TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 592.504 | Formula: C30H24O13
H donors: 10 H acceptors: 10 LogP: 2.03 Rotable bonds: 2
Rule of 5 violations (Lipinski): 3
SMILES: OC1Cc2c(O)cc3c(c2OC1c1ccc(c(c1)O)O)C1c2c(O)cc(c(c2OC(O3)(C1O)c1ccc(c(c1)O)O)O)O
InChi: 1S/C30H24O13/c31-13-3-1-10(5-16(13)34)26-20(38)7-12-15(33)9-21-23(27(12)41-26)24-22-18(36)8-19(37)25(39)28(22)43-30(42-21,29(24)40)11-2-4-14(32)17(35)6-11/h1-6,8-9,20,24,26,29,31-40H,7H2
InChiKey: IUPQNGNZYZDZOI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Plasmodium falciparum	Subtilisin-like serine protease	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	subtilisin SUB1	Get druggable targets OG5_138369	All targets in OG5_138369
Babesia bovis	subtilisin-like protein, putative	Get druggable targets OG5_138369	All targets in OG5_138369
Cryptosporidium hominis	subtilisin-like serine protease	Get druggable targets OG5_138369	All targets in OG5_138369
Plasmodium knowlesi	subtilisin-like protease 1, putative	Get druggable targets OG5_138369	All targets in OG5_138369
Plasmodium falciparum	subtilisin-like protease 1	Get druggable targets OG5_138369	All targets in OG5_138369
Plasmodium vivax	subtilisin-like protease 1	Get druggable targets OG5_138369	All targets in OG5_138369
Plasmodium berghei	subtilisin-like protease 1	Get druggable targets OG5_138369	All targets in OG5_138369
Plasmodium yoelii	PfSUB-1	Get druggable targets OG5_138369	All targets in OG5_138369
Neospora caninum	hypothetical protein	Get druggable targets OG5_138369	All targets in OG5_138369

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0587	0.0886
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0156	0.0235
Schistosoma mansoni	cpg binding protein	0.0032	0.0529	0.0529
Brugia malayi	celfurPC protein	0.0015	0.0156	0.0203
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Leishmania major	subtilisin-like serine peptidase	0.0015	0.0156	0.0203
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0953	0.1241
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0015	0.0156	0.0203
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0035	0.0035
Toxoplasma gondii	subtilisin SUB7	0.0015	0.0156	0.0203
Trichomonas vaginalis	CMGC family protein kinase	0.0095	0.1962	0.2964
Leishmania major	cyclin	0.0082	0.1669	0.2174
Toxoplasma gondii	subtilisin SUB6	0.0015	0.0156	0.0203
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0441	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0156	0.0203
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0095	0.1962	0.2557
Toxoplasma gondii	hypothetical protein	0.0026	0.04	0.0521
Echinococcus granulosus	cyclins	0.0034	0.0587	0.0587
Echinococcus multilocularis	cyclins	0.0034	0.0587	0.0587
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0015	0.0156	0.0156
Trypanosoma cruzi	cdc2-related kinase 3	0.0095	0.1962	0.2557
Giardia lamblia	Hypothetical protein	0.0034	0.0587	0.299
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0095	0.1962	0.2557
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0441	0.0575
Brugia malayi	hypothetical protein	0.0135	0.2864	0.3732
Echinococcus multilocularis	cyclins	0.0034	0.0587	0.0587
Trypanosoma brucei	cdc2-related kinase 3	0.0095	0.1962	0.2557
Trichomonas vaginalis	glutaminase, putative	0.0301	0.6621	1
Echinococcus granulosus	cyclins	0.0034	0.0587	0.0587
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0015	0.0156	0.5
Trypanosoma cruzi	cyclin 6, putative	0.0082	0.1669	0.2174
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0015	0.0156	0.0203
Toxoplasma gondii	subtilisin SUB12	0.0015	0.0156	0.0203
Echinococcus multilocularis	cyclin b3	0.0034	0.0587	0.0587
Trypanosoma cruzi	cyclin, putative	0.0082	0.1669	0.2174
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0953	0.1241
Echinococcus multilocularis	cpg binding protein	0.0033	0.0569	0.0569
Trichomonas vaginalis	cyclin B, putative	0.0082	0.1669	0.2521
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0034	0.0587	0.0765
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0095	0.1962	0.2557
Trypanosoma cruzi	cdc2-related kinase 3	0.0095	0.1962	0.2557
Echinococcus granulosus	cyclin dependent kinase 1	0.0095	0.1962	0.1962
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0082	0.1669	0.2174
Plasmodium vivax	subtilisin-like protease 2, putative	0.0015	0.0156	0.0331
Echinococcus granulosus	neuroendocrine convertase 2	0.0015	0.0156	0.0156
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0015	0.0156	0.0156
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0032	0.0041
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0095	0.1962	0.1962
Loa Loa (eye worm)	glutaminase 2	0.0301	0.6621	0.8626
Echinococcus granulosus	cyclin dependent kinase 5	0.0095	0.1962	0.1962
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0015	0.0156	0.0156
Echinococcus multilocularis	cyclins	0.0034	0.0587	0.0587
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0953	0.0953
Brugia malayi	endoprotease bli-4 precursor	0.0015	0.0156	0.0203
Echinococcus granulosus	cyclin b3	0.0034	0.0587	0.0587
Entamoeba histolytica	cyclin, putative	0.0082	0.1669	0.8504
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0441	0.0575
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.0129	0.2737	0.3566
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0095	0.1962	0.2557
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Trichomonas vaginalis	cyclins, putative	0.0056	0.1082	0.1634
Toxoplasma gondii	subtilisin SUB2	0.0015	0.0156	0.0203
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Schistosoma mansoni	cpg binding protein	0.0033	0.0569	0.0569
Trichomonas vaginalis	cyclin B, putative	0.0034	0.0587	0.0886
Schistosoma mansoni	furin-1 (S08 family)	0.0015	0.0156	0.0156
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0015	0.0156	0.5
Schistosoma mansoni	cpg binding protein	0.0033	0.0569	0.0569
Toxoplasma gondii	subtilisin SUB10	0.0015	0.0156	0.0203
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Mycobacterium leprae	Possible secreted protease	0.0015	0.0156	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0156	0.0203
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0953	0.0953
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0015	0.0156	0.0156
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0095	0.1962	0.2557
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0095	0.0095
Trichomonas vaginalis	CMGC family protein kinase	0.0095	0.1962	0.2964
Schistosoma mansoni	hypothetical protein	0.0012	0.0095	0.0095
Trichomonas vaginalis	cyclins, putative	0.0082	0.1669	0.2521
Onchocerca volvulus		0.0032	0.0529	0.3167
Echinococcus granulosus	furin	0.0015	0.0156	0.0156
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.0347	0.7676	0.7676
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0895	0.1167
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Echinococcus multilocularis	cyclin dependent kinase 5	0.0095	0.1962	0.1962
Plasmodium falciparum	subtilisin-like protease 2	0.0015	0.0156	0.0331
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.0347	0.7676	0.7676
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Trichomonas vaginalis	cyclin B, putative	0.0082	0.1669	0.2521
Entamoeba histolytica	cell division protein kinase 2, putative	0.0095	0.1962	1
Echinococcus granulosus	cyclin dependent kinase	0.0095	0.1962	0.1962
Trichomonas vaginalis	cyclins, putative	0.0034	0.0587	0.0886
Toxoplasma gondii	subtilisin SUB8	0.0015	0.0156	0.0203
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0015	0.0156	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0441	0.0575
Brugia malayi	proprotein convertase 2	0.0015	0.0156	0.0203
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0953	0.0953
Loa Loa (eye worm)	subtilase	0.0015	0.0156	0.0203
Giardia lamblia	G2/mitotic-specific cyclin B	0.0082	0.1669	0.8504
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0035	0.0035
Trichomonas vaginalis	cyclin B, putative	0.0082	0.1669	0.2521
Echinococcus multilocularis	dnaJ subfamily B	0.045	1	1
Trichomonas vaginalis	cyclins, putative	0.0082	0.1669	0.2521
Brugia malayi	neuroendocrine convertase 1 precursor	0.0015	0.0156	0.0203
Schistosoma mansoni	serine/threonine protein kinase	0.0095	0.1962	0.1962
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0015	0.0156	0.0156
Echinococcus granulosus	Furin 1	0.0015	0.0156	0.0156
Giardia lamblia	Kinase, CMGC CDK	0.0095	0.1962	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0953	0.0953
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0441	0.0935
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Toxoplasma gondii	subtilisin SUB11	0.0015	0.0156	0.0203
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Toxoplasma gondii	subtilisin SUB4	0.0015	0.0156	0.0203
Echinococcus multilocularis	Furin 1	0.0015	0.0156	0.0156
Trichomonas vaginalis	cyclin B3, putative	0.0034	0.0587	0.0886
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.0347	0.7676	0.7676
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0034	0.0587	0.0587
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0441	0.0935
Brugia malayi	hypothetical protein	0.0028	0.0441	0.0575
Trichomonas vaginalis	cyclin D, putative	0.0034	0.0587	0.0886
Trichomonas vaginalis	cyclin D, putative	0.0034	0.0587	0.0886
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Toxoplasma gondii	fructose-bisphospatase II	0.0347	0.7676	1
Trypanosoma cruzi	cdc2-related kinase 1	0.0095	0.1962	0.2557
Mycobacterium ulcerans	glutaminase	0.0301	0.6621	1
Echinococcus multilocularis	cyclins	0.0034	0.0587	0.0587
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0082	0.1669	0.2174
Trichomonas vaginalis	cyclin A, putative	0.0082	0.1669	0.2521
Brugia malayi	fructose-1,6-bisphosphatase	0.0347	0.7676	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Schistosoma mansoni	cyclin-dependent kinase 5 activator	0.0282	0.6187	0.6187
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0015	0.0156	0.0156
Echinococcus multilocularis	cyclin B3 1	0.0034	0.0587	0.0587
Plasmodium falciparum	protein kinase 5	0.0095	0.1962	0.416
Entamoeba histolytica	cell division protein kinase 2, putative	0.0095	0.1962	1
Entamoeba histolytica	cyclin, putative	0.0034	0.0587	0.299
Schistosoma mansoni	cyclins	0.0034	0.0587	0.0587
Echinococcus granulosus	membrane bound transcription factor site 1	0.0015	0.0156	0.0156
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0156	0.0235
Echinococcus multilocularis	neuroendocrine convertase 2	0.0015	0.0156	0.0156
Schistosoma mansoni	cyclin B	0.0082	0.1669	0.1669
Toxoplasma gondii	subtilisin SUB1	0.0217	0.4718	0.6146
Toxoplasma gondii	subtilisin SUB9	0.0015	0.0156	0.0203
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1939	0.2527
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0015	0.0156	0.5
Toxoplasma gondii	subtilisin SUB5	0.0015	0.0156	0.0203
Trypanosoma cruzi	cdc2-related kinase 1	0.0095	0.1962	0.2557
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0015	0.0156	0.5
Brugia malayi	hypothetical protein	0.0018	0.0219	0.0285
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Trichomonas vaginalis	CMGC family protein kinase	0.0095	0.1962	0.2964
Echinococcus granulosus	cyclins	0.0034	0.0587	0.0587
Brugia malayi	glutaminase DH11.1	0.0301	0.6621	0.8626
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0015	0.0156	0.0156
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.0129	0.2737	0.3566
Trichomonas vaginalis	cyclins, putative	0.0082	0.1669	0.2521
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.1168	0.1522
Plasmodium falciparum	subtilisin-like protease 1	0.0217	0.4718	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Schistosoma mansoni	cyclin B3	0.0034	0.0587	0.0587
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Echinococcus multilocularis	cyclins	0.0034	0.0587	0.0587
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Echinococcus multilocularis	cyclin dependent kinase 5 activator 1	0.0282	0.6187	0.6187
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Brugia malayi	cell division control protein 2 homolog	0.0095	0.1962	0.2557
Entamoeba histolytica	cyclin family protein	0.0034	0.0587	0.299
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.133	0.133
Echinococcus multilocularis		0.0015	0.0156	0.0156
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Leishmania major		0.0347	0.7676	1
Echinococcus multilocularis	cyclins	0.0034	0.0587	0.0587
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0015	0.0156	0.0203
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0156	0.0235
Loa Loa (eye worm)	proprotein convertase 2	0.0015	0.0156	0.0203
Trypanosoma brucei	subtilisin peptidase	0.0015	0.0156	0.0203
Echinococcus granulosus	cyclin B3 1	0.0034	0.0587	0.0587
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0529	0.0689
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0034	0.0587	0.0587
Giardia lamblia	Cyclin A	0.0034	0.0587	0.299
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1669	0.2174
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0015	0.0156	0.0156
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0015	0.0156	0.0156
Leishmania major	hypothetical protein, conserved	0.0028	0.0441	0.0575
Toxoplasma gondii	fructose-bisphospatase I	0.0129	0.2737	0.3566
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.0347	0.7676	1
Trypanosoma cruzi	cyclin, putative	0.0082	0.1669	0.2174
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0282	0.6187	0.806
Plasmodium vivax	subtilisin-like serine protease, putative	0.0015	0.0156	0.0331
Echinococcus multilocularis	cyclin dependent kinase 1	0.0095	0.1962	0.1962
Echinococcus granulosus	cyclin B	0.0082	0.1669	0.1669
Schistosoma mansoni	glutaminase	0.0301	0.6621	0.6621
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0129	0.2737	0.3566
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0156	0.0235
Brugia malayi	Protein kinase domain containing protein	0.0095	0.1962	0.2557
Loa Loa (eye worm)	cyclin domain-containing protein	0.0034	0.0587	0.0765
Loa Loa (eye worm)	glutaminase	0.0301	0.6621	0.8626
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0015	0.0156	0.5
Echinococcus granulosus	cyclins	0.0034	0.0587	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1669	0.2174
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Loa Loa (eye worm)	endoprotease bli-4	0.0015	0.0156	0.0203
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0953	0.0953
Echinococcus multilocularis	cyclin dependent kinase	0.0095	0.1962	0.1962
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0347	0.7676	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Echinococcus granulosus	cpg binding protein	0.0033	0.0569	0.0569
Onchocerca volvulus		0.0082	0.1669	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0082	0.1669	0.2174
Schistosoma mansoni	hypothetical protein	0.045	1	1
Trichomonas vaginalis	cyclins, putative	0.0082	0.1669	0.2521
Trichomonas vaginalis	cyclin B, putative	0.0082	0.1669	0.2521
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0529	0.0689
Brugia malayi	Subtilase family protein	0.0015	0.0156	0.0203
Echinococcus granulosus	cyclins	0.0034	0.0587	0.0587
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0015	0.0156	0.0203
Giardia lamblia	Kinase, CMGC CDK	0.0095	0.1962	1
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0129	0.2737	0.3566
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0082	0.1669	0.2174
Loa Loa (eye worm)	hypothetical protein	0.0135	0.2864	0.3732
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0015	0.0156	0.0156
Entamoeba histolytica	cyclin family protein	0.0034	0.0587	0.299
Echinococcus multilocularis	cyclin B	0.0082	0.1669	0.1669
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0015	0.0156	0.0203
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0095	0.1962	0.2557
Plasmodium falciparum	cyclin	0.0034	0.0587	0.1244
Plasmodium vivax	protein kinase Crk2	0.0095	0.1962	0.416
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0441	0.0575
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0015	0.0156	0.0156
Trypanosoma brucei	cdc2-related kinase 1	0.0095	0.1962	0.2557
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0347	0.7676	1
Onchocerca volvulus		0.0015	0.0156	0.0934
Echinococcus multilocularis	cyclins	0.0034	0.0587	0.0587
Plasmodium falciparum	subtilisin-like protease 3	0.0015	0.0156	0.0331
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0156	0.0235
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0035	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0135	0.2864	0.3732
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.0347	0.7676	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Echinococcus granulosus	cyclin dependent kinase 5 activator 1	0.0282	0.6187	0.6187
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0953	0.0953
Trypanosoma cruzi	subtilisin peptidase	0.0015	0.0156	0.0203
Schistosoma mansoni	serine/threonine protein kinase	0.0095	0.1962	0.1962
Echinococcus multilocularis	cyclin dependent kinase 1	0.0095	0.1962	0.1962
Trypanosoma brucei	mitotic cyclin 6	0.0082	0.1669	0.2174
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0015	0.0156	0.0235
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0015	0.0156	0.0203
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0441	0.0935
Plasmodium vivax	subtilisin-like protease 1	0.0217	0.4718	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0953	0.0953

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.3 uM	Inhibition of Plasmodium falciparum SUB1	ChEMBL.	25129616

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3325855

Bibliographic References

No literature references available for this target.

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Detailed information for compound 926381