TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 383.66 | Formula: C16H13Cl3N4O
H donors: 3 H acceptors: 2 LogP: 4.27 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c(c1)Cl)C(=O)Nc1ccc(cc1)c1cnc([nH]1)N.Cl
InChi: 1S/C16H12Cl2N4O.ClH/c17-10-3-6-12(13(18)7-10)15(23)21-11-4-1-9(2-5-11)14-8-20-16(19)22-14;/h1-8H,(H,21,23)(H3,19,20,22);1H
InChiKey: LSMKFVKBZHLARJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	amine GPCR	0.0066	0.9593	0.9589
Echinococcus granulosus	neuropeptide Y receptor	0.0066	0.9593	0.9589
Echinococcus granulosus	somatostatin receptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.3348	0.3348
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Echinococcus multilocularis	chromobox protein 2	0.0011	0.0775	0.0683
Echinococcus multilocularis	sex peptide receptor	0.0066	0.9593	0.9589
Echinococcus multilocularis	cpg binding protein	0.003	0.3776	0.3713
Brugia malayi	G protein-coupled receptor	0.0066	0.9593	0.9578
Onchocerca volvulus		0.0066	0.9593	1
Brugia malayi	ORL1-like opioid receptor	0.0066	0.9593	0.9578
Onchocerca volvulus		0.0066	0.9593	1
Brugia malayi	CHD4 protein	0.0013	0.1034	0.0701
Echinococcus multilocularis	neuropeptide s receptor	0.0066	0.9593	0.9589
Onchocerca volvulus		0.0066	0.9593	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0066	0.9593	0.9589
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.3517	0.3263
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.9593	0.9589
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.1947	0.1947
Schistosoma mansoni	ap endonuclease	0.0018	0.1947	0.1866
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0066	0.9593	0.9589
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.1947	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0066	0.9593	0.9589
Trichomonas vaginalis	Heterochromatin protein, putative	0.0011	0.0775	0.0775
Loa Loa (eye worm)	G-protein coupled receptor	0.0066	0.9593	0.9577
Schistosoma mansoni	amine GPCR	0.0066	0.9593	0.9589
Echinococcus granulosus	chromobox protein 2	0.0011	0.0775	0.0683
Schistosoma mansoni	chromobox protein	0.0068	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Echinococcus granulosus	hypothetical protein	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.5153	0.5153
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.5622	0.5622
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Brugia malayi	hypothetical protein	0.0066	0.9593	0.9578
Trichomonas vaginalis	hypothetical protein	0.0011	0.0775	0.0775
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0011	0.0775	0.0683
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0066	0.9593	0.9577
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0066	0.9593	0.9589
Echinococcus granulosus	orexin receptor type 2	0.0066	0.9593	0.9589
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0066	0.9593	0.9589
Onchocerca volvulus		0.0066	0.9593	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.1947	0.5
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.1947	0.5
Loa Loa (eye worm)	CHromoDomain protein family member	0.0013	0.1034	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Onchocerca volvulus		0.0066	0.9593	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0066	0.9593	0.9589
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.1805	0.1805
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.1947	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0066	0.9593	0.9589
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0775	0.0414
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.5153	0.5153
Brugia malayi	neuropeptide F receptor	0.0066	0.9593	0.9578
Brugia malayi	AKH receptor	0.0066	0.9593	0.9578
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0066	0.9593	0.9577
Echinococcus granulosus	tm gpcr rhodopsin	0.0066	0.9593	0.9589
Brugia malayi	M-phase phosphoprotein, mpp8	0.0011	0.0775	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0775	0.0414
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0066	0.9593	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0775	0.0775
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.1805	0.1805
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0775	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0066	0.9593	0.9578
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.9593	0.9589
Echinococcus multilocularis	g protein coupled receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	neuropeptide receptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Echinococcus granulosus	g protein coupled receptor	0.0066	0.9593	0.9589
Echinococcus multilocularis	g-protein coupled receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.9593	0.9589
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0066	0.9593	0.9589
Echinococcus granulosus	dro:myosuppressin receptor	0.0066	0.9593	0.9589
Echinococcus multilocularis	chromobox protein 1	0.0068	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0775	0.0775
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0775	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0011	0.0775	0.0683
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0775	0.0775
Brugia malayi	hypothetical protein	0.0066	0.9593	0.9578
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.1947	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Onchocerca volvulus		0.0066	0.9593	1
Schistosoma mansoni	chromobox protein	0.0011	0.0775	0.0683
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0066	0.9593	0.9589
Echinococcus granulosus	serotonin receptor	0.0066	0.9593	0.9589
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0066	0.9593	0.9589
Toxoplasma gondii	exonuclease III APE	0.0018	0.1947	0.1722
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.5622	0.5497
Schistosoma mansoni	biogenic amine receptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0066	0.9593	0.9589
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0015	0.1328	0.1328
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0066	0.9593	0.9589
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Brugia malayi	hypothetical protein	0.0066	0.9593	0.9578
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0066	0.9593	0.9589
Brugia malayi	larval opioid receptor	0.0066	0.9593	0.9578
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0066	0.9593	0.9589
Echinococcus multilocularis	neuropeptides capa receptor	0.0066	0.9593	0.9589
Echinococcus multilocularis	g protein coupled receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	hypothetical protein	0.0066	0.9593	0.9589
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0066	0.9593	0.9589
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0775	0.0775
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.1328	0.1328
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0775	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0775	0.0414
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.1947	0.5
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.1947	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0066	0.9593	0.9589
Onchocerca volvulus		0.0066	0.9593	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.1805	0.1805
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0066	0.9593	0.9577
Schistosoma mansoni	hypothetical protein	0.0011	0.0775	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Brugia malayi	neuropeptide F receptor	0.0066	0.9593	0.9578
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.1947	0.1866
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.9593	0.9589
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0775	0.0775
Echinococcus granulosus	biogenic amine 5HT receptor	0.0066	0.9593	0.9589
Onchocerca volvulus		0.0066	0.9593	1
Brugia malayi	Melatonin receptor type 1A	0.0066	0.9593	0.9578
Onchocerca volvulus		0.003	0.3817	0.345
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Schistosoma mansoni	cpg binding protein	0.003	0.3776	0.3713
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Echinococcus granulosus	neuropeptide receptor A26	0.0066	0.9593	0.9589
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0066	0.9593	0.9578
Echinococcus granulosus	g protein coupled receptor	0.0066	0.9593	0.9589
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0011	0.0775	0.0432
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.1947	0.5
Schistosoma mansoni	amine GPCR	0.0066	0.9593	0.9589
Loa Loa (eye worm)	neuropeptide F receptor	0.0066	0.9593	0.9577
Schistosoma mansoni	neuropeptide receptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Echinococcus granulosus	chromobox protein 1	0.0068	1	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Schistosoma mansoni	biogenic amine receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0066	0.9593	0.9589
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0775	0.0775
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.7584	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0066	0.9593	0.9578
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	chromobox protein	0.0011	0.0775	0.0683
Brugia malayi	hypothetical protein	0.0066	0.9593	0.9578
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Echinococcus granulosus	neuropeptide s receptor	0.0066	0.9593	0.9589
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0775	0.0775
Brugia malayi	Dopamine receptor protein 1	0.0066	0.9593	0.9578
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0066	0.9593	0.9589
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.1805	0.1805
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0775	0.0775
Echinococcus multilocularis	neuropeptide Y receptor	0.0066	0.9593	0.9589
Echinococcus granulosus	Chromo domain	0.0011	0.0775	0.0683
Onchocerca volvulus		0.0012	0.0874	0.0113
Echinococcus granulosus	g protein coupled receptor	0.0066	0.9593	0.9589
Onchocerca volvulus		0.0066	0.9593	1
Schistosoma mansoni	opsin-like receptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	G-protein coupled receptor	0.0066	0.9593	0.9577
Brugia malayi	sulfakinin receptor protein	0.0066	0.9593	0.9578
Schistosoma mansoni	hypothetical protein	0.0066	0.9593	0.9589
Onchocerca volvulus		0.0066	0.9593	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0066	0.9593	0.9589
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0775	0.0775
Echinococcus multilocularis	somatostatin receptor	0.0066	0.9593	0.9589
Brugia malayi	G-protein coupled receptor	0.0066	0.9593	0.9578
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.1805	0.1805
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0066	0.9593	0.9589
Echinococcus multilocularis	Chromobox protein 3	0.0011	0.0775	0.0683
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Brugia malayi	GnHR receptor homolog	0.0066	0.9593	0.9578
Brugia malayi	Serotonin receptor	0.0066	0.9593	0.9578
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0013	0.1034	0.0944
Echinococcus granulosus	g-protein coupled receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	cpg binding protein	0.003	0.3776	0.3713
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0066	0.9593	0.9589
Echinococcus granulosus	biogenic amine 5HT receptor	0.0066	0.9593	0.9589
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0066	0.9593	0.9589
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.9593	0.9589
Brugia malayi	putative neuropeptide receptor	0.0066	0.9593	0.9578
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0013	0.1034	0.0944
Echinococcus granulosus	neuropeptides capa receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	cpg binding protein	0.0028	0.3517	0.3452
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Echinococcus multilocularis	fmrfamide receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0.0775	0.0683
Brugia malayi	SET domain containing protein	0.0012	0.0874	0.0535
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.1947	0.1632
Echinococcus granulosus	fmrfamide receptor	0.0066	0.9593	0.9589
Echinococcus multilocularis	chromobox protein 1	0.0068	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0377	0.028
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0066	0.9593	0.9578
Echinococcus multilocularis	neuropeptide receptor	0.0066	0.9593	0.9589
Echinococcus multilocularis	orexin receptor type 2	0.0066	0.9593	0.9589
Brugia malayi	RE15519p	0.0066	0.9593	0.9578
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0066	0.9593	0.9589
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0066	0.9593	0.9578
Echinococcus granulosus	neuropeptide Y receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	opsin-like receptor	0.0066	0.9593	0.9589
Brugia malayi	Dopamine receptor	0.0066	0.9593	0.9578
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0775	0.0683
Echinococcus multilocularis	neuropeptide Y receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	neuropeptide F-like receptor	0.0066	0.9593	0.9589
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Echinococcus multilocularis	fmrfamide receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0775	0.0683
Brugia malayi	hypothetical protein	0.0066	0.9593	0.9578
Brugia malayi	Associated with TFs and helicases family protein	0.0011	0.0775	0.0432
Echinococcus granulosus	7tm_1 domain containing protein	0.0066	0.9593	0.9589
Echinococcus granulosus	neuropeptide FF receptor 2	0.0066	0.9593	0.9589
Brugia malayi	Protein cec-1.	0.0011	0.0775	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Loa Loa (eye worm)	hypothetical protein	0.0038	0.5153	0.4963
Schistosoma mansoni	histamine h1 receptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0775	0.0414
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.5153	0.4965
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0066	0.9593	0.9589
Schistosoma mansoni	hypothetical protein	0.0066	0.9593	0.9589
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0066	0.9593	0.9589
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0066	0.9593	0.9589
Onchocerca volvulus		0.0066	0.9593	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0377	0.028
Echinococcus granulosus	neuropeptides capa receptor	0.0066	0.9593	0.9589
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0775	0.0775
Echinococcus multilocularis	g protein coupled receptor	0.0066	0.9593	0.9589
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.3348	0.3348
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0066	0.9593	0.9589
Echinococcus multilocularis	neuropeptide receptor	0.0066	0.9593	0.9589
Echinococcus granulosus	tm gpcr rhodopsin	0.0066	0.9593	0.9589
Schistosoma mansoni	amine GPCR	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0775	0.0414
Trichomonas vaginalis	chromobox protein, putative	0.0068	1	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Echinococcus granulosus	allatostatin A receptor	0.0066	0.9593	0.9589
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.5622	0.5622
Brugia malayi	Dopamine receptor protein 2	0.0066	0.9593	0.9578
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.1253	0.1253
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Echinococcus multilocularis	Chromo domain	0.0011	0.0775	0.0683
Echinococcus granulosus	chromobox protein 1	0.0068	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0066	0.9593	0.9578
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0066	0.9593	0.9589
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0012	0.0874	0.0783
Brugia malayi	hypothetical protein	0.0066	0.9593	0.9578
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0066	0.9593	0.9578
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.1805	0.1805
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.1947	0.5
Schistosoma mansoni	neuropeptide receptor	0.0066	0.9593	0.9589
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.1805	0.1805
Onchocerca volvulus		0.0066	0.9593	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0775	0.0414
Brugia malayi	CXXC zinc finger family protein	0.0028	0.3517	0.3275
Echinococcus granulosus	neuropeptide receptor	0.0066	0.9593	0.9589
Brugia malayi	hypothetical protein	0.0066	0.9593	0.9578
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	TYRA-2 protein	0.0066	0.9593	0.9577
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.1947	0.1947
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0066	0.9593	0.9577
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0066	0.9593	1
Echinococcus multilocularis	serotonin receptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Brugia malayi	hypothetical protein	0.0011	0.0775	0.0432
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.1947	0.1648
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0066	0.9593	0.9589
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.1947	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0066	0.9593	0.9578
Brugia malayi	hypothetical protein	0.0066	0.9593	0.9578
Onchocerca volvulus		0.0066	0.9593	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Onchocerca volvulus		0.0066	0.9593	1
Brugia malayi	hypothetical protein	0.0066	0.9593	0.9578
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Schistosoma mansoni	biogenic amine receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.9593	0.9589
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.8614	0.86
Brugia malayi	G-protein coupled receptor	0.0066	0.9593	0.9578
Schistosoma mansoni	ap endonuclease	0.0018	0.1947	0.1866
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Trichomonas vaginalis	chromobox protein, putative	0.0068	1	1
Brugia malayi	Serotonin receptor	0.0066	0.9593	0.9578
Loa Loa (eye worm)	helicase	0.0011	0.0775	0.0414
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0775	0.0775
Brugia malayi	hypothetical protein	0.0066	0.9593	0.9578
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Schistosoma mansoni	opsin-like receptor	0.0066	0.9593	0.9589
Echinococcus multilocularis	serotonin receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	neuropeptide F-like receptor	0.0066	0.9593	0.9589
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.1947	0.1866
Schistosoma mansoni	growth hormone secretagogue receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	amine GPCR	0.0066	0.9593	0.9589
Schistosoma mansoni	neuropeptide f receptor 76f	0.0066	0.9593	0.9589
Echinococcus multilocularis	allatostatin A receptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.1947	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Echinococcus granulosus	Chromobox protein 3	0.0011	0.0775	0.0683
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Brugia malayi	chromobox protein homolog 3	0.0038	0.5153	0.4973
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0066	0.9593	0.9589
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0066	0.9593	0.9577
Loa Loa (eye worm)	hypothetical protein	0.003	0.3817	0.3575
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0775	0.0414
Echinococcus granulosus	cpg binding protein	0.003	0.3776	0.3713
Echinococcus multilocularis	neuropeptide receptor A26	0.0066	0.9593	0.9589
Brugia malayi	Valyl-tRNA synthetase	0.0011	0.0775	0.0432
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0066	0.9593	0.9589
Onchocerca volvulus		0.0066	0.9593	1
Echinococcus granulosus	sex peptide receptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	neuropeptide F receptor	0.0066	0.9593	0.9577
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Brugia malayi	follicle stimulating hormone receptor	0.0066	0.9593	0.9578
Echinococcus multilocularis	dro:myosuppressin receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	neuropeptide receptor	0.0066	0.9593	0.9589
Onchocerca volvulus		0.0028	0.3517	0.3109
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0013	0.1034	0.0944
Onchocerca volvulus		0.0066	0.9593	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0066	0.9593	0.9589
Onchocerca volvulus		0.0066	0.9593	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.9593	0.9589
Echinococcus granulosus	neuropeptide receptor	0.0066	0.9593	0.9589
Schistosoma mansoni	hypothetical protein	0.0066	0.9593	0.9589
Echinococcus multilocularis	G protein coupled receptor 139	0.0066	0.9593	0.9589
Loa Loa (eye worm)	melatonin receptor type 1A	0.0066	0.9593	0.9577
Schistosoma mansoni	chromobox protein	0.0068	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.9593	0.9589
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.1947	1
Schistosoma mansoni	myosin xvIII	0.0066	0.9593	0.9589
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.1805	0.1805
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0066	0.9593	0.9589
Echinococcus granulosus	G protein coupled receptor 139	0.0066	0.9593	0.9589
Schistosoma mansoni	adenoreceptor	0.0066	0.9593	0.9589
Loa Loa (eye worm)	hypothetical protein	0.0066	0.9593	0.9577
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.9593	0.9589
Echinococcus granulosus	tm gpcr rhodopsin	0.0066	0.9593	0.9589

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3326201

Bibliographic References

No literature references available for this target.

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Detailed information for compound 926195