Detailed information for compound 923848

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 217.224 | Formula: C11H11N3O2
  • H donors: 2 H acceptors: 2 LogP: 0.48 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)c(=O)n1c(n2)NCCC1
  • InChi: 1S/C11H11N3O2/c15-7-2-3-9-8(6-7)10(16)14-5-1-4-12-11(14)13-9/h2-3,6,15H,1,4-5H2,(H,12,13)
  • InChiKey: SQPUWEQANTVMHG-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0012 0.0055 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.3928 0.484
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0192 0.0138
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0354 0.1692
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0055 0.0261
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0471 0.0581
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0022
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0012 0.0055 0.052
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0055 0.052
Onchocerca volvulus 0.0034 0.051 0.0915
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0055 0.0063
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0186 0.0229
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0186 0.0244
Schistosoma mansoni hypothetical protein 0.0098 0.1828 0.2253
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0186 0.0229
Loa Loa (eye worm) hypothetical protein 0.0077 0.1399 0.1916
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0311 0.6204 0.8539
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0055 0.0103
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0354 0.0301
Entamoeba histolytica hypothetical protein 0.0036 0.0549 0.2623
Toxoplasma gondii ABC1 family protein 0.0077 0.1399 1
Brugia malayi glutathione reductase 0.0043 0.0682 0.0939
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0032 0.0044
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0061 0.1051 0.1002
Brugia malayi nuclear receptor NHR-88 0.0023 0.0273 0.0376
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0273 0.0336
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0785 0.0967
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0177 0.0218
Echinococcus granulosus survival motor neuron protein 1 0.0267 0.5301 0.6533
Brugia malayi CHE-14 protein 0.0048 0.0785 0.1081
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0032 0.0059
Loa Loa (eye worm) DR-78 0.0011 0.0024 0.0022
Schistosoma mansoni cpg binding protein 0.003 0.042 0.0517
Loa Loa (eye worm) hypothetical protein 0.002 0.0215 0.0284
Brugia malayi Cathepsin L-like precursor 0.0019 0.0186 0.0256
Schistosoma mansoni ap endonuclease 0.0061 0.1051 0.1295
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.1399 0.1352
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.1192 0.1469
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0107 0.0148
Schistosoma mansoni synaptojanin 0.0012 0.0055 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0136 0.2614 0.3221
Loa Loa (eye worm) hypothetical protein 0.0056 0.0953 0.1301
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0051 0.0063
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0186 0.0229
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0273 0.0336
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0107 0.0132
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0186 0.0229
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0177 0.0232
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0001
Brugia malayi Cathepsin L-like precursor 0.0019 0.0186 0.0256
Onchocerca volvulus Huntingtin homolog 0.0136 0.2605 0.4871
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0186 0.0888
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0055 0.0063
Brugia malayi Cathepsin L-like precursor 0.0019 0.0186 0.0256
Leishmania major trypanothione reductase 0.0043 0.0682 0.0871
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0012 0.0055 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0273 0.0336
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0273 0.0336
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0032 0.0059
Leishmania major pantothenate kinase subunit, putative 0.0013 0.0077 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0032 0.0059
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0055 0.0169
Mycobacterium tuberculosis Conserved protein 0.0077 0.1399 0.1352
Echinococcus granulosus GPCR family 2 0.0098 0.1828 0.2253
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0354 0.0552
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Brugia malayi CXXC zinc finger family protein 0.0028 0.0386 0.0532
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1262 0.1738
Brugia malayi nuclear receptor NHR-88 0.0011 0.0024 0.0034
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0024 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0077 0.1399 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0107 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0273 0.0364
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0362 0.7264 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.1964 0.2648
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0059 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0354 0.0301
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1399 0.1926
Mycobacterium ulcerans beta-lactamase 0.0077 0.1399 0.2202
Schistosoma mansoni smad1 5 8 and 0.0018 0.0177 0.0218
Leishmania major cathepsin L-like protease 0.0019 0.0186 0.0182
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0354 0.0552
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0032 0.0039
Schistosoma mansoni inositol monophosphatase 0.0036 0.0547 0.0675
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0547 0.5061
Echinococcus granulosus Niemann Pick C1 protein 0.0159 0.3074 0.3788
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0059 0.0282
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.1964 0.242
Loa Loa (eye worm) hypothetical protein 0.0098 0.1828 0.2508
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0273 0.0336
Echinococcus multilocularis protein dispatched 1 0.0054 0.0924 0.1139
Echinococcus granulosus geminin 0.0166 0.3219 0.3967
Plasmodium falciparum glutathione reductase 0.0043 0.0682 0.6493
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0872 0.1639
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0032 0.0039
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0055 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0273 0.0376
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.2614 0.359
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.051 0.3496
Brugia malayi nuclear receptor NHR-67 0.0011 0.0024 0.0034
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0055 0.0103
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0012 0.0055 0.052
Schistosoma mansoni synaptojanin 0.0012 0.0055 0.0067
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0107 0.0202
Entamoeba histolytica hypothetical protein 0.0036 0.0549 0.2623
Brugia malayi Cathepsin L-like precursor 0.0012 0.0059 0.0081
Onchocerca volvulus 0.0012 0.0055 0.0057
Loa Loa (eye worm) inositol-1 0.0036 0.0547 0.0742
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0107 0.0148
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0547 0.0675
Brugia malayi RNA binding protein 0.0136 0.2614 0.3598
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0024 0.0022
Trypanosoma brucei RNA editing exonuclease 2 0.0012 0.0055 0.0075
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0186 0.1767
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.1399 0.1926
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0024 0.0034
Schistosoma mansoni hypothetical protein 0.0166 0.3219 0.3967
Schistosoma mansoni ap endonuclease 0.0061 0.1051 0.1295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0059 0.0111
Mycobacterium leprae Probable lipase LipE 0.0077 0.1399 0.6832
Echinococcus multilocularis tumor protein p63 0.0381 0.7659 0.9439
Schistosoma mansoni Smad4 0.0018 0.0177 0.0218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0107 0.0148
Echinococcus granulosus cpg binding protein 0.003 0.042 0.0517
Loa Loa (eye worm) hypothetical protein 0.0058 0.1006 0.1375
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0273 0.0336
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0055 0.0075
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1192 0.1875
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1192 0.1875
Brugia malayi DKFZp564C0469 protein 0.0011 0.0032 0.0044
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0055 0.0063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.02 0.3928 0.484
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0273 0.0336
Leishmania major cathepsin L-like protease 0.0071 0.1262 0.1675
Leishmania major cathepsin L-like protease 0.0019 0.0186 0.0182
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0547 0.0857
Onchocerca volvulus 0.0077 0.1399 0.2594
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0012 0.0055 0.0261
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0273 0.0336
Loa Loa (eye worm) hypothetical protein 0.0136 0.2605 0.3579
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0058
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0107 0.0148
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.1051 0.7512
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0107 0.0132
Loa Loa (eye worm) cysteine protease 0.0019 0.0186 0.0244
Brugia malayi hypothetical protein 0.0267 0.5301 0.7298
Brugia malayi exodeoxyribonuclease III family protein 0.0061 0.1051 0.1447
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.1828 0.2253
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0107 0.0162
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0273 0.0336
Brugia malayi MH1 domain containing protein 0.001 0.001 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1399 0.2628
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0785 0.0967
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0032 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0872 0.1639
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.2614 0.3598
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0055 0.0075
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0215 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.1809 0.1764
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0107 0.0073
Schistosoma mansoni inositol monophosphatase 0.0036 0.0547 0.0675
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0354 0.0552
Schistosoma mansoni topbp1 0.0011 0.0032 0.0039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0069
Leishmania major hypothetical protein, conserved 0.0077 0.1399 0.1865
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0055 0.0075
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0055 0.0063
Schistosoma mansoni topbp1 0.0011 0.0032 0.0039
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0055 0.0063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0186 0.0349
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.1399 0.1352
Loa Loa (eye worm) hypothetical protein 0.0077 0.1399 0.1916
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0055 0.0075
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0055 0.0067
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0024 0.003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0354 0.1692
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0273 0.0469
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0785 0.0967
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0273 0.0376
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0055 0.0261
Loa Loa (eye worm) hypothetical protein 0.0023 0.0273 0.0364
Onchocerca volvulus 0.0027 0.0354 0.0622
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0785 0.107
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.1828 0.2253
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0055 0.0075
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0024 0.003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.051 0.0628
Loa Loa (eye worm) RNA binding protein 0.0136 0.2614 0.359
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0186 0.0229
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0059 0.0073
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0362 0.7264 1
Plasmodium vivax exodeoxyribonuclease III, putative 0.0012 0.0055 0.0391
Plasmodium vivax glutathione reductase, putative 0.0043 0.0682 0.4877
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0032 0.0301
Onchocerca volvulus 0.0023 0.0273 0.0469
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0186 0.0182
Echinococcus multilocularis tar DNA binding protein 0.0136 0.2614 0.3221
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0055 0.0075
Brugia malayi steroid hormone receptor 0.0023 0.0273 0.0376
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0273 0.0364
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0055 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0055 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1262 0.1738
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0107 0.0148
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0107 0.0148
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0273 0.0376
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0549 0.0676
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0055 0.0067
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0055 0.0075
Leishmania major cathepsin L-like protease 0.0071 0.1262 0.1675
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0273 0.0336
Schistosoma mansoni smad1 5 8 and 0.0018 0.0177 0.0218
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0107 0.0555
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1399 0.2628
Schistosoma mansoni hypothetical protein 0.0046 0.075 0.0924
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0273 0.0376
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0069
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.1262 0.1738
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0031
Echinococcus multilocularis synaptojanin 1 0.0012 0.0055 0.0067
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0032 0.0059
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0051 0.0058
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0055 0.0261
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0354 0.1611
Onchocerca volvulus 0.0019 0.0186 0.0304
Echinococcus multilocularis smad 0.0018 0.0177 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0136 0.2614 0.3221
Echinococcus multilocularis cysteine protease 0.0019 0.0186 0.0229
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0107 0.0053
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0186 0.0229
Brugia malayi MH2 domain containing protein 0.0267 0.5299 0.7296
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0107 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0273 0.0364
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0215 0.0161
Brugia malayi Latrophilin receptor protein 2 0.0098 0.1828 0.2517
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0051 0.007
Echinococcus granulosus Smad4 0.0018 0.0177 0.0218
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0354 0.0487
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0022
Trypanosoma brucei trypanothione reductase 0.0043 0.0682 0.0939
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Onchocerca volvulus 0.0019 0.0186 0.0304
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0682 0.4877
Mycobacterium leprae conserved hypothetical protein 0.0077 0.1399 0.6832
Loa Loa (eye worm) hypothetical protein 0.0185 0.3616 0.4972
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0273 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.3928 0.484
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0192 0.0138
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0055 0.0067
Brugia malayi CCR4 0.0012 0.0055 0.0075
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1399 0.1724
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0273 0.0336
Loa Loa (eye worm) glutathione reductase 0.0043 0.0682 0.0928
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1262 0.1738
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0186 0.0349
Plasmodium vivax vivapain-2 0.0019 0.0186 0.1328
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0024 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1262 0.1738
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.1399 0.1724
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0024 0.003
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0055 0.0075
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0177 0.0218
Giardia lamblia hypothetical protein 0.0012 0.0055 0.0119
Brugia malayi cathepsin L-like precursor 0.0012 0.0059 0.0081
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0107 0.0555
Brugia malayi latrophilin 2 splice variant baaae 0.0212 0.4178 0.5752
Loa Loa (eye worm) hypothetical protein 0.0023 0.0273 0.0364
Onchocerca volvulus 0.0011 0.0032 0.0014
Brugia malayi tailless protein 0.0011 0.0024 0.0034
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0547 0.3773
Onchocerca volvulus Huntingtin homolog 0.0136 0.2605 0.4871
Leishmania major cathepsin L-like protease 0.0019 0.0186 0.0182
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0069
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0024 0.003
Onchocerca volvulus 0.0012 0.0053 0.0054
Echinococcus granulosus tumor protein p63 0.0381 0.7659 0.9439
Brugia malayi nuclear hormone receptor 0.0023 0.0273 0.0376
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0107 0.0148
Brugia malayi MH1 domain containing protein 0.0018 0.0177 0.0244
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0012 0.0055 0.0075
Schistosoma mansoni hypothetical protein 0.0012 0.0055 0.0067
Brugia malayi Cathepsin L-like precursor 0.0019 0.0186 0.0256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0273 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1262 0.1738
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0024 0.003
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.2092 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1399 0.1916
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.1192 0.1143
Mycobacterium tuberculosis Conserved protein 0.0077 0.1399 0.1352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1262 0.1738
Brugia malayi Inositol-1 0.0036 0.0547 0.0754
Echinococcus multilocularis cpg binding protein 0.003 0.042 0.0517
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0032 0.0059
Schistosoma mansoni hypothetical protein 0.0212 0.4178 0.5149
Schistosoma mansoni coup transcription factor 0.0023 0.0273 0.0336
Onchocerca volvulus 0.0012 0.0059 0.0065
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.1399 0.1724
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0055 0.0261
Loa Loa (eye worm) hypothetical protein 0.0077 0.1399 0.1916
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.02 0.3928 0.484
Mycobacterium tuberculosis Conserved protein 0.0077 0.1399 0.1352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.3928 0.484
Echinococcus multilocularis protein patched 0.0048 0.0785 0.0967
Schistosoma mansoni hypothetical protein 0.0098 0.1828 0.2253
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.1964 0.2703
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0273 0.0336
Loa Loa (eye worm) hypothetical protein 0.0023 0.0273 0.0364
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0549 0.0676
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0547 0.1028
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.1399 0.2202
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0024 0.0022
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0024 0.0034
Mycobacterium tuberculosis Probable reductase 0.0097 0.1809 0.1764
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1964 0.3689
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0354 0.1692
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0186 0.0349
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0547 0.2617
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0055 0.0067
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0354 0.0487
Loa Loa (eye worm) hypothetical protein 0.0027 0.0354 0.0476
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0273 0.0364
Loa Loa (eye worm) hypothetical protein 0.0077 0.1399 0.1916
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0924 0.1272
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1066 0.1314
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0022
Brugia malayi topoisomerase 0.0011 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0186 0.0244
Onchocerca volvulus 0.0054 0.0924 0.1698
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0273 0.0376
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0024 0.003
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0061 0.1051 0.1295
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0012 0.0055 0.0075
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0055 0.0075
Loa Loa (eye worm) hypothetical protein 0.0212 0.4178 0.5747
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0107 0.0148
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0022
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0032 0.0044
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0682 0.0939
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0273 0.0376
Loa Loa (eye worm) transcription factor SMAD2 0.0267 0.5299 0.7293
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0051 0.007
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0055 0.0103
Echinococcus multilocularis GPCR, family 2 0.0098 0.1828 0.2253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0186 0.0349
Loa Loa (eye worm) beta-lactamase 0.0077 0.1399 0.1916
Onchocerca volvulus 0.0019 0.0186 0.0304
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0186 0.0349
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0061 0.1051 0.5023
Schistosoma mansoni zinc finger protein 0.0011 0.0024 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0024 0.003
Entamoeba histolytica hypothetical protein 0.0036 0.0549 0.2623
Onchocerca volvulus 0.0019 0.0186 0.0304
Brugia malayi nuclear receptor RXR 0.0012 0.0051 0.007
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0107 0.0744
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.0077 0.1399 0.1916
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0107 0.0148
Onchocerca volvulus 0.0019 0.0186 0.0304
Loa Loa (eye worm) hypothetical protein 0.002 0.0215 0.0284
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0055 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0273 0.0336
Echinococcus multilocularis survival motor neuron protein 1 0.0267 0.5301 0.6533
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.1135 0.1563
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0055 0.0075
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0055 0.0103
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0107 0.0768
Brugia malayi hypothetical protein 0.0012 0.0051 0.007
Schistosoma mansoni smad1 5 8 and 0.0018 0.0177 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0136 0.2614 0.3221
Loa Loa (eye worm) hypothetical protein 0.0034 0.051 0.069
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0051 0.0063
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0031
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0024 0.003
Loa Loa (eye worm) fibroinase 0.0019 0.0186 0.0244
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0682 0.0631
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0024 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Schistosoma mansoni cpg binding protein 0.003 0.042 0.0517
Echinococcus multilocularis Smad4 0.0018 0.0177 0.0218
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1262 0.1738
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0032 0.0059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0354 0.0476
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0177 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.1192 0.1469
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.2092 0.2578
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0215 0.0332
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0469 0.2188
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.1399 0.1352
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0055 0.0063
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0012 0.0055 0.0261
Loa Loa (eye worm) hypothetical protein 0.0267 0.5301 0.7295
Treponema pallidum NADH oxidase 0.0015 0.0107 0.0744
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0027 0.0037
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0032 0.0151
Toxoplasma gondii exonuclease III APE 0.0061 0.1051 0.7454
Schistosoma mansoni kinase 0.0053 0.0901 0.111
Loa Loa (eye worm) nuclear factor I 0.001 0.001 0.0001
Brugia malayi conserved hypotetical protein 0.0011 0.0024 0.0034
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0273 0.0336
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0273 0.0336
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0055 0.0261
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0012 0.0055 0.0075
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0107 0.0073
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0012 0.0055 0.0075
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0009 0.0011
Schistosoma mansoni cpg binding protein 0.0028 0.0386 0.0476
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0031
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0107 0.0768
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0024 0.003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0273 0.0376
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0177 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0273 0.0376
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0022
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0013 0.0077 0.0106
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0273 0.0336
Trichomonas vaginalis set domain proteins, putative 0.0268 0.5323 1
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1964 0.3689
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0273 0.0336
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0055 0.0261
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.2092 0.288
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0273 0.0336
Loa Loa (eye worm) hypothetical protein 0.0136 0.2605 0.3579
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0012 0.0055 0.0261
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0055 0.0075
Echinococcus granulosus dnaJ subfamily B 0.0403 0.8114 1
Toxoplasma gondii cathepsin CPL 0.0019 0.0186 0.1127
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0061 0.1051 1
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1964 0.3689
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0107 0.0393
Brugia malayi Cathepsin L-like precursor 0.0019 0.0186 0.0256
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0273 0.0336
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0273 0.0336
Plasmodium falciparum glutathione reductase 0.0015 0.0107 0.1023
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0055 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0024 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Brugia malayi hypothetical protein 0.0136 0.2605 0.3587
Schistosoma mansoni nocturnin 0.0012 0.0055 0.0067
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1262 0.1738
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1399 0.2628
Brugia malayi MH2 domain containing protein 0.0018 0.0177 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.051 0.0628
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.1964 0.2703
Schistosoma mansoni smad 0.0018 0.0177 0.0218
Brugia malayi hypothetical protein 0.0011 0.0032 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0055 0.0391
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.1809 0.1764
Schistosoma mansoni cript-related 0.0012 0.0055 0.0067
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0186 0.0244
Schistosoma mansoni hypothetical protein 0.0036 0.0549 0.0676
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0032 0.0226
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.1964 0.2694
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0055 0.0067
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1399 0.2628
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.007 0.0104
Schistosoma mansoni hypothetical protein 0.0098 0.1828 0.2253
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0061 0.1051 0.1295
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0058
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.095 0.1307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0055 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0032 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.051 0.0628
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.1192 0.1469
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0547 0.0684
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0024 0.003
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0051 0.0063
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.1051 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Loa Loa (eye worm) hypothetical protein 0.002 0.0215 0.0284
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0031
Trypanosoma brucei C-8 sterol isomerase, putative 0.0362 0.7264 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0107 0.0148
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0013 0.007 0.0194
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0273 0.0336
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.2092 0.2578
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0027 0.0037
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0273 0.0336
Brugia malayi hypothetical protein 0.0011 0.0024 0.0034
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0055 0.0067
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0177 0.0232
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0012 0.0055 0.0075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0186 0.0349
Schistosoma mansoni hypothetical protein 0.0098 0.1828 0.2253
Schistosoma mansoni hypothetical protein 0.0046 0.075 0.0924
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0055 0.0075
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.1399 0.2202
Loa Loa (eye worm) hypothetical protein 0.0111 0.2092 0.2871
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0273 0.0364
Onchocerca volvulus Putative neutral sphingomyelinase 0.0012 0.0055 0.0057
Echinococcus multilocularis geminin 0.0166 0.3219 0.3967
Echinococcus granulosus synaptojanin 1 0.0012 0.0055 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1262 0.1738
Schistosoma mansoni DNA ligase IV 0.0011 0.0032 0.0039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0311 0.6204 0.8541
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0024 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0186 0.0349
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.1399 0.1352
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0055 0.0169
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0317 0.6337 0.6317
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0107 0.0073
Onchocerca volvulus 0.0268 0.5323 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0061 0.1051 0.1447
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0273 0.0364
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0186 0.0349
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0273 0.0336
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0013 0.007 0.0016
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0107 0.4147
Brugia malayi Thioredoxin reductase 0.0043 0.0682 0.0939
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0055 0.0075
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0107 0.0148
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0547 0.0675
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0032 0.0044
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0055 0.0067
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0273 0.0364
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0024 0.003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0386 0.052
Brugia malayi Cathepsin L-like precursor 0.0012 0.0059 0.0081
Plasmodium falciparum thioredoxin reductase 0.0043 0.0682 0.6493
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.1964 0.242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0059 0.0111
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0273 0.0469
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0354 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0785 0.1475
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0058
Onchocerca volvulus 0.0028 0.0386 0.0683
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0273 0.0336
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0186 0.0888
Loa Loa (eye worm) hypothetical protein 0.0023 0.0273 0.0364
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.02 0.3928 0.484
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0107 0.0162
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0055 0.0391
Brugia malayi beta-lactamase family protein 0.0077 0.1399 0.1926
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0354 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0273 0.0376
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0024 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0032 0.0059
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0354 0.0552
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0032 0.0044
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0186 0.1767
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0192 0.0138
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0055 0.0067
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0055 0.0067
Schistosoma mansoni hypothetical protein 0.0054 0.0924 0.1139
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.02 0.3928 0.5407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1262 0.1738
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0273 0.0376
Schistosoma mansoni hypothetical protein 0.0046 0.075 0.0924
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0022
Leishmania major cathepsin L-like protease 0.0019 0.0186 0.0182
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0055 0.0067
Plasmodium falciparum DNase I-like protein, putative 0.0012 0.0055 0.052
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0061 0.1051 0.1436
Schistosoma mansoni tar DNA-binding protein 0.0136 0.2614 0.3221
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0107 0.0744
Brugia malayi MH2 domain containing protein 0.0018 0.0177 0.0244
Treponema pallidum exodeoxyribonuclease (exoA) 0.0061 0.1051 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0022
Mycobacterium ulcerans lipase LipD 0.0077 0.1399 0.2202
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.1809 0.8881
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0469 0.0417
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0273 0.0336
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0186 0.0229
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0055 0.052
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0273 0.0336
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.1964 0.2703
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.2033 1
Brugia malayi MH1 domain containing protein 0.0018 0.0177 0.0244
Brugia malayi Smad1 0.0018 0.0177 0.0244
Brugia malayi MH1 domain containing protein 0.001 0.001 0.0014
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0012 0.0055 0.0075
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0273 0.0376
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0061 0.1051 0.1382
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.1192 0.1469
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0107 0.0162
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0107 0.0073
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.2033 0.1989
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1964 0.3689
Echinococcus granulosus cathepsin l1 0.0012 0.0059 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0273 0.0376
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1399 0.1724
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0107 0.0202
Onchocerca volvulus 0.0056 0.0953 0.1752
Brugia malayi hypothetical protein 0.0012 0.0051 0.007
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0024 0.0034
Echinococcus multilocularis Niemann Pick C1 protein 0.0159 0.3074 0.3788
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1399 0.2628
Brugia malayi hypothetical protein 0.0036 0.0549 0.0755
Onchocerca volvulus 0.0019 0.0186 0.0304
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0061 0.1051 0.1447
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0273 0.0336
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0055 0.0075
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0235 0.4654 0.6404
Loa Loa (eye worm) hypothetical protein 0.0012 0.0055 0.0063
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0055 0.0261
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0009 0.0011
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0061 0.1051 0.1652
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0547 0.1028
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0186 0.0256
Giardia lamblia Kinase, PLK 0.0105 0.1964 1
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0215 0.1534
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0186 0.0304
Loa Loa (eye worm) hypothetical protein 0.0023 0.0273 0.0364
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0311 0.6204 0.8541
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.1828 0.2253
Onchocerca volvulus 0.0019 0.0186 0.0304
Brugia malayi beta-lactamase family protein 0.0077 0.1399 0.1926
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0055 0.0169
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0055 0.0103
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0055 0.0103
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0061 0.1051 0.1447
Mycobacterium ulcerans hypothetical protein 0.0077 0.1399 0.2202
Loa Loa (eye worm) TAR-binding protein 0.0136 0.2614 0.359
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.051 0.0628
Onchocerca volvulus 0.0077 0.1399 0.2594
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0547 0.0754
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0055 0.0103
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0055 0.0103
Entamoeba histolytica hypothetical protein 0.0011 0.0032 0.0151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0186 0.0349
Leishmania major C-8 sterol isomerase-like protein 0.0362 0.7264 1
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1399 0.1926
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1964 0.3689
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.1051 0.1974
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0012 0.0055 0.0075
Echinococcus multilocularis expressed conserved protein 0.0104 0.1953 0.2407
Plasmodium vivax SET domain protein, putative 0.0034 0.051 0.3643
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0186 0.0304
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0934 0.6599
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0022
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0215 0.2042
Loa Loa (eye worm) Smad1 0.0018 0.0177 0.0232
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0549 0.0676
Echinococcus granulosus tar DNA binding protein 0.0136 0.2614 0.3221
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0354 0.0552
Echinococcus granulosus smad 0.0018 0.0177 0.0218
Giardia lamblia Inositol 5-phosphatase 4 0.0012 0.0055 0.0119
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0107 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0273 0.0364
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.1964 0.242
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0177 0.0218
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0694 0.0855
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0055 0.0067
Brugia malayi Cathepsin L-like precursor 0.0019 0.0186 0.0256
Brugia malayi nuclear hormone receptor 0.0011 0.0024 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0273 0.0376
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0354 0.0415
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.1399 0.1926
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0055 0.0075
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0055 0.0067
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0273 0.0336
Loa Loa (eye worm) hypothetical protein 0.0027 0.0354 0.0476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Loa Loa (eye worm) hypothetical protein 0.002 0.0215 0.0284
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.1051 0.1974
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0032 0.0044
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.1964 0.9387
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0354 0.0552
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0055 0.0075
Loa Loa (eye worm) hypothetical protein 0.0048 0.0785 0.107
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1964 0.3689
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0031
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0547 0.0754
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0051 0.0063
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0547 0.0754
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.1828 0.2508
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0113 0.2127 0.2622
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0273 0.0364
Schistosoma mansoni hypothetical protein 0.0166 0.3219 0.3967
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0032 0.0059
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0273 0.0364
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0055 0.0075
Echinococcus granulosus expressed conserved protein 0.0104 0.1953 0.2407
Entamoeba histolytica cysteine protease, putative 0.0019 0.0186 0.0888
Leishmania major cathepsin L-like protease 0.0071 0.1262 0.1675
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0032 0.0043
Leishmania major cathepsin L-like protease 0.0019 0.0186 0.0182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1262 0.1738
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.8114 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0354 0.1611
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0186 0.0256
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0107 0.1023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1262 0.1738
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.051 0.0628
Brugia malayi ecdysteroid receptor 0.0023 0.0273 0.0376
Trichomonas vaginalis esterase, putative 0.0077 0.1399 0.2628
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0055 0.0391
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1964 0.3689
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.1964 0.366
Brugia malayi TAR-binding protein 0.0136 0.2614 0.3598
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0547 0.1028
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0107 0.1023
Loa Loa (eye worm) hypothetical protein 0.002 0.0215 0.0284
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0953 0.1174
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0055 0.0075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0186 0.0349
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.1399 0.1916
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0055 0.0169
Echinococcus granulosus nibrin 0.0011 0.0032 0.0039
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.1828 0.2517
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0024 0.0022
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0055 0.0169
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0022
Echinococcus multilocularis cysteine protease 0.0019 0.0186 0.0229
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0032 0.0039
Brugia malayi hypothetical protein 0.0011 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0311 0.6204 0.8539
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1192 0.1875
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.1192 0.1577
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0024 0.003
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0024 0.0034
Brugia malayi nuclear receptor RXR 0.0011 0.0024 0.0034
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.2033 0.1989
Loa Loa (eye worm) hypothetical protein 0.0362 0.7264 1
Schistosoma mansoni tar DNA-binding protein 0.0136 0.2614 0.3221
Loa Loa (eye worm) MH2 domain-containing protein 0.0267 0.5299 0.7293
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0192 0.0138
Onchocerca volvulus 0.0077 0.1399 0.2594
Echinococcus granulosus cathepsin l1 0.0019 0.0186 0.0229
Trypanosoma brucei polo-like protein kinase 0.0105 0.1964 0.2703
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.1399 0.1352
Brugia malayi hypothetical protein 0.0011 0.0024 0.0034
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0186 0.0349
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0032 0.0059
Mycobacterium ulcerans epoxide hydrolase EphA 0.0317 0.6337 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.1809 0.1764
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0061 0.1051 0.5275
Schistosoma mansoni hypothetical protein 0.0403 0.8114 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0354 0.0487
Schistosoma mansoni hypothetical protein 0.0046 0.075 0.0924
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0107 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0273 0.0376
Loa Loa (eye worm) hypothetical protein 0.0012 0.0055 0.0063
Mycobacterium ulcerans hypothetical protein 0.0027 0.0354 0.0552
Toxoplasma gondii thioredoxin reductase 0.0043 0.0682 0.4759
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0031
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.1192 0.8485
Brugia malayi ecdysone receptor 0.0011 0.0024 0.0034
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0354 0.0552
Brugia malayi Pre-SET motif family protein 0.0034 0.051 0.0701
Schistosoma mansoni nuclear receptor 0.0011 0.0024 0.003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.1399 0.1352
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0694 0.0855
Schistosoma mansoni nuclear receptor 0.0011 0.0024 0.003
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.051 0.0628
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0055 0.0067
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0006 0.0009
Schistosoma mansoni patched 1 0.0048 0.0785 0.0967
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0273 0.0376
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.1828 0.2253
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0022
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0055 0.0067
Brugia malayi beta-lactamase 0.0077 0.1399 0.1926
Plasmodium vivax vivapain-2 0.0019 0.0186 0.1328
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0186 0.0349
Echinococcus multilocularis nibrin 0.0011 0.0032 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.02 0.3928 0.484
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.051 0.0628
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0055 0.0169
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.1399 0.1352
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0055 0.0261
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0273 0.0336
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.2033 0.1989
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0273 0.0469
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.1809 0.1764
Onchocerca volvulus 0.0012 0.0055 0.0057
Loa Loa (eye worm) ctsf protein 0.0019 0.0186 0.0244
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.1809 0.1764
Treponema pallidum hypothetical protein 0.0012 0.0055 0.0226
Plasmodium falciparum thioredoxin reductase 0.0015 0.0107 0.1023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1262 0.1738
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.02 0.3928 0.5402
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0186 0.0304
Entamoeba histolytica hypothetical protein 0.0036 0.0549 0.2623
Schistosoma mansoni survival motor neuron protein 0.0054 0.0924 0.1139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1262 0.1738
Brugia malayi Pre-SET motif family protein 0.0235 0.4654 0.6408
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0682 0.0928
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0273 0.0364
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0186 0.0229
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0186 0.1767

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.26 Inhibition of electric eel AChE using ATC iodide substrate by DTNB based assay ChEMBL. 25059502
IC50 (binding) = 55.62 uM Inhibition of electric eel AChE using ATC iodide substrate by DTNB based assay ChEMBL. 25059502
Inhibition (binding) = 24 % Inhibition of equine serum BChE at 100 uM using ATC iodide substrate by DTNB based assay ChEMBL. 25059502

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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