Detailed information for compound 926356

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 263.332 | Formula: C15H21NO3
  • H donors: 2 H acceptors: 2 LogP: 1.52 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C[C@H]1C[C@@H](O)[C@@H]([C@H](N1)c1ccccc1)C
  • InChi: 1S/C15H21NO3/c1-10-13(17)8-12(9-14(18)19-2)16-15(10)11-6-4-3-5-7-11/h3-7,10,12-13,15-17H,8-9H2,1-2H3/t10-,12+,13+,15-/m0/s1
  • InChiKey: BJUVBIXENGXNQF-ZGFBFQLVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.006 0.0635
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0276 0.0271
Brugia malayi latrophilin 2 splice variant baaae 0.0065 0.0162 0.1783
Loa Loa (eye worm) glutathione reductase 0.0047 0.0111 0.1203
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0023
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0027 0.0022
Echinococcus multilocularis cpg binding protein 0.003 0.0065 0.0642
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0685 0.881
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0027 0.0346
Echinococcus multilocularis mothers against decapentaplegic 2 0.001 0.001 0.0085
Echinococcus granulosus dna repair and recombination protein rad54 0.0008 0.0004 0.0023
Brugia malayi hypothetical protein 0.0016 0.0026 0.0246
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0027 0.2138
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.0777 0.6046
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0006 0.0024
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0006 0.0023
Schistosoma mansoni hypothetical protein 0.003 0.0066 0.065
Schistosoma mansoni dep domain containing protein 0.0009 0.0006 0.0044
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.3629 1 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.2138
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0777 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0006 0.0023
Plasmodium falciparum glutathione reductase 0.0047 0.0111 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.2138
Brugia malayi CXXC zinc finger family protein 0.0028 0.006 0.0635
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.005 0.4276
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0048
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0006 0.0044
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0013 0.011
Echinococcus multilocularis expressed protein 0.0008 0.0005 0.0037
Echinococcus granulosus cpg binding protein 0.003 0.0065 0.0642
Brugia malayi Thioredoxin reductase 0.0047 0.0111 0.1203
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0685 0.881
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.0066 0.065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0777 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.2138
Echinococcus granulosus mothers against decapentaplegic 5 0.0022 0.0044 0.0433
Brugia malayi MH1 domain containing protein 0.0022 0.0044 0.0454
Echinococcus multilocularis dna repair and recombination protein rad54 0.0008 0.0004 0.0023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0148 0.1487
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0111 0.111
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.015 0.1507
Trichomonas vaginalis ferritin, putative 0.0008 0.0005 0.0069
Schistosoma mansoni lipoxygenase 0.0364 0.0986 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0027 0.0023
Echinococcus multilocularis mothers against decapentaplegic 6 0.001 0.001 0.0085
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.3629 1 1
Schistosoma mansoni hypothetical protein 0.0065 0.0162 0.1634
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0027 0.0023
Leishmania major hypothetical protein, conserved 0.0024 0.005 0.4276
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0443 0.5702
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0027 0.2138
Brugia malayi MH2 domain containing protein 0.0022 0.0044 0.0454
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0777 1
Schistosoma mansoni smad 0.001 0.001 0.0085
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0022 0.0044 0.0433
Echinococcus granulosus Polycystic kidney disease protein 0.0061 0.015 0.1507
Treponema pallidum NADH oxidase 0.0016 0.0027 0.0279
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.0777 1
Entamoeba histolytica fatty acid elongase, putative 0.0471 0.1283 1
Plasmodium falciparum LCCL domain-containing protein 0.0061 0.015 0.0146
Loa Loa (eye worm) hypothetical protein 0.0095 0.0246 0.2721
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.2138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.2138
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.3629 1 1
Brugia malayi Latrophilin receptor protein 2 0.003 0.0066 0.0694
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0256
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0027 0.1674
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.2138
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0022 0.0044 0.0433
Echinococcus multilocularis ferritin 0.0008 0.0005 0.0037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.2138
Echinococcus multilocularis SPRY domain containing protein 0.0008 0.0004 0.0023
Schistosoma mansoni hypothetical protein 0.003 0.0066 0.065
Echinococcus granulosus ferritin 0.0008 0.0005 0.0037
Mycobacterium tuberculosis Probable reductase 0.0106 0.0276 0.0271
Echinococcus granulosus RUN 0.0061 0.015 0.1507
Schistosoma mansoni loxhd1 0.0061 0.015 0.1507
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0777 1
Schistosoma mansoni cpg binding protein 0.003 0.0065 0.0642
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.0066 0.065
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0685 0.881
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0685 0.881
Echinococcus granulosus GPCR family 2 0.003 0.0066 0.065
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.001 0.0068
Toxoplasma gondii thioredoxin reductase 0.0047 0.0111 0.844
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0048
Schistosoma mansoni rab6-interacting 0.0061 0.015 0.1507
Schistosoma mansoni apoferritin-2 0.0008 0.0005 0.0037
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0006 0.0023
Schistosoma mansoni cpg binding protein 0.003 0.0065 0.0642
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.0777 1
Schistosoma mansoni apoferritin-2 0.0008 0.0005 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0443 0.5702
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0013 0.011
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.3629 1 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0006 0.0044
Loa Loa (eye worm) hypothetical protein 0.0061 0.015 0.1643
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0006 0.0044
Schistosoma mansoni polycystin 1-related 0.0061 0.015 0.1507
Echinococcus multilocularis Polycystic kidney disease protein 0.0061 0.015 0.1507
Echinococcus multilocularis dna repair and recombination protein rad54 0.0008 0.0004 0.0023
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.0465 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0276 0.74
Schistosoma mansoni smad1 5 8 and 0.0022 0.0044 0.0433
Loa Loa (eye worm) doublecortin family protein 0.0061 0.015 0.1643
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0111 0.1203
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0027 0.0023
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0006 0.0028
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.005 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0468 0.6021
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0006 0.0044
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.015 0.1507
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.0685 0.7661
Schistosoma mansoni Smad4 0.001 0.001 0.0085
Echinococcus multilocularis smad 0.0022 0.0044 0.0433
Schistosoma mansoni ferritin 0.0008 0.0005 0.0037
Schistosoma mansoni dishevelled 0.0009 0.0006 0.0044
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0276 0.0271
Plasmodium falciparum glutathione reductase 0.0016 0.0027 0.0023
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0027 0.0022
Brugia malayi hypothetical protein 0.0024 0.005 0.0514
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.015 0.1507
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0142
Brugia malayi Smad1 0.0022 0.0044 0.0454
Onchocerca volvulus 0.0061 0.015 0.3135
Schistosoma mansoni ferritin 0.0008 0.0005 0.0037
Brugia malayi MH1 domain containing protein 0.0022 0.0044 0.0454
Brugia malayi DIX domain containing protein 0.0009 0.0006 0.0023
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0256
Leishmania major trypanothione reductase 0.0047 0.0111 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0364 0.0986 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.005 0.4276
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0256
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0443 0.5702
Schistosoma mansoni smad1 5 8 and 0.0022 0.0044 0.0433
Echinococcus granulosus TGF beta signal transducer SmadC 0.0022 0.0044 0.0433
Echinococcus multilocularis 0.0008 0.0004 0.0023
Echinococcus granulosus SPRY domain containing protein 0.0008 0.0004 0.0023
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0371 0.0366
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0777 1
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.3629 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0276 0.0271
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0015 0.0124
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0027 0.2138
Schistosoma mansoni hypothetical protein 0.0061 0.015 0.1507
Entamoeba histolytica fatty acid elongase, putative 0.0471 0.1283 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.015 0.1507
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0006 0.0044
Loa Loa (eye worm) Smad1 0.0022 0.0044 0.0454
Brugia malayi MH2 domain containing protein 0.001 0.001 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0443 0.5702
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.0066 0.065
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0443 0.5702
Brugia malayi MH1 domain containing protein 0.0012 0.0017 0.0142
Echinococcus multilocularis mothers against decapentaplegic 5 0.0022 0.0044 0.0433
Schistosoma mansoni ferritin 0.0008 0.0005 0.0037
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.0777 0.6046
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.005 0.0046
Onchocerca volvulus 0.0028 0.006 0.1184
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0006 0.0044
Loa Loa (eye worm) nuclear factor I 0.0012 0.0017 0.0142
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0276 0.0271
Brugia malayi hypothetical protein 0.0009 0.0006 0.0023
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0027 0.2138
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.0066 0.065
Echinococcus granulosus smad 0.0022 0.0044 0.0433
Loa Loa (eye worm) hypothetical protein 0.0065 0.0162 0.1783
Brugia malayi hypothetical protein 0.0061 0.015 0.1643
Brugia malayi glutathione reductase 0.0047 0.0111 0.1203
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0006 0.0044
Schistosoma mansoni hypothetical protein 0.003 0.0066 0.065
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0006 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0685 0.881
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0443 0.5702
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0006 0.0044
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.0066 0.0694
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0111 0.0106
Echinococcus granulosus expressed protein 0.0008 0.0005 0.0037
Onchocerca volvulus Mothers against decapentaplegic homolog 0.001 0.001 0.0086
Schistosoma mansoni smad 0.0022 0.0044 0.0433
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0027 0.0022
Schistosoma mansoni lipoxygenase 0.0254 0.0684 0.6932
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.2138
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0027 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0685 0.881
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0006 0.0023
Echinococcus granulosus Smad4 0.0022 0.0044 0.0433
Echinococcus granulosus DNA repair and recombination protein RAD54B 0.0008 0.0004 0.0023
Schistosoma mansoni ferritin light chain 0.0008 0.0005 0.0037
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0.0044 0.0454
Onchocerca volvulus 0.0061 0.015 0.3135
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0006 0.0044
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.011
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0371 0.0366
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0027 0.2138
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0777 1
Plasmodium vivax glutathione reductase, putative 0.0047 0.0111 0.0107
Brugia malayi hypothetical protein 0.0009 0.0006 0.0023
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0111 0.111
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0309 0.8296
Brugia malayi MH2 domain containing protein 0.0022 0.0044 0.0454
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0006 0.0044
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0095 0.0246 0.2721
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0468 0.6021
Schistosoma mansoni ferritin light chain 0.0008 0.0005 0.0037
Loa Loa (eye worm) transcription factor SMAD2 0.033 0.0893 1
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0027 0.0346
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0008 0.0004 0.0023
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0309 0.0303
Echinococcus granulosus SPRY domain containing protein 0.0008 0.0004 0.0023
Loa Loa (eye worm) hypothetical protein 0.003 0.0066 0.0694
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0515
Loa Loa (eye worm) MH2 domain-containing protein 0.033 0.0893 1
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.3629 1 1
Echinococcus multilocularis Smad4 0.0022 0.0044 0.0433
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0027 0.2138
Entamoeba histolytica fatty acid elongase, putative 0.0471 0.1283 1
Brugia malayi N-terminal motif family protein 0.0175 0.0465 0.519
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0027 0.2138
Brugia malayi mothers against decapentaplegic homolog 3 0.001 0.001 0.0068
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0027 0.2138
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.005 0.0046
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0027 0.0023
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0008 0.0004 0.0023
Brugia malayi Doublecortin family protein 0.0061 0.015 0.1643
Entamoeba histolytica fatty acid elongase, putative 0.0471 0.1283 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0.0044 0.0454
Schistosoma mansoni Smad4 0.0022 0.0044 0.0433
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0027 0.0257
Echinococcus granulosus SPRY domain containing protein 0.0008 0.0004 0.0023
Echinococcus multilocularis dna repair and recombination protein rad54 0.0008 0.0004 0.0023
Entamoeba histolytica fatty acid elongase, putative 0.0471 0.1283 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0443 0.5702
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.013 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0061 0.015 0.0146
Loa Loa (eye worm) hypothetical protein 0.0175 0.0465 0.5191
Brugia malayi Calcitonin receptor-like protein seb-1 0.0095 0.0246 0.2721
Echinococcus granulosus mothers against decapentaplegic 6 0.001 0.001 0.0085
Schistosoma mansoni dishevelled 0.0009 0.0006 0.0044
Echinococcus granulosus mothers against decapentaplegic 2 0.001 0.001 0.0085
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0371 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0309 0.0303
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0022
Schistosoma mansoni hypothetical protein 0.003 0.0066 0.065
Schistosoma mansoni rab6-interacting 0.0061 0.015 0.1507
Echinococcus multilocularis 0.0008 0.0004 0.0023
Plasmodium falciparum thioredoxin reductase 0.0047 0.0111 0.0107
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0006 0.0044
Schistosoma mansoni ferritin 0.0008 0.0005 0.0037
Brugia malayi hypothetical protein 0.0061 0.015 0.1643
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.0066 0.0694
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0015 0.0124
Trypanosoma brucei trypanothione reductase 0.0047 0.0111 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.005 0.4276
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.001 0.0068
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0111 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0006 0.0044
Brugia malayi MH2 domain containing protein 0.033 0.0893 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.015 0.1643
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0443 0.952
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0276 0.0271
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0027 0.1674
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.005 0.3515
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.3629 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0309 0.0303
Plasmodium falciparum thioredoxin reductase 0.0016 0.0027 0.0023
Echinococcus multilocularis RUN 0.0061 0.015 0.1507
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.0685 0.7661
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0095 0.0246 0.2721
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0777 1
Echinococcus multilocularis GPCR, family 2 0.003 0.0066 0.065
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0111 0.0107
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0364 0.0986 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0027 0.2138
Schistosoma mansoni cpg binding protein 0.0028 0.006 0.0597
Echinococcus multilocularis SPRY domain containing protein 0.0008 0.0004 0.0023
Schistosoma mansoni smad1 5 8 and 0.0022 0.0044 0.0433
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0006 0.0023
Schistosoma mansoni Smad4 0.001 0.001 0.0085
Brugia malayi MH1 domain containing protein 0.0012 0.0017 0.0142
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.0777 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 34.6 uM Cytotoxicity against human A549 cells by MTT assay ChEMBL. 25172418

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.