Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | serotonin transporter b | 0.017 | 0.1804 | 0.1804 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0236 | 0.0236 |
Onchocerca volvulus | 0.0074 | 0.0732 | 0.3166 | |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.0516 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.1804 | 0.1804 |
Plasmodium falciparum | transporter, putative | 0.0029 | 0.0236 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.475 | 0.475 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0732 | 0.0732 |
Schistosoma mansoni | tyrosine kinase | 0.0291 | 0.3138 | 0.2972 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.017 | 0.1804 | 0.1606 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0291 | 0.3138 | 0.3138 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.0732 | 0.0508 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0029 | 0.0236 | 0.0236 |
Loa Loa (eye worm) | carboxylesterase | 0.0074 | 0.0732 | 0.0732 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.475 | 0.475 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.017 | 0.1804 | 0.1606 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0074 | 0.0732 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0074 | 0.0732 | 0.5 |
Onchocerca volvulus | 0.0074 | 0.0732 | 0.3166 | |
Schistosoma mansoni | tyrosine kinase | 0.0484 | 0.5277 | 0.5162 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0291 | 0.3138 | 0.3138 |
Schistosoma mansoni | gliotactin | 0.0074 | 0.0732 | 0.0508 |
Echinococcus granulosus | epidermal growth factor receptor | 0.091 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0732 | 0.0732 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0732 | 0.0732 |
Echinococcus granulosus | insulin receptor | 0.0291 | 0.3138 | 0.3138 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0029 | 0.0236 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0074 | 0.0732 | 0.0732 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0029 | 0.0236 | 0.0236 |
Echinococcus granulosus | acetylcholinesterase | 0.0436 | 0.475 | 0.475 |
Schistosoma mansoni | tyrosine kinase | 0.0484 | 0.5277 | 0.5162 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0236 | 0.5 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0029 | 0.0236 | 0.0236 |
Brugia malayi | Carboxylesterase family protein | 0.0436 | 0.475 | 0.475 |
Brugia malayi | hypothetical protein | 0.0265 | 0.2857 | 0.2857 |
Echinococcus granulosus | neuroligin | 0.0074 | 0.0732 | 0.0732 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0074 | 0.0732 | 0.0732 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0489 | 0.5334 | 0.5334 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.0732 | 0.0732 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0029 | 0.0236 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.1804 | 0.1804 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0074 | 0.0732 | 0.0732 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0363 | 0.5 |
Onchocerca volvulus | 0.0074 | 0.0732 | 0.3166 | |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0291 | 0.3138 | 0.3138 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0236 | 0.0236 |
Echinococcus granulosus | acetylcholinesterase | 0.0436 | 0.475 | 0.475 |
Plasmodium vivax | amine transporter, putative | 0.0029 | 0.0236 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.017 | 0.1804 | 0.1804 |
Echinococcus multilocularis | acetylcholinesterase | 0.0436 | 0.475 | 0.475 |
Plasmodium falciparum | amino acid transporter, putative | 0.0029 | 0.0236 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0436 | 0.475 | 0.475 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0029 | 0.0236 | 0.0236 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0363 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0732 | 0.0732 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0485 | 0.0485 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.0732 | 0.0732 |
Schistosoma mansoni | acetylcholinesterase | 0.0074 | 0.0732 | 0.0508 |
Schistosoma mansoni | tyrosine kinase | 0.0484 | 0.5277 | 0.5162 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0074 | 0.0732 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0074 | 0.0732 | 0.0732 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.0732 | 0.0508 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0489 | 0.5334 | 0.5334 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0489 | 0.5334 | 0.5334 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.091 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0489 | 0.5334 | 0.5221 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.0516 | 0.0516 |
Onchocerca volvulus | 0.0074 | 0.0732 | 0.3166 | |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0363 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0436 | 0.475 | 0.475 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0363 | 0.5 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0029 | 0.0236 | 0.0236 |
Toxoplasma gondii | hypothetical protein | 0.0029 | 0.0236 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0029 | 0.0236 | 0.5 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0029 | 0.0236 | 0.0236 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0436 | 0.475 | 0.4623 |
Echinococcus granulosus | serotonin transporter | 0.017 | 0.1804 | 0.1804 |
Echinococcus multilocularis | insulin receptor | 0.0291 | 0.3138 | 0.3138 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0236 | 0.0236 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0029 | 0.0236 | 0.5 |
Echinococcus multilocularis | 0.0282 | 0.3037 | 0.3037 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0436 | 0.475 | 0.475 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0074 | 0.0732 | 0.0508 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0029 | 0.0236 | 0.0236 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0029 | 0.0236 | 0.0236 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0029 | 0.0236 | 0.0236 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0029 | 0.0236 | 0.0236 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0074 | 0.0732 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0074 | 0.0732 | 0.0732 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.017 | 0.1804 | 0.1804 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0265 | 0.2857 | 0.2857 |
Brugia malayi | Carboxylesterase family protein | 0.0436 | 0.475 | 0.475 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0236 | 0.0236 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0485 | 0.0255 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0485 | 0.0485 |
Onchocerca volvulus | 0.017 | 0.1804 | 1 | |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.017 | 0.1804 | 0.1804 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.0485 | 0.0485 |
Onchocerca volvulus | 0.0074 | 0.0732 | 0.3166 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0074 | 0.0732 | 0.0732 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0029 | 0.0236 | 0.0236 |
Schistosoma mansoni | tyrosine kinase | 0.0291 | 0.3138 | 0.2972 |
Schistosoma mansoni | tyrosine kinase | 0.091 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0485 | 0.0255 |
Toxoplasma gondii | hypothetical protein | 0.0029 | 0.0236 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0363 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0732 | 0.0732 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.1804 | 0.1804 |
Loa Loa (eye worm) | carboxylesterase | 0.0074 | 0.0732 | 0.0732 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.0732 | 0.0732 |
Brugia malayi | hypothetical protein | 0.004 | 0.0363 | 0.0363 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0485 | 0.0255 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0485 | 0.0485 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0029 | 0.0236 | 0.0236 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.0732 | 0.0508 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0363 | 0.0363 |
Onchocerca volvulus | 0.0054 | 0.0516 | 0.1783 | |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0516 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0236 | 0.0236 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0485 | 0.0485 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.0732 | 0.0732 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0029 | 0.0236 | 0.0236 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0074 | 0.0732 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.091 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.017 | 0.1804 | 0.1804 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0029 | 0.0236 | 0.0236 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0029 | 0.0236 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.2857 | 0.2857 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0732 | 0.0732 |
Loa Loa (eye worm) | carboxylesterase | 0.0436 | 0.475 | 0.475 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0732 | 0.0732 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0436 | 0.475 | 0.475 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0074 | 0.0732 | 0.0732 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.0485 | 0.0485 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.017 | 0.1804 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0236 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0732 | 0.0732 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0363 | 0.0363 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0236 | 0.0236 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0363 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0074 | 0.0732 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0236 | 0.0236 |
Brugia malayi | Protein kinase domain containing protein | 0.0291 | 0.3138 | 0.3138 |
Schistosoma mansoni | tyrosine kinase | 0.0489 | 0.5334 | 0.5221 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0029 | 0.0236 | 0.0236 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0029 | 0.0236 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0074 | 0.0732 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0265 | 0.2857 | 0.2857 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100 uM | Inhibition of human GCN5 | ChEMBL. | No reference |
IC50 (binding) | = 500 uM | Inhibition of CBP (unknown origin) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.