Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0097 | 0.0197 | 0.5294 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0142 | 0.0359 | 0.0344 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2793 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0142 | 0.0359 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.0253 | 0.6931 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0092 | 0.0177 | 0.0162 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0047 | 0.0015 | 0.0015 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.1038 | 0.362 | 0.361 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0113 | 0.0253 | 0.6931 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0142 | 0.0359 | 1 |
Leishmania major | 0.2793 | 1 | 0.5 | |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0142 | 0.0359 | 0.0344 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0177 | 0.0177 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0097 | 0.0197 | 0.5294 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.2793 | 1 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0113 | 0.0253 | 0.0253 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0142 | 0.0359 | 1 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0068 | 0.0092 | 0.5 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0142 | 0.0359 | 0.0359 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.2793 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.2793 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.2793 | 1 | 1 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0142 | 0.0359 | 0.0185 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2793 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0063 | 0.0072 | 0.1637 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.2793 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0138 | 0.0344 | 0.9555 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0142 | 0.0359 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.2793 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0024 | 0.0024 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.1038 | 0.362 | 0.362 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0142 | 0.0359 | 0.0359 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0142 | 0.0359 | 0.0185 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.1038 | 0.362 | 0.362 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10.89 uM | Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensity using phosphorylated substrate | ChEMBL. | 25050878 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.