Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0223 | 0.0151 | 0.0151 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0442 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0442 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0442 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0442 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0442 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0442 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0442 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0442 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0273 | 0.2407 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0442 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0442 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0442 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0442 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0442 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0442 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0219 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0391 | 0.7743 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0442 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0442 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0219 | 0 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0442 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0391 | 0.7743 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0273 | 0.2407 | 0.2407 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0442 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0442 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0442 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0442 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.