Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0048 | 0.2363 | 0.4609 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0037 | 0.1094 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0055 | 0.3139 | 0.3139 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.5126 | 0.5126 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0037 | 0.1094 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0037 | 0.1094 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0115 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0037 | 0.1094 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0037 | 0.1094 | 0.1094 |
Trypanosoma brucei | cytochrome P450, putative | 0.0055 | 0.3139 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0055 | 0.3139 | 0.3139 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0037 | 0.1094 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.1094 | 0.1094 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0037 | 0.1094 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0048 | 0.2363 | 0.3147 |
Mycobacterium leprae | putative cytochrome p450 | 0.0037 | 0.1094 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0037 | 0.1094 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0037 | 0.1156 | 0.1156 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0037 | 0.1094 | 0.2134 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0037 | 0.1094 | 0.5 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0048 | 0.2363 | 0.4609 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0048 | 0.2363 | 0.4609 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0037 | 0.1094 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0037 | 0.1094 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0055 | 0.3139 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0055 | 0.3139 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0037 | 0.1094 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0072 | 0.5126 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0037 | 0.1094 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0037 | 0.1094 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0037 | 0.1094 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0055 | 0.3139 | 0.3139 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0055 | 0.3139 | 0.3139 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0037 | 0.1094 | 0.5 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.007 | 0.4854 | 0.9469 |
Brugia malayi | cytochrome P450 | 0.0037 | 0.1094 | 0.1094 |
Echinococcus multilocularis | 0.0037 | 0.1094 | 0.2134 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0037 | 0.1156 | 0.1156 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0072 | 0.5126 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0055 | 0.3139 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0037 | 0.1094 | 0.5 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0072 | 0.5126 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0037 | 0.1156 | 0.1156 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0037 | 0.1094 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0037 | 0.1094 | 0.5 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0072 | 0.5126 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0055 | 0.3139 | 0.3139 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.007 | 0.4854 | 0.9469 |
Schistosoma mansoni | transient receptor potential channel | 0.0048 | 0.2363 | 0.3147 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0037 | 0.1094 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0055 | 0.3139 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0037 | 0.1094 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0037 | 0.1094 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0048 | 0.2363 | 0.4609 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0037 | 0.1094 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2091 | 0.2091 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1156 | 0.1156 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | Agonist activity at human GABAAalpha1beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay | ChEMBL. | 25038482 | |
EC50 (binding) | Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay | ChEMBL. | 25038482 | |
Ki (binding) | > 100 uM | Displacement of [3H]muscimol from GABAA receptor in SPRD rat brain synaptic membranes by scintillation counting method | ChEMBL. | 25038482 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.