Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.009 | 0.1924 | 0.262 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0261 | 0.7341 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0036 | 0.0224 | 0.0305 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0261 | 0.7341 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0261 | 0.7341 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0036 | 0.0224 | 0.0305 |
Schistosoma mansoni | tar DNA-binding protein | 0.0214 | 0.5866 | 0.7928 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0261 | 0.7341 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0171 | 0.4493 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.3492 | 0.3492 |
Onchocerca volvulus | 0.0345 | 1 | 0.5 | |
Brugia malayi | isocitrate dehydrogenase | 0.0036 | 0.0224 | 0.0224 |
Schistosoma mansoni | hypothetical protein | 0.0231 | 0.6396 | 0.8673 |
Loa Loa (eye worm) | RNA binding protein | 0.0214 | 0.5866 | 0.5866 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0036 | 0.0224 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0214 | 0.5866 | 0.7928 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.7341 | 0.7341 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0036 | 0.0224 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.2464 | 0.3148 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0261 | 0.7341 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0338 | 0.9784 | 0.9784 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0338 | 0.9784 | 0.9784 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0261 | 0.7341 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0261 | 0.7341 | 1 |
Brugia malayi | RNA binding protein | 0.0214 | 0.5866 | 0.5866 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0107 | 0.2464 | 0.3148 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.009 | 0.1924 | 0.262 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0261 | 0.7341 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0107 | 0.2464 | 0.3148 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0036 | 0.0224 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0036 | 0.0224 | 0.0224 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0231 | 0.6396 | 0.6396 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0036 | 0.0224 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2464 | 0.2464 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0107 | 0.2464 | 0.2464 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0107 | 0.2464 | 0.3148 |
Schistosoma mansoni | tar DNA-binding protein | 0.0214 | 0.5866 | 0.7928 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0261 | 0.7341 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0107 | 0.2464 | 0.3148 |
Echinococcus granulosus | tar DNA binding protein | 0.0214 | 0.5866 | 0.7928 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0171 | 0.4493 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0214 | 0.5866 | 0.7928 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.2464 | 0.3148 |
Brugia malayi | Isocitrate dehydrogenase | 0.0036 | 0.0224 | 0.0224 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0261 | 0.7341 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0214 | 0.5866 | 0.5866 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0261 | 0.7341 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0214 | 0.5866 | 0.5866 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0171 | 0.4493 | 0.5999 |
Echinococcus multilocularis | GPCR, family 2 | 0.0107 | 0.2464 | 0.3148 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0036 | 0.0224 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.6396 | 0.6396 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0107 | 0.2464 | 0.3148 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0171 | 0.4493 | 0.4744 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0107 | 0.2464 | 0.2464 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0338 | 0.9784 | 0.9784 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0036 | 0.0224 | 0.0305 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.009 | 0.1924 | 0.262 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.3492 | 0.3492 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.2464 | 0.3148 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.2464 | 0.3148 |
Schistosoma mansoni | tar DNA-binding protein | 0.0214 | 0.5866 | 0.7928 |
Brugia malayi | Probable ClpP-like protease | 0.0261 | 0.7341 | 0.7341 |
Brugia malayi | TAR-binding protein | 0.0214 | 0.5866 | 0.5866 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0261 | 0.7341 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0261 | 0.7341 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0036 | 0.0224 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0214 | 0.5866 | 0.5866 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0107 | 0.2464 | 0.2464 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.3492 | 0.3492 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0171 | 0.4493 | 0.5999 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.9784 | 0.9784 |
Echinococcus multilocularis | tar DNA binding protein | 0.0214 | 0.5866 | 0.7928 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0261 | 0.7341 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.