Detailed information for compound 925113

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 464.558 | Formula: C24H25FN6OS
  • H donors: 3 H acceptors: 3 LogP: 4.35 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCCNc1nc(nc2c1scc2)c1ccc(cc1)NC(=O)Nc1ccccc1F)C
  • InChi: 1S/C24H25FN6OS/c1-31(2)14-5-13-26-23-21-20(12-15-33-21)28-22(30-23)16-8-10-17(11-9-16)27-24(32)29-19-7-4-3-6-18(19)25/h3-4,6-12,15H,5,13-14H2,1-2H3,(H,26,28,30)(H2,27,29,32)
  • InChiKey: WMAULADTYUXHSK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Neuronal symmetry protein 1 0.0203 0.2442 0.5471
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0401 0.0429
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0087 0.099 0.099
Brugia malayi serine/threonine-protein kinase PAK 7 0.0017 0.0108 0.0243
Echinococcus multilocularis g protein coupled receptor 0.0087 0.099 0.099
Schistosoma mansoni hypothetical protein 0.0087 0.099 0.1314
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0401 0.1308
Entamoeba histolytica Ran family GTPase 0.0042 0.0425 0.2181
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0363 0.1183
Brugia malayi Cyclin, N-terminal domain containing protein 0.0023 0.0191 0.0428
Schistosoma mansoni hypothetical protein 0.0031 0.0286 0.038
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0413 0.0925
Mycobacterium ulcerans beta-lactamase 0.0107 0.1235 1
Echinococcus granulosus cyclin A3 4 0.0023 0.0191 0.0254
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0187
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.017 0.0226
Echinococcus multilocularis cyclins 0.0097 0.1111 0.1111
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0401 0.2048
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0286 0.038
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0401 0.2048
Brugia malayi hypothetical protein 0.0365 0.4463 1
Giardia lamblia DINP protein human, muc B family 0.004 0.0401 0.1955
Schistosoma mansoni cyclin G 0.0023 0.0191 0.0254
Schistosoma mansoni hypothetical protein 0.0031 0.0286 0.038
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0286 0.038
Entamoeba histolytica protein kinase, putative 0.0038 0.0379 0.1924
Echinococcus multilocularis g-protein coupled receptor 0.0087 0.099 0.099
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0141 0.0316
Schistosoma mansoni importin-beta 2 0.0011 0.0034 0.0045
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0141 0.0141
Brugia malayi putative neuropeptide receptor 0.0087 0.099 0.2218
Toxoplasma gondii cyclin 4, putative 0.0023 0.0191 0.1309
Loa Loa (eye worm) TYRA-2 protein 0.0087 0.099 0.1314
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0528 0.1724
Loa Loa (eye worm) hypothetical protein 0.0038 0.0375 0.0498
Echinococcus granulosus PAK box P21 Rho binding 0.0016 0.0094 0.0125
Echinococcus multilocularis somatostatin receptor 0.0087 0.099 0.099
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0141 0.0187
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0141 0.0187
Echinococcus multilocularis cyclins 0.0097 0.1111 0.1111
Leishmania major DNA polymerase eta, putative 0.004 0.0401 0.2048
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0363 0.0812
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0413 0.0548
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.014 0.0886
Echinococcus granulosus cyclin G2 0.0023 0.0191 0.0254
Trichomonas vaginalis cyclin D, putative 0.0097 0.1111 0.3624
Schistosoma mansoni protein kinase 0.0203 0.2442 0.3242
Echinococcus granulosus RUN 0.0019 0.014 0.0186
Schistosoma mansoni tyrosine kinase 0.0245 0.2963 0.3934
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.3065 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Trichomonas vaginalis STE family protein kinase 0.0038 0.0379 0.1236
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0528 0.0701
Brugia malayi ecdysteroid receptor 0.0041 0.0413 0.0925
Brugia malayi Doublecortin family protein 0.0019 0.014 0.0314
Echinococcus granulosus importin 5 0.0011 0.0034 0.0045
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0614 0.0614
Trypanosoma brucei cdc2-related kinase 3 0.005 0.0528 0.2758
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0098 0.0098
Brugia malayi cell division control protein 2 homolog 0.005 0.0528 0.1184
Brugia malayi hypothetical protein 0.0087 0.099 0.2218
Schistosoma mansoni hypothetical protein 0.0016 0.0094 0.0125
Brugia malayi G-protein coupled receptor 0.0087 0.099 0.2218
Trichomonas vaginalis esterase, putative 0.0107 0.1235 0.403
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.014 0.014
Echinococcus granulosus dna polymerase eta 0.004 0.0401 0.0532
Loa Loa (eye worm) hypothetical protein 0.008 0.0906 0.1203
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0412 0.0922
Echinococcus multilocularis neuropeptide receptor 0.0087 0.099 0.099
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0925 0.1228
Entamoeba histolytica cyclin family protein 0.0097 0.1111 0.6007
Trichomonas vaginalis STE family protein kinase 0.0038 0.0379 0.1236
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0087 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0425 0.2181
Schistosoma mansoni hypothetical protein 0.0011 0.0041 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0413 0.0548
Brugia malayi hypothetical protein 0.0087 0.099 0.2218
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0401 0.2048
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0413 0.0925
Echinococcus granulosus g protein coupled receptor 0.0087 0.099 0.1314
Echinococcus multilocularis cyclin dependent kinase 0.005 0.0528 0.0528
Loa Loa (eye worm) cyclin domain-containing protein 0.0023 0.0191 0.0254
Loa Loa (eye worm) neuropeptide F receptor 0.0087 0.099 0.1314
Echinococcus granulosus peptide allatostatin:somatostatin 0.0087 0.099 0.1314
Echinococcus granulosus protein tyrosine kinase 0.0245 0.2963 0.3934
Echinococcus multilocularis cyclin B 0.0154 0.1827 0.1827
Leishmania major mitotic cyclin, putative 0.0023 0.0191 0.0877
Entamoeba histolytica cyclin, putative 0.0097 0.1111 0.6007
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Echinococcus granulosus transportin 1 0.0011 0.0034 0.0045
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0016 0.0094 0.0125
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0098 0.0131
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0381 0.1901
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0413 0.0925
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Loa Loa (eye worm) cyclin domain-containing protein 0.0023 0.0191 0.0254
Plasmodium vivax cyclin 4, putative 0.0023 0.0191 0.1309
Trichomonas vaginalis STE family protein kinase 0.0038 0.0379 0.1236
Loa Loa (eye worm) hypothetical protein 0.0049 0.0514 0.0682
Mycobacterium leprae Probable lipase LipE 0.0107 0.1235 1
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0413 0.0925
Schistosoma mansoni neuropeptide F-like receptor 0.0087 0.099 0.1314
Trichomonas vaginalis cyclins, putative 0.0023 0.0191 0.0623
Echinococcus multilocularis serotonin receptor 0.0087 0.099 0.099
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0401 0.0898
Echinococcus granulosus importin subunit beta 1 0.0057 0.0614 0.0815
Entamoeba histolytica hypothetical protein 0.0035 0.034 0.1706
Mycobacterium leprae conserved hypothetical protein 0.0107 0.1235 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0413 0.0413
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0016 0.0094 0.0125
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0412 0.0412
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0286 0.038
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0191 0.1309
Brugia malayi sulfakinin receptor protein 0.0087 0.099 0.2218
Loa Loa (eye worm) TK/FAK protein kinase 0.0248 0.2999 0.3982
Echinococcus granulosus biogenic amine 5HT receptor 0.0087 0.099 0.1314
Loa Loa (eye worm) hypothetical protein 0.004 0.0394 0.0523
Echinococcus multilocularis cyclin y 0.0023 0.0191 0.0191
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0087 0.099 0.099
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0413 0.0548
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0413 0.0548
Trypanosoma cruzi cyclin 9, putative 0.0023 0.0191 0.0839
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0034 0.0045
Mycobacterium ulcerans hypothetical protein 0.0107 0.1235 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0381 0.0505
Loa Loa (eye worm) hypothetical protein 0.0023 0.0191 0.0254
Schistosoma mansoni neuropeptide receptor 0.0087 0.099 0.1314
Echinococcus multilocularis cyclin dependent kinase 5 0.005 0.0528 0.0528
Trypanosoma cruzi mitotic cyclin, putative 0.0023 0.0191 0.0839
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0187
Mycobacterium tuberculosis Conserved protein 0.0107 0.1235 0.1422
Loa Loa (eye worm) hypothetical protein 0.0036 0.0344 0.0457
Loa Loa (eye worm) inositol-1 0.0039 0.0381 0.0505
Echinococcus granulosus tm gpcr rhodopsin 0.0087 0.099 0.1314
Entamoeba histolytica hypothetical protein 0.0023 0.0191 0.0877
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0141 0.0316
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0528 0.0701
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0087 0.099 0.2218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.099 0.1314
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Onchocerca volvulus 0.0087 0.099 0.2042
Schistosoma mansoni importin beta-1 0.0057 0.0614 0.0815
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.0048 0.008
Echinococcus granulosus cyclin k 0.0023 0.0191 0.0254
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0187
Plasmodium falciparum protein kinase 5 0.005 0.0528 0.4592
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0682 0.8437 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0413 0.0548
Brugia malayi larval opioid receptor 0.0087 0.099 0.2218
Echinococcus multilocularis cyclin 0.0023 0.0191 0.0191
Onchocerca volvulus 0.0087 0.099 0.2042
Schistosoma mansoni myosin xvIII 0.0087 0.099 0.1314
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0154 0.1827 1
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0401 0.2048
Schistosoma mansoni opsin-like receptor 0.0087 0.099 0.1314
Schistosoma mansoni biogenic amine receptor 0.0087 0.099 0.1314
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.099 0.1314
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0448 0.1004
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0401 0.0898
Echinococcus multilocularis PAK box P21 Rho binding 0.0017 0.0108 0.0108
Schistosoma mansoni nuclear receptor 0.0019 0.0141 0.0187
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0413 0.0548
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.099 0.1314
Schistosoma mansoni loxhd1 0.0019 0.014 0.0186
Echinococcus multilocularis RUN 0.0019 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0381 0.5
Echinococcus multilocularis G1:S specific cyclin D1 0.0023 0.0191 0.0191
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0107 0.0142
Schistosoma mansoni cyclins 0.0097 0.1111 0.1475
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0141 0.0187
Plasmodium falciparum cyclin 1 0.0023 0.0191 0.1461
Echinococcus multilocularis pyruvate kinase 0.0019 0.0137 0.0137
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0141 0.0316
Schistosoma mansoni hypothetical protein 0.0023 0.0191 0.0254
Trichomonas vaginalis cyclin A, putative 0.0023 0.0191 0.0623
Schistosoma mansoni hypothetical protein 0.0016 0.0094 0.0125
Echinococcus granulosus cyclin 0.0023 0.0191 0.0254
Brugia malayi follicle stimulating hormone receptor 0.0087 0.099 0.2218
Schistosoma mansoni neuropeptide f receptor 76f 0.0087 0.099 0.1314
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.0062 0.0675 0.0897
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0054 0.0172
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.005 0.0528 0.4117
Brugia malayi Cyclin, N-terminal domain containing protein 0.0023 0.0191 0.0428
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0381 0.0381
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0137 0.0956
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0023 0.0191 0.1309
Loa Loa (eye worm) hypothetical protein 0.0057 0.0614 0.0816
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0413 0.0548
Entamoeba histolytica hypothetical protein 0.0016 0.0094 0.0336
Schistosoma mansoni lipoxygenase 0.0054 0.0575 0.0764
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0087 0.099 0.1314
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni hypothetical protein 0.0016 0.0098 0.0131
Brugia malayi conserved hypotetical protein 0.0019 0.0141 0.0316
Echinococcus multilocularis g protein coupled receptor 0.0087 0.099 0.099
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0401 0.2015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0413 0.0925
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0087 0.099 0.1314
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.0022 0.0169 0.0224
Loa Loa (eye worm) hypothetical protein 0.0082 0.0925 0.1228
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1976 0.6447
Leishmania major cyclin 9, putative 0.0023 0.0191 0.0877
Brugia malayi hypothetical protein 0.0087 0.099 0.2218
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0087 0.099 0.2218
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Brugia malayi Melatonin receptor type 1A 0.0087 0.099 0.2218
Schistosoma mansoni tyrosine kinase 0.0017 0.0107 0.0142
Brugia malayi hypothetical protein 0.0087 0.099 0.2218
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0528 0.1724
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0054 0.0116
Schistosoma mansoni g1/s-specific cyclin C 0.0023 0.0191 0.0254
Leishmania major DNA polymerase kappa, putative 0.004 0.0401 0.2048
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0394 0.0523
Giardia lamblia Cyclin A 0.0097 0.1111 0.596
Loa Loa (eye worm) hypothetical protein 0.0037 0.0364 0.0484
Toxoplasma gondii cyclin dependent kinase binding protein 0.0023 0.0191 0.1309
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0925 0.1228
Loa Loa (eye worm) hypothetical protein 0.0098 0.1124 0.1492
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.034 0.034
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.017 0.0381
Echinococcus granulosus serotonin receptor 0.0087 0.099 0.1314
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0087 0.099 0.1314
Echinococcus multilocularis Ankyrin 0.0016 0.01 0.01
Leishmania major cyclin 0.0154 0.1827 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0087 0.099 0.1314
Schistosoma mansoni opsin-like receptor 0.0087 0.099 0.1314
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0203 0.2442 0.2442
Brugia malayi Cyclin C 0.0023 0.0191 0.0428
Schistosoma mansoni hypothetical protein 0.0016 0.0094 0.0125
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.3065 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1235 0.403
Schistosoma mansoni hypothetical protein 0.0031 0.0286 0.038
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0413 0.0548
Entamoeba histolytica hypothetical protein 0.0035 0.034 0.1706
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0203 0.2442 0.3242
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0425 0.2148
Entamoeba histolytica cyclin, putative 0.0154 0.1827 1
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0137 0.0857
Brugia malayi Protein kinase domain containing protein 0.0017 0.0113 0.0253
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0413 0.0548
Onchocerca volvulus 0.0023 0.0191 0.0212
Echinococcus granulosus neuropeptides capa receptor 0.0087 0.099 0.1314
Schistosoma mansoni intermediate filament proteins 0.0082 0.0925 0.1228
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0187
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0087 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0063
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0023 0.0191 0.0254
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.017 0.0226
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0425 0.0564
Brugia malayi nuclear receptor NHR-67 0.0019 0.0141 0.0316
Entamoeba histolytica protein kinase, putative 0.0017 0.0108 0.0416
Brugia malayi Tachykinin-like peptides receptor 99D 0.0087 0.099 0.2218
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.0226
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0363 0.0605
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0023 0.0191 0.0254
Loa Loa (eye worm) hypothetical protein 0.0145 0.171 0.227
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0141 0.0141
Onchocerca volvulus 0.0087 0.099 0.2042
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0413 0.072
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.01 0.0133
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1124 0.2518
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0151 0.02
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0459 0.0609
Echinococcus multilocularis sex peptide receptor 0.0087 0.099 0.099
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0054 0.0192
Schistosoma mansoni pyruvate kinase 0.0037 0.0363 0.0481
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0038 0.0379 0.0503
Echinococcus multilocularis dro:myosuppressin receptor 0.0087 0.099 0.099
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0413 0.0548
Mycobacterium ulcerans lipase LipD 0.0107 0.1235 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0087 0.099 0.1314
Onchocerca volvulus 0.0087 0.099 0.2042
Echinococcus multilocularis cyclins 0.0097 0.1111 0.1111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.099 0.099
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0412 0.0547
Schistosoma mansoni cyclin B3 0.0225 0.2715 0.3605
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0054 0.0116
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0023 0.0191 0.0254
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0087 0.099 0.099
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.1235 0.1422
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0087 0.099 0.099
Echinococcus granulosus neuropeptide receptor A26 0.0087 0.099 0.1314
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0401 0.0401
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0528 0.2758
Echinococcus granulosus 7TM GPCR rhodopsin 0.0087 0.099 0.1314
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0087 0.099 0.1314
Giardia lamblia Kinase, STE STE20 0.0038 0.0379 0.183
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni hypothetical protein 0.0067 0.0736 0.0977
Onchocerca volvulus Cyclin L homolog 0.0023 0.0191 0.0212
Brugia malayi Cytochrome P450 family protein 0.0011 0.0041 0.0092
Trypanosoma cruzi cyclin, putative 0.0154 0.1827 1
Echinococcus multilocularis neuropeptide Y receptor 0.0087 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0016 0.01 0.0133
Trypanosoma brucei mitotic cyclin 6 0.0154 0.1827 1
Trypanosoma brucei mitotic cyclin 0.0023 0.0191 0.0877
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0054 0.0116
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0478 0.2448
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni hypothetical protein 0.0087 0.099 0.1314
Trichomonas vaginalis cyclin B3, putative 0.0023 0.0191 0.0623
Entamoeba histolytica cyclin, domain containing protein 0.0023 0.0191 0.0877
Loa Loa (eye worm) cyclin domain-containing protein 0.0225 0.2715 0.3605
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.0226
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0034 0.0045
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0151 0.0613
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.099 0.1314
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0413 0.0548
Schistosoma mansoni ran 0.0042 0.0425 0.0564
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0413 0.0548
Echinococcus multilocularis transportin 1 0.0011 0.0034 0.0034
Loa Loa (eye worm) CYP4Cod1 0.002 0.0151 0.02
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.014 0.0186
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0381 0.1935
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0363 0.18
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0413 0.0925
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0141 0.0098
Echinococcus multilocularis g protein coupled receptor 0.0087 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0413 0.0925
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0087 0.099 0.2218
Echinococcus multilocularis muscleblind protein 1 0.0145 0.171 0.171
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Brugia malayi hypothetical protein 0.0019 0.0141 0.0316
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0528 0.0701
Loa Loa (eye worm) melatonin receptor type 1A 0.0087 0.099 0.1314
Onchocerca volvulus 0.0087 0.099 0.2042
Giardia lamblia Kinase, CMGC CDK 0.005 0.0528 0.2674
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0401 0.1308
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0413 0.0548
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0087 0.099 0.1314
Brugia malayi hypothetical protein 0.0022 0.017 0.0381
Loa Loa (eye worm) hypothetical protein 0.0107 0.1235 0.164
Brugia malayi hypothetical protein 0.0035 0.034 0.0761
Echinococcus granulosus 7tm_1 domain containing protein 0.0087 0.099 0.1314
Leishmania major cytochrome p450-like protein 0.0011 0.0041 0.0042
Schistosoma mansoni cyclin d 0.0023 0.0191 0.0254
Onchocerca volvulus Neuropeptide F receptor homolog 0.0087 0.099 0.2042
Schistosoma mansoni protein kinase 0.0038 0.0379 0.0503
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0413 0.0925
Loa Loa (eye worm) doublecortin family protein 0.0019 0.014 0.0186
Onchocerca volvulus 0.0019 0.0141 0.0098
Echinococcus granulosus pyruvate kinase 0.0019 0.0137 0.0181
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.1235 0.2767
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1235 0.6686
Loa Loa (eye worm) hypothetical protein 0.0145 0.171 0.227
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0087 0.099 0.099
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0363 0.0383
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.099 0.1314
Loa Loa (eye worm) hypothetical protein 0.0107 0.1235 0.164
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.1111 0.3624
Loa Loa (eye worm) hypothetical protein 0.0107 0.1235 0.164
Entamoeba histolytica p21-activated kinase 0.0038 0.0379 0.1924
Trypanosoma cruzi mitotic cyclin, putative 0.0023 0.0191 0.0839
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni polycystin 1-related 0.0019 0.014 0.0186
Onchocerca volvulus 0.0087 0.099 0.2042
Toxoplasma gondii ABC1 family protein 0.0107 0.1235 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0413 0.0925
Echinococcus multilocularis cyclin k 0.0023 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0413 0.0548
Echinococcus granulosus cyclins 0.0097 0.1111 0.1475
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0082 0.0923 0.0923
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0054 0.0172
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0087 0.099 0.1314
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0286 0.0641
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0187
Echinococcus granulosus pyruvate kinase 0.0037 0.0363 0.0481
Giardia lamblia Cyclin fold protein 1, putative 0.0023 0.0191 0.0771
Echinococcus granulosus alpha 1A adrenergic receptor 0.0087 0.099 0.1314
Schistosoma mansoni rab6-interacting 0.0019 0.014 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.099 0.099
Schistosoma mansoni amine GPCR 0.0087 0.099 0.1314
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0151 0.0613
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0191 0.1461
Schistosoma mansoni nuclear receptor 0.0019 0.0141 0.0187
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.1235 1
Brugia malayi GnHR receptor homolog 0.0087 0.099 0.2218
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0401 0.2015
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0087 0.099 0.2042
Trichomonas vaginalis cyclin B3, putative 0.0097 0.1111 0.3624
Brugia malayi WH1 domain containing protein 0.0016 0.0094 0.0211
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0023 0.0191 0.1309
Loa Loa (eye worm) cyclin domain-containing protein 0.0023 0.0191 0.0254
Schistosoma mansoni hypothetical protein 0.059 0.7277 0.9662
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0087 0.099 0.1314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.099 0.099
Brugia malayi P21-Rho-binding domain containing protein 0.0016 0.0094 0.0211
Entamoeba histolytica cyclin C, putative 0.0023 0.0191 0.0877
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0528 0.0528
Echinococcus multilocularis dna polymerase eta 0.004 0.0401 0.0401
Echinococcus granulosus neuropeptides capa receptor 0.0087 0.099 0.1314
Onchocerca volvulus 0.0107 0.1235 0.2604
Echinococcus multilocularis importin 5 0.0011 0.0034 0.0034
Schistosoma mansoni amine GPCR 0.0087 0.099 0.1314
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0141 0.0098
Echinococcus multilocularis fmrfamide receptor 0.0087 0.099 0.099
Onchocerca volvulus 0.0087 0.099 0.2042
Echinococcus granulosus death domain containing protein 0.0016 0.0098 0.0131
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0381 0.1242
Echinococcus multilocularis allatostatin A receptor 0.0087 0.099 0.099
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0141 0.0316
Leishmania major DNA polymerase eta, putative 0.0012 0.0054 0.0116
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.017 0.0226
Echinococcus multilocularis protein tyrosine kinase 0.0245 0.2963 0.2963
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0087 0.099 0.1314
Trypanosoma cruzi DNA polymerase eta, putative 0.0012 0.0054 0.0074
Onchocerca volvulus 0.0019 0.0141 0.0098
Schistosoma mansoni biogenic amine receptor 0.0087 0.099 0.1314
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0363 0.2738
Brugia malayi hypothetical protein 0.0087 0.099 0.2218
Brugia malayi AKH receptor 0.0087 0.099 0.2218
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0413 0.0413
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2088 0.6812
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0401 0.2048
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0736 0.165
Echinococcus multilocularis neuropeptides capa receptor 0.0087 0.099 0.099
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0141 0.0187
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0023 0.0183 0.0598
Loa Loa (eye worm) hypothetical protein 0.0038 0.0375 0.0498
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.099 0.099
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.1235 0.1422
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Trypanosoma brucei cyclin 3 0.0023 0.0191 0.0877
Echinococcus granulosus sex peptide receptor 0.0087 0.099 0.1314
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0187
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.014 0.0186
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.1235 0.164
Brugia malayi G-protein coupled receptor 0.0087 0.099 0.2218
Loa Loa (eye worm) cyclin domain-containing protein 0.0023 0.0191 0.0254
Echinococcus multilocularis translational activator gcn1 0.0011 0.0034 0.0034
Echinococcus granulosus cyclin y 0.0023 0.0191 0.0254
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni adenoreceptor 0.0087 0.099 0.1314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.099 0.099
Brugia malayi hypothetical protein 0.0019 0.014 0.0314
Onchocerca volvulus 0.0019 0.014 0.0096
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0425 0.0425
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0041 0.0042
Echinococcus multilocularis 0.0011 0.0041 0.0041
Brugia malayi nuclear receptor RXR 0.0022 0.017 0.0381
Echinococcus multilocularis cyclins 0.0097 0.1111 0.1111
Onchocerca volvulus 0.0107 0.1235 0.2604
Brugia malayi Cyclin, N-terminal domain containing protein 0.0023 0.0191 0.0428
Echinococcus multilocularis cyclins 0.0097 0.1111 0.1111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0413 0.0548
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0141 0.0187
Entamoeba histolytica cyclin family protein 0.0097 0.1111 0.6007
Brugia malayi Cyclin, N-terminal domain containing protein 0.0023 0.0191 0.0428
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0401 0.2048
Loa Loa (eye worm) hypothetical protein 0.0016 0.0098 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.099 0.1314
Schistosoma mansoni cytochrome P450 0.0011 0.0041 0.0055
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0378 0.1233
Loa Loa (eye worm) hypothetical protein 0.0031 0.0286 0.038
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.099 0.1314
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.033 0.242
Entamoeba histolytica hypothetical protein 0.0016 0.0094 0.0336
Echinococcus granulosus g protein coupled receptor 0.0087 0.099 0.1314
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0528 0.2728
Trichomonas vaginalis cyclin B, putative 0.0097 0.1111 0.3624
Leishmania major pyruvate kinase 0.0037 0.0363 0.1834
Schistosoma mansoni neuropeptide receptor 0.0087 0.099 0.1314
Loa Loa (eye worm) hypothetical protein 0.0057 0.0614 0.0815
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.099 0.099
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.061 0.7532 1
Brugia malayi ORL1-like opioid receptor 0.0087 0.099 0.2218
Echinococcus granulosus snurportin 1 0.061 0.7532 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0087 0.099 0.1314
Trypanosoma cruzi cyclin 6, putative 0.0154 0.1827 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0087 0.099 0.099
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0401 0.0429
Brugia malayi cyclin fold protein 1 variant b 0.0023 0.0191 0.0428
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0401 0.2015
Loa Loa (eye worm) hypothetical protein 0.0041 0.0413 0.0548
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0413 0.0548
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0413 0.0548
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0054 0.0116
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0363 0.1834
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.099 0.1314
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1235 0.164
Echinococcus multilocularis Cyclin L1 0.0023 0.0191 0.0191
Onchocerca volvulus 0.0087 0.099 0.2042
Brugia malayi beta-lactamase family protein 0.0107 0.1235 0.2767
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0054 0.0116
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.017 0.0381
Brugia malayi beta-lactamase family protein 0.0107 0.1235 0.2767
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0478 0.1561
Giardia lamblia Kinase, CMGC CDK 0.005 0.0528 0.2674
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0286 0.0641
Echinococcus granulosus Cyclin L1 0.0023 0.0191 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0413 0.0925
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0363 0.0812
Onchocerca volvulus 0.0087 0.099 0.2042
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0087 0.099 0.1314
Onchocerca volvulus 0.0087 0.099 0.2042
Mycobacterium tuberculosis Conserved protein 0.0107 0.1235 0.1422
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.099 0.1314
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0041 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0191 0.0623
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0401 0.2048
Plasmodium vivax hypothetical protein, conserved 0.0107 0.1235 1
Echinococcus granulosus cyclin B3 1 0.0097 0.1111 0.1475
Echinococcus multilocularis orexin receptor type 2 0.0087 0.099 0.099
Echinococcus multilocularis musashi 0.0082 0.0925 0.0925
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.005 0.0528 0.2758
Giardia lamblia Hypothetical protein 0.0097 0.1111 0.596
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0286 0.0286
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.014 0.014
Echinococcus granulosus translational activator gcn1 0.0011 0.0034 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0401 0.2048
Echinococcus granulosus biogenic amine 5HT receptor 0.0087 0.099 0.1314
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0381 0.2888
Brugia malayi ecdysone receptor 0.0019 0.0141 0.0316
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0191 0.0839
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1235 0.403
Schistosoma mansoni protein kinase 0.0038 0.0379 0.0503
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1976 0.6447
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0062 0.0675 0.3552
Trichomonas vaginalis cyclin B, putative 0.0023 0.0191 0.0623
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0413 0.0925
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.1976 0.4302
Onchocerca volvulus 0.0087 0.099 0.2042
Leishmania major cytochrome p450-like protein 0.002 0.0151 0.0652
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.099 0.1314
Leishmania major cytochrome p450-like protein 0.0011 0.0041 0.0042
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0413 0.0548
Plasmodium falciparum cyclin 0.0097 0.1111 1
Brugia malayi intermediate filament protein 0.0082 0.0925 0.2072
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0425 0.3255
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0413 0.0548
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0141 0.0187
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0448 0.0595
Schistosoma mansoni inositol monophosphatase 0.0039 0.0381 0.0505
Brugia malayi hypothetical protein 0.0022 0.017 0.0381
Onchocerca volvulus 0.0087 0.099 0.2042
Brugia malayi hypothetical protein 0.0087 0.099 0.2218
Trichomonas vaginalis cyclin B, putative 0.0154 0.1827 0.5961
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.3065 1
Brugia malayi RNA, U transporter 1 0.0162 0.1932 0.4329
Leishmania major hypothetical protein, conserved 0.0107 0.1235 0.67
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0528 0.0528
Brugia malayi Protein kinase domain containing protein 0.005 0.0528 0.1184
Echinococcus multilocularis pyruvate kinase 0.0037 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0023 0.0183 0.0243
Brugia malayi Serotonin receptor 0.0087 0.099 0.2218
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0187
Brugia malayi nuclear hormone receptor 0.0019 0.0141 0.0316
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0087 0.099 0.1314
Onchocerca volvulus 0.0082 0.0925 0.1893
Loa Loa (eye worm) hypothetical protein 0.0041 0.0413 0.0548
Schistosoma mansoni opsin-like receptor 0.0087 0.099 0.1314
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0186
Echinococcus granulosus fmrfamide receptor 0.0087 0.099 0.1314
Brugia malayi Serotonin receptor 0.0087 0.099 0.2218
Echinococcus granulosus cyclin dependent kinase 1 0.005 0.0528 0.0701
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.014 0.0186
Loa Loa (eye worm) hypothetical protein 0.0365 0.4463 0.5925
Loa Loa (eye worm) hypothetical protein 0.0041 0.0413 0.0548
Schistosoma mansoni cyclin l 0.0023 0.0191 0.0254
Trichomonas vaginalis ran, putative 0.0042 0.0425 0.1386
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0413 0.0413
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0413 0.0413
Brugia malayi Protein kinase domain containing protein 0.0248 0.2999 0.672
Echinococcus granulosus Ankyrin 0.0016 0.01 0.0133
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1235 0.403
Echinococcus granulosus cyclin dependent kinase 5 0.005 0.0528 0.0701
Plasmodium falciparum pyruvate kinase 0.0037 0.0363 0.3054
Trichomonas vaginalis cyclin B, putative 0.0154 0.1827 0.5961
Trypanosoma cruzi CYC2-like cyclin, putative 0.0154 0.1827 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0087 0.099 0.1314
Brugia malayi Cyclin, N-terminal domain containing protein 0.0023 0.0191 0.0428
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0401 0.0532
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.1235 0.1422
Brugia malayi Cyclin, N-terminal domain containing protein 0.0225 0.2715 0.6084
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0364 0.1189
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0363 0.0605
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0478 0.1561
Echinococcus granulosus orexin receptor type 2 0.0087 0.099 0.1314
Echinococcus granulosus neuropeptide receptor 0.0087 0.099 0.1314
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.005 0.0528 0.2758
Echinococcus multilocularis snurportin 1 0.061 0.7532 0.7532
Brugia malayi nuclear receptor RXR 0.0019 0.0141 0.0316
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Echinococcus granulosus G1:S specific cyclin D1 0.0023 0.0191 0.0254
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.1235 0.67
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0413 0.0548
Brugia malayi nuclear receptor NHR-88 0.0019 0.0141 0.0316
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Leishmania major GTP-binding protein, putative 0.0042 0.0425 0.2181
Trypanosoma brucei cytochrome P450, putative 0.002 0.0151 0.0652
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0363 0.1183
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Trypanosoma brucei unspecified product 0.0028 0.0245 0.1178
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1976 0.6447
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1124 0.2518
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0413 0.0413
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.3065 1
Onchocerca volvulus 0.0087 0.099 0.2042
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0245 0.1178
Giardia lamblia Hypothetical protein 0.0023 0.0191 0.0771
Loa Loa (eye worm) hypothetical protein 0.0365 0.4463 0.5925
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0528 0.2728
Echinococcus granulosus g protein coupled receptor 0.0087 0.099 0.1314
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0141 0.0187
Leishmania major pyruvate kinase 0.0037 0.0363 0.1834
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0363 0.2692
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0413 0.0925
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Loa Loa (eye worm) cyclin domain-containing protein 0.0023 0.0191 0.0254
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.017 0.017
Loa Loa (eye worm) neuropeptide F receptor 0.0087 0.099 0.1314
Brugia malayi Muscleblind-like protein 0.0145 0.171 0.3831
Loa Loa (eye worm) hypothetical protein 0.0041 0.0413 0.0548
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0413 0.0548
Schistosoma mansoni ran 0.0042 0.0425 0.0564
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0038 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0528 0.0701
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.034 0.0451
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0575 0.0764
Loa Loa (eye worm) cyclin C 0.0023 0.0191 0.0254
Schistosoma mansoni lamin 0.0082 0.0925 0.1228
Schistosoma mansoni neuropeptide receptor 0.0087 0.099 0.1314
Schistosoma mansoni cyclin k 0.0023 0.0191 0.0254
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0087 0.099 0.1314
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0038 0.0379 0.0503
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.034 0.0451
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.3065 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0225 0.2715 0.2715
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0381 0.0505
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0023 0.0183 0.0795
Schistosoma mansoni biogenic amine (5HT) receptor 0.0087 0.099 0.1314
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0394 0.0394
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0141 0.0187
Echinococcus granulosus neuropeptide receptor 0.0087 0.099 0.1314
Plasmodium vivax protein kinase Crk2 0.005 0.0528 0.4117
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0087 0.099 0.1314
Trichomonas vaginalis cyclins, putative 0.0154 0.1827 0.5961
Entamoeba histolytica protein kinase, putative 0.0017 0.0108 0.0416
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0039 0.0087
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0528 0.2728
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0017 0.0108 0.0144
Loa Loa (eye worm) hypothetical protein 0.0107 0.1235 0.164
Echinococcus multilocularis serotonin receptor 0.0087 0.099 0.099
Echinococcus granulosus lamin 0.0082 0.0925 0.1228
Onchocerca volvulus 0.0041 0.0413 0.072
Brugia malayi polk-prov protein 0.0012 0.0054 0.0122
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Loa Loa (eye worm) hypothetical protein 0.0041 0.0413 0.0548
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.3065 0.6867
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0098 0.0221
Brugia malayi hypothetical protein 0.0023 0.0191 0.0428
Schistosoma mansoni alpha-1 adrenergic receptor 0.0087 0.099 0.1314
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0087 0.099 0.099
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0141 0.0316
Loa Loa (eye worm) DR-78 0.0019 0.0141 0.0187
Echinococcus granulosus neuropeptide Y receptor 0.0087 0.099 0.1314
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.033 0.0344
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0011
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0038 0.0379 0.0379
Brugia malayi Cyclin, N-terminal domain containing protein 0.0154 0.1827 0.4093
Onchocerca volvulus Huntingtin homolog 0.0365 0.4463 1
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0038 0.0379 0.0503
Echinococcus granulosus muscleblind protein 0.0145 0.171 0.227
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0401 0.0532
Trichomonas vaginalis cyclins, putative 0.0154 0.1827 0.5961
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1976 0.6447
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0413 0.072
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0401 0.2015
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.014 0.014
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0363 0.0481
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0401 0.2015
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0413 0.0548
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0054 0.0074
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0087 0.099 0.1314
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0087 0.099 0.099
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0087 0.099 0.1314
Schistosoma mansoni growth hormone secretagogue receptor 0.0087 0.099 0.1314
Echinococcus granulosus cyclin dependent kinase 0.005 0.0528 0.0701
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0381 0.1242
Schistosoma mansoni lipoxygenase 0.0019 0.014 0.0186
Onchocerca volvulus 0.0019 0.014 0.0096
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Echinococcus multilocularis pyruvate kinase 0.0019 0.0137 0.0137
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0401 0.2048
Giardia lamblia G2/mitotic-specific cyclin B 0.0154 0.1827 1
Trypanosoma brucei cdc2-related kinase 1 0.005 0.0528 0.2758
Schistosoma mansoni pyruvate kinase 0.0019 0.0137 0.0181
Brugia malayi nuclear receptor NHR-88 0.0041 0.0413 0.0925
Mycobacterium ulcerans hypothetical protein 0.0012 0.0054 0.0111
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0047 0.0063
Echinococcus granulosus tachykinin peptides receptor 99D 0.0087 0.099 0.1314
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0047 0.0063
Entamoeba histolytica cyclin, domain containing protein 0.0023 0.0191 0.0877
Schistosoma mansoni hypothetical protein 0.0035 0.034 0.0451
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0413 0.0548
Onchocerca volvulus 0.0087 0.099 0.2042
Echinococcus granulosus tm gpcr rhodopsin 0.0087 0.099 0.1314
Brugia malayi hypothetical protein 0.0023 0.0191 0.0428
Echinococcus granulosus intermediate filament protein 0.0082 0.0925 0.1228
Loa Loa (eye worm) hypothetical protein 0.0061 0.0661 0.0878
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0087 0.099 0.1314
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0413 0.0548
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0041 0.0062
Echinococcus multilocularis cyclin b3 0.0097 0.1111 0.1111
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0183 0.0243
Giardia lamblia Hypothetical protein 0.0023 0.0191 0.0771
Schistosoma mansoni histamine h1 receptor 0.0087 0.099 0.1314
Schistosoma mansoni netrin receptor unc5 0.0016 0.0098 0.0131
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0528 0.2758
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0413 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0191 0.0623
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0141 0.0187
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0363 0.0481
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0401 0.2048
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0054 0.0116
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.1235 0.164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0413 0.0548
Chlamydia trachomatis pyruvate kinase 0.0037 0.0363 0.5
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0016 0.0094 0.0125
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0047 0.0106
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0425 0.2148
Schistosoma mansoni DNA polymerase eta 0.004 0.0401 0.0532
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0023 0.0191 0.0191
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0087 0.099 0.1314
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0614 0.3234
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0023 0.0191 0.0191
Brugia malayi hypothetical protein 0.0019 0.0141 0.0316
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0098 0.0098
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0413 0.0548
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0381 0.1242
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0087 0.099 0.099
Entamoeba histolytica hypothetical protein 0.0035 0.034 0.1706
Schistosoma mansoni Cyclin fold protein 0.0023 0.0191 0.0254
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Leishmania major importin beta-1 subunit, putative 0.0046 0.0478 0.2479
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0363 0.0605
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0478 0.1561
Echinococcus granulosus GPCR family 2 0.0031 0.0286 0.038
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2088 0.6812
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0925 0.2072
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0413 0.0548
Trichomonas vaginalis cyclin B, putative 0.0154 0.1827 0.5961
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0401 0.2048
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0087 0.099 0.099
Plasmodium vivax cyclin homologue, putative 0.0023 0.0191 0.1309
Leishmania major DNA polymerase kappa, putative 0.0012 0.0054 0.0116
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0286 0.0286
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0381 0.1935
Loa Loa (eye worm) hypothetical protein 0.004 0.0401 0.0532
Loa Loa (eye worm) cyclin domain-containing protein 0.0023 0.0191 0.0254
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1235 0.403
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0047 0.0047
Brugia malayi P21-Rho-binding domain containing protein 0.0016 0.0094 0.0211
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0401 0.3014
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0459 0.0609
Echinococcus multilocularis GPCR, family 2 0.0031 0.0286 0.0286
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0425 0.2089
Echinococcus multilocularis neuropeptide receptor 0.0087 0.099 0.099
Brugia malayi Cyclin, N-terminal domain containing protein 0.0154 0.1827 0.4093
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1976 0.6447
Echinococcus multilocularis muscleblind protein 0.0145 0.171 0.171
Echinococcus granulosus g-protein coupled receptor 0.0087 0.099 0.1314
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0363 0.2738
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0023 0.0191 0.0877
Trichomonas vaginalis cyclins, putative 0.0023 0.0191 0.0623
Brugia malayi G protein-coupled receptor 0.0087 0.099 0.2218
Loa Loa (eye worm) hypothetical protein 0.0067 0.0736 0.0977
Schistosoma mansoni amine GPCR 0.0087 0.099 0.1314
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.0226
Trypanosoma cruzi cyclin, putative 0.0154 0.1827 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0363 0.0481
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0054 0.0172
Mycobacterium tuberculosis Conserved protein 0.0107 0.1235 0.1422
Echinococcus multilocularis cyclin B3 1 0.0097 0.1111 0.1111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.099 0.1314
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0401 0.2048
Onchocerca volvulus 0.0082 0.0925 0.1893
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0098 0.0131
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0363 0.18
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0023 0.0191 0.1309
Trichomonas vaginalis cyclins, putative 0.0097 0.1111 0.3624
Echinococcus multilocularis G-protein coupled receptor, putative 0.0087 0.099 0.099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.099 0.1314
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0401 0.2048
Brugia malayi Dopamine receptor protein 2 0.0087 0.099 0.2218
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0401 0.2048
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0141 0.0141
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0381 0.1901
Loa Loa (eye worm) hypothetical protein 0.0041 0.0413 0.0548
Brugia malayi Dopamine receptor protein 1 0.0087 0.099 0.2218
Trichomonas vaginalis cyclin D, putative 0.0023 0.0191 0.0623
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0087 0.099 0.1314
Brugia malayi G protein-coupled receptor F59B2.13 0.0087 0.099 0.2218
Brugia malayi tailless protein 0.0019 0.0141 0.0316
Echinococcus multilocularis cyclins 0.0097 0.1111 0.1111
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0054 0.0074
Brugia malayi hypothetical protein 0.0087 0.099 0.2218
Echinococcus granulosus pyruvate kinase 0.0037 0.0363 0.0481
Schistosoma mansoni cyclin G2 0.0023 0.0191 0.0254
Loa Loa (eye worm) G-protein coupled receptor 0.0087 0.099 0.1314
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0087 0.099 0.1314
Echinococcus granulosus cyclin B 0.0154 0.1827 0.2425
Echinococcus multilocularis neuropeptide s receptor 0.0087 0.099 0.099
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0401 0.3014
Echinococcus multilocularis cyclin G2 0.0023 0.0191 0.0191
Echinococcus granulosus hypothetical protein 0.0087 0.099 0.1314
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0023 0.0191 0.1461
Brugia malayi cytochrome P450 0.0011 0.0041 0.0092
Trichomonas vaginalis cyclin B3, putative 0.0023 0.0191 0.0623
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0413 0.0413
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1124 0.1492
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0425 0.0564
Brugia malayi putative neuropeptide receptor NPR1 0.0087 0.099 0.2218
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0378 0.1233
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0225 0.2715 0.3605
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0528 0.2728
Echinococcus granulosus lamin dm0 0.0082 0.0925 0.1228
Brugia malayi Cyclin, N-terminal domain containing protein 0.0023 0.0191 0.0428
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.1235 1
Onchocerca volvulus 0.0154 0.1827 0.396
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0054 0.0172
Brugia malayi Uncoordinated protein 44 0.0016 0.0098 0.0221
Echinococcus granulosus cyclin t1 0.0023 0.0191 0.0254
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni zinc finger protein 0.0019 0.0141 0.0187
Trichomonas vaginalis cyclin A, putative 0.0154 0.1827 0.5961
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0141 0.0141
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0047 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.099 0.1314
Echinococcus granulosus cyclins 0.0097 0.1111 0.1475
Giardia lamblia Pyruvate kinase 0.0019 0.0137 0.0464
Plasmodium vivax importin-beta 2, putative 0.0057 0.0614 0.4827
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0038 0.0379 0.0379
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0023 0.0183 0.041
Echinococcus multilocularis PAK box P21 Rho binding 0.0016 0.0094 0.0094
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0222 0.0295
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0363 0.1834
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0062 0.0675 0.3552
Echinococcus multilocularis pyruvate kinase 0.0019 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0186
Echinococcus multilocularis neuropeptide FF receptor 2 0.0087 0.099 0.099
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.099 0.1314
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0087 0.099 0.1314
Brugia malayi neuropeptide F receptor 0.0087 0.099 0.2218
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1235 0.164
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0087 0.099 0.1314
Schistosoma mansoni biogenic amine receptor 0.0087 0.099 0.1314
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0087 0.099 0.1314
Echinococcus multilocularis lamin 0.0082 0.0925 0.0925
Schistosoma mansoni neuropeptide receptor 0.0087 0.099 0.1314
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0141 0.0141
Schistosoma mansoni protein kinase 0.0203 0.2442 0.3242
Schistosoma mansoni cyclin B 0.0154 0.1827 0.2425
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0141 0.0141
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0413 0.0925
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0187
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0087 0.099 0.1314
Trichomonas vaginalis cyclins, putative 0.0081 0.0907 0.296
Brugia malayi beta-lactamase 0.0107 0.1235 0.2767
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0413 0.0548
Trichomonas vaginalis cyclin B, putative 0.0154 0.1827 0.5961
Schistosoma mansoni hypothetical protein 0.061 0.7532 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0082 0.0923 0.1225
Toxoplasma gondii hypothetical protein 0.0023 0.0191 0.1309
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0413 0.0413
Entamoeba histolytica protein kinase, putative 0.0017 0.0108 0.0416
Schistosoma mansoni rab6-interacting 0.0019 0.014 0.0186
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni hypothetical protein 0.0023 0.0191 0.0254
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0187
Onchocerca volvulus 0.0087 0.099 0.2042
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.0226
Schistosoma mansoni hypothetical protein 0.0087 0.099 0.1314
Echinococcus granulosus dna polymerase kappa 0.004 0.0401 0.0532
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.3065 0.4069
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0151 0.0917
Loa Loa (eye worm) cytochrome P450 0.0011 0.0041 0.0055
Brugia malayi Cyclin, N-terminal domain containing protein 0.0023 0.0191 0.0428
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0072
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0401 0.0532
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0087 0.099 0.099
Echinococcus granulosus pyruvate kinase 0.0019 0.0137 0.0181
Echinococcus multilocularis lamin dm0 0.0082 0.0925 0.0925
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0023 0.0183 0.0243
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0381 0.1935
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0413 0.0413
Echinococcus multilocularis cyclin t1 0.0023 0.0191 0.0191
Leishmania major DNA damage repair protein, putative 0.0012 0.0054 0.0116
Brugia malayi hypothetical protein 0.0087 0.099 0.2218
Trichomonas vaginalis cyclin B, putative 0.0023 0.0191 0.0623
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0425 0.3631
Echinococcus multilocularis neuropeptide Y receptor 0.0087 0.099 0.099
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0401 0.2048
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0137 0.0857
Brugia malayi neuropeptide F receptor 0.0087 0.099 0.2218
Loa Loa (eye worm) hypothetical protein 0.0107 0.1235 0.164
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0614 0.3234
Loa Loa (eye worm) hypothetical protein 0.0107 0.1235 0.164
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.1235 0.1235
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.014 0.0989
Echinococcus granulosus somatostatin receptor 0.0087 0.099 0.1314
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0528 0.1724
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.3065 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0413 0.0925
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1235 0.6686
Echinococcus granulosus cyclins 0.0097 0.1111 0.1475
Schistosoma mansoni amine GPCR 0.0087 0.099 0.1314
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0413 0.0548
Echinococcus granulosus cyclins 0.0023 0.0191 0.0254
Echinococcus multilocularis neuropeptide receptor A26 0.0087 0.099 0.099
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0141 0.0187
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.1235 0.1422
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0222 0.1051
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Entamoeba histolytica hypothetical protein 0.0035 0.034 0.1706
Brugia malayi steroid hormone receptor 0.0041 0.0413 0.0925
Echinococcus multilocularis pyruvate kinase 0.0037 0.0363 0.0363
Trichomonas vaginalis cyclins, putative 0.0154 0.1827 0.5961
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0087 0.099 0.099
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0087 0.099 0.2218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0087 0.099 0.099
Echinococcus multilocularis cyclin G2 0.0023 0.0191 0.0191
Schistosoma mansoni protein kinase 0.0017 0.0108 0.0144
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0047 0.0063
Brugia malayi hypothetical protein 0.0087 0.099 0.2218
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0413 0.0925
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0151 0.02
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.1235 0.1422
Onchocerca volvulus Protein CNPPD1 homolog 0.0023 0.0191 0.0212
Echinococcus multilocularis cyclin y 0.0023 0.0191 0.0191
Plasmodium falciparum importin beta, putative 0.0057 0.0614 0.5384
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0413 0.0925
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0016 0.0094 0.0094
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0054 0.0116
Loa Loa (eye worm) hypothetical protein 0.0154 0.1827 0.2425
Trypanosoma brucei unspecified product 0.004 0.0401 0.2048
Loa Loa (eye worm) hypothetical protein 0.0202 0.2427 0.3223
Brugia malayi Protein kinase domain 0.0038 0.0379 0.0849
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0614 0.4827
Echinococcus granulosus G protein coupled receptor 139 0.0087 0.099 0.1314
Giardia lamblia Pyruvate kinase 0.0037 0.0363 0.1739
Brugia malayi Cytochrome P450 family protein 0.0011 0.0041 0.0092
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0047 0.0063
Schistosoma mansoni lamin 0.0082 0.0925 0.1228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0295
Brugia malayi Dopamine receptor 0.0087 0.099 0.2218
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0054 0.0072
Echinococcus granulosus allatostatin A receptor 0.0087 0.099 0.1314
Trypanosoma cruzi p21-activated kinase 3, putative 0.0023 0.0183 0.0795
Onchocerca volvulus Huntingtin homolog 0.0365 0.4463 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0187
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0054 0.0074
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.1235 0.1422
Trypanosoma brucei unspecified product 0.0028 0.0245 0.1178
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Brugia malayi hypothetical protein 0.0087 0.099 0.2218
Trichomonas vaginalis hypothetical protein 0.0011 0.0034 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0183 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0245 0.1178
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0023 0.0191 0.0254
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.005 0.0528 0.0701
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0098 0.0131
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0087 0.099 0.2218
Brugia malayi Cytochrome P450 family protein 0.002 0.0151 0.0338
Toxoplasma gondii hypothetical protein 0.0073 0.0818 0.653
Schistosoma mansoni coup transcription factor 0.0041 0.0413 0.0548
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1976 0.6447
Onchocerca volvulus Cyclin L homolog 0.0023 0.0191 0.0212
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1235 0.403
Brugia malayi Death domain containing protein 0.0016 0.0098 0.0221
Echinococcus granulosus rhodopsin orphan GPCR 0.0087 0.099 0.1314
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0041 0.0042
Giardia lamblia Cyclin B-like protein 0.0023 0.0191 0.0771
Schistosoma mansoni protein kinase 0.0016 0.0094 0.0125
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0363 0.0481
Trichomonas vaginalis STE family protein kinase 0.0038 0.0379 0.1236
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0191 0.0623
Echinococcus granulosus cyclin G2 0.0023 0.0191 0.0254
Loa Loa (eye worm) beta-lactamase 0.0107 0.1235 0.164
Brugia malayi Cytochrome P450 family protein 0.002 0.0151 0.0338
Loa Loa (eye worm) hypothetical protein 0.0154 0.1827 0.2425
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0413 0.0548
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0413 0.072
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0141 0.0187
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1976 0.6447
Entamoeba histolytica hypothetical protein 0.0046 0.0478 0.2479
Echinococcus granulosus cyclins 0.0097 0.1111 0.1475
Trichomonas vaginalis cyclin D, putative 0.0097 0.1111 0.3624
Onchocerca volvulus 0.0087 0.099 0.2042
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0041 0.0055
Echinococcus multilocularis G protein coupled receptor 139 0.0087 0.099 0.099
Echinococcus multilocularis fmrfamide receptor 0.0087 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0187
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0187
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.1235 0.1422
Brugia malayi RE15519p 0.0087 0.099 0.2218
Echinococcus multilocularis pyruvate kinase 0.0029 0.0265 0.0265
Onchocerca volvulus 0.0107 0.1235 0.2604
Echinococcus multilocularis cyclin A3 4 0.0023 0.0191 0.0191
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0141 0.0187
Echinococcus granulosus neuropeptide FF receptor 2 0.0087 0.099 0.1314
Loa Loa (eye worm) hypothetical protein 0.0041 0.0413 0.0548
Loa Loa (eye worm) G-protein coupled receptor 0.0087 0.099 0.1314
Schistosoma mansoni hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.017 0.0226
Echinococcus granulosus cyclins 0.0097 0.1111 0.1475
Trichomonas vaginalis STE family protein kinase 0.0017 0.0108 0.0353
Schistosoma mansoni hypothetical protein 0.0019 0.014 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0401 0.2048
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Schistosoma mansoni pyruvate kinase 0.0037 0.0363 0.0481
Schistosoma mansoni amine GPCR 0.0087 0.099 0.1314
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Loa Loa (eye worm) CYL-1 protein 0.0023 0.0191 0.0254
Trypanosoma brucei cyclin 9 0.0023 0.0191 0.0877
Brugia malayi Inositol-1 0.0039 0.0381 0.0853
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0141 0.0187
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0425 0.3255
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0245 0.1178
Loa Loa (eye worm) hypothetical protein 0.0087 0.099 0.1314
Echinococcus granulosus neuropeptide s receptor 0.0087 0.099 0.1314
Echinococcus granulosus dro:myosuppressin receptor 0.0087 0.099 0.1314
Echinococcus granulosus cyclin b3 0.0097 0.1111 0.1475
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0401 0.0532
Leishmania major mitotic cyclin, putative 0.0023 0.0191 0.0877
Brugia malayi Importin beta-1 subunit 0.0057 0.0614 0.1375
Echinococcus granulosus cyclin y 0.0023 0.0191 0.0254
Brugia malayi hypothetical protein 0.0019 0.014 0.0314
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0381 0.2843
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0141 0.0187
Echinococcus granulosus pyruvate kinase 0.0019 0.0137 0.0181
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0141 0.0316
Loa Loa (eye worm) hypothetical protein 0.0023 0.0191 0.0254
Echinococcus granulosus tm gpcr rhodopsin 0.0087 0.099 0.1314
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0191 0.0623
Echinococcus multilocularis cyclins 0.0097 0.1111 0.1111
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0016 0.0094 0.0125
Echinococcus granulosus neuropeptide Y receptor 0.0087 0.099 0.1314
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.005 0.0528 0.0701
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.0226
Echinococcus multilocularis neuropeptides capa receptor 0.0087 0.099 0.099
Brugia malayi kap beta 3 protein 0.0011 0.0034 0.0076
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0412 0.0547
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0425 0.0952
Brugia malayi nuclear hormone receptor 0.0041 0.0413 0.0925
Echinococcus multilocularis dna polymerase kappa 0.004 0.0401 0.0401
Onchocerca volvulus 0.0087 0.099 0.2042
Trichomonas vaginalis cyclins, putative 0.0154 0.1827 0.5961
Schistosoma mansoni neuropeptide F-like receptor 0.0087 0.099 0.1314
Schistosoma mansoni hypothetical protein 0.0031 0.0286 0.038
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0098 0.0131
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0363 0.2692
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0054 0.0074

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.47 umol/L Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay ChEMBL. 25086238

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 25086238

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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