TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 471.634 | Formula: C30H37N3O2
H donors: 1 H acceptors: 1 LogP: 5.27 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1N1CCN(CC1)CCCCCC(=O)NCc1ccccc1c1ccccc1
InChi: 1S/C30H37N3O2/c1-35-29-17-10-9-16-28(29)33-22-20-32(21-23-33)19-11-3-6-18-30(34)31-24-26-14-7-8-15-27(26)25-12-4-2-5-13-25/h2,4-5,7-10,12-17H,3,6,11,18-24H2,1H3,(H,31,34)
InChiKey: XNINUOTXWAEWTL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	biogenic amine (5HT) receptor	Get druggable targets OG5_133074	All targets in OG5_133074
Schistosoma mansoni	biogenic amine (5HT) receptor	Get druggable targets OG5_133074	All targets in OG5_133074
Echinococcus granulosus	biogenic amine 5HT receptor	Get druggable targets OG5_133074	All targets in OG5_133074

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	G protein coupled receptor 139	0.0015	0.0056	0.011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0018	0.0085	0.0173
Schistosoma mansoni	cathepsin C	0.0012	0.002	0.004
Schistosoma mansoni	hypothetical protein	0.0015	0.0056	0.011
Echinococcus multilocularis	transcription factor btf3	0.0034	0.0272	0.0272
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0015	0.0056	0.011
Schistosoma mansoni	cathepsin S (C01 family)	0.0012	0.002	0.004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Brugia malayi	beta-lactamase family protein	0.0036	0.0289	0.0961
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0015	0.0056	0.0186
Echinococcus multilocularis	neuropeptide Y receptor	0.0015	0.0056	0.0056
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0267	0.0886
Toxoplasma gondii	ABC1 family protein	0.0036	0.0289	0.2907
Echinococcus granulosus	geminin	0.0165	0.1718	0.3378
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0015	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0961
Onchocerca volvulus		0.0015	0.0056	0.0227
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0012	0.002	0.004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Trypanosoma cruzi	cruzipain precursor, putative	0.0076	0.0734	0.2386
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.0734	0.2386
Brugia malayi	G-protein coupled receptor	0.0015	0.0056	0.0186
Onchocerca volvulus		0.0036	0.0289	0.1173
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0095	0.0945	0.8616
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0016	0.0068	0.1887
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0085	0.061
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0272	0.084
Leishmania major	cathepsin L-like protease	0.0026	0.0181	0.111
Onchocerca volvulus		0.0026	0.0181	0.0733
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0216	0.0425
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0282	0.301	0.5917
Trypanosoma cruzi	cysteine proteinase, putative	0.0018	0.0085	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Plasmodium vivax	vivapain-2	0.0026	0.0181	0.5969
Echinococcus granulosus	neuropeptide s receptor	0.0015	0.0056	0.011
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0015	0.0056	0.0186
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0093	0.0244
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0015	0.0056	0.0056
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0012	0.002	0.004
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0026	0.0181	0.0356
Echinococcus multilocularis	G protein coupled receptor 139	0.0015	0.0056	0.0056
Brugia malayi	cathepsin L-like precursor	0.002	0.0116	0.0385
Echinococcus granulosus	cysteine protease	0.0018	0.0085	0.0168
Giardia lamblia	Hypothetical protein	0.0108	0.1086	1
Onchocerca volvulus		0.0015	0.0056	0.0227
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0015	0.0056	0.011
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0018	0.0085	0.0168
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0026	0.0181	0.6386
Leishmania major	cysteine peptidase A (CPA)	0.0026	0.0181	0.111
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0085	0.061
Brugia malayi	Cathepsin L-like precursor	0.002	0.0116	0.0385
Brugia malayi	Cathepsin L-like cysteine proteinase	0.002	0.0116	0.0385
Onchocerca volvulus		0.0026	0.0181	0.0733
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0012	0.002	0.0068
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0015	0.0056	0.011
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0056	0.011
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0015	0.0056	0.0186
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0012	0.002	0.004
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0056	0.011
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Onchocerca volvulus		0.0015	0.0056	0.0227
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0056	0.011
Loa Loa (eye worm)	transcriptional regulator	0.0016	0.0068	0.0225
Brugia malayi	AKH receptor	0.0015	0.0056	0.0186
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0093	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0961
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0015	0.0056	0.0186
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0015	0.0056	0.011
Leishmania major	silent information regulator 2, putative	0.0108	0.1086	1
Brugia malayi	Dopamine receptor protein 2	0.0015	0.0056	0.0186
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0181	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0012	0.002	0.004
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0289	1
Brugia malayi	Papain family cysteine protease containing protein	0.0012	0.002	0.0068
Echinococcus granulosus	7tm_1 domain containing protein	0.0015	0.0056	0.011
Plasmodium vivax	vivapain-1	0.0018	0.0085	0.242
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0015	0.0056	0.0056
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0085	0.061
Entamoeba histolytica	hypothetical protein	0.0034	0.0272	0.2358
Brugia malayi	RNA binding protein	0.0196	0.2063	0.6853
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0015	0.0056	0.011
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0272	0.1027
Leishmania major	cathepsin L-like protease	0.0026	0.0181	0.111
Schistosoma mansoni	neuropeptide F-like receptor	0.0015	0.0056	0.011
Brugia malayi	follicle stimulating hormone receptor	0.0015	0.0056	0.0186
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0289	0.0936
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0093	0.025
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0272	0.1027
Echinococcus granulosus	cathepsin L cysteine protease	0.0018	0.0085	0.0168
Schistosoma mansoni	hypothetical protein	0.0015	0.0056	0.011
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0068	0.0225
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0085	0.061
Plasmodium falciparum	basic transcription factor 3b, putative	0.0034	0.0272	1
Brugia malayi	hypothetical protein	0.0015	0.0056	0.0186
Onchocerca volvulus		0.0026	0.0181	0.0733
Schistosoma mansoni	hypothetical protein	0.0165	0.1718	0.3378
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0095	0.0945	0.1858
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0012	0.002	0.004
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0093	0.0244
Echinococcus granulosus	neuropeptides capa receptor	0.0015	0.0056	0.011
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0016	0.0068	0.1887
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0181	0.1506
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0108	0.1086	0.4356
Echinococcus granulosus	7TM GPCR rhodopsin	0.0015	0.0056	0.011
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0289	0.0936
Plasmodium vivax	SET domain protein, putative	0.0029	0.0216	0.7281
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0016	0.0068	0.0225
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.0702	0.2333
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Echinococcus granulosus	neuropeptide receptor	0.0015	0.0056	0.011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0056	0.0056
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0267	0.0525
Giardia lamblia	Sirtuin type 2	0.0016	0.0068	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0282	0.301	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Brugia malayi	GnHR receptor homolog	0.0015	0.0056	0.0186
Leishmania major	basic transcription factor 3a, putative	0.0034	0.0272	0.2002
Brugia malayi	G-protein coupled receptor	0.0015	0.0056	0.0186
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0095	0.0945	0.378
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0093	0.0093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Schistosoma mansoni	neuropeptide f receptor 76f	0.0015	0.0056	0.011
Brugia malayi	hypothetical protein	0.0015	0.0056	0.0186
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0282	0.301	0.5917
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0093	0.2712
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0961
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0734	0.6541
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0085	0.061
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0289	0.1099
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0289	0.0936
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0095	0.0945	0.8616
Echinococcus multilocularis	neuropeptide receptor	0.0015	0.0056	0.0056
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0093	0.115
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0181	0.0601
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0016	0.0068	0.0159
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0093	0.031
Onchocerca volvulus		0.0015	0.0056	0.0227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0734	0.6541
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0015	0.0056	0.0186
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0181	0.0601
Echinococcus granulosus	neuropeptide Y receptor	0.0015	0.0056	0.011
Onchocerca volvulus		0.0026	0.0181	0.0733
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0056	0.011
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0289	0.0568
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0093	0.5
Trichomonas vaginalis	esterase, putative	0.0036	0.0289	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Brugia malayi	beta-lactamase	0.0036	0.0289	0.0961
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0015	0.0056	0.0186
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0181	0.0356
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0289	0.5
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0282	0.301	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0181	0.0656
Onchocerca volvulus		0.0015	0.0056	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0015	0.0056	0.011
Echinococcus granulosus	cathepsin b	0.0282	0.301	0.5917
Toxoplasma gondii	histone deacetylase SIR2-like	0.0016	0.0068	0.0513
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0289	0.0936
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0056	0.0056
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0056	0.011
Brugia malayi	putative neuropeptide receptor	0.0015	0.0056	0.0186
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0068	0.0194
Brugia malayi	hypothetical protein	0.0015	0.0056	0.0186
Trypanosoma cruzi	cysteine proteinase, putative	0.0018	0.0085	0.0218
Echinococcus multilocularis	fmrfamide receptor	0.0015	0.0056	0.0056
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.018	0.1885	0.7643
Schistosoma mansoni	hypothetical protein	0.0034	0.0267	0.0525
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0095	0.0945	0.3093
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Echinococcus granulosus	fmrfamide receptor	0.0015	0.0056	0.011
Brugia malayi	Papain family cysteine protease containing protein	0.0012	0.002	0.0068
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0015	0.0056	0.0186
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0289	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0734	0.6541
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0108	0.1086	0.2135
Onchocerca volvulus		0.0015	0.0056	0.0227
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0181	0.0601
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0018	0.0085	0.0168
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0181	0.0733
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0016	0.0068	0.0068
Giardia lamblia	Cathepsin B precursor	0.0095	0.0945	0.8678
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0289	0.0936
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0734	0.6541
Brugia malayi	neuropeptide F receptor	0.0015	0.0056	0.0186
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0289	0.0289
Brugia malayi	hypothetical protein	0.0015	0.0056	0.0186
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0015	0.0056	0.011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0056	0.011
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0108	0.1086	0.4356
Leishmania major	cathepsin L-like protease	0.0076	0.0734	0.6541
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0085	0.061
Echinococcus granulosus	cathepsin l1	0.0026	0.0181	0.0356
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0289	0.0961
Schistosoma mansoni	chromatin regulatory protein sir2	0.0016	0.0068	0.0133
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0085	0.061
Plasmodium vivax	vivapain-2	0.0026	0.0181	0.5969
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0056	0.011
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0015	0.0056	0.0186
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0016	0.0068	0.0225
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0181	0.0656
Echinococcus granulosus	neuropeptide receptor	0.0015	0.0056	0.011
Toxoplasma gondii	histone deacetylase SIR2	0.0016	0.0068	0.0513
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0056	0.011
Echinococcus multilocularis	cathepsin b	0.0282	0.301	0.301
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0289	0.2174
Leishmania major	hypothetical protein, conserved	0.0036	0.0289	0.2174
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0181	0.0181
Schistosoma mansoni	tar DNA-binding protein	0.0196	0.2063	0.4055
Giardia lamblia	Cathepsin B precursor	0.0095	0.0945	0.8678
Onchocerca volvulus		0.0015	0.0056	0.0227
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0196	0.2063	0.6853
Leishmania major	cathepsin L-like protease	0.0026	0.0181	0.111
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0093	0.2901
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0012	0.002	0.0068
Leishmania major	cathepsin L-like protease	0.0026	0.0181	0.111
Trypanosoma cruzi	cysteine protease, putative	0.0018	0.0085	0.0218
Loa Loa (eye worm)	RNA binding protein	0.0196	0.2063	0.6853
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.0056	0.011
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.0056	0.0056
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0289	0.1099
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0068	0.0194
Schistosoma mansoni	hypothetical protein	0.0034	0.0267	0.0525
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0289	0.0899
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0016	0.0068	0.0133
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Brugia malayi	G protein-coupled receptor	0.0015	0.0056	0.0186
Schistosoma mansoni	chromatin regulatory protein sir2	0.0108	0.1086	0.2135
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0015	0.0056	0.011
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0289	0.1099
Echinococcus multilocularis	cathepsin L	0.0012	0.002	0.002
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0289	0.0936
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.0056	0.0056
Schistosoma mansoni	ap endonuclease	0.0018	0.0093	0.0183
Echinococcus granulosus	orexin receptor type 2	0.0015	0.0056	0.011
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0016	0.0068	0.0445
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0272	0.1027
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0085	0.061
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0181	0.1506
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0093	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0181	0.0181
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.0056	0.011
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0085	0.061
Schistosoma mansoni	tar DNA-binding protein	0.0196	0.2063	0.4055
Plasmodium vivax	vivapain-3	0.0018	0.0085	0.242
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0056	0.011
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0015	0.0056	0.011
Brugia malayi	ORL1-like opioid receptor	0.0015	0.0056	0.0186
Schistosoma mansoni	amine GPCR	0.0015	0.0056	0.011
Schistosoma mansoni	chromatin regulatory protein sir2	0.0016	0.0068	0.0133
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0012	0.002	0.0068
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0015	0.0056	0.0056
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0012	0.002	0.004
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0216	0.2116
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Toxoplasma gondii	NAC domain-containing protein	0.0034	0.0272	0.2717
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0015	0.0056	0.011
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0016	0.0068	0.0133
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0181	0.1506
Onchocerca volvulus		0.0026	0.0181	0.0733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0116	0.039
Echinococcus granulosus	serotonin receptor	0.0015	0.0056	0.011
Echinococcus multilocularis	neuropeptide receptor	0.0015	0.0056	0.0056
Schistosoma mansoni	hypothetical protein	0.0015	0.0056	0.011
Echinococcus multilocularis	cysteine protease	0.0026	0.0181	0.0181
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0289	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0961
Onchocerca volvulus		0.0015	0.0056	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1078	0.3579
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0016	0.0068	0.0225
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0107	0.1078	0.3579
Schistosoma mansoni	cathepsin B (C01 family)	0.0012	0.002	0.004
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0181	0.0601
Schistosoma mansoni	transcription factor btf3	0.0034	0.0272	0.0534
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0015	0.0056	0.0186
Onchocerca volvulus		0.0015	0.0056	0.0227
Echinococcus multilocularis	serotonin receptor	0.0015	0.0056	0.0056
Mycobacterium ulcerans	lipase LipD	0.0036	0.0289	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Brugia malayi	larval opioid receptor	0.0015	0.0056	0.0186
Schistosoma mansoni	chromatin regulatory protein sir2	0.0108	0.1086	0.2135
Schistosoma mansoni	amine GPCR	0.0015	0.0056	0.011
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Brugia malayi	cathepsin L precursor	0.0012	0.002	0.0068
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0015	0.0056	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0181	0.0601
Onchocerca volvulus		0.0015	0.0056	0.0227
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0016	0.0068	0.0445
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0085	0.061
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0108	0.1086	0.3564
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0056	0.011
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0085	0.061
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0289	0.0961
Brugia malayi	TAR-binding protein	0.0196	0.2063	0.6853
Brugia malayi	beta-NAC-like protein	0.0034	0.0272	0.0902
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0056	0.011
Brugia malayi	cathepsin B-like cysteine proteinase	0.0282	0.301	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0216	0.0425
Echinococcus granulosus	cathepsin l1	0.002	0.0116	0.0228
Brugia malayi	Dopamine receptor protein 1	0.0015	0.0056	0.0186
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0056	0.0056
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0289	0.1099
Onchocerca volvulus		0.0036	0.0289	0.1173
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0267	0.0267
Brugia malayi	G protein-coupled receptor F59B2.13	0.0015	0.0056	0.0186
Schistosoma mansoni	hypothetical protein	0.0034	0.0267	0.0525
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0107	0.1078	0.3579
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0015	0.0056	0.0056
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0012	0.002	0.004
Echinococcus granulosus	g-protein coupled receptor	0.0015	0.0056	0.011
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0015	0.0056	0.011
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0015	0.0056	0.011
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0093	0.0684
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0734	0.6541
Schistosoma mansoni	tar DNA-binding protein	0.0196	0.2063	0.4055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0181	0.0181
Echinococcus granulosus	neuropeptide FF receptor 2	0.0015	0.0056	0.011
Brugia malayi	hypothetical protein	0.0015	0.0056	0.0186
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0085	0.0218
Schistosoma mansoni	hypothetical protein	0.0034	0.0267	0.0525
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0026	0.0181	0.6386
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0016	0.0068	0.0068
Schistosoma mansoni	ap endonuclease	0.0018	0.0093	0.0183
Brugia malayi	cathepsin L-like cysteine proteinase	0.0012	0.002	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0026	0.0181	0.0356
Plasmodium vivax	basic transcription factor 3b, putative	0.0034	0.0272	0.9348
Brugia malayi	RE15519p	0.0015	0.0056	0.0186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Echinococcus granulosus	chromatin regulatory protein sir2	0.0108	0.1086	0.2135
Onchocerca volvulus		0.0026	0.0181	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0181	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Schistosoma mansoni	tar DNA-binding protein	0.0196	0.2063	0.4055
Brugia malayi	N-terminal motif family protein	0.018	0.1885	0.6262
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0289	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0015	0.0056	0.0056
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0056	0.0056
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0085	0.0266
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.0056	0.0056
Echinococcus multilocularis	g-protein coupled receptor	0.0015	0.0056	0.0056
Brugia malayi	Serotonin receptor	0.0015	0.0056	0.0186
Toxoplasma gondii	cathepsin B	0.0095	0.0945	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0012	0.002	0.004
Schistosoma mansoni	amine GPCR	0.0015	0.0056	0.011
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0181	0.0656
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0056	0.011
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0068	0.0194
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0289	0.0568
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0289	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Trichomonas vaginalis	set domain proteins, putative	0.0233	0.2466	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Echinococcus multilocularis	allatostatin A receptor	0.0015	0.0056	0.0056
Echinococcus multilocularis	neuropeptide receptor A26	0.0015	0.0056	0.0056
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0015	0.0056	0.011
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0015	0.0056	0.0056
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0056	0.011
Plasmodium vivax	unspecified product	0.0018	0.0085	0.242
Brugia malayi	Pre-SET motif family protein	0.0204	0.2154	0.7155
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0272	0.084
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0015	0.0056	0.0056
Echinococcus multilocularis	tar DNA binding protein	0.0196	0.2063	0.2063
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0181	0.0537
Schistosoma mansoni	histamine h1 receptor	0.0015	0.0056	0.011
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0093	0.0684
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.0056	0.011
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0469	0.5087	1
Echinococcus granulosus	sex peptide receptor	0.0015	0.0056	0.011
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Schistosoma mansoni	opsin-like receptor	0.0015	0.0056	0.011
Giardia lamblia	Cathepsin B precursor	0.0095	0.0945	0.8678
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0734	0.6541
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0289	0.0936
Onchocerca volvulus		0.0026	0.0181	0.0733
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0015	0.0056	0.0056
Echinococcus multilocularis	dro:myosuppressin receptor	0.0015	0.0056	0.0056
Loa Loa (eye worm)	sirtuin 4	0.0016	0.0068	0.0225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0181	0.0656
Onchocerca volvulus		0.0015	0.0056	0.0227
Echinococcus multilocularis	neuropeptides capa receptor	0.0015	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Echinococcus multilocularis	fmrfamide receptor	0.0015	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.018	0.1885	0.6262
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Onchocerca volvulus		0.0029	0.0216	0.0876
Echinococcus granulosus	GPCR family 2	0.0034	0.0267	0.0525
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0734	0.6541
Loa Loa (eye worm)	cathepsin B	0.0095	0.0945	0.314
Loa Loa (eye worm)	hypothetical protein	0.0012	0.002	0.0068
Loa Loa (eye worm)	ctsf protein	0.0026	0.0181	0.0601
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0056	0.011
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0181	0.0601
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0018	0.0085	0.2589
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Echinococcus multilocularis	somatostatin receptor	0.0015	0.0056	0.0056
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0108	0.1086	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0016	0.0068	0.1764
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0734	0.6541
Brugia malayi	Cathepsin L-like precursor	0.002	0.0116	0.0385
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0181	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0012	0.002	0.0068
Schistosoma mansoni	tar DNA-binding protein	0.0196	0.2063	0.4055
Echinococcus granulosus	biogenic amine 5HT receptor	0.0015	0.0056	0.011
Schistosoma mansoni	hypothetical protein	0.0073	0.0702	0.138
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0181	0.0181
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0015	0.0056	0.0227
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.0734	0.2386
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0216	0.0425
Echinococcus multilocularis	cysteine protease	0.0026	0.0181	0.0181
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0181	0.0656
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0056	0.011
Echinococcus multilocularis	cathepsin L	0.0018	0.0085	0.0085
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.0056	0.0186
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0181	0.0601
Onchocerca volvulus		0.0015	0.0056	0.0227
Leishmania major	cathepsin L-like protease	0.0026	0.0181	0.111
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Schistosoma mansoni	opsin-like receptor	0.0015	0.0056	0.011
Brugia malayi	Melatonin receptor type 1A	0.0015	0.0056	0.0186
Onchocerca volvulus		0.002	0.0116	0.047
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0056	0.0056
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0734	0.6541
Giardia lamblia	Transcriptional regulator, Sir2 family	0.0016	0.0068	0.0445
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.0056	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0702	0.2333
Loa Loa (eye worm)	hypothetical protein	0.002	0.0116	0.0385
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0181	0.0656
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0068	0.0194
Entamoeba histolytica	transcription factor BTF3, putative	0.0034	0.0272	0.2358
Schistosoma mansoni	adenoreceptor	0.0015	0.0056	0.011
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0085	0.061
Leishmania major	cathepsin L-like protease	0.0076	0.0734	0.6541
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0108	0.1086	0.1086
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0289	0.0936
Brugia malayi	fibroinase precursor	0.0012	0.002	0.0068
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0018	0.0085	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0216	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0181	0.0656
Toxoplasma gondii	cathepsin CPL	0.0026	0.0181	0.1735
Onchocerca volvulus		0.0015	0.0056	0.0227
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0056	0.0056
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0085	0.061
Loa Loa (eye worm)	hypothetical protein	0.0012	0.002	0.0068
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0056	0.011
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0015	0.0056	0.011
Onchocerca volvulus		0.0015	0.0056	0.0227
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.2432	1
Loa Loa (eye worm)	transcriptional regulator	0.0016	0.0068	0.0225
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0734	0.6541
Toxoplasma gondii	exonuclease III APE	0.0018	0.0093	0.0788
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0015	0.0056	0.011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0056	0.0056
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0093	0.0108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0018	0.0085	0.0173
Echinococcus granulosus	cathepsin L	0.0018	0.0085	0.0168
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0107	0.1078	0.3579
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0018	0.0085	0.0168
Echinococcus granulosus	tar DNA binding protein	0.0196	0.2063	0.4055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Loa Loa (eye worm)	fibroinase	0.0026	0.0181	0.0601
Onchocerca volvulus		0.0233	0.2466	1
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0108	0.1086	0.3564
Trypanosoma cruzi	major cysteine proteinase, putative	0.0062	0.0573	0.1849
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0056	0.0056
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0085	0.061
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0108	0.1086	0.1086
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0289	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0267	0.0886
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0068	0.0194
Brugia malayi	cathepsin F-like cysteine proteinase	0.0012	0.002	0.0068
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0108	0.1086	0.3608
Loa Loa (eye worm)	melatonin receptor type 1A	0.0015	0.0056	0.0186
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0026	0.0181	0.6386
Brugia malayi	Pre-SET motif family protein	0.0029	0.0216	0.0718
Brugia malayi	hypothetical protein	0.0015	0.0056	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Echinococcus multilocularis	neuropeptide Y receptor	0.0015	0.0056	0.0056
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0093	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0289	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0015	0.0056	0.0056
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0026	0.0181	0.0601
Schistosoma mansoni	amine GPCR	0.0015	0.0056	0.011
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0204	0.0401
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0056	0.011
Loa Loa (eye worm)	TYRA-2 protein	0.0015	0.0056	0.0186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0012	0.002	0.0068
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.0056	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0012	0.002	0.0068
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0289	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0012	0.002	0.004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0116	0.0228
Loa Loa (eye worm)	transcriptional regulator	0.0108	0.1086	0.3608
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0469	0.5087	0.5087
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0289	0.0936
Brugia malayi	hypothetical protein	0.0015	0.0056	0.0186
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0012	0.002	0.0068
Brugia malayi	beta-lactamase family protein	0.0036	0.0289	0.0961
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0282	0.301	0.5917
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0056	0.011
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0085	0.0284
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0289	0.0899
Schistosoma mansoni	opsin-like receptor	0.0015	0.0056	0.011
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0116	0.039
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.0669	0.2168
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0093	0.025
Loa Loa (eye worm)	ICD-1 protein	0.0034	0.0272	0.0902
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0016	0.0068	0.0133
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0056	0.0056
Brugia malayi	neuropeptide F receptor	0.0015	0.0056	0.0186
Echinococcus granulosus	neuropeptide Y receptor	0.0015	0.0056	0.011
Onchocerca volvulus	Cathepsin L homolog	0.0012	0.002	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Echinococcus granulosus	cathepsin b	0.0282	0.301	0.5917
Echinococcus multilocularis	orexin receptor type 2	0.0015	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0012	0.002	0.0068
Brugia malayi	putative neuropeptide receptor NPR1	0.0015	0.0056	0.0186
Brugia malayi	RNA recognition motif domain containing protein	0.0196	0.2063	0.6853
Echinococcus granulosus	neuropeptides capa receptor	0.0015	0.0056	0.011
Brugia malayi	Papain family cysteine protease containing protein	0.0012	0.002	0.0068
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0267	0.0267
Echinococcus multilocularis	neuropeptides capa receptor	0.0015	0.0056	0.0056
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0068	0.0194
Echinococcus granulosus	cathepsin L	0.0012	0.002	0.004
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0016	0.0068	0.0445
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0015	0.0056	0.011
Loa Loa (eye worm)	hypothetical protein	0.0012	0.002	0.0068
Echinococcus granulosus	neuropeptide receptor A26	0.0015	0.0056	0.011
Schistosoma mansoni	amine GPCR	0.0015	0.0056	0.011
Leishmania major	cathepsin L-like protease	0.0076	0.0734	0.6541
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0016	0.0068	0.0159
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0015	0.0056	0.011
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0016	0.0068	0.0068
Loa Loa (eye worm)	TAR-binding protein	0.0196	0.2063	0.6853
Echinococcus granulosus	hypothetical protein	0.0015	0.0056	0.011
Echinococcus granulosus	somatostatin receptor	0.0015	0.0056	0.011
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0085	0.0284
Schistosoma mansoni	chromatin regulatory protein sir2	0.0016	0.0068	0.0133
Onchocerca volvulus		0.0015	0.0056	0.0227
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0015	0.0056	0.011
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.0734	0.2386
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0734	0.6541
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0216	0.0216
Entamoeba histolytica	cysteine proteinase 1, putative	0.0018	0.0085	0.061
Echinococcus multilocularis	geminin	0.0165	0.1718	0.1718
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0015	0.0056	0.011
Onchocerca volvulus		0.0015	0.0056	0.0227
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0267	0.0886
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0181	0.0656
Plasmodium vivax	hypothetical protein, conserved	0.0016	0.0068	0.1764
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0093	0.0183
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0056	0.011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0056	0.011
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0015	0.0056	0.011
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0015	0.0056	0.0056
Brugia malayi	Serotonin receptor	0.0015	0.0056	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0289	0.0961
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0068	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0015	0.0056	0.011
Echinococcus granulosus	dro:myosuppressin receptor	0.0015	0.0056	0.011
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0015	0.0056	0.0186
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0056	0.011
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0012	0.002	0.0068
Brugia malayi	hypothetical protein	0.0015	0.0056	0.0186
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0056	0.011
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0056	0.011
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0068	0.0194
Echinococcus multilocularis	sex peptide receptor	0.0015	0.0056	0.0056
Onchocerca volvulus		0.0012	0.002	0.0083
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0181	0.0601
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0015	0.0056	0.0186
Schistosoma mansoni	myosin xvIII	0.0015	0.0056	0.011
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0116	0.0895
Echinococcus granulosus	allatostatin A receptor	0.0015	0.0056	0.011
Brugia malayi	hypothetical protein	0.0015	0.0056	0.0186
Schistosoma mansoni	neuropeptide F-like receptor	0.0015	0.0056	0.011
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0085	0.061
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Schistosoma mansoni	hypothetical protein	0.0165	0.1718	0.3378
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0056	0.011
Schistosoma mansoni	growth hormone secretagogue receptor	0.0015	0.0056	0.011
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0216	0.0425
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0056	0.011
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0068	0.0194
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0093	0.031
Entamoeba histolytica	cysteine proteinase 2	0.0018	0.0085	0.061
Trypanosoma brucei	transcription factor BTF3, putative	0.0034	0.0272	0.2002
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0181	0.0356
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0267	0.0886
Onchocerca volvulus		0.0036	0.0289	0.1173
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0015	0.0056	0.0056
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0056	0.011
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0181	0.0733
Schistosoma mansoni	chromatin regulatory protein sir2	0.0016	0.0068	0.0133
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0108	0.1086	1
Brugia malayi	Dopamine receptor	0.0015	0.0056	0.0186
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0056	0.011
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Onchocerca volvulus		0.0015	0.0056	0.0227
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0056	0.0056
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.0056	0.0186
Echinococcus granulosus	transcription factor btf3	0.0034	0.0272	0.0534
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0282	0.301	0.5917
Echinococcus multilocularis	serotonin receptor	0.0015	0.0056	0.0056
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.2154	0.7155
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0289	0.0936
Schistosoma mansoni	chromatin regulatory protein sir2	0.0108	0.1086	0.2135
Loa Loa (eye worm)	hypothetical protein	0.002	0.0116	0.0385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0085	0.0266
Echinococcus granulosus	biogenic amine 5HT receptor	0.0469	0.5087	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0116	0.0385
Echinococcus multilocularis	neuropeptide s receptor	0.0015	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0216	0.0216
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0056	0.011
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0289	0.1099
Brugia malayi	hypothetical protein	0.0015	0.0056	0.0186
Onchocerca volvulus	Cathepsin F homolog	0.0026	0.0181	0.0733
Entamoeba histolytica	hypothetical protein, conserved	0.0016	0.0068	0.0445
Schistosoma mansoni	hypothetical protein	0.0015	0.0056	0.011
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0267	0.0525
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0056	0.011
Loa Loa (eye worm)	cysteine protease	0.0026	0.0181	0.0601
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0216	0.0425
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0108	0.1086	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0181	0.0656
Brugia malayi	sulfakinin receptor protein	0.0015	0.0056	0.0186
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0085	0.061
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0181	0.0656
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0085	0.061
Echinococcus multilocularis	cathepsin b	0.0282	0.301	0.301
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0056	0.0186

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 43.7 nM	Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method	ChEMBL.	25127461

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3326978

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 926407