Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosylhomocysteinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | heat shock protein 90 | 0.0085 | 0.337 | 0.1047 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0156 | 1 | 1 |
Schistosoma mansoni | heat shock protein | 0.0107 | 0.5402 | 0.1723 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Trichomonas vaginalis | heat shock protein, putative | 0.0085 | 0.337 | 0.337 |
Treponema pallidum | heat shock protein 90 | 0.0085 | 0.337 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0156 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0066 | 0.1545 | 0.1545 |
Echinococcus granulosus | heat shock protein | 0.0107 | 0.5402 | 0.3791 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Echinococcus granulosus | heat shock protein 90 | 0.0085 | 0.337 | 0.1047 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Schistosoma mansoni | heat shock protein | 0.0107 | 0.5402 | 0.1723 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0156 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0156 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0085 | 0.337 | 0.5 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0156 | 1 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0156 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Chlamydia trachomatis | glutamine binding protein | 0.0055 | 0.0582 | 0.5 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0156 | 1 | 1 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0107 | 0.5402 | 0.4706 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0156 | 1 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0055 | 0.0582 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Trichomonas vaginalis | endoplasmin, putative | 0.0066 | 0.1545 | 0.1545 |
Trichomonas vaginalis | heat shock protein, putative | 0.0085 | 0.337 | 0.337 |
Trichomonas vaginalis | heat shock protein, putative | 0.0085 | 0.337 | 0.337 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0156 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 1 | 1 |
Schistosoma mansoni | endoplasmin | 0.0107 | 0.5402 | 0.1723 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0107 | 0.5402 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0107 | 0.5402 | 0.4706 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0085 | 0.337 | 0.296 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0085 | 0.337 | 0.296 |
Schistosoma mansoni | endoplasmin | 0.0107 | 0.5402 | 0.1723 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0107 | 0.5402 | 0.4706 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0085 | 0.337 | 0.2367 |
Echinococcus multilocularis | heat shock protein | 0.0107 | 0.5402 | 0.3791 |
Echinococcus granulosus | heat shock protein 90 | 0.0107 | 0.5402 | 0.3791 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0085 | 0.337 | 0.1047 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0156 | 1 | 1 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0156 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Plasmodium falciparum | heat shock protein 90 | 0.0107 | 0.5402 | 0.4561 |
Trichomonas vaginalis | heat shock protein, putative | 0.0107 | 0.5402 | 0.5402 |
Echinococcus multilocularis | endoplasmin | 0.0085 | 0.337 | 0.1047 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0156 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0156 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0085 | 0.337 | 0.2367 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0107 | 0.5402 | 0.4706 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Echinococcus multilocularis | heat shock protein 90 | 0.0107 | 0.5402 | 0.3791 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 1 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0107 | 0.5402 | 0.4706 |
Leishmania major | heat shock protein 83-1 | 0.0107 | 0.5402 | 0.3064 |
Echinococcus granulosus | endoplasmin | 0.0085 | 0.337 | 0.1047 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.89 uM | Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysis | ChEMBL. | 25022879 |
IC50 (binding) | = 0.89 uM | Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysis | ChEMBL. | 26037610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.