Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | leucine-rich repeat kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | TKL/LRRK protein kinase | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ras-related protein Rab-5A | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1497 | 0.1497 |
Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.1497 | 0.1497 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1497 | 0.1497 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0132 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.1497 | 0.1497 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0.1497 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.1497 | 0.1497 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0022 | 0.1497 | 1 |
Echinococcus multilocularis | neuroligin | 0.0022 | 0.1497 | 0.1497 |
Onchocerca volvulus | 0.0022 | 0.1497 | 1 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0022 | 0.1497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1497 | 0.1497 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0132 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0022 | 0.1497 | 0.1497 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0022 | 0.1497 | 0.1497 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0132 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0022 | 0.1497 | 0.1497 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.1497 | 0.1497 |
Trypanosoma cruzi | Rab-like 5, small G protein | 0.0003 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0003 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0022 | 0.1497 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0022 | 0.1497 | 0.1497 |
Trypanosoma brucei | Rab-like 5, small G protein | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1497 | 0.1497 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1497 | 0.1497 |
Schistosoma mansoni | gliotactin | 0.0022 | 0.1497 | 0.1497 |
Onchocerca volvulus | 0.0022 | 0.1497 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.007 | 0.5206 | 0.5206 |
Onchocerca volvulus | 0.0022 | 0.1497 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.1497 | 0.1497 |
Leishmania major | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.1497 | 0.1497 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0022 | 0.1497 | 0.1497 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0022 | 0.1497 | 0.1497 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1497 | 0.1497 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0071 | 0.5243 | 0.5243 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1497 | 0.1497 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0022 | 0.1497 | 0.1497 |
Plasmodium vivax | ras-related protein Rab-5A, putative | 0.0003 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0022 | 0.1497 | 0.1497 |
Brugia malayi | hypothetical protein | 0.0022 | 0.1497 | 0.1497 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0.1497 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.1497 | 0.1497 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0022 | 0.1497 | 0.1497 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0022 | 0.1497 | 0.1497 |
Entamoeba histolytica | hypothetical protein | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.007 | 0.5206 | 0.5206 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 0.1497 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.007 | 0.5206 | 0.5206 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 0.1497 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.1497 | 0.1497 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0022 | 0.1497 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.1497 | 0.1497 |
Leishmania major | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 116 ml/min.kg | Clearance in human liver microsomes | ChEMBL. | 25113930 |
IC50 (binding) | = 224 nM | Inhibition of GST-tagged truncated LRRK2 (unknown origin) using fluorescein-labeled peptide LRRKtide as substrate by LANTHA screen assay in presence of 1 mM ATP | ChEMBL. | 25113930 |
IC50 (binding) | = 2760 nM | Inhibition of phosphorylation at S935 residue of wild-type full-length LRRK2 kinase (unknown origin) expressed in HEK 293 cells after 90 mins by ELISA | ChEMBL. | 25113930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.