Detailed information for compound 926989

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 345.481 | Formula: C23H27N3
  • H donors: 0 H acceptors: 1 LogP: 5.09 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)n1c(C[C@H]2CCCN3[C@@H]2CCCC3)nc2c1cccc2
  • InChi: 1S/C23H27N3/c1-2-10-19(11-3-1)26-22-14-5-4-12-20(22)24-23(26)17-18-9-8-16-25-15-7-6-13-21(18)25/h1-5,10-12,14,18,21H,6-9,13,15-17H2/t18-,21-/m1/s1
  • InChiKey: PFHCXDJMWPEVPE-WIYYLYMNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis tubulin alpha chain, putative 0.0588 0.5534 0.5469
Brugia malayi tubulin alpha-2 chain 0.0784 0.7423 0.7423
Echinococcus multilocularis Tubulin alpha 1 chain 0.0784 0.7423 0.7421
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0323 0.0315
Brugia malayi PHD-finger family protein 0.0028 0.0156 0.0156
Brugia malayi Cell division protein ftsZ 0.0269 0.2471 0.2471
Brugia malayi Bromodomain containing protein 0.0031 0.0178 0.0178
Trichomonas vaginalis tubulin, putative 0.0323 0.2988 0.2887
Leishmania major beta tubulin 0.1052 1 1
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0156 0.0156
Echinococcus multilocularis hypothetical protein 0.0784 0.7423 0.7421
Plasmodium vivax delta tubulin, putative 0.0269 0.2471 0.2389
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0038 0.0038
Giardia lamblia Alpha-tubulin 0.0784 0.7423 0.7382
Mycobacterium leprae cell division protein FtsZ 0.0269 0.2471 1
Echinococcus granulosus tubulin alpha chain 0.0784 0.7423 0.7421
Echinococcus multilocularis chromobox protein 1 0.0068 0.0536 0.0529
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0235 0.0228
Toxoplasma gondii alpha tubulin TUBA1 0.0784 0.7423 0.7394
Leishmania major beta tubulin 0.1052 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0372 0.0372
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0513 0.0513
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0212 0.0071
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0235 0.0235
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0109 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0249 0.0109
Trichomonas vaginalis tubulin beta chain, putative 0.0784 0.7423 0.7385
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.013 0.0022
Schistosoma mansoni tubulin subunit delta 0.0269 0.2471 0.2466
Echinococcus multilocularis tubulin beta 1 chain 0.1052 1 1
Loa Loa (eye worm) alpha-tubulin 0.0784 0.7423 0.7423
Loa Loa (eye worm) hypothetical protein 0.0035 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.003 0.017 0.017
Giardia lamblia Delta tubulin 0.0269 0.2471 0.2352
Echinococcus granulosus Tubulin beta 2C chain 0.1052 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0784 0.7423 0.7421
Toxoplasma gondii tubulin, putative 0.0053 0.0391 0.0286
Loa Loa (eye worm) hypothetical protein 0.0042 0.0283 0.0283
Treponema pallidum cell division protein FtsZ 0.0269 0.2471 0.5
Echinococcus granulosus tubulin beta 1 chain 0.1052 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.0641 0.6042 0.6042
Leishmania major alpha tubulin 0.0784 0.7423 0.7423
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0323 0.0315
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0848 0.0716
Echinococcus granulosus tubulin gamma 1 chain 0.0642 0.605 0.6047
Echinococcus granulosus mitogen activated protein kinase 0.01 0.0848 0.0841
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0848 0.0716
Loa Loa (eye worm) hypothetical protein 0.0037 0.0243 0.0243
Echinococcus granulosus geminin 0.0173 0.1547 0.1541
Toxoplasma gondii beta tubulin 0.1052 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0188
Trypanosoma cruzi tubulin delta chain 0.0601 0.5659 0.5659
Leishmania major delta tubulin, putative 0.0601 0.5659 0.5659
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0267 0.026
Echinococcus multilocularis tubulin alpha 3 chain 0.0784 0.7423 0.7421
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.2471 0.2363
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0212 0.0071
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0043 0.0035
Schistosoma mansoni tubulin subunit beta 0.1052 1 1
Echinococcus granulosus tubulin alpha 0.0588 0.5534 0.553
Brugia malayi SWIRM domain containing protein 0.0023 0.0109 0.0109
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0214 0.0206
Echinococcus multilocularis peroxisome assembly protein 26 0.0784 0.7423 0.7421
Brugia malayi Pre-SET motif family protein 0.0203 0.1835 0.1835
Leishmania major beta tubulin 0.1052 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0319 0.2945 0.2843
Trypanosoma brucei alpha tubulin 0.0784 0.7423 0.7423
Schistosoma mansoni hypothetical protein 0.0035 0.0217 0.021
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0443 0.0436
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0779 0.0772
Brugia malayi jmjC domain containing protein 0.0093 0.0779 0.0779
Brugia malayi Tubulin gamma chain 0.0642 0.605 0.605
Leishmania major beta tubulin 0.1052 1 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0023 0.0109 0.0109
Echinococcus granulosus Tubulin beta 2C chain 0.1052 1 1
Schistosoma mansoni tubulin subunit beta 0.0269 0.2471 0.2466
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0513 0.0513
Brugia malayi Tubulin alpha chain 0.0784 0.7423 0.7423
Echinococcus multilocularis beta tubulin 0.1052 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.1052 1 1
Onchocerca volvulus 0.003 0.017 0.0216
Schistosoma mansoni hypothetical protein 0.002 0.0076 0.0069
Echinococcus multilocularis tubulin alpha chain 0.0784 0.7423 0.7421
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0232 0.0224
Schistosoma mansoni bromodomain containing protein 0.0062 0.0476 0.0469
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0038 0.0037
Trichomonas vaginalis tubulin beta chain, putative 0.0319 0.2945 0.2843
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.013 0.013
Leishmania major beta tubulin 0.1052 1 1
Echinococcus multilocularis tubulin alpha 0.0588 0.5534 0.553
Echinococcus granulosus Tubulin beta 2C chain 0.1052 1 1
Leishmania major alpha tubulin 0.0784 0.7423 0.7423
Trichomonas vaginalis tubulin epsilon chain, putative 0.1052 1 1
Loa Loa (eye worm) tubulin beta-4 chain 0.1052 1 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0466 0.436 0.436
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.003
Echinococcus granulosus peroxisome assembly protein 26 0.0784 0.7423 0.7421
Leishmania major alpha tubulin 0.0784 0.7423 0.7423
Echinococcus multilocularis Tubulin beta 2C chain 0.1052 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.01 0.0848 0.0847
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0515 0.4834 0.4834
Trypanosoma cruzi ISWI complex protein 0.0015 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0323 0.0323
Trichomonas vaginalis tubulin alpha chain, putative 0.1052 1 1
Brugia malayi jmjC domain containing protein 0.0036 0.0232 0.0232
Echinococcus multilocularis tubulin alpha chain 0.0784 0.7423 0.7421
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0248 0.024
Plasmodium falciparum alpha tubulin 2 0.0784 0.7423 0.7394
Leishmania major alpha tubulin 0.0784 0.7423 0.7423
Trypanosoma cruzi tubulin delta chain 0.0601 0.5659 0.5659
Brugia malayi Bromodomain containing protein 0.0073 0.0586 0.0586
Brugia malayi tubulin alpha chain - mouse 0.0784 0.7423 0.7423
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0094 0.0087
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0038 0.003
Trypanosoma brucei epsilon tubulin 0.0641 0.6042 0.6042
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0372 0.0372
Echinococcus granulosus chromobox protein 1 0.0068 0.0536 0.0529
Onchocerca volvulus 0.0231 0.2105 0.704
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.013 0.013
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0269 0.2471 0.5
Trypanosoma cruzi zeta tubulin, putative 0.0824 0.7801 0.7801
Schistosoma mansoni alpha tubulin 0.0784 0.7423 0.7421
Plasmodium vivax SET domain protein, putative 0.0029 0.0163 0.0055
Brugia malayi Pre-SET motif family protein 0.0029 0.0163 0.0163
Toxoplasma gondii beta-tubulin, putative 0.1052 1 1
Leishmania major beta tubulin 0.1052 1 1
Plasmodium falciparum tubulin delta chain, putative 0.0269 0.2471 0.2389
Loa Loa (eye worm) BEN-1 protein 0.1052 1 1
Giardia lamblia Beta tubulin 0.1052 1 1
Trypanosoma brucei protein kinase, putative 0.01 0.0848 0.0847
Echinococcus multilocularis 0.0023 0.0109 0.0101
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.01 0.0848 0.0847
Echinococcus granulosus Tubulin alpha 1 chain 0.0784 0.7423 0.7421
Echinococcus multilocularis zinc finger protein 0.0019 0.0066 0.0059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0038 0.0037
Leishmania major zeta tubulin, putative 0.0824 0.7801 0.7801
Schistosoma mansoni chromobox protein 0.0068 0.0536 0.0529
Leishmania major beta tubulin 0.1052 1 1
Echinococcus granulosus zinc finger protein 0.0019 0.0066 0.0059
Trypanosoma cruzi tubulin gamma chain 0.0642 0.605 0.605
Leishmania major beta tubulin 0.1052 1 1
Brugia malayi alpha-tubulin 0.0784 0.7423 0.7423
Echinococcus multilocularis tubulin alpha chain 0.0784 0.7423 0.7421
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0319 0.2945 0.2843
Loa Loa (eye worm) hypothetical protein 0.004 0.0265 0.0265
Trichomonas vaginalis tubulin beta chain, putative 0.0784 0.7423 0.7385
Echinococcus granulosus tubulin alpha 1C chain 0.0784 0.7423 0.7421
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0156 0.0149
Trypanosoma brucei alpha tubulin, putative 0.0319 0.2945 0.2945
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0048 0.0048
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0779 0.0772
Echinococcus granulosus peregrin 0.0031 0.0178 0.0171
Leishmania major alpha tubulin 0.0784 0.7423 0.7423
Loa Loa (eye worm) tubulin alpha chain 0.0784 0.7423 0.7423
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0043 0.0035
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1835 0.1835
Leishmania major beta tubulin 0.1052 1 1
Plasmodium falciparum phd finger protein, putative 0.0028 0.0156 0.0048
Plasmodium falciparum tubulin beta chain 0.1052 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0108
Leishmania major alpha tubulin 0.0784 0.7423 0.7423
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0466 0.436 0.4279
Echinococcus granulosus tubulin epsilon chain 0.0641 0.6042 0.6039
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0448 0.0447
Schistosoma mansoni alpha tubulin 0.0784 0.7423 0.7421
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.022 0.0212
Brugia malayi Tubulin beta chain 0.0269 0.2471 0.2471
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0163 0.0155
Leishmania major beta tubulin 0.1052 1 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0043 0.0035
Schistosoma mansoni zinc finger protein 0.0019 0.0066 0.0059
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0163 0.0155
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0108
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0156 0.0048
Loa Loa (eye worm) hypothetical protein 0.0466 0.436 0.436
Schistosoma mansoni tubulin subunit alpha 0.0784 0.7423 0.7421
Onchocerca volvulus 0.0319 0.2945 1
Echinococcus multilocularis Tubulin beta 2C chain 0.1052 1 1
Leishmania major beta tubulin 0.1052 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0784 0.7423 0.7421
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0094 0.0087
Leishmania major beta tubulin 0.1052 1 1
Loa Loa (eye worm) hypothetical protein 0.0515 0.4834 0.4834
Trichomonas vaginalis tubulin epsilon chain, putative 0.0784 0.7423 0.7385
Echinococcus granulosus chromobox protein 1 0.0068 0.0536 0.0529
Giardia lamblia Beta tubulin 0.1052 1 1
Trypanosoma brucei ISWI complex protein 0.0015 0.0026 0.0026
Trichomonas vaginalis tubulin beta chain, putative 0.0784 0.7423 0.7385
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0513 0.0506
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0108
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0513 0.0513
Echinococcus granulosus beta tubulin 0.1052 1 1
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0267 0.026
Trypanosoma brucei beta tubulin 0.1052 1 1
Loa Loa (eye worm) tubulin beta chain 0.0269 0.2471 0.2471
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.022 0.0212
Schistosoma mansoni tubulin subunit beta 0.1052 1 1
Schistosoma mansoni amine oxidase 0.0023 0.0109 0.0101
Leishmania major hypothetical protein, conserved 0.0026 0.013 0.013
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0235 0.0235
Trichomonas vaginalis tubulin alpha chain, putative 0.0319 0.2945 0.2843
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0443 0.0436
Echinococcus granulosus tubulin delta chain 0.0269 0.2471 0.2466
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0248 0.024
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.0848 0.0847
Trypanosoma brucei alpha tubulin 0.0784 0.7423 0.7423
Echinococcus multilocularis protoporphyrinogen oxidase 0.0023 0.0109 0.0101
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.01 0.0848 0.0847
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0109 0.0101
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.003
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.003
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0513 0.0506
Entamoeba histolytica tubulin gamma chain 0.0642 0.605 0.5836
Trichomonas vaginalis tubulin epsilon chain, putative 0.0784 0.7423 0.7385
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0038 0.003
Schistosoma mansoni hypothetical protein 0.0173 0.1547 0.1541
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0152 0.0145
Trypanosoma brucei beta tubulin 0.1052 1 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0513 0.0513
Leishmania major beta tubulin 0.1052 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.013 0.0022
Echinococcus multilocularis tubulin alpha chain 0.0784 0.7423 0.7421
Echinococcus multilocularis tubulin epsilon chain 0.0641 0.6042 0.6039
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0008 0.0007
Echinococcus multilocularis mitogen activated protein kinase 0.01 0.0848 0.0841
Schistosoma mansoni tubulin subunit beta 0.1052 1 1
Trypanosoma brucei epsilon tubulin 0.0641 0.6042 0.6042
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.013 0.0022
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0372 0.0372
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0848 0.0716
Echinococcus multilocularis tubulin delta chain 0.0269 0.2471 0.2466
Echinococcus multilocularis tubulin gamma 1 chain 0.0642 0.605 0.6047
Echinococcus granulosus tubulin beta 4A class IVa 0.1052 1 1
Loa Loa (eye worm) alpha-tubulin 0.0784 0.7423 0.7423
Plasmodium falciparum alpha tubulin 1 0.0784 0.7423 0.7394
Schistosoma mansoni zinc finger protein 0.0015 0.0026 0.0019
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2105 0.1991
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0536 0.0536
Trypanosoma cruzi epsilon tubulin, putative 0.0641 0.6042 0.6042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0352 0.0351
Trichomonas vaginalis tubulin beta chain, putative 0.0784 0.7423 0.7385
Schistosoma mansoni chromobox protein 0.0068 0.0536 0.0529
Giardia lamblia Alpha-tubulin 0.0784 0.7423 0.7382
Loa Loa (eye worm) BEN-1 protein 0.1052 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0269 0.2471 0.2363
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0277 0.0137
Echinococcus multilocularis tubulin alpha 1C chain 0.0784 0.7423 0.7421
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0515 0.4834 0.4759
Loa Loa (eye worm) tubulin alpha 2 0.0196 0.1772 0.1771
Loa Loa (eye worm) beta-tubulin 0.1052 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.027 0.0262
Mycobacterium ulcerans cell division protein FtsZ 0.0269 0.2471 0.7997
Loa Loa (eye worm) hypothetical protein 0.0028 0.0156 0.0156
Chlamydia trachomatis protoporphyrinogen oxidase 0.0023 0.0109 0.5
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0513 0.0513
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0108
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0019
Trichomonas vaginalis tubulin gamma chain, putative 0.1052 1 1
Trypanosoma brucei epsilon tubulin 0.0588 0.5534 0.5534
Echinococcus multilocularis tubulin subunit TubB 0.0784 0.7423 0.7421
Loa Loa (eye worm) hypothetical protein 0.0784 0.7423 0.7423
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.003
Entamoeba histolytica tubulin alpha chain, putative 0.0784 0.7423 0.7283
Plasmodium vivax tubulin beta chain, putative 0.1052 1 1
Brugia malayi Bromodomain containing protein 0.0037 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0069 0.0546 0.0546
Trichomonas vaginalis tubulin alpha chain, putative 0.0319 0.2945 0.2843
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0269 0.2471 0.2363
Brugia malayi hypothetical protein 0.0017 0.0043 0.0043
Echinococcus multilocularis GPCR, family 2 0.0016 0.0038 0.003
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0536 0.04
Echinococcus multilocularis Tubulin alpha 1 chain 0.0784 0.7423 0.7421
Trichomonas vaginalis tubulin beta chain, putative 0.0784 0.7423 0.7385
Schistosoma mansoni tubulin subunit alpha 0.0784 0.7423 0.7421
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0277 0.0594
Giardia lamblia Kinase, CMGC MAPK 0.01 0.0848 0.0702
Trypanosoma cruzi alpha tubulin, putative 0.0784 0.7423 0.7423
Leishmania major alpha tubulin 0.0784 0.7423 0.7423
Leishmania major hypothetical protein, conserved 0.0015 0.0026 0.0026
Trypanosoma brucei zeta tubulin 0.0824 0.7801 0.7801
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0588 0.5534 0.5485
Brugia malayi Tubulin alpha-2 chain 0.0784 0.7423 0.7423
Trypanosoma cruzi ISWI complex protein 0.0015 0.0026 0.0026
Loa Loa (eye worm) tubulin beta-2A chain 0.1052 1 1
Schistosoma mansoni tubulin subunit beta 0.1052 1 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0076 0.0076
Entamoeba histolytica tubulin family protein 0.1052 1 1
Schistosoma mansoni tubulin subunit alpha 0.0269 0.2471 0.2466
Trypanosoma brucei alpha tubulin 0.0784 0.7423 0.7423
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0023 0.0109 0.0101
Leishmania major alpha tubulin 0.0784 0.7423 0.7423
Trypanosoma brucei beta tubulin 0.0588 0.5534 0.5534
Trichomonas vaginalis tubulin, putative 0.1052 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.1052 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.2471 0.2363
Loa Loa (eye worm) tubulin alpha 2 0.0515 0.4834 0.4834
Echinococcus multilocularis beta tubulin 0.1052 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0323 0.0315
Loa Loa (eye worm) tubulin beta-1 chain 0.1052 1 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0023 0.0109 0.0101
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0323 0.0315
Trypanosoma brucei tubulin delta chain 0.0601 0.5659 0.5659
Plasmodium falciparum tubulin epsilon chain, putative 0.0641 0.6042 0.5999
Plasmodium falciparum tubulin gamma chain 0.0642 0.605 0.6006
Brugia malayi Heterochromatin protein 1 0.0068 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0108
Plasmodium vivax tubulin epsilon chain, putative 0.0641 0.6042 0.5999
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0601 0.5659 0.5612
Schistosoma mansoni tubulin subunit gamma 0.0642 0.605 0.6047
Onchocerca volvulus Alhambra homolog 0.0028 0.0156 0.0168
Leishmania major beta tubulin 0.1052 1 1
Schistosoma mansoni tubulin subunit epsilon 0.0641 0.6042 0.6039
Trichomonas vaginalis tubulin gamma chain, putative 0.0642 0.605 0.5993
Entamoeba histolytica tubulin alpha-1 chain 0.0784 0.7423 0.7283
Trichomonas vaginalis tubulin epsilon chain, putative 0.1052 1 1
Onchocerca volvulus 0.004 0.027 0.0568
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0109 0.0108
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0038 0.003
Schistosoma mansoni tubulin subunit alpha 0.0784 0.7423 0.7421
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0249 0.0109
Echinococcus granulosus tubulin alpha chain 0.0784 0.7423 0.7421
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0232 0.0224
Brugia malayi MAP kinase sur-1 0.01 0.0848 0.0848
Echinococcus granulosus beta tubulin 0.1052 1 1
Echinococcus granulosus tubulin alpha chain 0.0784 0.7423 0.7421
Echinococcus granulosus Tubulin beta 2C chain 0.1052 1 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0269 0.2471 0.8573
Leishmania major UDP-galactopyranose mutase 0.0023 0.0109 0.0108
Trichomonas vaginalis tubulin beta chain, putative 0.0784 0.7423 0.7385
Trichomonas vaginalis tubulin, putative 0.0319 0.2945 0.2843
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0513 0.0513
Schistosoma mansoni tubulin subunit beta 0.1052 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0232 0.0224
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0784 0.7423 0.7385
Echinococcus granulosus tubulin alpha chain 0.0784 0.7423 0.7421
Echinococcus granulosus tubulin alpha chain 0.0784 0.7423 0.7421
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.01 0.0848 0.0747
Plasmodium vivax tubulin alpha chain, putative 0.0784 0.7423 0.7394
Echinococcus granulosus alpha tubulin 0.0784 0.7423 0.7421
Echinococcus multilocularis tubulin subunit beta 0.1052 1 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.01 0.0848 0.0847
Brugia malayi hypothetical protein 0.0023 0.0109 0.0109
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0536 0.04
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0277 0.0137
Trypanosoma brucei beta tubulin 0.1052 1 1
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0263 0.0256
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0163 0.0055
Toxoplasma gondii beta-1 tubulin, putative 0.1052 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.0784 0.7423 0.7421
Brugia malayi PHD-finger family protein 0.0024 0.0116 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0848 0.0841
Echinococcus granulosus GPCR family 2 0.0016 0.0038 0.003
Echinococcus multilocularis mitogen activated protein kinase 3 0.01 0.0848 0.0841
Echinococcus multilocularis tubulin alpha 1C chain 0.0784 0.7423 0.7421
Brugia malayi beta-tubulin, identical 0.1052 1 1
Echinococcus granulosus tubulin subunit beta 0.1052 1 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0156 0.0149
Echinococcus granulosus tubulin alpha 3 chain 0.0784 0.7423 0.7421
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.01 0.0848 0.0847
Trichomonas vaginalis tubulin beta chain, putative 0.1052 1 1
Brugia malayi Tubulin beta chain 0.0319 0.2945 0.2945
Echinococcus granulosus tubulin alpha 3 chain 0.0784 0.7423 0.7421
Schistosoma mansoni hypothetical protein 0.0028 0.0156 0.0149
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0372 0.0372
Trichomonas vaginalis tubulin gamma chain, putative 0.0269 0.2471 0.2363
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0094 0.0087
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0023 0.0109 0.0351
Echinococcus multilocularis Tubulin alpha 1 chain 0.0784 0.7423 0.7421
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0513 0.0506
Mycobacterium ulcerans dehydrogenase 0.0023 0.0109 0.0351
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.031 0.2865 1
Entamoeba histolytica tubulin family protein 0.1052 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.2095 0.2095
Leishmania major alpha tubulin 0.0784 0.7423 0.7423
Echinococcus granulosus Tubulin beta 2C chain 0.1052 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0156 0.0048
Schistosoma mansoni hypothetical protein 0.0173 0.1547 0.1541
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0043 0.0035
Loa Loa (eye worm) tubulin alpha 2 0.0515 0.4834 0.4834
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0109 0.0108
Toxoplasma gondii alpha-tubulin I, putative 0.0784 0.7423 0.7394
Plasmodium vivax tubulin alpha chain, putative 0.0784 0.7423 0.7394
Echinococcus multilocularis tubulin alpha chain 0.0784 0.7423 0.7421
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0249 0.0495
Loa Loa (eye worm) hypothetical protein 0.0026 0.013 0.013
Trypanosoma brucei alpha tubulin 0.0784 0.7423 0.7423
Trypanosoma brucei zeta tubulin, putative 0.0824 0.7801 0.7801
Plasmodium vivax tubulin gamma chain, putative 0.0642 0.605 0.6006
Leishmania major beta tubulin 0.1052 1 1
Echinococcus granulosus jumonji domain containing protein 0.004 0.0263 0.0256
Loa Loa (eye worm) tubulin gamma chain 0.0642 0.605 0.605
Brugia malayi CHD4 protein 0.0013 0.0008 0.0008
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0594 0.0587
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.013 0.0022
Trypanosoma brucei tubulin gamma chain 0.0642 0.605 0.605
Echinococcus multilocularis geminin 0.0173 0.1547 0.1541
Leishmania major beta tubulin 0.1052 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0641 0.6042 0.5985
Echinococcus granulosus tubulin subunit TubB 0.0784 0.7423 0.7421
Loa Loa (eye worm) tubulin alpha chain 0.0784 0.7423 0.7423
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0156 0.0149
Leishmania major alpha tubulin 0.0784 0.7423 0.7423
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0156 0.0048
Brugia malayi Tubulin alpha chain 0.0269 0.2471 0.2471
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.01 0.0848 0.0847
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0038 0.003
Mycobacterium ulcerans monoamine oxidase 0.0023 0.0109 0.0351
Schistosoma mansoni alpha tubulin 0.0784 0.7423 0.7421
Giardia lamblia Epsilon tubulin 0.0322 0.298 0.2869
Leishmania major gamma-tubulin 0.0642 0.605 0.605
Schistosoma mansoni amine oxidase 0.0023 0.0109 0.0101
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0038 0.0038
Trypanosoma cruzi beta tubulin, putative 0.1052 1 1
Loa Loa (eye worm) tubulin beta chain 0.1052 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.013 0.013
Echinococcus granulosus mitogen activated protein kinase 3 0.01 0.0848 0.0841
Echinococcus multilocularis Tubulin beta 2C chain 0.1052 1 1
Leishmania major alpha tubulin 0.0784 0.7423 0.7423
Trypanosoma brucei beta tubulin 0.1052 1 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.0536 0.0529
Leishmania major alpha tubulin 0.0784 0.7423 0.7423
Brugia malayi chromobox protein homolog 3 0.0038 0.0249 0.0249
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0334 0.3091 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0023 0.0109 0.0101
Brugia malayi Tubulin alpha-2 chain 0.0784 0.7423 0.7423
Echinococcus granulosus Tubulin alpha 1 chain 0.0784 0.7423 0.7421
Brugia malayi follicle stimulating hormone receptor 0.023 0.2095 0.2095
Loa Loa (eye worm) hypothetical protein 0.0038 0.0249 0.0249
Leishmania major epsilon tubulin, putative 0.0641 0.6042 0.6042
Giardia lamblia Beta tubulin 0.1052 1 1
Trypanosoma cruzi zeta tubulin, putative 0.0824 0.7801 0.7801
Leishmania major beta tubulin 0.1052 1 1
Brugia malayi hypothetical protein 0.0026 0.013 0.013
Mycobacterium ulcerans oxidoreductase 0.0023 0.0109 0.0351
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0322 0.298 0.2903
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0217 0.0217
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.0848 0.0847
Schistosoma mansoni tubulin subunit beta 0.1052 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0235 0.0228
Giardia lamblia Gamma tubulin 0.0642 0.605 0.5987
Loa Loa (eye worm) tubulin alpha-2 chain 0.0784 0.7423 0.7423
Leishmania major beta tubulin 0.1052 1 1
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0848 0.0716
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0232 0.0232
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0334 0.3091 1
Trichomonas vaginalis tubulin, putative 0.0319 0.2945 0.2843
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1052 1 1
Echinococcus multilocularis peregrin 0.0031 0.0178 0.0171

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 42 uM Cytotoxicity against mock-infected human MT4 cells after 96 hrs by MTT assay ChEMBL. 25082514

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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