Detailed information for compound 925859

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 577.956 | Formula: C26H27Cl3N6OS
  • H donors: 3 H acceptors: 3 LogP: 7.2 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN(CCCNc1nc(nc2c1sc(c2Cl)Cl)c1ccc(cc1)NC(=O)Nc1ccccc1Cl)CC
  • InChi: 1S/C26H27Cl3N6OS/c1-3-35(4-2)15-7-14-30-25-22-21(20(28)23(29)37-22)33-24(34-25)16-10-12-17(13-11-16)31-26(36)32-19-9-6-5-8-18(19)27/h5-6,8-13H,3-4,7,14-15H2,1-2H3,(H,30,33,34)(H2,31,32,36)
  • InChiKey: IQJGGEOOQOYBOA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.003 0.0146 0.0328
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0059 0.0198
Schistosoma mansoni adenoreceptor 0.0022 0.0059 0.0198
Schistosoma mansoni lozenge 0.0054 0.0408 0.1371
Echinococcus multilocularis tar DNA binding protein 0.0199 0.1965 0.1965
Onchocerca volvulus 0.0021 0.0052 0.0048
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.0059 0.0198
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0227 0.0961
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Echinococcus granulosus geminin 0.0168 0.1628 0.5474
Schistosoma mansoni chromatin regulatory protein sir2 0.011 0.1005 0.3378
Schistosoma mansoni peroxidasin 0.0025 0.0099 0.0333
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0022 0.0073
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0031 0.0069
Schistosoma mansoni hypothetical protein 0.0034 0.0191 0.0642
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.0059 0.0132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Loa Loa (eye worm) hypothetical protein 0.0037 0.0227 0.051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0022 0.0215
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0025 0.025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0059 0.0059
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0099 0.0222
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0201 0.8839
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0059 0.0198
Schistosoma mansoni hypothetical protein 0.0034 0.0191 0.0642
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0675 0.6716
Onchocerca volvulus Huntingtin homolog 0.0119 0.1109 0.2432
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0025 0.0084
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0615 0.1377
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Brugia malayi GnHR receptor homolog 0.0022 0.0059 0.0132
Onchocerca volvulus 0.0022 0.0059 0.0063
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0201 0.045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0059 0.0198
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0191 0.0428
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.0059 0.0198
Loa Loa (eye worm) hypothetical protein 0.0037 0.0227 0.051
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0025 0.1105
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Brugia malayi cathepsin B-like cysteine proteinase 0.0293 0.2975 0.6664
Brugia malayi Cathepsin L-like cysteine proteinase 0.0021 0.0052 0.0117
Brugia malayi neuropeptide F receptor 0.0022 0.0059 0.0132
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Giardia lamblia Cathepsin B precursor 0.0099 0.089 0.8852
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0073 0.0609 0.2048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0118 0.0497
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0305 0.0683
Loa Loa (eye worm) runx1 0.0054 0.0408 0.0914
Schistosoma mansoni chromatin regulatory protein sir2 0.011 0.1005 0.3378
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.0118 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0059 0.0198
Echinococcus multilocularis cathepsin b 0.0293 0.2975 0.2975
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0059 0.0059
Onchocerca volvulus 0.0022 0.0059 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0099 0.089 0.3759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0031 0.0031
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) cathepsin B 0.0099 0.089 0.1993
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Echinococcus granulosus neuropeptide s receptor 0.0022 0.0059 0.0198
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Schistosoma mansoni neuropeptide receptor 0.0022 0.0059 0.0198
Loa Loa (eye worm) cysteine protease 0.0027 0.0118 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0675 0.6716
Loa Loa (eye worm) hypothetical protein 0.0431 0.4464 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0118 0.0264
Schistosoma mansoni biogenic amine receptor 0.0022 0.0059 0.0198
Brugia malayi Cathepsin L-like precursor 0.0027 0.0118 0.0264
Leishmania major hypothetical protein, conserved 0.0037 0.0227 0.2264
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0099 0.0222
Brugia malayi beta-lactamase family protein 0.0037 0.0227 0.051
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0059 0.0059
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0227 0.0952
Schistosoma mansoni hypothetical protein 0.0022 0.0059 0.0198
Echinococcus multilocularis cathepsin b 0.0293 0.2975 0.2975
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0059 0.0059
Onchocerca volvulus 0.0022 0.0059 0.0063
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0022 0.0091
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0059 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0227 0.0765
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0052 0.022
Schistosoma mansoni opsin-like receptor 0.0022 0.0059 0.0198
Brugia malayi larval opioid receptor 0.0022 0.0059 0.0132
Brugia malayi Cathepsin L-like precursor 0.0027 0.0118 0.0264
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0215
Echinococcus granulosus serotonin receptor 0.0022 0.0059 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0022 0.0215
Brugia malayi beta-lactamase family protein 0.0037 0.0227 0.051
Echinococcus granulosus RUN 0.0019 0.0031 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0675 0.6716
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0022 0.0215
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.0059 0.0059
Leishmania major cathepsin L-like protease 0.0079 0.0675 0.6716
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0227 0.0227
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0227 0.0765
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Echinococcus multilocularis geminin 0.0168 0.1628 0.1628
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0059 0.0132
Brugia malayi beta-NAC-like protein 0.0035 0.0201 0.045
Onchocerca volvulus 0.0025 0.0099 0.0154
Plasmodium vivax SET domain protein, putative 0.003 0.0146 0.6429
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0118 0.1171
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0201 0.226
Echinococcus granulosus cathepsin b 0.0293 0.2975 1
Leishmania major cathepsin L-like protease 0.0079 0.0675 0.6716
Schistosoma mansoni hypothetical protein 0.0022 0.0059 0.0198
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0227 0.0952
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.098 0.2195
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0099 0.0222
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0059 0.0198
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0059 0.0132
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0084
Brugia malayi putative neuropeptide receptor 0.0022 0.0059 0.0132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.0118 0.5855
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0031 0.0104
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0146 0.0492
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0134 0.0452
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Loa Loa (eye worm) fibroinase 0.0027 0.0118 0.0264
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0191 0.0642
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0215
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0264
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.0059 0.0198
Brugia malayi Cathepsin L-like precursor 0.0027 0.0118 0.0264
Brugia malayi RE15519p 0.0022 0.0059 0.0132
Schistosoma mansoni lipoxygenase 0.0114 0.1051 0.3533
Brugia malayi hypothetical protein 0.0022 0.0059 0.0132
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0059 0.0198
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.0059 0.0198
Plasmodium vivax unspecified product 0.0018 0.0022 0.0949
Echinococcus multilocularis neuropeptide receptor A26 0.0022 0.0059 0.0059
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0025 0.0084
Echinococcus granulosus g protein coupled receptor 0.0022 0.0059 0.0198
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0059 0.0132
Echinococcus multilocularis neuropeptide s receptor 0.0022 0.0059 0.0059
Brugia malayi hypothetical protein 0.0022 0.0059 0.0132
Onchocerca volvulus 0.0027 0.0118 0.0196
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.0059 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0117
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0022 0.0048
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0227 0.0765
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0215
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0099 0.0222
Brugia malayi hypothetical protein 0.0019 0.0031 0.0069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Brugia malayi beta-lactamase 0.0037 0.0227 0.051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0305 0.1025
Schistosoma mansoni neuropeptide receptor 0.0022 0.0059 0.0198
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.0059 0.0198
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.011 0.1005 0.3378
Brugia malayi hypothetical protein 0.0022 0.0059 0.0132
Onchocerca volvulus 0.0037 0.0227 0.0444
Brugia malayi hypothetical protein 0.0022 0.0059 0.0132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0118 0.0497
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0201 0.2001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Plasmodium vivax vivapain-2 0.0027 0.0118 0.5175
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0059 0.0059
Echinococcus granulosus peroxidasin 0.0025 0.0099 0.0333
Schistosoma mansoni opsin-like receptor 0.0022 0.0059 0.0198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0059 0.0198
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0059 0.0059
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0022 0.0073
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0059 0.0198
Toxoplasma gondii exonuclease III APE 0.0019 0.0025 0.0282
Brugia malayi hypothetical protein 0.0025 0.0099 0.0222
Brugia malayi RNA binding protein 0.0199 0.1965 0.4401
Loa Loa (eye worm) blistered cuticle protein 3 0.0025 0.0099 0.0222
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0084
Schistosoma mansoni biogenic amine receptor 0.0022 0.0059 0.0198
Onchocerca volvulus Cathepsin F homolog 0.0027 0.0118 0.0196
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0031 0.1357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0059 0.0198
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0059 0.0198
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0146 0.0146
Echinococcus multilocularis allatostatin A receptor 0.0022 0.0059 0.0059
Echinococcus granulosus GPCR family 2 0.0034 0.0191 0.0642
Leishmania major basic transcription factor 3a, putative 0.0035 0.0201 0.2001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Echinococcus granulosus allatostatin A receptor 0.0022 0.0059 0.0198
Loa Loa (eye worm) hypothetical protein 0.003 0.0146 0.0328
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0191 0.0428
Onchocerca volvulus 0.0022 0.0059 0.0063
Mycobacterium tuberculosis Conserved protein 0.0037 0.0227 0.0952
Echinococcus granulosus chromatin regulatory protein sir2 0.011 0.1005 0.3378
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Trypanosoma brucei Silent information regulator 2 related protein 1 0.011 0.1005 1
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0022 0.0215
Leishmania major cathepsin L-like protease 0.0027 0.0118 0.1171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0022 0.0091
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0227 0.0952
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0227 0.0961
Schistosoma mansoni cathepsin F (C01 family) 0.0021 0.0052 0.0175
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.0059 0.0132
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.011 0.1005 0.4246
Loa Loa (eye worm) hypothetical protein 0.0037 0.0227 0.051
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0059 0.0059
Onchocerca volvulus 0.0022 0.0059 0.0063
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0059 0.0059
Brugia malayi hypothetical protein 0.0119 0.1109 0.2484
Schistosoma mansoni peroxidasin 0.0025 0.0099 0.0333
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0059 0.0198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0305 0.0305
Brugia malayi cathepsin L-like precursor 0.0021 0.0052 0.0117
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.0059 0.0198
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0191 0.0191
Onchocerca volvulus 0.0022 0.0059 0.0063
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0215
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0059 0.0059
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0059 0.0132
Echinococcus multilocularis peroxidasin 0.0025 0.0099 0.0099
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.0059 0.0198
Brugia malayi Dopamine receptor 0.0022 0.0059 0.0132
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0227 0.2264
Mycobacterium tuberculosis Conserved protein 0.0037 0.0227 0.0952
Loa Loa (eye worm) hypothetical protein 0.0037 0.0227 0.051
Mycobacterium ulcerans hypothetical protein 0.0037 0.0227 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.0059 0.0198
Loa Loa (eye worm) transcriptional regulator 0.011 0.1005 0.2251
Schistosoma mansoni tar DNA-binding protein 0.0199 0.1965 0.6604
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0201 0.0676
Echinococcus granulosus neuropeptide receptor A26 0.0022 0.0059 0.0198
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0201 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0293 0.2975 1
Onchocerca volvulus 0.0027 0.0118 0.0196
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0215
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0025 0.1105
Schistosoma mansoni hypothetical protein 0.0022 0.0059 0.0198
Schistosoma mansoni hypothetical protein 0.0019 0.0031 0.0104
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.0059 0.0198
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0215
Echinococcus granulosus hypothetical protein 0.0022 0.0059 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0059 0.0132
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0187 0.1839 0.4078
Trichomonas vaginalis esterase, putative 0.0037 0.0227 0.0961
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.011 0.1005 0.1005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0305 0.1025
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0059 0.0198
Schistosoma mansoni amine GPCR 0.0022 0.0059 0.0198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0059 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0025 0.025
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0215
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0025 0.0106
Plasmodium falciparum cysteine proteinase falcipain 1 0.0018 0.0022 0.1073
Mycobacterium leprae Probable lipase LipE 0.0037 0.0227 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0227 0.051
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0025 0.025
Onchocerca volvulus Peroxidase homolog 0.0025 0.0099 0.0154
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0146 0.0492
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0107 0.098 0.2195
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0099 0.089 0.8852
Entamoeba histolytica cysteine protease, putative 0.0027 0.0118 0.1171
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.011 0.1005 0.3378
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.0059 0.0132
Leishmania major cysteine peptidase A (CPA) 0.0027 0.0118 0.1171
Trypanosoma cruzi major cysteine proteinase, putative 0.0064 0.0513 0.1725
Leishmania major cathepsin L-like protease 0.0079 0.0675 0.6716
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.0059 0.0198
Loa Loa (eye worm) hypothetical protein 0.0073 0.0615 0.1377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0059 0.0198
Schistosoma mansoni hypothetical protein 0.0073 0.0615 0.2066
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.0059 0.0059
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.0118 0.5855
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0099 0.0222
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.0059 0.0198
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0031 0.0031
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.011 0.1005 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Trypanosoma brucei cysteine peptidase C (CPC) 0.0099 0.089 0.8852
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0118 0.0118
Echinococcus granulosus cathepsin b 0.0293 0.2975 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0191 0.0642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0305 0.1025
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0227 0.0952
Schistosoma mansoni tar DNA-binding protein 0.0199 0.1965 0.6604
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.098 0.2195
Brugia malayi RNA recognition motif domain containing protein 0.0199 0.1965 0.4401
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Schistosoma mansoni histamine h1 receptor 0.0022 0.0059 0.0198
Brugia malayi hypothetical protein 0.0022 0.0059 0.0132
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0059 0.0198
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0118 0.0396
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.0059 0.0059
Brugia malayi Serotonin receptor 0.0022 0.0059 0.0132
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.0059 0.0198
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0022 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.2058 0.4611
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0025 0.0056
Echinococcus multilocularis serotonin receptor 0.0022 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0675 0.6716
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0022 0.0073
Leishmania major cathepsin L-like protease 0.0027 0.0118 0.1171
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0305 0.1025
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0099 0.0222
Brugia malayi Doublecortin family protein 0.0019 0.0031 0.0069
Onchocerca volvulus 0.0037 0.0227 0.0444
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0227 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.0118 0.5855
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.0059 0.0059
Onchocerca volvulus Huntingtin homolog 0.0119 0.1109 0.2432
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0059 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0059 0.0198
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0227 0.5
Plasmodium vivax vivapain-1 0.0018 0.0022 0.0949
Echinococcus granulosus cysteine protease 0.0018 0.0022 0.0073
Loa Loa (eye worm) TAR-binding protein 0.0199 0.1965 0.4401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0675 0.6716
Brugia malayi hypothetical protein 0.0019 0.0031 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0118 0.0497
Onchocerca volvulus 0.0022 0.0059 0.0063
Echinococcus multilocularis sex peptide receptor 0.0022 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0675 0.6716
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0118 0.0396
Onchocerca volvulus 0.0027 0.0118 0.0196
Leishmania major cathepsin L-like protease 0.0027 0.0118 0.1171
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0099 0.089 0.2991
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.0118 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0201 0.085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0146 0.1644
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.0059 0.0198
Onchocerca volvulus 0.0022 0.0059 0.0063
Schistosoma mansoni amine GPCR 0.0022 0.0059 0.0198
Onchocerca volvulus Peroxidasin homolog 0.0025 0.0099 0.0154
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.0059 0.0063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0118 0.0497
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0099 0.089 0.2991
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) ctsf protein 0.0027 0.0118 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0675 0.6716
Brugia malayi hypothetical protein 0.0022 0.0059 0.0132
Onchocerca volvulus 0.0027 0.0118 0.0196
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.0059 0.0198
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0675 0.6716
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0305 0.0683
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0022 0.0073
Schistosoma mansoni chromatin regulatory protein sir2 0.011 0.1005 0.3378
Onchocerca volvulus Peroxidasin homolog 0.0025 0.0099 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0201 0.085
Schistosoma mansoni polycystin 1-related 0.0019 0.0031 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0118 0.0497
Loa Loa (eye worm) hypothetical protein 0.0037 0.0227 0.051
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Schistosoma mansoni neuropeptide receptor 0.0022 0.0059 0.0198
Echinococcus granulosus orexin receptor type 2 0.0022 0.0059 0.0198
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.0059 0.0198
Onchocerca volvulus 0.0022 0.0059 0.0063
Onchocerca volvulus 0.0236 0.2367 0.5269
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.0059 0.0059
Toxoplasma gondii cathepsin B 0.0099 0.089 1
Brugia malayi follicle stimulating hormone receptor 0.0022 0.0059 0.0132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0118 0.0497
Onchocerca volvulus 0.0022 0.0059 0.0063
Echinococcus granulosus sex peptide receptor 0.0022 0.0059 0.0198
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0215
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Brugia malayi hypothetical protein 0.0022 0.0059 0.0132
Brugia malayi Cathepsin L-like precursor 0.0027 0.0118 0.0264
Brugia malayi Peroxidasin 0.0025 0.0099 0.0222
Leishmania major silent information regulator 2, putative 0.011 0.1005 1
Echinococcus granulosus tar DNA binding protein 0.0199 0.1965 0.6604
Onchocerca volvulus Peroxidase homolog 0.0025 0.0099 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0118 0.0497
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.0059 0.0198
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.011 0.1005 0.4246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0675 0.6716
Loa Loa (eye worm) beta-lactamase 0.0037 0.0227 0.051
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0215
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0118 0.0118
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0293 0.2975 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.1051 0.3533
Trypanosoma cruzi cruzipain precursor, putative 0.0079 0.0675 0.2269
Brugia malayi Blistered cuticle protein 3 0.0025 0.0099 0.0222
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0118 0.0497
Onchocerca volvulus 0.003 0.0146 0.026
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Brugia malayi Dopamine receptor protein 2 0.0022 0.0059 0.0132
Onchocerca volvulus 0.0025 0.0099 0.0154
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0146 0.0492
Loa Loa (eye worm) hypothetical protein 0.0037 0.0227 0.051
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Schistosoma mansoni tar DNA-binding protein 0.0199 0.1965 0.6604
Onchocerca volvulus 0.0027 0.0118 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0675 0.6716
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0146 0.0146
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0201 0.2001
Schistosoma mansoni opsin-like receptor 0.0022 0.0059 0.0198
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0118 0.0196
Brugia malayi transcriptional regulator, Sir2 family protein 0.011 0.1005 0.2251
Onchocerca volvulus 0.0025 0.0099 0.0154
Entamoeba histolytica cysteine proteinase 1, putative 0.0018 0.0022 0.0215
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0031 0.1535
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0199 0.1965 0.4401
Loa Loa (eye worm) hypothetical protein 0.0187 0.1839 0.4119
Mycobacterium tuberculosis Conserved protein 0.0037 0.0227 0.0952
Echinococcus granulosus somatostatin receptor 0.0022 0.0059 0.0198
Echinococcus granulosus fmrfamide receptor 0.0022 0.0059 0.0198
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0118 0.0396
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0022 0.0215
Brugia malayi Cathepsin L-like precursor 0.0021 0.0052 0.0117
Leishmania major cathepsin L-like protease 0.0027 0.0118 0.1171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0059 0.0059
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0059 0.0059
Brugia malayi neuropeptide F receptor 0.0022 0.0059 0.0132
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.011 0.1005 0.3378
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0215
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.0059 0.0132
Echinococcus granulosus cathepsin l1 0.0027 0.0118 0.0396
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0059 0.0198
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0059 0.0132
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0227 0.0952
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0099 0.0222
Brugia malayi hypothetical protein 0.0022 0.0059 0.0132
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0059 0.0198
Brugia malayi Pre-SET motif family protein 0.0208 0.2058 0.4611
Entamoeba histolytica hypothetical protein 0.0035 0.0201 0.2001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0059 0.0198
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0227 0.0952
Brugia malayi G-protein coupled receptor 0.0022 0.0059 0.0132
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.2391 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0146 0.0492
Echinococcus multilocularis serotonin receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0025 0.0084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0059 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.0059 0.0132
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.098 0.2195
Echinococcus multilocularis cathepsin L 0.0018 0.0022 0.0022
Giardia lamblia Cathepsin B precursor 0.0099 0.089 0.8852
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0305 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.0059 0.0059
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0059 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0059 0.0059
Loa Loa (eye worm) RNA binding protein 0.0199 0.1965 0.4401
Leishmania major cathepsin L-like protease 0.0027 0.0118 0.1171
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0025 0.025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0118 0.0497
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0025 0.5
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0025 0.5
Brugia malayi hypothetical protein 0.0431 0.4464 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0052 0.022
Schistosoma mansoni biogenic amine receptor 0.0022 0.0059 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Brugia malayi TAR-binding protein 0.0199 0.1965 0.4401
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0117
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0201 0.0676
Mycobacterium ulcerans lipase LipD 0.0037 0.0227 1
Onchocerca volvulus 0.0022 0.0059 0.0063
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0025 0.0056
Brugia malayi Cathepsin L-like precursor 0.0021 0.0052 0.0117
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.0059 0.0059
Echinococcus multilocularis chromatin regulatory protein sir2 0.011 0.1005 0.1005
Onchocerca volvulus 0.0022 0.0059 0.0063
Onchocerca volvulus 0.0022 0.0059 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.0675 0.6716
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.011 0.1005 1
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0022 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0059 0.0198
Brugia malayi Cathepsin L-like precursor 0.0027 0.0118 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Echinococcus multilocularis orexin receptor type 2 0.0022 0.0059 0.0059
Onchocerca volvulus 0.0022 0.0059 0.0063
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.0059 0.0198
Schistosoma mansoni loxhd1 0.0019 0.0031 0.0104
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0059 0.0198
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0022 0.0073
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0059 0.0198
Brugia malayi ORL1-like opioid receptor 0.0022 0.0059 0.0132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Toxoplasma gondii ABC1 family protein 0.0037 0.0227 0.2557
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0059 0.0198
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0059 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0031 0.0104
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0022 0.0048
Brugia malayi Serotonin receptor 0.0022 0.0059 0.0132
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0118 0.0118
Brugia malayi G protein-coupled receptor 0.0022 0.0059 0.0132
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0059 0.0198
Onchocerca volvulus 0.0027 0.0118 0.0196
Echinococcus multilocularis RUN 0.0019 0.0031 0.0031
Echinococcus granulosus neuropeptide receptor 0.0022 0.0059 0.0198
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0022 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0146 0.0492
Echinococcus granulosus neuropeptide receptor 0.0022 0.0059 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0201 0.085
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.0059 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Brugia malayi hypothetical protein 0.0022 0.0059 0.0132
Onchocerca volvulus 0.0027 0.0118 0.0196
Brugia malayi Melatonin receptor type 1A 0.0022 0.0059 0.0132
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0059 0.0198
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.0059 0.0059
Brugia malayi N-terminal motif family protein 0.0187 0.1839 0.4119
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0025 0.0106
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0428
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0059 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Giardia lamblia Hypothetical protein 0.011 0.1005 1
Brugia malayi Dopamine receptor protein 1 0.0022 0.0059 0.0132
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0059 0.0198
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0069
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0227 0.0961
Echinococcus multilocularis GPCR, family 2 0.0034 0.0191 0.0191
Schistosoma mansoni transcription factor btf3 0.0035 0.0201 0.0676
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0227 0.0765
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0059 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2367 1
Echinococcus multilocularis Protein lozenge 0.0054 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0119 0.1109 0.2484
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Echinococcus granulosus g-protein coupled receptor 0.0022 0.0059 0.0198
Onchocerca volvulus 0.0022 0.0059 0.0063
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0227 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0293 0.2975 1
Schistosoma mansoni amine GPCR 0.0022 0.0059 0.0198
Toxoplasma gondii cathepsin CPL 0.0027 0.0118 0.1323
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.0059 0.0059
Schistosoma mansoni myosin xvIII 0.0022 0.0059 0.0198
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0227 0.051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0222
Loa Loa (eye worm) hypothetical protein 0.0431 0.4464 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.0118 0.0396
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0059 0.0198
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.0059 0.0063
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0191 0.0428
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0059 0.0198
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0227 1
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0059 0.0132
Plasmodium vivax vivapain-2 0.0027 0.0118 0.5175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0118 0.0497
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0293 0.2975 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0059 0.0059
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0025 0.0105
Echinococcus multilocularis cysteine protease 0.0027 0.0118 0.0118
Echinococcus multilocularis transcription factor btf3 0.0035 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0119 0.1109 0.2484
Echinococcus multilocularis cysteine protease 0.0027 0.0118 0.0118
Schistosoma mansoni amine GPCR 0.0022 0.0059 0.0198
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0099 0.0222
Onchocerca volvulus 0.0022 0.0059 0.0063
Schistosoma mansoni hypothetical protein 0.0034 0.0191 0.0642
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.0059 0.0198
Brugia malayi G-protein coupled receptor 0.0022 0.0059 0.0132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0118 0.0497
Echinococcus granulosus g protein coupled receptor 0.0022 0.0059 0.0198
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0022 0.0073
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.1051 0.1051
Echinococcus granulosus cathepsin l1 0.0021 0.0052 0.0175
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0118 0.0264
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0118 0.0118
Schistosoma mansoni neuropeptide receptor 0.0022 0.0059 0.0198
Schistosoma mansoni rab6-interacting 0.0019 0.0031 0.0104
Schistosoma mansoni hypothetical protein 0.0034 0.0191 0.0642
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0227 0.0952
Echinococcus granulosus g protein coupled receptor 0.0022 0.0059 0.0198
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0215
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0022 0.0059 0.0132
Brugia malayi Cathepsin L-like precursor 0.0027 0.0118 0.0264
Onchocerca volvulus 0.0431 0.4464 1
Schistosoma mansoni hypothetical protein 0.0168 0.1628 0.5474
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0305 0.1025
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0059 0.0132
Echinococcus multilocularis somatostatin receptor 0.0022 0.0059 0.0059
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0118 0.0196
Echinococcus granulosus cathepsin L 0.0018 0.0022 0.0073
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.0059 0.0059
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0025 0.0025
Plasmodium vivax vivapain-3 0.0018 0.0022 0.0949
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0227 0.0765
Onchocerca volvulus 0.0037 0.0227 0.0444
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.0059 0.0198
Entamoeba histolytica cysteine proteinase, putative 0.0021 0.0052 0.0519
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0118 0.1171
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0675 0.2269
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0031 0.0104
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0675 0.2269
Loa Loa (eye worm) hypothetical protein 0.0293 0.2975 0.6664
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0031 0.0031
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.0059 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0069
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0293 0.2975 1
Onchocerca volvulus 0.0022 0.0059 0.0063
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0059 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0227 0.0961
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0059 0.0059
Schistosoma mansoni amine GPCR 0.0022 0.0059 0.0198
Brugia malayi AKH receptor 0.0022 0.0059 0.0132
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0059 0.0198
Brugia malayi sulfakinin receptor protein 0.0022 0.0059 0.0132
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0215
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Entamoeba histolytica cysteine proteinase 2 0.0018 0.0022 0.0215
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0215
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0199 0.1965 0.6604
Mycobacterium ulcerans beta-lactamase 0.0037 0.0227 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.0059 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0199 0.1965 0.6604
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Brugia malayi hypothetical protein 0.0022 0.0059 0.0132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0099 0.0222
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0059 0.0132
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.0059 0.0059
Schistosoma mansoni rab6-interacting 0.0019 0.0031 0.0104
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0059 0.0132
Schistosoma mansoni hypothetical protein 0.0022 0.0059 0.0198
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0022 0.0215
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0059 0.0198
Giardia lamblia Cathepsin B precursor 0.0099 0.089 0.8852
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0059 0.0059
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0227 0.0961
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0118 0.0497
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0059 0.0059
Onchocerca volvulus Dual oxidase homolog 0.0025 0.0099 0.0154
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0059 0.0198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0132
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.0675 0.2269
Schistosoma mansoni lipoxygenase 0.008 0.0683 0.2294
Echinococcus granulosus transcription factor btf3 0.0035 0.0201 0.0676
Onchocerca volvulus Chorion peroxidase homolog 0.0025 0.0099 0.0154
Schistosoma mansoni hypothetical protein 0.0168 0.1628 0.5474
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0025 0.125
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0059 0.0132

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.41 umol/L Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay ChEMBL. 25086238

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 25086238

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.