TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 522.47 | Formula: C20H22F4N4O6S
H donors: 0 H acceptors: 6 LogP: 3.37 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: C[C@H](C(F)(F)F)OC(=O)N1CCC(CC1)Oc1ncnc(c1F)Oc1ccc(nc1C)S(=O)(=O)C
InChi: 1S/C20H22F4N4O6S/c1-11-14(4-5-15(27-11)35(3,30)31)34-18-16(21)17(25-10-26-18)33-13-6-8-28(9-7-13)19(29)32-12(2)20(22,23)24/h4-5,10,12-13H,6-9H2,1-3H3/t12-/m1/s1
InChiKey: LDCKFNQAGLBTSF-GFCCVEGCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	G protein-coupled receptor 119	Starlite/ChEMBL	References
Rattus norvegicus	Glucose-dependent insulinotropic receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Glucose-dependent insulinotropic receptor	468 aa	383 aa	21.4 %
Brugia malayi	follicle stimulating hormone receptor	G protein-coupled receptor 119	335 aa	274 aa	22.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	BC026374 protein (S09 family)	0.0099	0.0444	0.0136
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Echinococcus multilocularis	serotonin receptor	0.0119	0.0835	0.0835
Echinococcus granulosus	g protein coupled receptor	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0119	0.0835	0.0835
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	neuropeptide Y receptor	0.0119	0.0835	0.0835
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0099	0.0444	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0119	0.0835	0.0835
Mycobacterium ulcerans	carboxylesterase, LipT	0.0099	0.0444	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0119	0.0835	0.0835
Brugia malayi	hypothetical protein	0.0119	0.0835	0.0408
Brugia malayi	Melatonin receptor type 1A	0.0119	0.0835	0.0408
Schistosoma mansoni	neuropeptide receptor	0.0119	0.0835	0.0538
Echinococcus multilocularis	para nitrobenzyl esterase	0.0099	0.0444	0.0444
Brugia malayi	hypothetical protein	0.0119	0.0835	0.0408
Schistosoma mansoni	biogenic amine receptor	0.0119	0.0835	0.0538
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0588	1	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0119	0.0835	0.0538
Schistosoma mansoni	biogenic amine receptor	0.0119	0.0835	0.0538
Onchocerca volvulus		0.0119	0.0835	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0588	1	1
Schistosoma mansoni	amine GPCR	0.0119	0.0835	0.0538
Brugia malayi	G protein-coupled receptor F59B2.13	0.0119	0.0835	0.0408
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0119	0.0835	1
Echinococcus granulosus	g protein coupled receptor	0.0119	0.0835	0.0835
Brugia malayi	Serotonin receptor	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0119	0.0835	0.0835
Brugia malayi	GnHR receptor homolog	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	carboxylesterase 5A	0.0588	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0119	0.0835	0.0835
Brugia malayi	G-protein coupled receptor	0.0119	0.0835	0.0408
Echinococcus multilocularis	g protein coupled receptor	0.0119	0.0835	0.0835
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Schistosoma mansoni	gliotactin	0.0099	0.0444	0.0136
Onchocerca volvulus		0.0119	0.0835	1
Onchocerca volvulus		0.0119	0.0835	1
Echinococcus multilocularis	somatostatin receptor	0.0119	0.0835	0.0835
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0119	0.0835	0.0538
Schistosoma mansoni	hypothetical protein	0.0119	0.0835	0.0538
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0119	0.0835	0.0835
Brugia malayi	hypothetical protein	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	nmda type glutamate receptor	0.0084	0.0145	0.0145
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	allatostatin A receptor	0.0119	0.0835	0.0835
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0099	0.0444	0.0444
Echinococcus granulosus	biogenic amine 5HT receptor	0.0119	0.0835	0.0835
Echinococcus granulosus	serotonin receptor	0.0119	0.0835	0.0835
Echinococcus granulosus	nmda type glutamate receptor	0.0091	0.0282	0.0282
Echinococcus granulosus	neuropeptides capa receptor	0.0119	0.0835	0.0835
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0119	0.0835	0.0835
Echinococcus multilocularis	neuropeptide s receptor	0.0119	0.0835	0.0835
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0099	0.0444	0.0136
Onchocerca volvulus		0.0119	0.0835	1
Brugia malayi	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus granulosus	tm gpcr rhodopsin	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus granulosus	dro:myosuppressin receptor	0.0119	0.0835	0.0835
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0119	0.0835	0.0835
Brugia malayi	Dopamine receptor	0.0119	0.0835	0.0408
Schistosoma mansoni	hypothetical protein	0.0119	0.0835	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0588	1	1
Schistosoma mansoni	neuropeptide receptor	0.0119	0.0835	0.0538
Brugia malayi	hypothetical protein	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Brugia malayi	follicle stimulating hormone receptor	0.0119	0.0835	0.0408
Echinococcus granulosus	neuropeptide receptor	0.0119	0.0835	0.0835
Schistosoma mansoni	amine GPCR	0.0119	0.0835	0.0538
Loa Loa (eye worm)	TYRA-2 protein	0.0119	0.0835	0.0408
Schistosoma mansoni	myosin xvIII	0.0119	0.0835	0.0538
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0119	0.0835	0.0835
Schistosoma mansoni	neuropeptide F-like receptor	0.0119	0.0835	0.0538
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0119	0.0835	0.0538
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0119	0.0835	0.0835
Loa Loa (eye worm)	melatonin receptor type 1A	0.0119	0.0835	0.0408
Echinococcus multilocularis	nmda type glutamate receptor	0.0091	0.0282	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	G protein coupled receptor 139	0.0119	0.0835	0.0835
Echinococcus granulosus	BC026374 protein S09 family	0.0099	0.0444	0.0444
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0119	0.0835	0.0408
Schistosoma mansoni	neuropeptide receptor	0.0119	0.0835	0.0538
Brugia malayi	hypothetical protein	0.0119	0.0835	0.0408
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0119	0.0835	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	serotonin receptor	0.0119	0.0835	0.0835
Echinococcus granulosus	fmrfamide receptor	0.0119	0.0835	0.0835
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.0835	0.0538
Schistosoma mansoni	opsin-like receptor	0.0119	0.0835	0.0538
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0119	0.0835	0.0835
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Echinococcus granulosus	acetylcholinesterase	0.0588	1	1
Brugia malayi	neuropeptide F receptor	0.0119	0.0835	0.0408
Brugia malayi	sulfakinin receptor protein	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Loa Loa (eye worm)	G-protein coupled receptor	0.0119	0.0835	0.0408
Echinococcus multilocularis	acetylcholinesterase	0.0588	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0119	0.0835	0.0835
Echinococcus granulosus	para nitrobenzyl esterase	0.0099	0.0444	0.0444
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0119	0.0835	0.0538
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0099	0.0444	0.0444
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Schistosoma mansoni	neuropeptide receptor	0.0119	0.0835	0.0538
Brugia malayi	larval opioid receptor	0.0119	0.0835	0.0408
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Onchocerca volvulus		0.0119	0.0835	1
Brugia malayi	RE15519p	0.0119	0.0835	0.0408
Loa Loa (eye worm)	neuropeptide F receptor	0.0119	0.0835	0.0408
Echinococcus granulosus	neuropeptide Y receptor	0.0119	0.0835	0.0835
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0119	0.0835	0.0538
Onchocerca volvulus		0.0119	0.0835	1
Schistosoma mansoni	acetylcholinesterase	0.0099	0.0444	0.0136
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0119	0.0835	0.0408
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0119	0.0835	0.0538
Echinococcus multilocularis	neuropeptide receptor	0.0119	0.0835	0.0835
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0119	0.0835	0.0538
Schistosoma mansoni	neuropeptide f receptor 76f	0.0119	0.0835	0.0538
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0119	0.0835	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0119	0.0835	0.0538
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0119	0.0835	0.0538
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0099	0.0444	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Echinococcus granulosus	nmda type glutamate receptor	0.0084	0.0145	0.0145
Onchocerca volvulus		0.0119	0.0835	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.0835	0.0538
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0119	0.0835	0.0408
Echinococcus multilocularis	neuropeptides capa receptor	0.0119	0.0835	0.0835
Brugia malayi	G protein-coupled receptor	0.0119	0.0835	0.0408
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.0835	0.0538
Echinococcus multilocularis	sex peptide receptor	0.0119	0.0835	0.0835
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0119	0.0835	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0119	0.0835	0.0538
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Onchocerca volvulus		0.0119	0.0835	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.0835	0.0538
Schistosoma mansoni	amine GPCR	0.0119	0.0835	0.0538
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0119	0.0835	0.0835
Echinococcus granulosus	somatostatin receptor	0.0119	0.0835	0.0835
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0119	0.0835	0.0835
Echinococcus granulosus	tm gpcr rhodopsin	0.0119	0.0835	0.0835
Echinococcus multilocularis	acetylcholinesterase	0.0588	1	1
Echinococcus granulosus	G protein coupled receptor 139	0.0119	0.0835	0.0835
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0099	0.0444	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Schistosoma mansoni	opsin-like receptor	0.0119	0.0835	0.0538
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0119	0.0835	0.0835
Brugia malayi	Dopamine receptor protein 2	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Brugia malayi	Carboxylesterase family protein	0.0588	1	1
Brugia malayi	hypothetical protein	0.0119	0.0835	0.0408
Brugia malayi	putative neuropeptide receptor NPR1	0.0119	0.0835	0.0408
Loa Loa (eye worm)	acetylcholinesterase 1	0.0588	1	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	g protein coupled receptor	0.0119	0.0835	0.0835
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0119	0.0835	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0119	0.0835	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Schistosoma mansoni	hypothetical protein	0.0119	0.0835	0.0538
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0099	0.0444	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0099	0.0444	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Schistosoma mansoni	amine GPCR	0.0119	0.0835	0.0538
Echinococcus granulosus	orexin receptor type 2	0.0119	0.0835	0.0835
Onchocerca volvulus		0.0119	0.0835	1
Echinococcus granulosus	hypothetical protein	0.0119	0.0835	0.0835
Onchocerca volvulus		0.0119	0.0835	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Brugia malayi	AKH receptor	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0119	0.0835	0.0835
Echinococcus granulosus	neuropeptide receptor A26	0.0119	0.0835	0.0835
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.0835	0.0538
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.0835	0.0538
Echinococcus granulosus	g-protein coupled receptor	0.0119	0.0835	0.0835
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0119	0.0835	0.0538
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0119	0.0835	0.0538
Schistosoma mansoni	adenoreceptor	0.0119	0.0835	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Brugia malayi	ORL1-like opioid receptor	0.0119	0.0835	0.0408
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0119	0.0835	0.0408
Brugia malayi	Serotonin receptor	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Brugia malayi	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus granulosus	7tm_1 domain containing protein	0.0119	0.0835	0.0835
Schistosoma mansoni	histamine h1 receptor	0.0119	0.0835	0.0538
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0119	0.0835	0.0835
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus granulosus	tm gpcr rhodopsin	0.0119	0.0835	0.0835
Loa Loa (eye worm)	neuropeptide F receptor	0.0119	0.0835	0.0408
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0099	0.0444	0.5
Onchocerca volvulus		0.0119	0.0835	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	g-protein coupled receptor	0.0119	0.0835	0.0835
Echinococcus multilocularis	fmrfamide receptor	0.0119	0.0835	0.0835
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.0835	0.0538
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0119	0.0835	0.0408
Echinococcus granulosus	neuropeptide receptor	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Brugia malayi	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	g protein coupled receptor	0.0119	0.0835	0.0835
Echinococcus granulosus	biogenic amine 5HT receptor	0.0119	0.0835	0.0835
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus granulosus	neuropeptides capa receptor	0.0119	0.0835	0.0835
Schistosoma mansoni	biogenic amine receptor	0.0119	0.0835	0.0538
Trichomonas vaginalis	spcc417.12 protein, putative	0.0099	0.0444	0.5
Schistosoma mansoni	opsin-like receptor	0.0119	0.0835	0.0538
Schistosoma mansoni	amine GPCR	0.0119	0.0835	0.0538
Echinococcus granulosus	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Brugia malayi	Dopamine receptor protein 1	0.0119	0.0835	0.0408
Schistosoma mansoni	glutamate receptor NMDA	0.0123	0.0907	0.0613
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Onchocerca volvulus		0.0119	0.0835	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0093	0.0313	0.0313
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	neuropeptides capa receptor	0.0119	0.0835	0.0835
Brugia malayi	neuropeptide F receptor	0.0119	0.0835	0.0408
Echinococcus granulosus	carboxylesterase 5A	0.0588	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0119	0.0835	0.0408
Brugia malayi	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	neuropeptide receptor	0.0119	0.0835	0.0835
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Echinococcus granulosus	allatostatin A receptor	0.0119	0.0835	0.0835
Onchocerca volvulus		0.0119	0.0835	1
Echinococcus granulosus	g protein coupled receptor	0.0119	0.0835	0.0835
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0119	0.0835	0.0835
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0119	0.0835	0.0835
Onchocerca volvulus		0.0119	0.0835	1
Echinococcus multilocularis	fmrfamide receptor	0.0119	0.0835	0.0835
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0119	0.0835	0.0835
Echinococcus multilocularis	neuroligin	0.0099	0.0444	0.0444
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0119	0.0835	0.0538
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0119	0.0835	0.0835
Echinococcus multilocularis	neuropeptide receptor A26	0.0119	0.0835	0.0835
Echinococcus granulosus	neuroligin	0.0099	0.0444	0.0444
Echinococcus multilocularis	neuropeptide Y receptor	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.0835	0.0538
Echinococcus granulosus	neuropeptide Y receptor	0.0119	0.0835	0.0835
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0119	0.0835	0.0835
Echinococcus granulosus	sex peptide receptor	0.0119	0.0835	0.0835
Echinococcus granulosus	neuropeptide s receptor	0.0119	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Onchocerca volvulus		0.0119	0.0835	1
Onchocerca volvulus		0.0119	0.0835	1
Loa Loa (eye worm)	carboxylesterase	0.0588	1	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0099	0.0444	0.5
Schistosoma mansoni	hypothetical protein	0.0119	0.0835	0.0538
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0119	0.0835	0.0408
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0119	0.0835	0.0538
Schistosoma mansoni	neuropeptide F-like receptor	0.0119	0.0835	0.0538
Onchocerca volvulus		0.0119	0.0835	1
Echinococcus granulosus	acetylcholinesterase	0.0588	1	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0835	0.0408
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0099	0.0444	0.0136
Brugia malayi	G-protein coupled receptor	0.0119	0.0835	0.0408
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0093	0.0313	0.0313
Brugia malayi	putative neuropeptide receptor	0.0119	0.0835	0.0408

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 9.2 nM	Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay	ChEMBL.	25088191
EC50 (binding)	= 110 nM	Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay	ChEMBL.	25088191
Efficacy (binding)	= 56 %	Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay relative to AR231453	ChEMBL.	25088191
Efficacy (binding)	= 85 %	Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay relative to AR231453	ChEMBL.	25088191

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3325852

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 926378