Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aurora kinase A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aurora kinase | 0.0068 | 0.4671 | 1 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0068 | 0.4671 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0056 | 0.3585 | 0.7674 |
Entamoeba histolytica | protein kinase, putative | 0.0068 | 0.4671 | 0.5 |
Brugia malayi | serine/threonine kinase 12 | 0.0068 | 0.4671 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0056 | 0.3585 | 0.3585 |
Echinococcus granulosus | aurora kinase A | 0.0068 | 0.4671 | 0.5099 |
Schistosoma mansoni | jumonji domain containing protein | 0.0056 | 0.3585 | 0.3585 |
Schistosoma mansoni | thyroid hormone receptor | 0.0129 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0068 | 0.4671 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0068 | 0.4671 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0056 | 0.3585 | 0.3585 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.4671 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0068 | 0.4671 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0068 | 0.4671 | 0.4671 |
Trypanosoma brucei | aurora B kinase | 0.0068 | 0.4671 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0068 | 0.4671 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0068 | 0.4671 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0068 | 0.4671 | 0.5099 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0056 | 0.3585 | 0.7674 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.4671 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.4671 | 0.5 |
Leishmania major | protein kinase, putative | 0.0068 | 0.4671 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0068 | 0.4671 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0056 | 0.3585 | 0.3585 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0068 | 0.4671 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0068 | 0.4671 | 0.4671 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0119 | 0.916 | 0.916 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0056 | 0.3585 | 0.3913 |
Schistosoma mansoni | hypothetical protein | 0.0119 | 0.916 | 0.916 |
Entamoeba histolytica | protein kinase , putative | 0.0068 | 0.4671 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0068 | 0.4671 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0068 | 0.4671 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0068 | 0.4671 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0068 | 0.4671 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0129 | 1 | 1 |
Giardia lamblia | Aurora kinase | 0.0068 | 0.4671 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0119 | 0.916 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0056 | 0.3585 | 0.3913 |
Schistosoma mansoni | protein kinase | 0.0068 | 0.4671 | 0.4671 |
Loa Loa (eye worm) | AUR protein kinase | 0.0068 | 0.4671 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0068 | 0.4671 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0056 | 0.3585 | 0.7674 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0056 | 0.3585 | 0.3585 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0068 | 0.4671 | 0.4671 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.89 uM | Inhibition of Aurora A (unknown origin) using [33P]-ATP and 10 uM ATP after 2 hrs | ChEMBL. | 25042560 |
IC50 (binding) | = 47.5 uM | Inhibition of Aurora B (unknown origin) using [33P]-ATP and 10 uM ATP after 2 hrs | ChEMBL. | 25042560 |
Inhibition (binding) | = 56.3 % | Inhibition of Aurora B (unknown origin) at 10 uM using [33P]-ATP and 10 uM ATP after 2 hrs | ChEMBL. | 25042560 |
Inhibition (binding) | = 91.8 % | Inhibition of Aurora A (unknown origin) at 10 uM using [33P]-ATP and 10 uM ATP after 2 hrs | ChEMBL. | 25042560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.