Detailed information for compound 925649

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 245.32 | Formula: C14H19N3O
  • H donors: 1 H acceptors: 2 LogP: 2.68 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCn1c(NC(=O)C)nc2c1cccc2
  • InChi: 1S/C14H19N3O/c1-3-4-7-10-17-13-9-6-5-8-12(13)16-14(17)15-11(2)18/h5-6,8-9H,3-4,7,10H2,1-2H3,(H,15,16,18)
  • InChiKey: YGRZQFQJNVKVOL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nucleotide-binding oligomerization domain containing 1 Starlite/ChEMBL References
Homo sapiens nucleotide-binding oligomerization domain containing 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.2768 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0033 0.0267
Schistosoma mansoni hypothetical protein 0.005 0.0153 0.1219
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0028 0.1599
Entamoeba histolytica deoxycytidyl transferase, putative 0.001 0.0009 0.0507
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0033 0.0184
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0008 0.0004 0.0203
Brugia malayi nuclear hormone receptor family member nhr-6 0.0008 0.0001 0.0044
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0033 0.0267
Loa Loa (eye worm) hypothetical protein 0.0044 0.0131 0.3841
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0055 0.0173 0.5061
Giardia lamblia DINP protein human, muc B family 0.001 0.0009 0.0507
Mycobacterium tuberculosis Probable dehydrogenase 0.0099 0.0333 0.0324
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0052 0.0163 0.1301
Brugia malayi ecdysteroid receptor 0.0017 0.0033 0.0976
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0033 0.0976
Loa Loa (eye worm) nuclear hormone receptor 0.0008 0.0001 0.0044
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0028 0.1599
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0144
Echinococcus multilocularis caspase 2 0.0075 0.0243 0.1345
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0028 0.1599
Trichomonas vaginalis alpha-glucosidase, putative 0.0008 0.0004 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0009 0.0507
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0012 0.0016 0.0945
Mycobacterium tuberculosis Probable oxidoreductase 0.011 0.0373 0.0364
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0035 0.0101 0.0092
Plasmodium vivax basic transcription factor 3b, putative 0.001 0.001 0.0582
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0055 0.0173 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0012 0.0016 0.0945
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0019 0.0041 0.0033
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0008 0.0004 0.0203
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0044
Trypanosoma cruzi DNA polymerase eta, putative 0.0016 0.0031 0.181
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.1211
Trichomonas vaginalis alpha-glucosidase, putative 0.0008 0.0004 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.001 0.001 0.0582
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0033 0.0976
Trichomonas vaginalis conserved hypothetical protein 0.001 0.001 0.0582
Leishmania major alpha glucosidase II subunit, putative 0.0023 0.0055 0.3172
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0055 0.0173 0.1383
Echinococcus granulosus beta LACTamase domain containing family member 0.0019 0.0041 0.0331
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0033 0.0267
Mycobacterium ulcerans hypothetical protein 0.0019 0.0041 0.0033
Brugia malayi orphan nuclear receptor NR2E1 0.0008 0.0001 0.0044
Brugia malayi tailless protein 0.0008 0.0001 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0055 0.3172
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0052 0.0163 0.09
Toxoplasma gondii thioredoxin reductase 0.0044 0.0131 0.7553
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0012 0.0016 0.0945
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.1599
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0131 0.3822
Trichomonas vaginalis alpha-glucosidase, putative 0.0008 0.0004 0.0203
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0033 0.0976
Echinococcus multilocularis lysosomal alpha glucosidase 0.0102 0.0342 0.189
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0099 0.0333 0.0324
Schistosoma mansoni alpha glucosidase 0.0023 0.0055 0.0439
Brugia malayi steroid hormone receptor 0.0017 0.0033 0.0976
Schistosoma mansoni transcription factor btf3 0.001 0.001 0.0081
Echinococcus granulosus dna polymerase eta 0.0023 0.0056 0.0447
Loa Loa (eye worm) hypothetical protein 0.0075 0.0243 0.7115
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.1599
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0041 0.2394
Entamoeba histolytica hypothetical protein 0.0011 0.0011 0.0645
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0019 0.0041 0.1211
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0008 0.0001 0.0012
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.2768 1 1
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0144 0.0496 0.0488
Echinococcus granulosus dna polymerase kappa 0.001 0.0009 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0033 0.0267
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0075 0.0243 0.7115
Schistosoma mansoni coup transcription factor 0.0017 0.0033 0.0267
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0044
Brugia malayi nuclear receptor RXR 0.0009 0.0005 0.0144
Echinococcus granulosus geminin 0.005 0.0153 0.1219
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0033 0.0267
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0041 0.2394
Trypanosoma cruzi DNA polymerase kappa, putative 0.001 0.0009 0.0507
Trichomonas vaginalis alpha-glucosidase, putative 0.0008 0.0004 0.0203
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0131 0.7553
Mycobacterium ulcerans beta-lactamase 0.0019 0.0041 0.0033
Schistosoma mansoni microtubule-associated protein tau 0.0353 0.1252 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0023 0.0055 0.0303
Brugia malayi Glycosyl hydrolases family 31 protein 0.0023 0.0055 0.1605
Trypanosoma cruzi transcription factor btf3, putative 0.001 0.001 0.0582
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0976
Trypanosoma cruzi DNA polymerase kappa, putative 0.001 0.0009 0.0507
Echinococcus granulosus L aminoadipate semialdehyde 0.0043 0.0127 0.1015
Echinococcus granulosus apoptotic protease activating factor 1 0.0075 0.0243 0.1944
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0033 0.0267
Entamoeba histolytica hypothetical protein 0.0011 0.0011 0.0645
Trichomonas vaginalis maltase-glucoamylase, putative 0.0008 0.0004 0.0203
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0033 0.1319
Onchocerca volvulus 0.0017 0.0033 0.1319
Echinococcus multilocularis apoptotic protease activating factor 1 0.0075 0.0243 0.1345
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0009 0.0507
Trypanosoma brucei DNA polymerase IV, putative 0.001 0.0009 0.0507
Brugia malayi nuclear receptor NHR-88 0.0017 0.0033 0.0976
Echinococcus multilocularis neuropeptide receptor A26 0.0136 0.0465 0.2569
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0013 0.0385
Trichomonas vaginalis D-aminoacylase, putative 0.0019 0.0041 0.2394
Mycobacterium tuberculosis Probable lipase LipE 0.0019 0.0041 0.0033
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.1674 0.6036 0.6029
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0055 0.0173 1
Schistosoma mansoni hypothetical protein 0.0059 0.0187 0.1491
Trichomonas vaginalis conserved hypothetical protein 0.001 0.001 0.0582
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0033 0.0267
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0008 0.0001 0.0008
Brugia malayi hypothetical protein 0.0009 0.0005 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0055 0.3172
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0052 0.0163 0.1301
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0033 0.0976
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0011 0.0011 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.0019 0.0041 0.2394
Echinococcus granulosus lysosomal alpha glucosidase 0.0102 0.0342 0.2732
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.0001 0.0008
Echinococcus multilocularis L aminoadipate semialdehyde 0.0043 0.0127 0.0702
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0019 0.0041 0.0331
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0033 0.0976
Mycobacterium tuberculosis Probable esterase LipL 0.0019 0.0041 0.0033
Leishmania major DNA polymerase kappa, putative 0.001 0.0009 0.0507
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0121 0.041 0.0402
Brugia malayi nuclear hormone receptor family member odr-7 0.0008 0.0001 0.0044
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0028 0.0221
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0033 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0033 0.0976
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0055 0.0173 0.1383
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.001 0.0009 0.007
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0028 0.1599
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 0.0055 0.0173 0.0157
Schistosoma mansoni terminal deoxycytidyl transferase 0.001 0.0009 0.007
Trichomonas vaginalis alpha-glucosidase, putative 0.0023 0.0055 0.3172
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0044
Schistosoma mansoni nuclear receptor 0.0008 0.0001 0.0012
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0028 0.0236
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0019 0.0041 0.0331
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0131 0.7553
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0033 0.0267
Schistosoma mansoni transcription factor LCR-F1 0.0011 0.0011 0.0089
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0028 0.0153
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0033 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0033 0.0976
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.1599
Trypanosoma cruzi DNA polymerase kappa, putative 0.001 0.0009 0.0507
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0044
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0008 0.0004 0.0203
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0144 0.0496 1
Mycobacterium tuberculosis Conserved protein 0.0019 0.0041 0.0033
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0132 0.0728
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0043 0.0127 0.3716
Schistosoma mansoni nuclear receptor 0.0008 0.0001 0.0012
Schistosoma mansoni zinc finger protein 0.0008 0.0001 0.0012
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0056 0.3234
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.011 0.0373 0.0357
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0144 0.0496 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0028 0.1599
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0033 0.0267
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.2768 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0033 0.0976
Onchocerca volvulus 0.0043 0.0127 0.5193
Toxoplasma gondii ABC1 family protein 0.0019 0.0041 0.2394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0033 0.0976
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0012 0.0016 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0144
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.001 0.0009 0.0257
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0056 0.3234
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0001 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0033 0.0976
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0028 0.1599
Echinococcus multilocularis beta LACTamase domain containing family member 0.0019 0.0041 0.0229
Brugia malayi Thioredoxin reductase 0.0044 0.0131 0.3822
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0028 0.0019
Brugia malayi nuclear receptor NHR-88 0.0008 0.0001 0.0044
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0028 0.1599
Trichomonas vaginalis maltase-glucoamylase, putative 0.0023 0.0055 0.3172
Mycobacterium tuberculosis Probable lipase LipD 0.0019 0.0041 0.0033
Schistosoma mansoni DNA polymerase eta 0.0023 0.0056 0.0447
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0055 0.0173 0.0956
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbB 0.2768 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0976
Onchocerca volvulus 0.0019 0.0041 0.1651
Echinococcus granulosus caspase 2 0.0075 0.0243 0.1944
Echinococcus granulosus microtubule associated protein 2 0.0353 0.1252 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0028 0.0221
Trypanosoma cruzi DNA polymerase kappa, putative 0.001 0.0009 0.0507
Plasmodium falciparum glutathione reductase 0.0015 0.0028 0.1599
Mycobacterium tuberculosis Probable hydrolase 0.0019 0.0041 0.0033
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0019 0.0041 0.1211
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0173 0.0164
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.1211
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0044
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.1674 0.6036 0.6032
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.011 0.0373 0.0364
Echinococcus granulosus nuclear receptor nhr 48 0.0008 0.0001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0976
Trichomonas vaginalis sucrase-isomaltase, putative 0.0023 0.0055 0.3172
Echinococcus multilocularis neuropeptide s receptor 0.0136 0.0465 0.2569
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.0005 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0033 0.0976
Trichomonas vaginalis penicillin-binding protein, putative 0.0019 0.0041 0.2394
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0056 0.1637
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0008 0.0001 0.0044
Brugia malayi conserved hypotetical protein 0.0008 0.0001 0.0044
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0044
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0028 0.0019
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0008 0.0004 0.0203
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0131 0.0122
Echinococcus multilocularis geminin 0.005 0.0153 0.0844
Echinococcus multilocularis muscleblind protein 1 0.0044 0.0131 0.0726
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0028 0.1599
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0028 0.1599
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.011 0.0373 0.0364
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0011 0.0011 0.0062
Brugia malayi Melibiase family protein 0.0035 0.01 0.2912
Onchocerca volvulus 0.0025 0.0065 0.2612
Schistosoma mansoni cellular tumor antigen P53 0.0025 0.0065 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0033 0.0976
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0052 0.0163 0.09
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0052 0.0163 0.1301
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0055 0.0173 1
Brugia malayi nuclear hormone receptor 0.0017 0.0033 0.0976
Schistosoma mansoni hypothetical protein 0.0011 0.0011 0.0089
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0055 0.0173 1
Echinococcus multilocularis transcription factor btf3 0.001 0.001 0.0056
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0033 0.0267
Brugia malayi Glycosyl hydrolases family 31 protein 0.0102 0.0342 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0035 0.01 0.0796
Echinococcus multilocularis lysosomal alpha glucosidase 0.0102 0.0342 0.189
Brugia malayi hypothetical protein 0.0008 0.0001 0.0044
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0033 0.0184
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0033 0.0184
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0132 0.1052
Entamoeba histolytica hypothetical protein 0.001 0.001 0.0582
Trichomonas vaginalis D-aminoacylase, putative 0.0019 0.0041 0.2394
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0041 0.2394
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0055 0.0173 1
Leishmania major DNA polymerase eta, putative 0.0023 0.0056 0.3234
Brugia malayi beta-lactamase family protein 0.0019 0.0041 0.1211
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbA 0.2768 1 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0012 0.0016 0.0945
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0005 0.0039
Leishmania major glycosyl hydrolase-like protein 0.0008 0.0004 0.0203
Loa Loa (eye worm) DR-78 0.0008 0.0001 0.0044
Loa Loa (eye worm) glutathione reductase 0.0044 0.0131 0.3822
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.1211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.1211
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0028 0.1599
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0005 0.0039
Brugia malayi beta-lactamase 0.0019 0.0041 0.1211
Mycobacterium tuberculosis Conserved protein 0.0019 0.0041 0.0033
Schistosoma mansoni alpha-glucosidase 0.0088 0.0291 0.2322
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.1674 0.6036 0.6032
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0033 0.0976
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0144
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0033 0.0267
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0033 0.0267
Trichomonas vaginalis DNA polymerase eta, putative 0.001 0.0009 0.0507
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0976
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.0055 0.0173 0.0164
Brugia malayi glutathione reductase 0.0044 0.0131 0.3822
Trypanosoma brucei transcription factor BTF3, putative 0.001 0.001 0.0582
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.001 0.0009 0.0049
Schistosoma mansoni alpha-glucosidase 0.0088 0.0291 0.2322
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0055 0.0173 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0033 0.0976
Mycobacterium leprae Probable lipase LipE 0.0019 0.0041 0.0025
Leishmania major DNA polymerase eta, putative 0.0016 0.0031 0.181
Loa Loa (eye worm) hypothetical protein 0.0023 0.0056 0.1637
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0044
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0008 0.0004 0.0084
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0028 0.1599
Onchocerca volvulus 0.0019 0.0041 0.1651
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0028 0.1599
Leishmania major hypothetical protein, conserved 0.0019 0.0041 0.2394
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.0103
Echinococcus multilocularis nuclear receptor nhr 48 0.0008 0.0001 0.0008
Plasmodium falciparum thioredoxin reductase 0.0015 0.0028 0.1599
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0009 0.0507
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) 0.2768 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0131 0.3841
Leishmania major phosphopantetheinyl transferase-like protein 0.0012 0.0016 0.0945
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0023 0.0055 0.1605
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0023 0.0055 0.3172
Echinococcus granulosus thyroid hormone receptor alpha 0.0008 0.0001 0.0012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0033 0.0184
Leishmania major basic transcription factor 3a, putative 0.001 0.001 0.0582
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0052 0.0163 0.1301
Plasmodium falciparum thioredoxin reductase 0.0044 0.0131 0.7553
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0008 0.0001 0.0044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0033 0.0976
Echinococcus multilocularis dna polymerase eta 0.0023 0.0056 0.0309
Echinococcus multilocularis muscleblind protein 0.0044 0.0131 0.0726
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0976
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.1599
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.2912
Leishmania major trypanothione reductase 0.0044 0.0131 0.7553
Trypanosoma brucei DNA polymerase IV, putative 0.001 0.0009 0.0507
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0033 0.0267
Brugia malayi hypothetical protein 0.0075 0.0243 0.7115
Trichomonas vaginalis esterase, putative 0.0019 0.0041 0.2394
Brugia malayi nuclear receptor RXR 0.0008 0.0001 0.0044
Schistosoma mansoni caspase-7 (C14 family) 0.0075 0.0243 0.1944
Brugia malayi nuclear receptor NHR-67 0.0008 0.0001 0.0044
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0035 0.01 0.0796
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0001 0.0012
Schistosoma mansoni nuclear receptor nhr-48 0.0008 0.0001 0.0012
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0028 0.0809
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0055 0.0173 0.5061
Brugia malayi nuclear hormone receptor 0.0008 0.0001 0.0044
Onchocerca volvulus 0.0019 0.0041 0.1651
Schistosoma mansoni hypothetical protein 0.005 0.0153 0.1219
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0976
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbC 0.2768 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0068 0.0221 0.6463
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.0001 0.0012
Brugia malayi Nuclear hormone receptor E75 0.0008 0.0001 0.0044
Brugia malayi Nuclear hormone receptor E75 0.0008 0.0001 0.0044
Loa Loa (eye worm) ICD-1 protein 0.001 0.001 0.0295
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0044
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0144
Brugia malayi beta-NAC-like protein 0.001 0.001 0.0295
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.1599
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0055 0.0173 1
Plasmodium falciparum basic transcription factor 3b, putative 0.001 0.001 0.0582
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0033 0.0976
Echinococcus granulosus tumor protein p63 0.0173 0.0599 0.4786
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0009 0.0507
Trypanosoma cruzi transcription factor btf3, putative 0.001 0.001 0.0582
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0055 0.0173 1
Schistosoma mansoni hypothetical protein 0.0075 0.0243 0.1944
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0005 0.0027
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0019 0.0041 0.0033
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0023 0.0055 0.3172
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0019 0.0041 0.0033
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0033 0.1319
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0028 0.0236
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0976
Entamoeba histolytica hypothetical protein 0.0012 0.0016 0.0945
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0033 0.0976
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0144
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0023 0.0055 0.3172
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0033 0.0267
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0005 0.0144
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0033 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0009 0.0507
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0005 0.0144
Echinococcus granulosus neuropeptide receptor A26 0.0136 0.0465 0.3714
Entamoeba histolytica transcription factor BTF3, putative 0.001 0.001 0.0582
Brugia malayi hypothetical protein 0.0011 0.0011 0.0326
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0028 0.1599
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0008 0.0001 0.0012
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0028 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0008 0.0004 0.0203
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0099 0.0333 0.0324
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0012 0.0016 0.0008
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0055 0.0173 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.0001 0.0012
Trichomonas vaginalis alpha-glucosidase, putative 0.0023 0.0055 0.3172
Echinococcus multilocularis microtubule associated protein 2 0.0353 0.1252 0.6917
Mycobacterium ulcerans esterase/lipase LipP 0.0019 0.0041 0.0033
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0028 0.1599
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0039 0.0115 0.6657
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0144 0.0496 0.0481
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0008 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0044
Echinococcus granulosus muscleblind protein 0.0044 0.0131 0.1049
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0028 0.0019
Trypanosoma brucei DNA polymerase IV, putative 0.001 0.0009 0.0507
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0001 0.0008
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0013 0.0385
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0033 0.0184
Plasmodium vivax glutathione reductase, putative 0.0044 0.0131 0.7553
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0028 0.1599
Entamoeba histolytica hypothetical protein 0.0011 0.0011 0.0645
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0052 0.0163 0.1301
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0055 0.0173 1
Treponema pallidum NADH oxidase 0.0015 0.0028 0.0236
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0033 0.1319
Onchocerca volvulus 0.0059 0.0186 0.7647
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0023 0.0055 0.3172
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0008 0.0001 0.0012
Trypanosoma brucei unspecified product 0.001 0.0009 0.0507
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0033 0.0267
Trypanosoma brucei glucosidase, putative 0.0023 0.0055 0.3172
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0044
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0019 0.0041 0.0033
Trichomonas vaginalis alpha-glucosidase, putative 0.0023 0.0055 0.3172
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0043 0.0127 0.1015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.1599
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0009 0.0507
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0033 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0009 0.0507
Trypanosoma brucei glycosyl hydrolase-like protein 0.0008 0.0004 0.0203
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0033 0.0267
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.1599
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.1599
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0033 0.0976
Loa Loa (eye worm) beta-lactamase 0.0019 0.0041 0.1211
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0099 0.0333 0.0324
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0023 0.0055 0.3172
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.001 0.0009 0.0507
Brugia malayi ImpB/MucB/SamB family protein 0.001 0.0009 0.0257
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0976
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0099 0.0333 0.0324
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0035 0.01 0.5754
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0028 0.1599
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0016 0.0945
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0008 0.0004 0.0203
Brugia malayi Muscleblind-like protein 0.0044 0.0131 0.3841
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.001 0.0009 0.0507
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0033 0.0184
Brugia malayi Cell death protein 3 precursor 0.0075 0.0243 0.7115
Loa Loa (eye worm) hypothetical protein 0.0043 0.0127 0.3716
Toxoplasma gondii melibiase subfamily protein 0.0052 0.0163 0.9407
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.0005 0.0144
Echinococcus granulosus transcription factor btf3 0.001 0.001 0.0081
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0033 0.0267
Onchocerca volvulus Cell death protein 3 homolog 0.0075 0.0243 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0033 0.0976
Echinococcus multilocularis dna polymerase kappa 0.001 0.0009 0.0049
Echinococcus granulosus neutral alpha glucosidase AB 0.0023 0.0055 0.0439
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0028 0.1599
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0012 0.0016 0.0008
Plasmodium falciparum glutathione reductase 0.0044 0.0131 0.7553
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0033 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0009 0.0507
Brugia malayi hypothetical protein 0.0008 0.0001 0.0044
Mycobacterium tuberculosis Conserved protein 0.0019 0.0041 0.0033
Echinococcus granulosus neuropeptide s receptor 0.0136 0.0465 0.3714
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0102 0.0342 1
Toxoplasma gondii NAC domain-containing protein 0.001 0.001 0.0582
Brugia malayi beta-lactamase family protein 0.0019 0.0041 0.1211
Mycobacterium leprae conserved hypothetical protein 0.0019 0.0041 0.0025
Brugia malayi ecdysone receptor 0.0008 0.0001 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.1211
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0033 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0033 0.0976
Entamoeba histolytica hypothetical protein 0.0011 0.0011 0.0645
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0033 0.0976
Loa Loa (eye worm) nuclear receptor NHR-67 0.0008 0.0001 0.0044
Loa Loa (eye worm) hypothetical protein 0.0025 0.0065 0.1891
Trichomonas vaginalis alpha-glucosidase, putative 0.0023 0.0055 0.3172
Brugia malayi follicle stimulating hormone receptor 0.0068 0.0221 0.6463
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0033 0.0976
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0009 0.0507
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0028 0.1599
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0033 0.0267
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0044
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.001 0.0009 0.007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0507 0.181 1
Mycobacterium tuberculosis Probable reductase 0.0099 0.0333 0.0324
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0041 0.2394
Trichomonas vaginalis penicillin-binding protein, putative 0.0019 0.0041 0.2394
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.2768 1 1
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0144 0.0496 1
Mycobacterium ulcerans lipase LipD 0.0019 0.0041 0.0033
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0028 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0033 0.0976
Trichomonas vaginalis alpha-glucosidase, putative 0.0023 0.0055 0.3172
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0055 0.0173 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0008 0.0004 0.0103
Onchocerca volvulus 0.0075 0.0243 1
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0009 0.0507
Trypanosoma brucei trypanothione reductase 0.0044 0.0131 0.7553
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0031 0.181
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.1211
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0033 0.0976
Echinococcus multilocularis tumor protein p63 0.0173 0.0599 0.3311
Brugia malayi hypothetical protein 0.0009 0.0005 0.0144
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0099 0.0333 0.0317

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Agonist activity at human NOD2 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay ChEMBL. 25102141
Activity (binding) Agonist activity at human NOD1 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay ChEMBL. 25102141
Activity (binding) Agonist activity at human TLR5 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay ChEMBL. 25102141
Activity (binding) Agonist activity at human TLR3 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay ChEMBL. 25102141
Activity (binding) Agonist activity at human TLR4 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay ChEMBL. 25102141
Activity (binding) Agonist activity at human TLR9 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay ChEMBL. 25102141
Activity (binding) Agonist activity at human TLR7 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay ChEMBL. 25102141
Activity (binding) Agonist activity at human TLR2 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay ChEMBL. 25102141
EC50 (binding) Agonist activity at human TLR8 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay ChEMBL. 25102141
IC50 (binding) > 10 uM Antagonist activity at human NOD1 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay ChEMBL. 25102141
IC50 (binding) > 10 uM Antagonist activity at human NOD2 stably expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as NF-kappaB induction by liquid handler-assisted reporter gene assay ChEMBL. 25102141

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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