Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | AXL receptor tyrosine kinase | Starlite/ChEMBL | References |
Homo sapiens | MER proto-oncogene, tyrosine kinase | Starlite/ChEMBL | References |
Homo sapiens | TYRO3 protein tyrosine kinase | Starlite/ChEMBL | References |
Homo sapiens | fms-related tyrosine kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR008957,Fibronectin, type III-like fold,domain-containing | Get druggable targets OG5_132328 | All targets in OG5_132328 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Immunoglobulin | 0.003 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0039 | 0.0319 | 0.0319 |
Echinococcus granulosus | roundabout 2 | 0.0021 | 0.0052 | 0.0052 |
Schistosoma mansoni | cell adhesion molecule | 0.0021 | 0.0052 | 0.0022 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0236 | 0.0236 |
Echinococcus multilocularis | neuroglian | 0.0034 | 0.0235 | 0.0235 |
Schistosoma mansoni | nephrin | 0.0021 | 0.0052 | 0.0022 |
Schistosoma mansoni | cell adhesion molecule | 0.0047 | 0.0433 | 0.0404 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0021 | 0.0052 | 0.0052 |
Echinococcus multilocularis | roundabout 2 | 0.0051 | 0.0485 | 0.0485 |
Echinococcus granulosus | twitchin | 0.0034 | 0.0235 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0288 | 0.0288 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0021 | 0.0052 | 0.0052 |
Echinococcus granulosus | Immunoglobulin | 0.003 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.038 | 0.038 |
Echinococcus multilocularis | neuroglian | 0.0021 | 0.0052 | 0.0052 |
Leishmania major | 0.071 | 1 | 0.5 | |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0021 | 0.0052 | 0.0052 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0019 | 0.0029 | 0.0029 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.003 | 0.0183 | 0.0183 |
Brugia malayi | hypothetical protein | 0.0044 | 0.038 | 0.038 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.071 | 1 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0021 | 0.0052 | 0.0022 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0021 | 0.0052 | 0.0022 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0021 | 0.0052 | 0.0052 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.0052 | 0.0052 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.0052 | 0.0052 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.003 | 0.0183 | 0.0154 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0044 | 0.038 | 0.038 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.071 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.071 | 1 | 1 |
Schistosoma mansoni | neuroglian | 0.0021 | 0.0052 | 0.0022 |
Toxoplasma gondii | fructose-bisphospatase II | 0.071 | 1 | 1 |
Echinococcus granulosus | neuroglian | 0.0034 | 0.0235 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.038 | 0.038 |
Echinococcus multilocularis | roundabout 2 | 0.0021 | 0.0052 | 0.0052 |
Echinococcus granulosus | neuroglian | 0.0021 | 0.0052 | 0.0052 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0034 | 0.0236 | 0.0236 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0044 | 0.038 | 0.038 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0019 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0183 | 0.0183 |
Echinococcus granulosus | roundabout 2 | 0.0021 | 0.0052 | 0.0052 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.071 | 1 | 1 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0021 | 0.0052 | 0.0052 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0021 | 0.0052 | 0.0052 |
Echinococcus granulosus | defective proboscis extension response | 0.003 | 0.0183 | 0.0183 |
Echinococcus granulosus | roundabout 2 | 0.0051 | 0.0485 | 0.0485 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0288 | 0.0288 |
Schistosoma mansoni | nephrin | 0.0047 | 0.0432 | 0.0403 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.0052 | 0.0052 |
Echinococcus multilocularis | Immunoglobulin | 0.003 | 0.0183 | 0.0183 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0183 | 0.0183 |
Echinococcus granulosus | contactin | 0.0021 | 0.0052 | 0.0052 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.038 | 0.038 |
Echinococcus multilocularis | roundabout 2 | 0.0021 | 0.0052 | 0.0052 |
Schistosoma mansoni | vesicular amine transporter | 0.003 | 0.0183 | 0.0154 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.003 | 0.0183 | 0.0154 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0039 | 0.0319 | 0.0319 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0021 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0052 | 0.0052 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
F (ADMET) | = 67 % | Oral bioavailability in Swiss albino mouse at 3 mg/kg | ChEMBL. | 25068800 |
IC50 (binding) | = 1.6 nM | Inhibition of Mer (unknown origin) by Off-chip Mobility Shift Assay | ChEMBL. | 25068800 |
IC50 (binding) | = 3 nM | Inhibition of Flt3 (unknown origin) by Off-chip Mobility Shift Assay | ChEMBL. | 25068800 |
IC50 (binding) | = 32 nM | Inhibition of Axl (unknown origin) by Off-chip Mobility Shift Assay | ChEMBL. | 25068800 |
IC50 (binding) | = 45 nM | Inhibition of Tyro3 (unknown origin) by Off-chip Mobility Shift Assay | ChEMBL. | 25068800 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.