Detailed information for compound 926798

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 328.369 | Formula: C18H23F3O2
  • H donors: 1 H acceptors: 2 LogP: 6.14 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(F)(F)F)/C=C/c1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C
  • InChi: 1S/C18H23F3O2/c1-16(2,3)12-9-11(7-8-14(22)18(19,20)21)10-13(15(12)23)17(4,5)6/h7-10,23H,1-6H3/b8-7+
  • InChiKey: OHFARESQLDMXLC-BQYQJAHWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0187 0.1974 0.3002
Schistosoma mansoni loxhd1 0.0013 0.007 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0419 0.0579
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0036 0.0322 0.0487
Brugia malayi Cytochrome P450 family protein 0.001 0.0043 0.0413
Brugia malayi cytoplasmic intermediate filament protein 0.0011 0.0055 0.0582
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0087 0.0878 0.0878
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0076 0.0756 0.0745
Echinococcus granulosus chromobox protein 1 0.0045 0.0419 0.0408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0419 0.0579
Onchocerca volvulus 0.0012 0.006 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0013 0.0071 0.0784
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.2102
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0607 0.655 0.6546
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0076 0.0762 0.116
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.012
Giardia lamblia Rrm3p helicase 0.0607 0.655 1
Echinococcus multilocularis cpg binding protein 0.0043 0.0403 0.0392
Schistosoma mansoni hypothetical protein 0.0013 0.007 0.007
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0058 0.0562 0.7326
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0061 0.0596 0.7806
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0607 0.655 1
Onchocerca volvulus 0.002 0.0146 0.2299
Onchocerca volvulus 0.0012 0.006 0.0826
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.00000000075171
Trichomonas vaginalis CMGC family protein kinase 0.0036 0.0322 0.0474
Toxoplasma gondii 6-phosphofructokinase 0.0021 0.0156 0.2013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0059 0.0072
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0021 0.0156 0.5
Brugia malayi 6-phosphofructokinase 0.0076 0.0762 1
Onchocerca volvulus Cathepsin L homolog 0.0012 0.006 0.0826
Brugia malayi MAP kinase sur-1 0.0036 0.0322 0.4128
Trichomonas vaginalis phosphofructokinase, putative 0.0076 0.0762 0.1148
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0027 0.0226 0.3664
Trichomonas vaginalis CMGC family protein kinase 0.0036 0.0322 0.0474
Echinococcus multilocularis dnaJ subfamily C 6 0.0039 0.036 0.0349
Brugia malayi Associated with TFs and helicases family protein 0.0007 0.0012 0.00000000076082
Schistosoma mansoni intermediate filament proteins 0.0021 0.0162 0.0162
Plasmodium vivax vivapain-2 0.0012 0.006 0.3836
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0092 0.093 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0021 0.0156 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.2047
Onchocerca volvulus Cathepsin F homolog 0.0012 0.006 0.0826
Schistosoma mansoni lamin 0.0021 0.0162 0.0162
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.006 0.0074
Schistosoma mansoni chromodomain helicase DNA binding protein 0.001 0.0037 0.0037
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0068 0.0753
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0156 0.0221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.006 0.0074
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0007 0.0012 0.0012
Schistosoma mansoni DNA helicase recq5 0.0013 0.0071 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0596 0.0893
Giardia lamblia Fructose-bisphosphate aldolase 0.0187 0.1974 0.2938
Echinococcus multilocularis musashi 0.0021 0.0162 0.0151
Loa Loa (eye worm) ctsf protein 0.0012 0.006 0.0754
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0125 0.0174
Echinococcus granulosus cpg binding protein 0.0043 0.0403 0.0392
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0419 0.0579
Loa Loa (eye worm) hypothetical protein 0.0013 0.0071 0.0894
Schistosoma mansoni hypothetical protein 0.0262 0.279 0.279
Echinococcus multilocularis cathepsin L cysteine protease 0.0012 0.006 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0021 0.0156 0.0132
Schistosoma mansoni chromobox protein 0.0007 0.0012 0.0012
Echinococcus multilocularis GPCR, family 2 0.001 0.0042 0.0031
Trichomonas vaginalis phosphofructokinase, putative 0.0076 0.0762 0.1148
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0033 0.0033
Leishmania major cathepsin L-like protease 0.0012 0.006 0.0026
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0007 0.0012 0.00000000076082
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.0018
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.0003 0.0003
Schistosoma mansoni lipoxygenase 0.0053 0.0508 0.0508
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0021 0.0156 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0566 0.6097 0.6092
Brugia malayi hypothetical protein 0.0013 0.007 0.0774
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0043 0.0031
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0156 0.0221
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0013 0.0071 0.0894
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0013 0.0071 0.0909
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0187 0.1974 0.3002
Brugia malayi Cathepsin L-like precursor 0.0012 0.006 0.0642
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0596 0.0893
Loa Loa (eye worm) CHromoDomain protein family member 0.001 0.0037 0.0454
Loa Loa (eye worm) hypothetical protein 0.0058 0.0562 0.7358
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0043 0.0031
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0187 0.1974 0.3014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.001 0.0042 0.0407
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0607 0.655 1
Trypanosoma cruzi cruzipain precursor, putative 0.0045 0.0419 0.0636
Echinococcus granulosus lamin dm0 0.0021 0.0162 0.0151
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0021 0.0156 0.078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0036 0.0322 0.0487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Schistosoma mansoni kinase 0.0031 0.0271 0.0271
Onchocerca volvulus 0.0008 0.0022 0.0167
Echinococcus granulosus lipoxygenase domain containing protein 0.0013 0.007 0.0058
Entamoeba histolytica hypothetical protein 0.0055 0.0535 0.0817
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.001 0.0043 0.0031
Loa Loa (eye worm) CXXC zinc finger family protein 0.0041 0.0378 0.4941
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.0018
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0419 0.0623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0419 0.0579
Loa Loa (eye worm) apoptosis regulator protein 0.0058 0.0562 0.7358
Schistosoma mansoni chromobox protein 0.0045 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.012
Toxoplasma gondii phosphofructokinase PFKII 0.0021 0.0156 0.2013
Brugia malayi Cathepsin L-like precursor 0.0012 0.006 0.0642
Onchocerca volvulus 0.0012 0.006 0.0826
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0058 0.0562 0.0562
Brugia malayi Cathepsin L-like precursor 0.0012 0.006 0.0642
Brugia malayi Calcitonin receptor-like protein seb-1 0.0032 0.028 0.3579
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0071 0.0043
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0043 0.0061
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0156 0.0221
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0012 0.006 0.0048
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0007 0.0012 0.00000000005717
Echinococcus multilocularis cysteine protease 0.0012 0.006 0.0048
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0113 0.0155
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0006 0.0003 0.0172
Echinococcus multilocularis Chromo domain 0.0007 0.0012 0.00000000005717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Schistosoma mansoni hypothetical protein 0.001 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0013 0.0071 0.0909
Brugia malayi cathepsin L-like precursor 0.0008 0.0018 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Entamoeba histolytica hypothetical protein 0.0007 0.0012 0.0018
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0092 0.093 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0012 0.006 0.0048
Onchocerca volvulus 0.0021 0.0162 0.2579
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0113 0.0155
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0071 0.0108
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0021 0.0156 0.0239
Mycobacterium ulcerans aldehyde dehydrogenase 0.0039 0.0356 0.3536
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0187 0.1974 0.3002
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.006 0.0092
Plasmodium vivax hypothetical protein, conserved 0.0007 0.0012 0.0753
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0607 0.655 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0061 0.0596 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0036 0.0322 0.0487
Trichomonas vaginalis helicase, putative 0.0009 0.0033 0.0033
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0007 0.0012 0.0000000039486
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0187 0.1974 0.3002
Brugia malayi Intermediate filament tail domain containing protein 0.0021 0.0162 0.2007
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0607 0.655 0.6546
Trichomonas vaginalis phosphofructokinase, putative 0.0076 0.0762 0.1148
Trypanosoma cruzi polo-like protein kinase, putative 0.0061 0.0596 0.0906
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0187 0.1974 0.3002
Echinococcus multilocularis cathepsin L cysteine protease 0.0012 0.006 0.0048
Loa Loa (eye worm) CYP4Cod1 0.001 0.0043 0.0528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0058 0.0562 0.055
Schistosoma mansoni hypothetical protein 0.0058 0.0562 0.0562
Onchocerca volvulus 0.0012 0.006 0.0826
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0033 0.0033
Echinococcus multilocularis microtubule associated protein 2 0.0924 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0596 0.0893
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0596 0.0893
Loa Loa (eye worm) hypothetical protein 0.0013 0.007 0.0884
Leishmania major cathepsin L-like protease 0.0012 0.006 0.0026
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0754
Echinococcus granulosus dnaJ subfamily C 6 0.0039 0.036 0.0349
Trichomonas vaginalis CMGC family protein kinase 0.0036 0.0322 0.0474
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0013 0.0071 0.0059
Echinococcus multilocularis chromobox protein 1 0.0045 0.0419 0.0408
Trichomonas vaginalis chromobox protein, putative 0.0027 0.0226 0.0327
Echinococcus multilocularis chromobox protein 1 0.0045 0.0419 0.0408
Echinococcus multilocularis cysteine protease 0.0012 0.006 0.0048
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0607 0.655 1
Echinococcus granulosus GPCR family 2 0.001 0.0042 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0419 0.0579
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0058 0.0562 0.055
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.012
Echinococcus multilocularis lipoxygenase domain containing protein 0.0013 0.007 0.0058
Echinococcus multilocularis mitogen activated protein kinase 0.0036 0.0322 0.031
Entamoeba histolytica hypothetical protein 0.0055 0.0535 0.0817
Loa Loa (eye worm) latrophilin receptor protein 2 0.001 0.0042 0.0522
Echinococcus multilocularis 6 phosphofructokinase 0.0076 0.0762 0.0751
Brugia malayi SET domain containing protein 0.0008 0.0022 0.013
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0007 0.0012 0.0152
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0607 0.655 1
Loa Loa (eye worm) doublecortin family protein 0.0013 0.007 0.0884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0033 0.0033
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0041 0.0377 0.0572
Leishmania major cysteine peptidase A (CPA) 0.0012 0.006 0.0026
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0061 0.0596 0.0585
Leishmania major cathepsin L-like protease 0.0012 0.006 0.0026
Loa Loa (eye worm) hypothetical protein 0.0025 0.0205 0.2663
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0419 0.0579
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0076 0.0762 0.708
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.006 0.0642
Loa Loa (eye worm) DnaJ domain-containing protein 0.0039 0.036 0.4705
Loa Loa (eye worm) 6-phosphofructokinase 0.0076 0.0762 1
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0156 0.0221
Entamoeba histolytica phosphofructokinase, putative 0.0076 0.0762 0.1164
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0008 0.0022 0.0022
Entamoeba histolytica DNA repair and recombination protein, putative 0.0607 0.655 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0205 0.0296
Leishmania major cathepsin L-like protease 0.0045 0.0419 0.0579
Schistosoma mansoni hypothetical protein 0.0022 0.017 0.017
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0156 0.0221
Trichomonas vaginalis DNA helicase recq1, putative 0.0013 0.0071 0.009
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0071 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0205 0.0296
Treponema pallidum fructose-bisphosphate aldolase 0.0187 0.1974 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0076 0.0762 0.1106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0113 0.0155
Onchocerca volvulus 0.0012 0.006 0.0826
Echinococcus granulosus cathepsin l1 0.0012 0.006 0.0048
Brugia malayi serine/threonine-protein kinase plk-2 0.0061 0.0596 0.7779
Echinococcus granulosus Chromo domain 0.0007 0.0012 0.00000000005717
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0187 0.1974 0.3002
Brugia malayi Cathepsin L-like cysteine proteinase 0.0008 0.0018 0.0079
Plasmodium vivax hypothetical protein, conserved 0.0007 0.0012 0.0753
Loa Loa (eye worm) RecQ helicase 0.0013 0.0071 0.0894
Onchocerca volvulus 0.0013 0.007 0.0995
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0419 0.0579
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.006 0.0074
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0033 0.0033
Schistosoma mansoni 6-phosphofructokinase 0.0076 0.0762 0.0762
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.00000000008734
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.006 0.0092
Schistosoma mansoni 6-phosphofructokinase 0.0076 0.0762 0.0762
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.006 0.0074
Brugia malayi Cytochrome P450 family protein 0.001 0.0043 0.0413
Onchocerca volvulus 0.0012 0.006 0.0826
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0013 0.0071 0.0059
Trypanosoma brucei polo-like protein kinase 0.0061 0.0596 0.085
Plasmodium vivax 6-phosphofructokinase, putative 0.0021 0.0156 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0035 0.0315 0.0477
Schistosoma mansoni aldehyde dehydrogenase 0.0039 0.0356 0.0356
Echinococcus multilocularis lipoxygenase domain containing protein 0.0013 0.007 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0187 0.1974 0.3002
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0058 0.0562 0.055
Schistosoma mansoni chromobox protein 0.0007 0.0012 0.0012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.00000000008734
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0607 0.655 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0187 0.1974 0.3002
Brugia malayi Cathepsin L-like precursor 0.0012 0.006 0.0642
Brugia malayi intermediate filament protein 0.0021 0.0162 0.2007
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0522
Echinococcus multilocularis dnaJ subfamily B 0.0262 0.279 0.2782
Echinococcus multilocularis mitogen activated protein kinase 3 0.0036 0.0322 0.031
Entamoeba histolytica hypothetical protein 0.0055 0.0535 0.0817
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0018 0.0009
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0007 0.0012 0.0012
Echinococcus granulosus intermediate filament protein 0.0021 0.0162 0.0151
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0262 0.0383
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0013 0.0071 0.0059
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.1887
Toxoplasma gondii histone lysine methyltransferase SET1 0.0078 0.0777 1
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0596 0.0893
Loa Loa (eye worm) hypothetical protein 0.0008 0.0018 0.0198
Giardia lamblia Kinase, CMGC MAPK 0.0036 0.0322 0.0387
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0043 0.0528
Mycobacterium ulcerans aldehyde dehydrogenase 0.0039 0.0356 0.3536
Schistosoma mansoni rab6-interacting 0.0013 0.007 0.007
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0007 0.0012 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0419 0.0636
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0012 0.006 0.0074
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0012 0.006 0.0048
Onchocerca volvulus 0.0013 0.007 0.0995
Schistosoma mansoni DNA helicase recq1 0.0013 0.0071 0.0071
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0039 0.0356 0.0345
Echinococcus multilocularis lamin 0.0021 0.0162 0.0151
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0032 0.028 0.3656
Schistosoma mansoni cathepsin F (C01 family) 0.0008 0.0018 0.0018
Onchocerca volvulus 0.0012 0.006 0.0826
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0032 0.028 0.3579
Schistosoma mansoni transcription factor LCR-F1 0.0055 0.0535 0.0535
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.006 0.0074
Entamoeba histolytica phosphofructokinase, putative 0.0076 0.0762 0.1164
Loa Loa (eye worm) heterochromatin protein 1 0.0045 0.0419 0.5479
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0021 0.0156 0.2013
Mycobacterium ulcerans 6-phosphofructokinase 0.0076 0.0762 0.8113
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0113 0.0155
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.001 0.0042 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0039 0.0356 0.3536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Schistosoma mansoni hypothetical protein 0.001 0.0042 0.0042
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0187 0.1974 0.3014
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.007 0.0058
Schistosoma mansoni chromobox protein 0.0045 0.0419 0.0419
Echinococcus granulosus 6 phosphofructokinase 0.0076 0.0762 0.0751
Echinococcus granulosus dnaJ subfamily B 0.0262 0.279 0.2782
Brugia malayi Heterochromatin protein 1 0.0045 0.0419 0.5425
Leishmania major cathepsin L-like protease 0.0012 0.006 0.0026
Echinococcus granulosus cytoplasmic intermediate filament protein 0.001 0.0043 0.0031
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0012 0.006 0.3334
Brugia malayi chromobox protein homolog 3 0.0025 0.0205 0.2574
Trichomonas vaginalis CMGC family protein kinase 0.0036 0.0322 0.0474
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0043 0.0528
Brugia malayi DnaJ domain containing protein 0.0039 0.036 0.4641
Schistosoma mansoni lipoxygenase 0.0076 0.0756 0.0756
Leishmania major cathepsin L-like protease 0.0045 0.0419 0.0579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.006 0.0074
Brugia malayi Latrophilin receptor protein 2 0.001 0.0042 0.0407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0419 0.0579
Echinococcus granulosus lipoxygenase domain containing protein 0.0013 0.007 0.0058
Onchocerca volvulus 0.0021 0.0162 0.2579
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.006 0.0074
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.001 0.0042 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0012 0.006 0.0074
Loa Loa (eye worm) hypothetical protein 0.0013 0.007 0.0884
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0419 0.0579
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0013 0.0071 0.0784
Loa Loa (eye worm) phosphofructokinase 0.0076 0.0762 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.001 0.0042 0.0031
Trichomonas vaginalis phosphofructokinase, putative 0.0076 0.0762 0.1148
Plasmodium falciparum LCCL domain-containing protein 0.0013 0.007 0.4017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.006 0.0074
Brugia malayi Cathepsin L-like precursor 0.0012 0.006 0.0642
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0076 0.0756 0.0745
Trypanosoma cruzi polo-like protein kinase, putative 0.0061 0.0596 0.0906
Schistosoma mansoni hypothetical protein 0.001 0.0042 0.0042
Echinococcus granulosus lamin 0.0021 0.0162 0.0151
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0021 0.0156 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.006 0.0754
Schistosoma mansoni hypothetical protein 0.0109 0.1116 0.1116
Brugia malayi Cytochrome P450 family protein 0.0017 0.0115 0.1374
Echinococcus multilocularis RUN 0.0013 0.007 0.0058
Toxoplasma gondii cathepsin CPL 0.0012 0.006 0.0772
Schistosoma mansoni hypothetical protein 0.0607 0.655 0.655
Giardia lamblia Kinase, PLK 0.0061 0.0596 0.081
Brugia malayi hypothetical protein 0.0013 0.007 0.0774
Brugia malayi latrophilin 2 splice variant baaae 0.0022 0.017 0.2111
Echinococcus granulosus mitogen activated protein kinase 3 0.0036 0.0322 0.031
Echinococcus granulosus chromobox protein 1 0.0045 0.0419 0.0408
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0043 0.0031
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0058 0.0562 0.055
Schistosoma mansoni hypothetical protein 0.0058 0.0562 0.0562
Onchocerca volvulus 0.0041 0.0378 0.6273
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0033 0.0033
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0058 0.0562 0.0562
Brugia malayi Cathepsin L-like precursor 0.0012 0.006 0.0642
Schistosoma mansoni apoptosis regulator bax 0.0058 0.0562 0.0562
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0113 0.0155
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0013 0.0071 0.4066
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0113 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0018 0.0009
Brugia malayi CXXC zinc finger family protein 0.0041 0.0378 0.4879
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0007 0.0012 0.0152
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0478
Schistosoma mansoni cpg binding protein 0.0043 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0008 0.0018 0.0198
Echinococcus granulosus bloom syndrome protein 0.0013 0.0071 0.0059
Brugia malayi Bloom's syndrome protein homolog 0.0013 0.0071 0.0784
Schistosoma mansoni hypothetical protein 0.001 0.0042 0.0042
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0113 0.0155
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0076 0.0762 0.3853
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0262 0.0383
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0055 0.0535 0.0524
Schistosoma mansoni cpg binding protein 0.0043 0.0403 0.0403
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0025 0.0205 0.3309
Onchocerca volvulus 0.0008 0.0018 0.0102
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.001 0.0037 0.0025
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0419 0.0623
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0061 0.0596 0.0585
Schistosoma mansoni aldehyde dehydrogenase 0.0039 0.0356 0.0356
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0109 0.1116 0.1116
Plasmodium vivax multidomain scavenger receptor, putative 0.0013 0.007 0.4468
Leishmania major ATP-dependent phosphofructokinase 0.0076 0.0762 0.1106
Echinococcus multilocularis lamin dm0 0.0021 0.0162 0.0151
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0036 0.0322 0.0429
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0003 0.0004
Entamoeba histolytica cysteine protease, putative 0.0012 0.006 0.0092
Brugia malayi Cathepsin L-like precursor 0.0008 0.0018 0.0079
Schistosoma mansoni hypothetical protein 0.0055 0.0535 0.0535
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.007 0.0058
Entamoeba histolytica phosphofructokinase, putative 0.0076 0.0762 0.1164
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0013 0.0071 0.0059
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0007 0.0012 0.0152
Echinococcus multilocularis geminin 0.0109 0.1116 0.1106
Echinococcus multilocularis bloom syndrome protein 0.0013 0.0071 0.0059
Loa Loa (eye worm) cysteine protease 0.0012 0.006 0.0754
Entamoeba histolytica hypothetical protein 0.0007 0.0012 0.0018
Echinococcus granulosus RUN 0.0013 0.007 0.0058
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0036 0.0322 0.0487
Schistosoma mansoni cpg binding protein 0.0041 0.0378 0.0378
Trypanosoma brucei protein kinase, putative 0.0036 0.0322 0.0429
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0021 0.0156 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0018 0.0198
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.012
Plasmodium falciparum cysteine proteinase falcipain 3 0.0012 0.006 0.3334
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.2205
Schistosoma mansoni lamin 0.0021 0.0162 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0596 0.0893
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0043 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0033 0.0033
Brugia malayi 6-phosphofructokinase 0.0076 0.0762 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0092 0.093 1
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0322 0.0322
Leishmania major cathepsin L-like protease 0.0045 0.0419 0.0579
Trichomonas vaginalis chromobox protein, putative 0.0027 0.0226 0.0327
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.001 0.0037 0.0025
Trichomonas vaginalis protein kinase inhibitor, putative 0.0039 0.036 0.0533
Schistosoma mansoni rab6-interacting 0.0013 0.007 0.007
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0036 0.0322 0.414
Entamoeba histolytica hypothetical protein 0.0055 0.0535 0.0817
Onchocerca volvulus Cathepsin L homolog 0.0012 0.006 0.0826
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0036 0.0322 0.0429
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0066 0.0083
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0003 0.0035
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0478
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0596 0.0596
Schistosoma mansoni hypothetical protein 0.0039 0.036 0.036
Entamoeba histolytica hypothetical protein 0.0007 0.0012 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0021 0.0156 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0607 0.655 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0012 0.006 0.3334
Plasmodium vivax heterochromatin protein 1, putative 0.0007 0.0012 0.0753
Echinococcus multilocularis Polycystic kidney disease protein 0.0013 0.007 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.006 0.0074
Echinococcus granulosus cathepsin L cysteine proteinase 0.0012 0.006 0.0048
Brugia malayi hypothetical protein 0.0055 0.0535 0.6977
Loa Loa (eye worm) 6-phosphofructokinase 0.0076 0.0762 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0021 0.0162 0.2102
Leishmania major cathepsin L-like protease 0.0012 0.006 0.0026
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0036 0.0322 0.0429
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0607 0.655 1
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0596 0.0893
Trypanosoma cruzi cysteine peptidase, putative 0.0012 0.006 0.0088
Schistosoma mansoni microtubule-associated protein tau 0.0924 1 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0061 0.0596 0.085
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0007 0.0012 0.00000000005717
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0071 0.009
Loa Loa (eye worm) hypothetical protein 0.001 0.0043 0.0534
Loa Loa (eye worm) helicase 0.0007 0.0012 0.012
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0018 0.0027
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0036 0.0322 0.4198
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0071 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0033 0.0033
Echinococcus granulosus geminin 0.0109 0.1116 0.1106
Loa Loa (eye worm) histone methyltransferase 0.0013 0.007 0.0887
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0021 0.0156 0.0221
Brugia malayi phosphofructokinase 0.0076 0.0762 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.001 0.0042 0.0031
Echinococcus granulosus Polycystic kidney disease protein 0.0013 0.007 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0066 0.0083
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0055 0.0535 0.0524
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0039 0.0356 0.0345
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0115 0.1477
Entamoeba histolytica serine/threonine protein kinase, putative 0.0061 0.0596 0.0909
Echinococcus granulosus cathepsin l1 0.0008 0.0018 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.00000000008734
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0011 0.0055 0.0695
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0043 0.0043
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0012 0.006 0.0754
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0071 0.009
Brugia malayi Cathepsin L-like precursor 0.0008 0.0018 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.3656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0419 0.0579
Brugia malayi Doublecortin family protein 0.0013 0.007 0.0774
Schistosoma mansoni polycystin 1-related 0.0013 0.007 0.007
Entamoeba histolytica hypothetical protein, conserved 0.0607 0.655 1
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0419 0.0636
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.006 0.0074
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0039 0.0356 0.0482
Loa Loa (eye worm) fibroinase 0.0012 0.006 0.0754
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0419 0.0579
Toxoplasma gondii aldehyde dehydrogenase 0.0039 0.0356 0.4587
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0419 0.0636
Echinococcus granulosus mitogen activated protein kinase 0.0036 0.0322 0.031
Loa Loa (eye worm) intermediate filament protein 0.0021 0.0162 0.2102
Schistosoma mansoni hypothetical protein 0.0007 0.0012 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0113 0.0155
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0013 0.0071 0.4066
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0125 0.0174
Plasmodium vivax vivapain-2 0.0012 0.006 0.3836
Brugia malayi CHD4 protein 0.001 0.0037 0.0339
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0043 0.0031

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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