Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.0104 | 0.1782 | 0.1782 |
Mycobacterium ulcerans | hydrolase | 0.0052 | 0 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0104 | 0.1782 | 0.1782 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0095 | 0.1485 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0052 | 0 | 0.5 |
Leishmania major | 0.0341 | 1 | 0.5 | |
Brugia malayi | Hemopexin family protein | 0.0061 | 0.0297 | 0.0297 |
Schistosoma mansoni | voltage-gated cation channel | 0.0076 | 0.0819 | 0.0538 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0341 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0819 | 0.0819 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0341 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0341 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0341 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0341 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0095 | 0.1485 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0156 | 0.3591 | 0.302 |
Loa Loa (eye worm) | calcium channel | 0.0076 | 0.0819 | 0.0819 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0076 | 0.0819 | 0.0538 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0076 | 0.0819 | 0.0819 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0341 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0095 | 0.1485 | 0.1485 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0156 | 0.3591 | 0.302 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0341 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0341 | 1 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0076 | 0.0819 | 0.0538 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.