granulosus	flap endonuclease 1	0.0025	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0291	0.1302	0.4146
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0062	0.0193	0.0344
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0043	0.0098	0.0098
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0065	0.0204	0.0363
Loa Loa (eye worm)	DNA topoisomerase I	0.0576	0.268	0.8532
Toxoplasma gondii	ABC1 family protein	0.0072	0.0241	0.0901
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.0338	0.0338
Leishmania major	DNA topoisomerase IB, large subunit	0.0576	0.268	1
Echinococcus granulosus	BC026374 protein S09 family	0.0113	0.044	0.044
Trichomonas vaginalis	prokaryotic DNA topoisomerase, putative	0.0023	0.0004	0.0007
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0117	0.0374
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0038	0.0077	0.0289
Treponema pallidum	DNA topoisomerase I (topA)	0.0023	0.0004	0.0007
Leishmania major	hypothetical protein, conserved	0.0072	0.0241	0.0901
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0087	0.0087
Schistosoma mansoni	inositol monophosphatase	0.0074	0.0247	0.0247
Brugia malayi	Bromodomain containing protein	0.0078	0.0267	0.0851
Brugia malayi	Flap endonuclease-1	0.0025	0.0014	0.0045
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0062	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.004	0.0087	0.0275
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.004	0.0087	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0219	0.0697
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0338	0.0602
Toxoplasma gondii	ThiF family protein	0.0031	0.0041	0.0152
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.007	0.0221
Echinococcus multilocularis	transfer RNA-Lys	0.0037	0.007	0.007
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0148	0.0263
Echinococcus multilocularis	lamin dm0	0.0081	0.0285	0.0285
Echinococcus granulosus	geminin	0.034	0.1539	0.1539
Brugia malayi	DNA topoisomerase III	0.0023	0.0004	0.0012
Brugia malayi	PHD-finger family protein	0.0026	0.0016	0.0052
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0065	0.0204	0.065
Trypanosoma brucei	DNA topoisomerase III, putative	0.0023	0.0004	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0241	0.0768
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.007	0.026
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0003	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0113	0.044	0.1402
Giardia lamblia	DNA repair protein RAD52	0.1052	0.4984	0.886
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0053	0.0148	0.0553
Schistosoma mansoni	thyroid hormone receptor	0.004	0.0087	0.0087
Toxoplasma gondii	DNA topoisomerase I, putative	0.0576	0.268	1
Schistosoma mansoni	lamin	0.0081	0.0285	0.0285
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0038	0.0077	0.0246
Brugia malayi	Cell division protein ftsZ	0.0141	0.0575	0.1832
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0431	0.1976	0.1976
Entamoeba histolytica	hypothetical protein	0.0035	0.0061	0.0108
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.004	0.0087	0.0275
Plasmodium vivax	amine transporter, putative	0.005	0.0131	0.049
Echinococcus granulosus	dna polymerase kappa	0.0038	0.0077	0.0077
Schistosoma mansoni	sodium/chloride dependent transporter	0.0292	0.1305	0.1305
Echinococcus granulosus	sentrin specific protease 8	0.0065	0.0204	0.0204
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.005	0.0131	0.0131
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1184	0.5625	1
Echinococcus granulosus	hypothetical protein	0.0689	0.3227	0.3227
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.004	0.0087	0.0275
Schistosoma mansoni	hypothetical protein	0.0096	0.0356	0.0356
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0131	0.0131
Brugia malayi	hypothetical protein	0.0168	0.0702	0.2237
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.007	0.0124
Brugia malayi	GRF zinc finger family protein	0.0023	0.0004	0.0012
Mycobacterium leprae	Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0112	0.0433	0.1609
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.005	0.0131	0.0131
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.007	0.0124
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0113	0.044	0.044
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.0241	0.0901
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0003	0.0011
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0131	0.0131
Brugia malayi	hypothetical protein	0.0035	0.0061	0.0194
Brugia malayi	hypothetical protein	0.0025	0.0011	0.0034
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0241	0.0429
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0004	0.0004
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0004	0.0004
Loa Loa (eye worm)	cytochrome P450 family protein	0.0057	0.0165	0.0527
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.004	0.0087	0.0275
Schistosoma mansoni	hypothetical protein	0.0062	0.0193	0.0193
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0431	0.1976	0.1976
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.004	0.0087	0.0275
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1184	0.5625	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0053	0.0148	0.0148
Leishmania major	DNA topoisomerase III, putative	0.0023	0.0004	0.0014
Trypanosoma cruzi	DNA topoisomerase IA, putative	0.0023	0.0004	0.0014
Brugia malayi	ecdysteroid receptor	0.004	0.0087	0.0275
Chlamydia trachomatis	DNA gyrase subunit B	0.0251	0.1107	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0241	0.0768
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0407	0.1864	0.6955
Brugia malayi	Nuclear hormone receptor-like 1	0.004	0.0087	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0471	0.217	0.691
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0071	0.0071
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0113	0.044	0.044
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0074	0.0237
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0092	0.0338	0.1078
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0038	0.0077	0.0077
Loa Loa (eye worm)	glutaminase 2	0.0267	0.1185	0.3774
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1305	0.4155
Brugia malayi	Steroid receptor seven-up type 2	0.004	0.0087	0.0275
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.0093	0.034	0.0604
Loa Loa (eye worm)	hypothetical protein	0.005	0.0131	0.0418
Trypanosoma brucei	ubiquitin-activating enzyme E1, putative	0.0031	0.0041	0.0152
Mycobacterium tuberculosis	Probable lipase LipE	0.0072	0.0241	0.0896
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0003	0.001
Schistosoma mansoni	hypothetical protein	0.034	0.1539	0.1539
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1305	0.4155
Trypanosoma brucei	DNA polymerase kappa, putative	0.0026	0.002	0.0073
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.007	0.0124
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.004	0.0087	0.0087
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0431	0.1976	0.3513
Trypanosoma brucei	cytochrome P450, putative	0.0057	0.0165	0.0617
Echinococcus granulosus	DNA topoisomerase 1	0.0576	0.268	0.268
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0407	0.1864	0.6955
Loa Loa (eye worm)	Ulp1 protease	0.0065	0.0204	0.065
Brugia malayi	bHLH-PAS transcription factor	0.0037	0.007	0.0224
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0062	0.0193	0.0615
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0789	0.371	0.371
Giardia lamblia	Flap structure-specific endonuclease	0.0025	0.0014	0.0025
Loa Loa (eye worm)	hypothetical protein	0.005	0.0131	0.0418
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.005	0.0131	0.0131
Brugia malayi	photoreceptor-specific nuclear receptor	0.004	0.0087	0.0275
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.0191	0.0607
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0131	0.0131
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0148	0.0263
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0077	0.0289
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.0087	0.0275
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0047	0.0117	0.0117
Entamoeba histolytica	hypothetical protein	0.0299	0.134	0.2383
Onchocerca volvulus		0.0096	0.0356	0.2712
Echinococcus multilocularis	microtubule associated protein 2	0.2088	1	1
Brugia malayi	Carboxylesterase family protein	0.0113	0.044	0.1402
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0032	0.0032
Brugia malayi	glutaminase DH11.1	0.0267	0.1185	0.3774
Echinococcus granulosus	acetylcholinesterase	0.0671	0.3141	0.3141
Brugia malayi	ThiF family protein	0.0031	0.0041	0.013
Loa Loa (eye worm)	hypothetical protein	0.004	0.0087	0.0275
Mycobacterium ulcerans	esterase/lipase LipP	0.0072	0.0241	0.0896
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0131	0.049
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0431	0.1976	0.6292
Entamoeba histolytica	Flap nuclease, putative	0.0025	0.0014	0.0025
Trypanosoma cruzi	hypothetical protein	0.0065	0.0204	0.0762
Loa Loa (eye worm)	hypothetical protein	0.004	0.0087	0.0275
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0003	0.0011
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.004	0.0087	0.0087
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0148	0.0263
Giardia lamblia	DNA topoisomerase III	0.0023	0.0004	0.0007
Echinococcus granulosus	ecdysone induced protein 78C	0.004	0.0087	0.0087
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0038	0.0077	0.0077
Loa Loa (eye worm)	beta-lactamase	0.0072	0.0241	0.0768
Trypanosoma brucei	polo-like protein kinase	0.0092	0.0338	0.1263
Echinococcus multilocularis	mitogen activated protein kinase	0.0053	0.0148	0.0148
Echinococcus granulosus	mitogen activated protein kinase	0.0053	0.0148	0.0148
Echinococcus granulosus	sumo-activating enzyme subunit 2	0.0031	0.0041	0.0041
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0011	0.004
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.004	0.0087	0.0087

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	< 3 nM	Displacement of [3H]Nisoxetine from human NET expressed in HEK293E cells after 1 hr by liquid scintillation counting	ChEMBL.	25050161
IC50 (binding)	= 4.4 nM	Displacement of [3H]Citolapram from human SERT expressed in HEK293E cells after 1 hr by liquid scintillation counting	ChEMBL.	25050161
IC50 (binding)	= 5.3 nM	Displacement of [3H]WIN 35,428 from human DAT expressed in HEK293E cells after 1 hr by liquid scintillation counting	ChEMBL.	25050161
Ki (binding)	< 3 nM	Binding Assay	BINDINGDB.	No reference
Ki (binding)	= 3.4 nM	BindingDB_Patents: Binding Assay. In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express each of the three human transporters. cDNAs containing the complete coding regions of each transporter were amplified by PCR from human brain libraries. The cDNAs contained in pCRII vectors were sequenced to verify their identity and then subcloned into an Epstein-Barr virus based expression plasmid (Shen et al., Gene 156:235-239 (1995), which is hereby incorporated by reference in its entirety). This plasmid containing the coding sequence for one of the human transporters was transfected into HEK93E cells. Successful transfection was verified by the ability of known reuptake blockers to inhibit the uptake of tritiated NE, DA or 5HT.For binding, cells were homogenized, centrifuged, and then resuspended in incubation buffer (5 mM Tris, 120 mM NaCl, 5 mM KCl, pH 7.4). Then, the appropriate radioligand was added.	ChEMBL.	No reference
Ki (binding)	= 4.4 nM	Binding Assay	BINDINGDB.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3323179

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 923730