Detailed information for compound 925643

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 283.285 | Formula: C14H13N5O2
  • H donors: 1 H acceptors: 4 LogP: 1.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cn2c(c1)c(ncn2)Nc1ccncc1
  • InChi: 1S/C14H13N5O2/c1-2-21-14(20)10-7-12-13(16-9-17-19(12)8-10)18-11-3-5-15-6-4-11/h3-9H,2H2,1H3,(H,15,16,17,18)
  • InChiKey: XCBIDOKUYQPEQW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Mitogen-activated protein kinase kinase kinase kinase 4, putative Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus multilocularis Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Loa Loa (eye worm) STE/STE20/MSN protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing Get druggable targets OG5_128641 All targets in OG5_128641
Brugia malayi probable protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus serine:threonine protein kinase mig 15 Get druggable targets OG5_128641 All targets in OG5_128641
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0005 0.0003 0.0048
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0031 0.0112 0.1667
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0003 0.0048
Brugia malayi steroid hormone receptor 0.0005 0.0003 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0005 0.0003 0.0048
Brugia malayi hypothetical protein 0.0069 0.0273 0.4069
Brugia malayi Isocitrate dehydrogenase 0.0004 0.0001 0.0018
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0007 0.0011 0.0171
Schistosoma mansoni protein kinase 0.0073 0.0285 0.4257
Plasmodium vivax basic transcription factor 3b, putative 0.0009 0.0022 0.1108
Schistosoma mansoni hypothetical protein 0.0009 0.0023 0.0337
Brugia malayi Temporarily assigned gene name protein 59 0.003 0.011 0.1644
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0009 0.0023 0.0337
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0112 0.1667
Onchocerca volvulus 0.0069 0.0273 1
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.003 0.011 0.5946
Echinococcus multilocularis DNA directed RNA polymerase II subunit RPB2 0.0007 0.0011 0.0171
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0031 0.0112 0.1667
Loa Loa (eye worm) isocitrate dehydrogenase 0.0004 0.0001 0.0018
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0004 0.0001 0.0018
Trypanosoma cruzi transcription factor btf3, putative 0.0009 0.0022 0.1108
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0005 0.0003 0.0048
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0005 0.0003 0.0048
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbC 0.2416 1 1
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.003 0.011 0.1644
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0048 0.0184 0.2752
Trypanosoma cruzi DNA-directed RNA polymerase II subunit 2, putative 0.0004 0.0002 0.0059
Schistosoma mansoni protein kinase 0.0103 0.0411 0.6133
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0004 0.0001 0.0018
Brugia malayi hypothetical protein 0.0009 0.0023 0.0337
Echinococcus multilocularis 0.0073 0.0285 0.4257
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0112 0.1667
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.2416 1 1
Echinococcus granulosus insulin receptor 0.0053 0.0203 0.3038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0005 0.0003 0.0048
Echinococcus multilocularis epidermal growth factor receptor 0.0089 0.0353 0.5266
Brugia malayi probable protein kinase 0.0103 0.0411 0.6133
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0005 0.0003 0.0048
Entamoeba histolytica hypothetical protein 0.0009 0.0023 0.0645
Plasmodium falciparum DNA-directed RNA polymerase I subunit RPA2, putative 0.0005 0.0004 0.0143
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0048 0.0184 1
Echinococcus multilocularis epidermal growth factor receptor 0.0165 0.067 1
Schistosoma mansoni transcription factor btf3 0.0009 0.0022 0.0321
Plasmodium falciparum DNA-directed RNA polymerase III subunit RPC2, putative 0.0007 0.0011 0.0558
Schistosoma mansoni tyrosine kinase 0.0089 0.0353 0.5266
Echinococcus granulosus DNA directed RNA polymerase III subunit RPC2 0.0007 0.0011 0.0171
Echinococcus multilocularis FTZ F1 alpha 0.0005 0.0003 0.0048
Trypanosoma cruzi RNA polymerase I second largest subunit, putative 0.0005 0.0004 0.0143
Loa Loa (eye worm) hypothetical protein 0.0038 0.0143 0.213
Trypanosoma cruzi transcription factor btf3, putative 0.0009 0.0022 0.1108
Schistosoma mansoni hypothetical protein 0.0043 0.0164 0.2447
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0004 0.0001 0.0018
Brugia malayi Protein kinase domain containing protein 0.0053 0.0203 0.3038
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0005 0.0003 0.0048
Onchocerca volvulus 0.003 0.011 0.3968
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0126 0.0507 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0005 0.0003 0.0048
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0048 0.0184 1
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0007 0.0011 0.0171
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0005 0.0003 0.0048
Loa Loa (eye worm) DNA-directed RNA polymerase 0.0005 0.0007 0.0099
Loa Loa (eye worm) follicle stimulating hormone receptor 0.006 0.0232 0.3467
Loa Loa (eye worm) transcription factor SMAD2 0.0055 0.0212 0.3166
Plasmodium falciparum DNA-directed RNA polymerase II subunit RPB2, putative 0.0007 0.0011 0.0558
Loa Loa (eye worm) steroid hormone receptor 0.0005 0.0003 0.0048
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0048 0.0184 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0053 0.0203 0.3038
Schistosoma mansoni DNA-directed rna polymerase II subunit 0.0007 0.0011 0.0171
Echinococcus granulosus transcription factor btf3 0.0009 0.0022 0.0321
Schistosoma mansoni hypothetical protein 0.003 0.011 0.1644
Trypanosoma cruzi DNA-directed RNA polymerase III, putative 0.0007 0.0011 0.0558
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.1461 0.604 0.604
Trypanosoma brucei RNA polymerase I second largest subunit 0.0005 0.0004 0.0143
Schistosoma mansoni tyrosine kinase 0.0088 0.0349 0.5208
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0089 0.0353 0.5266
Echinococcus multilocularis ecdysone induced protein 78C 0.0005 0.0003 0.0048
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0048 0.0184 1
Entamoeba histolytica hypothetical protein 0.0009 0.0023 0.0645
Echinococcus multilocularis neuropeptide s receptor 0.0119 0.0476 0.7104
Schistosoma mansoni tyrosine kinase 0.0088 0.0349 0.5208
Schistosoma mansoni RAR-like nuclear receptor 0.0005 0.0003 0.0048
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0048 0.0184 1
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) 0.2416 1 1
Echinococcus granulosus FTZ F1 alpha 0.0005 0.0003 0.0048
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0005 0.0003 0.0048
Loa Loa (eye worm) DNA-directed RNA polymerase II second largest subunit 0.0007 0.0011 0.0171
Schistosoma mansoni retinoic acid receptor RXR 0.0005 0.0003 0.0048
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0048
Echinococcus multilocularis DNA directed RNA polymerase III subunit RPC2 0.0007 0.0011 0.0171
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbB 0.2416 1 1
Toxoplasma gondii DNA-directed RNA polymerase III RPC2 0.0007 0.0011 0.0558
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0048 0.0184 1
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0048 0.0184 0.2752
Brugia malayi isocitrate dehydrogenase 0.0004 0.0001 0.0018
Loa Loa (eye worm) TK/EGFR protein kinase 0.0165 0.067 1
Echinococcus multilocularis transcription factor btf3 0.0009 0.0022 0.0321
Leishmania major RNA polymerase I second largest subunit, putative 0.0005 0.0004 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0005 0.0003 0.0048
Schistosoma mansoni tyrosine kinase 0.0053 0.0203 0.3038
Brugia malayi hypothetical protein 0.003 0.011 0.1644
Echinococcus multilocularis DNA directed RNA polymerase I subunit RPA2 0.0007 0.0011 0.0171
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.1644
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0053 0.0203 0.3038
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0048
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0048 0.0184 0.2752
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.1644
Echinococcus granulosus neuropeptide s receptor 0.0119 0.0476 0.7104
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0005 0.0003 0.0048
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0031 0.0112 0.1667
Mycobacterium tuberculosis Conserved hypothetical protein 0.0048 0.0184 0.0183
Echinococcus multilocularis muscleblind protein 1 0.0038 0.0143 0.213
Brugia malayi DNA-directed RNA polymerase II second largest subunit, putative 0.0007 0.0011 0.0171
Loa Loa (eye worm) hypothetical protein 0.0102 0.0409 0.611
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.003 0.011 0.1644
Entamoeba histolytica hypothetical protein 0.0009 0.0022 0.0582
Entamoeba histolytica transcription factor BTF3, putative 0.0009 0.0022 0.0582
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0005 0.0003 0.0048
Loa Loa (eye worm) MH2 domain-containing protein 0.0055 0.0212 0.3166
Brugia malayi Muscleblind-like protein 0.0038 0.0143 0.213
Echinococcus granulosus protein kinase 0.0073 0.0285 0.4257
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0009 0.0023 0.0337
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0126 0.0507 0.0329
Schistosoma mansoni rap gtpase-activating protein 0.003 0.011 0.1644
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0048
Loa Loa (eye worm) RNA polymerase III 128kD subunit-PA 0.0007 0.0011 0.0171
Echinococcus multilocularis 0.0051 0.0197 0.2935
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0003 0.0048
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0005 0.0003 0.0048
Toxoplasma gondii NAC domain-containing protein 0.0009 0.0022 0.1108
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0034 0.0127 0.6843
Toxoplasma gondii DNA-directed RNA polymerase II RPB2 0.0007 0.0011 0.0558
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0048 0.0184 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0005 0.0003 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0022 0.0582
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0005 0.0003 0.0048
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.1461 0.604 0.5966
Echinococcus granulosus epidermal growth factor receptor 0.0165 0.067 1
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0073 0.0285 0.4257
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0031 0.0112 0.0111
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0031 0.0112 0.1667
Schistosoma mansoni thyroid hormone receptor 0.0005 0.0003 0.0048
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0053 0.0203 0.3038
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.2416 1 1
Entamoeba histolytica hypothetical protein 0.0009 0.0023 0.0645
Leishmania major basic transcription factor 3a, putative 0.0009 0.0022 0.1108
Brugia malayi photoreceptor-specific nuclear receptor 0.0005 0.0003 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0022 0.0582
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0003 0.0048
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.2416 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0005 0.0003 0.0048
Entamoeba histolytica hypothetical protein 0.0009 0.0023 0.0645
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0031 0.0112 0.1667
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0005 0.0003 0.0048
Plasmodium vivax DNA-directed RNA polymerase III subunit, putative 0.0007 0.0011 0.0558
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0005 0.0003 0.0048
Brugia malayi Protein kinase domain containing protein 0.0031 0.0112 0.1667
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0048
Giardia lamblia DNA-directed RNA polymerase RPB2 0.0007 0.0011 0.0421
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0003 0.0048
Echinococcus granulosus Vam6:Vps39 protein 0.003 0.011 0.1644
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0005 0.0003 0.0048
Trypanosoma brucei transcription factor BTF3, putative 0.0009 0.0022 0.1108
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0126 0.0507 0.0329
Brugia malayi ecdysteroid receptor 0.0005 0.0003 0.0048
Echinococcus multilocularis neuropeptide receptor A26 0.0119 0.0476 0.7104
Brugia malayi DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide 0.0007 0.0011 0.0171
Echinococcus multilocularis muscleblind protein 0.0038 0.0143 0.213
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0004 0.0001 0.0018
Schistosoma mansoni protein kinase 0.0031 0.0112 0.1667
Echinococcus multilocularis thyroid hormone receptor alpha 0.0005 0.0003 0.0048
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.1644
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0048 0.0184 1
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbA 0.2416 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0119 0.0476 0.7104
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0102 0.0409 0.611
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0005 0.0003 0.0048
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.003 0.011 0.1644
Brugia malayi Furin-like cysteine rich region family protein 0.0165 0.067 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0005 0.0003 0.0048
Schistosoma mansoni coup transcription factor 0.0005 0.0003 0.0048
Loa Loa (eye worm) hypothetical protein 0.0069 0.0273 0.4069
Trypanosoma brucei DNA-directed RNA polymerase II subunit 2, putative 0.0007 0.0011 0.0558
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0003 0.0048
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0048
Echinococcus multilocularis insulin receptor 0.0053 0.0203 0.3038
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0005 0.0003 0.0048
Toxoplasma gondii DNA-directed RNA polymerase I RPA2 0.0005 0.0004 0.0143
Giardia lamblia DNA-directed RNA polymerase subunit B 0.0007 0.0011 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0005 0.0003 0.0048
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0048 0.0184 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0005 0.0003 0.0048
Schistosoma mansoni DNA-directed RNA polymerase I subunit 0.0005 0.0004 0.0057
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0126 0.0507 0.5
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.1461 0.604 0.5966
Brugia malayi Steroid receptor seven-up type 2 0.0005 0.0003 0.0048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0005 0.0003 0.0048
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0004 0.0001 0.0018
Echinococcus multilocularis isocitrate dehydrogenase 0.0004 0.0001 0.0018
Brugia malayi MH2 domain containing protein 0.0055 0.0212 0.3166
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0048 0.0184 1
Plasmodium vivax DNA-directed RNA polymerase II subunit RPB2, putative 0.0007 0.0011 0.0558
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0022 0.0582
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0005 0.0003 0.0048
Schistosoma mansoni tyrosine kinase 0.0089 0.0353 0.5266
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.003 0.011 0.5946
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0048 0.0184 0.2752
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0031 0.0112 0.1667
Schistosoma mansoni vam6/vps39 related 0.003 0.011 0.1644
Echinococcus granulosus muscleblind protein 0.0038 0.0143 0.213
Echinococcus multilocularis geminin 0.0043 0.0164 0.2447
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.003 0.011 0.5946
Schistosoma mansoni thyroid hormone receptor 0.0005 0.0003 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0005 0.0003 0.0048
Echinococcus granulosus DNA directed RNA polymerase II subunit RPB2 0.0007 0.0011 0.0171
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0126 0.0507 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0005 0.0003 0.0048
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0048 0.0184 0.2752
Echinococcus granulosus geminin 0.0043 0.0164 0.2447
Schistosoma mansoni transcription factor LCR-F1 0.0009 0.0023 0.0337
Trypanosoma brucei DNA-directed RNA polymerase III, putative 0.0007 0.0011 0.0558
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0005 0.0003 0.0048
Brugia malayi nuclear hormone receptor 0.0005 0.0003 0.0048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0004 0.0001 0.0018
Echinococcus granulosus epidermal growth factor receptor 0.0089 0.0353 0.5266
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0031 0.0112 0.1667
Brugia malayi DNA-directed RNA polymerase, beta subunit family protein 0.0007 0.0011 0.0171
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0003 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0005 0.0003 0.0048
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0048 0.0184 1
Schistosoma mansoni tyrosine kinase 0.0088 0.0349 0.5208
Schistosoma mansoni hypothetical protein 0.0043 0.0164 0.2447
Echinococcus granulosus DNA directed RNA polymerase I subunit RPA2 0.0007 0.0011 0.0171
Plasmodium falciparum basic transcription factor 3b, putative 0.0009 0.0022 0.1108
Leishmania major DNA-directed RNA polymerase polypeptide, putative 0.0007 0.0011 0.0558
Schistosoma mansoni steroid hormone receptor ad4bp 0.0005 0.0003 0.0048
Loa Loa (eye worm) ICD-1 protein 0.0009 0.0022 0.0321
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0005 0.0003 0.0048
Brugia malayi beta-NAC-like protein 0.0009 0.0022 0.0321
Brugia malayi follicle stimulating hormone receptor 0.006 0.0232 0.3467
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0005 0.0003 0.0048
Loa Loa (eye worm) hypothetical protein 0.0038 0.0143 0.213
Brugia malayi nuclear receptor NHR-88 0.0005 0.0003 0.0048
Schistosoma mansoni tyrosine kinase 0.0053 0.0203 0.3038
Schistosoma mansoni tyrosine kinase 0.0165 0.067 1
Plasmodium vivax DNA-directed RNA polymerase I subunit RPA2, putative 0.0005 0.0004 0.0143
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0003 0.0048
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.003 0.011 0.1644
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0005 0.0003 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0005 0.0003 0.0048
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.2416 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.07 uM Inhibition of human MAP4K4 using LGRDKYKTLRQIRQ-COOH peptide substrate by LC3K assay ChEMBL. 25139565

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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