Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.4685 | 0.4685 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0325 | 0.3955 | 0.3955 |
Echinococcus granulosus | insulin receptor | 0.0104 | 0.0671 | 0.1566 |
Echinococcus multilocularis | acetylcholinesterase | 0.0347 | 0.4285 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0347 | 0.4285 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0347 | 0.4285 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0347 | 0.4285 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0104 | 0.0671 | 0.1566 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0731 | 1 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0059 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0731 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0347 | 0.4285 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0104 | 0.0671 | 0.1566 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0174 | 0.1722 | 0.4018 |
Echinococcus multilocularis | acetylcholinesterase | 0.0347 | 0.4285 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.4285 | 0.4285 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0174 | 0.1722 | 0.4018 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0731 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.4285 | 0.4285 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Echinococcus multilocularis | insulin receptor | 0.0104 | 0.0671 | 0.1566 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0347 | 0.4285 | 0.4285 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0059 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0347 | 0.4285 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0104 | 0.0671 | 0.0671 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0325 | 0.3955 | 0.923 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0325 | 0.3955 | 0.3955 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0173 | 0.1695 | 0.3954 |
Brugia malayi | Carboxylesterase family protein | 0.0347 | 0.4285 | 0.4285 |
Schistosoma mansoni | tyrosine kinase | 0.0174 | 0.1722 | 0.4018 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0731 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0347 | 0.4285 | 0.4285 |
Schistosoma mansoni | tyrosine kinase | 0.0104 | 0.0671 | 0.1566 |
Schistosoma mansoni | tyrosine kinase | 0.0174 | 0.1722 | 0.4018 |
Echinococcus multilocularis | 0.01 | 0.0623 | 0.1453 | |
Schistosoma mansoni | tyrosine kinase | 0.0104 | 0.0671 | 0.1566 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0325 | 0.3955 | 0.923 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0347 | 0.4285 | 0.4285 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0174 | 0.1722 | 0.4018 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0104 | 0.0671 | 0.0671 |
Schistosoma mansoni | tyrosine kinase | 0.0173 | 0.1695 | 0.3954 |
Schistosoma mansoni | tyrosine kinase | 0.0173 | 0.1695 | 0.3954 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0059 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0325 | 0.3955 | 0.923 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 43.24 % | Cytotoxicity against human MDA-MB-231 cells assessed as cell viability at 100 ug/ml after 24 to 48 hrs by trypan blue exclusion assay (Rvb = 86.21 +/- 1.80%) | ChEMBL. | 25131536 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.